Demyelinating neuropathy in patients with hepatitis B virus: A case report

作     者：Xiao-Xiao Yan Jin Huang Jing Lin 

作者机构：Department of NeurologyThe Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第10期

页      面：1766-1771页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

主　　题：Hepatitis B virus infection Extrahepatic manifestations Demyelinating neuropathy Intravenous immunoglobulin Electroneuromyography Case report 

摘      要：BACKGROUND Hepatitis B rarely leads to demyelinating neuropathy,despite peripheral neuropathy being the first symptom of hepatitis B infection.CASE SUMMARY A 64-year-old man presented with sensorimotor symptoms in multiple peripheral nerves.Serological testing showed that these symptoms were due to hepatitis B.After undergoing treatment involving intravenous immunoglobulin and an antiviral agent,there was a notable improvement in his symptoms.CONCLUSION Although hepatitis B virus(HBV)infection is known to affect hepatocytes,it is crucial to recognize the range of additional manifestations linked to this infection.The connection between long-term HBV infection and demyelinating neuropathy has seldom been documented;hence,prompt diagnostic and treatment are essential.The patient s positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.