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Biomedical and Environmental Sciences 2024年第4期37卷 418-422页

作者： ZHOU Jun yan yan dong Ya Wei LIU xiao Yu WANG Ping LIN Jia Ming dong Peng Xuan QUAN Rui WANG Rong Tian MI Bao Hong CHEN Wei Heng Beijing University of Chinese Medicine Third Affiliated Hospital Beijing 100029China Engineering Research Center of Chinese Orthopaedics and Sports Rehabilitation Artificial Intelligent Ministry of EducationBeijing 100029China Beijing Hepingli Community Health Service Center Beijing 100013China Minimally Invasive Joint Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China

Knee osteoarthritis(KOA)is a common progressive joint disease with chronic pain and movement disorders as the main clinical *** is a major public health problem worldwide and it imposes serious medical and economic *** accounts for nearly four-fifths of the global Osteoarthritis burden and increases with rising obesity and age[1].There are many reasons for the change in disease prevalence and risk factors,such as urbanization,lifestyle changes,population aging,and sex imbalances.

关键词： Osteoarthritis clinical obesity

Kinetic Resolution of Racemic 4-Substituted Chroman-2-ones Through Asymmetric Lactone Hydrogenation

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CCS Chemistry 2024年第10期6卷 2560-2576页

作者： Xiong Wu Hai-Tao Yue xiao-dong Zuo xiao-Hui yang Pu-Cha yan Jian-Hua Xie Qi-Lin Zhou State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryFrontiers Science Center for New Organic MatterNankai UniversityTianjin 300071 Zhejiang Jiuzhou Pharmaceutical Co. Ltd.TaizhouZhejiang 318000

Esters are abundant in natural and synthetic products and their conversion into primary alcohols holds great importance in fine chemical ***,achieving asymmetric hydrogenation(AH)of racemic esters with remote stereocenters via kinetic resolution(KR)remains a formidable challenge due to the difficulties associated with discerning spatially distant *** address this issue,we have designed a hydroxy-assisted strategy that introduces a hydroxy group into racemicβ-aryl esters to facilitate hydrogenation and enhance chiral discrimination through a lactone *** employing chiral Ir-SpiroPAP catalysts,we achieved exceptional AH of racemic 4-substituted chroman-2-ones,lactone form of ortho-hydroxylatedβ-aryl esters,via KR,resulting in impressive selectivity factor(s)values of up to *** approach exhibited significant efficacy for racemic chroman-2-ones containingβ-aryl,alkenyl,alkynyl,and alkyl groups,enabling the synthesis of chiralγ-aryl primary alcohols and the recovery of chiralβ-aryl esters or chroman-2-ones,typically difficult to access using existing *** scalability and broad synthetic applications of this method were exemplified by successfully synthesizing chiral drugs(R)-fesoterodine and enrasentan,alongside various chiral intermediates essential for producing chiral drugs and natural *** promising results highlight the potential of this approach as a powerful tool for synthesizing valuable chiral compounds.

关键词： asymmetric hydrogenation chiralγ-aryl primary alcohols hydrogenation of esters iridium catalysts kinetic resolution

Nanopore design of sulfur doped hollow carbon nanospheres for superior potassium-ion battery anodes

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Rare Metals 2024年第5期43卷 2103-2114页

作者： Zhen-dong Liu Hui-yan Feng Yu-Chen Wang Fei Wang Yue Liu Jian-xiao yang Yue Gu Jun Tan Chong Ye Cheng-Zhi Zhang Ji Hua Laboratory Foshan 528000China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology College of Materials Science and EngineeringHunan UniversityChangsha 410082China

Sulfur doped carbonaceous materials are promising anodes for potassium-ion batteries because of their ability to bridge active sites and induce C/S electron coupling,resulting in increased ion storage capacitance However,the large potassium ions could cause significant volume expansion and structure collapse during operation in sulfur doped carbonaceous anodes,which lead to rapidly capacity sacrifice during long-term *** design for anchoring sulfur atom in carbon skeleton is a novel way to alleviate the structure collapse and maintain the cycling ***,this study developed a controlled nanopore and sulfur doped carbon sphere structure(S-NPHCSs).In potassium-ion batteries S-NPHCSs anode demonstrated exceptional performance with a high reversible capacity of 247 mAh·g^(–1)after 50 cycles at 0.2 A·g^(–1)and delivered a long cycle stability of 600 cycles at a high current density of 1.0 A·g^(–1).Interconnected nanopores and doped sulfur structure not only expand the accumulation space and offer ample active sites for diffusion and adsorption of potassium ions,but also build stable channels through nanopore structure to ensure the cyclic *** finding provides a fundamental theory for designing nanopore structures and introducing sulfur doped carbonaceous materials to enhance capacitive potassium storage and long cycle stability.

关键词： Nanopore Carbon materials Sulfur doping Anode Potassium-ionbatteries

Demyelinating neuropathy in patients with hepatitis B virus: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1766-1771页

作者： xiao-xiao yan Jin Huang Jing Lin Department of Neurology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Hepatitis B rarely leads to demyelinating neuropathy,despite peripheral neuropathy being the first symptom of hepatitis B *** SUMMARY A 64-year-old man presented with sensorimotor symptoms in multiple peripheral *** testing showed that these symptoms were due to hepatitis *** undergoing treatment involving intravenous immunoglobulin and an antiviral agent,there was a notable improvement in his *** Although hepatitis B virus(HBV)infection is known to affect hepatocytes,it is crucial to recognize the range of additional manifestations linked to this *** connection between long-term HBV infection and demyelinating neuropathy has seldom been documented;hence,prompt diagnostic and treatment are *** patient's positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.

关键词： Hepatitis B virus infection Extrahepatic manifestations Demyelinating neuropathy Intravenous immunoglobulin Electroneuromyography Case report

Chemical components in cultivated Cordyceps sinensis and their effects on fibrosis

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Chinese Herbal Medicines 2024年第1期16卷 162-167页

作者： Zhonghua dong xiao Sun Department of Clinical Pharmacy The First Affiliated Hospital of Shandong First Medical University&Shandong Provincial Qianfoshan HospitalShandong Engineering and Technology Research Center for Pediatric Drug DevelopmentShandong Medicine and Health Key Laboratory of Clinical PharmacyJinan 250014China Department of Emergency Medicine Qilu Hospital of Shandong UniversityJinan 250012China Shandong Provincial Clinical Research Center for Emergency and Critical Care Medicine Institute of Emergency and Critical Care Medicine of Shandong UniversityChest Pain CenterQilu Hospital of Shandong UniversityJinan 250012China Key Laboratory of Emergency and Critical Care Medicine of Shandong Province Key Laboratory of Cardiopulmonary-Cerebral Resuscitation Research of Shandong ProvinceShandong Provincial Engineering Laboratory for Emergency and Critical Care MedicineShandong Key Laboratory:Magnetic Field-free Medicine&Functional ImagingQilu Hospital of Shandong UniversityJinan 250012China NMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug Qilu Hospital of Shandong UniversityJinan 250012China

Objective:Cultivated Cordyceps sinensis powder has been used as clinical drug and healthy food to nourish the lung and kidney,which solves the problem of serious shortage of wild *** study aims to explore the chemical components and compared their anti-fibrotic effects in cultivated ***:Nucleosides,sterols and polysaccharides were separated and purified from cultivated ***,and analyzed by high performance liquid chromatography,gas chromatography-mass spectrometry and chemical chromogenic methods,*** high glucose-induced rat mesangial cell models,fibronectin and type 1 collagen were used as evaluation ***:There were 10 kinds of nucleosides and one sterol in cultivated *** contents of nucleosides,sterols and polysaccharides in the cultivated *** were close to 2%,0.55%and 4.4%,***,nucleoside,sterol and polysaccharide components exhibited varying degrees of antifibrotic *** nucleoside components and sterol components inhibited the expression of extracellular matrix more effectively in the three main ***:Cultivated *** remains the similar compounds with the wild ***,and nucleosides and sterols may be the main active substances that contribute to its anti-fibrotic *** project of this study may provide valuable information on further optimization of more effective remedies with few side effects based on cultivated ***.

关键词： anti-fibrotic effects cultivated Cordyceps sinensis ergosterol nucleosides polysaccharides

Field-based evidence for the enrichment of intrinsic antibiotic resistome stimulated by plant-derived fertilizer in agricultural soil

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Journal of Environmental Sciences 2024年第1期135卷 728-740页

作者： Shihai Liu Ziming Han dong Zhu xiao Luan Liujie Deng Liping dong Min yang Yu Zhang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China State Environmental Protection Engineering Center for Harmless Treatment and Resource Utilization of Antibiotic Residues Khorgos 835007China University of Chinese Academy of Sciences Beijing 100049China

Animal manures have been demonstrated to enhance antibiotic resistance in agricultural ***,little is known about the effects of plant-derived fertilizer on soil antibiotic ***,metagenomic sequencing was used to investigate the effects of a plantderived fertilizer processed from sugarcane and beet on soil antibiotic resistance genes(ARGs)in a soybean field along crop growth *** profiles in the soils amended by plant-derived fertilizer were compared with those in the soils amended by chicken *** abundance and diversity of total ARGs in the soils amended by plant-derived fertilizer were significantly(P<0.05)elevated at the sprout stage,to a level comparable to that in the manured ***,unlike chicken manure mainly introducing manure-borne ARGs to soil,the plant-derived fertilizer was indicated to mainly enrich multidrug resistance genes in soil by nourishing indigenous *** with abundances in amended soils significantly(P<0.05)higher than in unamended soils at the sprout stage of soybean were considered as enriched *** in the abundance of the enriched ARGs was observed in both the amended soils from the sprout to the *** analysis further identified Proteobacteria and Bacteroidetes as the primary bacterial taxa involved in the temporal variation of the enriched ARGs in the soils amended by plant-derived fertilizer,while in manured soils were Firmicutes and *** revealed by multivariate statistical analyses,variation of the enriched ARGs in the soils amended by plant-derived fertilizer was majorly attributed to the response of co-occurred bacteria to depleting nutrients,which was different from the failed establishment of manure-borne bacteria in the manured *** study provided field-based evidence that plant-derived fertilizer stimulated the intrinsic antibiotic resistome,and proposed attention to the un-perceived risk since some clinically relevant ARGs originate and evolve fr

关键词： Organic fertilizer Intrinsic antibiotic resistance Indigenous bacteria Metagenomic sequencing

A Hybrid Level Set Optimization Design Method of Functionally Graded Cellular Structures Considering Connectivity

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Computers, Materials & Continua 2024年第4期79卷 1-18页

作者： yan dong Kang Zhao Liang Gao Hao Li The State Key Lab of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074China Institute of Systems Engineering China Academy of Engineering PhysicsMianyang621900China

With the continuous advancement in topology optimization and additive manufacturing(AM)technology,the capability to fabricate functionally graded materials and intricate cellular structures with spatially varying microstructures has grown ***,a critical challenge is encountered in the design of these structures–the absence of robust interface connections between adjacent microstructures,potentially resulting in diminished efficiency or macroscopic failure.A Hybrid Level Set Method(HLSM)is proposed,specifically designed to enhance connectivity among non-uniform microstructures,contributing to the design of functionally graded cellular *** HLSM introduces a pioneering algorithm for effectively blending heterogeneous microstructure ***,an interpolation algorithm is presented to construct transition microstructures seamlessly connected on both ***,the algorithm enables the morphing of non-uniform unit cells to seamlessly adapt to interconnected adjacent *** method,seamlessly integrated into a multi-scale topology optimization framework using the level set method,exhibits its efficacy through numerical examples,showcasing its prowess in optimizing 2D and 3D functionally graded materials(FGM)and multi-scale topology *** essence,the pressing issue of interface connections in complex structure design is not only addressed but also a robust methodology is introduced,substantiated by numerical evidence,advancing optimization capabilities in the realm of functionally graded materials and cellular structures.

关键词： Hybrid level set method functionally graded cellular structure connectivity interpolated transition optimization design

Regulated reaction pathway of CO_(2)photoreduction into CH_(4)by metal atom pair sites

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Rare Metals 2024年第9期43卷 4620-4627页

作者： dong-Po He Guang-Bing Huang Jun Hu yang Wu xiao-dong Li Qing-Xia Chen Shan Zhu Wen-Sheng yan Jun-Fa Zhu yang Pan Xing-Chen Jiao Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringJiangnan UniversityWuxi 214122China Hefei National Research Center for Physical Sciences at Microscale National Synchrotron Radiation LaboratoryUniversity of Science and Technology of ChinaHefei 230026China Max Planck Institute of Microstructure Physics Weinberg 206120 HalleGermany State Grid Anhui Electric Power Research Institute Hefei 230601China

The carbon dioxide(CO_(2))reduction process involves complex protonation,making the resulting product often *** achieve the desired product,it is crucial to manipulate the reaction ***,we build the metal atom pair sites for selective CO_(2)photoreduction into *** a prototype,Ni atom pair sites loaded on the Mo S_(2)nanosheets were synthesized and verified by highresolution transmission electron microscopy(HRTEM),X-ray photoelectron spectroscopy(XPS)and X-rayabsorption near edge structure spectra(XANES).In-situ Fourier transform infrared spectroscopy(FTIR)monitors the*CHO group,a crucial intermediate in CH_(4)production,during CO_(2)photoreduction on the Ni-Mo S_(2)nanosheets,whereas this monitoring is not observed for the Mo S_(2)***,theoretical calculations disclose that over the Ni-Mo S_(2)nanosheet slab,the formation energy of*CHO intermediates is determined to be lower(0.585 e V)than the desorption energy of*CO intermediates for CO production(0.64 e V),implying the higher selectivity of CH_(4)production.

关键词： steps dioxide desired

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中间梁方式下压电式能量采集器发电性能研究

电子学报 2022年第2期50卷 404-414页

作者：闫晓东周公博江苏省矿山机电装备重点实验室江苏徐州221116 中国矿业大学机电工程学院江苏徐州221116

压电式能量采集器(Piezoelectric Energy Harvester,PEH)固定方式的改变会直接影响其发电性能,而传统悬臂梁固定方式(Cantilever Beam Fixed Mode,CBFM)调频范围窄且发电性能较差.为了使PEH的发电性能最大化,提出了一种适用于任意尺寸... 详细信息

压电式能量采集器(Piezoelectric Energy Harvester,PEH)固定方式的改变会直接影响其发电性能,而传统悬臂梁固定方式(Cantilever Beam Fixed Mode,CBFM)调频范围窄且发电性能较差.为了使PEH的发电性能最大化,提出了一种适用于任意尺寸压电片的中间梁固定方式(Intermediate Beam Fixed Mode,IBFM).同时,通过仿真和实验的方法研究了添加不同质量块后CBFM和IBFM两种固定方式的发电性能.结果表明,在相交频带处,与CBFM相比,采用IBFM后,PEH在单位加速度条件下最大开路电压和发电功率分别平均提升了95.19%和205.88%.此外,机电耦合系数(Electromechanical coupling coefficient,EMCC)平均提升了11.60%.因此,所提出的方法可以为PEH在不同频段处固定方式的选择提供指导.

关键词：压电式能量采集器发电性能悬臂梁固定方式中间梁固定方式相交频带

Understanding Discrepancy of Power System Dynamic Security Assessment with Unknown Faults: A Reliable Transfer Learning-based Method

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 427-431页

作者： Chao Ren Han Yu yan Xu Zhao yang dong School of Computer Science and Engineering Nanyang Technological UniversitySingapore School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore

This letter proposes a reliable transfer learning(RTL)method for pre-fault dynamic security assessment(DSA)in power systems to improve DSA performance in the presence of potentially related unknown *** takes individual discrepancies into consideration and can handle unknown faults with incomplete *** experiment results demonstrate high DSA accuracy and computational efficiency of the proposed RTL *** analysis shows RTL can guarantee system performance.

关键词： Adversarial training dynamic security assessment maximum classifier discrepancy missing data transfer learning