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Values of debulking surgery for unresectable well-differentiated metastatic pancreatic neuroendocrine tumors:a comparative study

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Gastroenterology Report 2023年第1期11卷 247-253页

作者： Xi-Tai Huang Jin-zhao Xie Liu-Hua Chen Jian-Peng Cai Wei Chen Li-Jian Liang Ning Zhang xiao-Yu Yin Department of Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background and objective:The value of debulking surgery for unresectable well-differentiated metastatic pancreatic neuroendocrine tumor(m-PNET)remains poorly *** study aimed to evaluate the outcomes of m-PNET following debulking surgery in our ***:Patients with well-differentiated m-PNET in our hospital between February 2014 and March 2022 were *** and long-term outcomes of patients treated with radical resection,debulking surgery,and conservative therapy were compared ***:Fifty-three patients with well-differentiated m-PNET were reviewed,including 47 patients with unresectable m-PNET(debulking surgery,25;conservative therapy,22)and 6 patients with resectable m-PNET(radical resection).Patients undergoing debulking surgery had a post-operative Clavien–DindoIII complication rate of 16.0%without *** 5-year overall survival(OS)rate of patients treated with debulking surgery was significantly higher than that of those treated with conservative therapy alone(87.5%vs 37.8%,log-rank P=0.022).Besides,the 5-year OS rate of patients treated with debulking surgery was comparable to that of patients with resectable m-PNET undergoing radical resection(87.5%vs 100%,log-rank P=0.724).Conclusions:Patients with unresectable well-differentiated m-PNET who underwent resection had better long-term outcomes than those who received conservative therapy *** 5-year OS of patients undergoing debulking surgery and radical resection were *** surgery could be considered for patients with unresectable well-differentiated m-PNET if no contraindication exists.

关键词： pancreatic neuroendocrine tumor metastasis debulking surgery prognosis

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Backflow Transformation for A=3 Nuclei with Artificial Neural Networks

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原子能科学技术 2023年第4期57卷 673-678页

作者： YANG Yilong zhao Pengwei State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

A novel variational wave function defined as a Jastrow factor multiplying a backflow transformed Slater determinant was developed for A=3 *** Jastrow factor and backflow transformation were represented by artificial neural *** this newly developed wave function,variational Monte Carlo calculations were carried out for3H and3He nuclei starting from a nuclear Hamiltonian based on the leadingorder pionless effective field *** obtained ground-state energy and charge radii were successfully benchmarked against the results of the highly-accurate hypersphericalharmonics *** backflow transformation plays a crucial role in improving the nodal surface of the Slater determinant and,thus,providing accurate ground-state energy.

关键词： nuclear many-body problem quantum Monte Carlo artificial neural network backflow transformation

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Revisit of GeV Gamma-Ray Emission from Orion B with the Fermi Large Area Telescope

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Research in Astronomy and Astrophysics 2024年第9期24卷 128-135页

作者： Wei Zeng xiao-Na Sun Rui-Zhi Yang Jia-Chun He zhao-Dong Shi Ting-Ting Ge Yun-Feng Liang En-Wei Liang Guangxi Key Laboratory for Relativistic Astrophysics School of Physics Science and TechnologyGuangxi UniversityNanning 530004China Department of Astronomy School of Physical SciencesUniversity of Science and Technology of ChinaHefei 230026China CAS Key Labrotory for Research in Galaxies and Cosmology University of Science and Technology of ChinaHefei 230026China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China School of Physics and Astronomy Sun Yat-sen UniversityZhuhai 519082China

We revisit the γ-ray emission above 300 Me V towards the massive star-forming region of Orion B by adopting14 yr observations with the Fermi Large Area Telescope and utilizing the updated software *** extended γ-ray emission region around Orion B is resolved into two components(region Ⅰ and region Ⅱ).The γ-ray spectrum of region I agrees with the predicted γ-ray spectrum assuming the cosmic ray(CR)density is the same as that of Alpha Magnetic Spectrometer(AMS-02)measured ***γ-ray emissivity of region II appears to be deficit at low energy band(E<3 GeV).Through modeling we find that CR densities exhibit a significant deficit below 20 Ge V,which may be caused by a slow diffusion inside the dense *** is probably caused by an increased magnetic field whose strength increases with the gas density.

关键词： (ISM:)cosmic rays gamma-rays:ISM (Galaxy:)open clusters and associations:individual(NGC 2023 NGC 2024 NGC 2068 and NGC 2071)

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PID control of uncertain nonlinear stochastic systems with state observer

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Science China(Information Sciences) 2021年第9期64卷 139-150页

作者： Xinrong CONG Cheng zhao School of Mathematics and Statistics Beijing Technology and Business University Research Center for Mathematics and Interdisciplinary Sciences Shandong University

The classical proportional-integral-derivative(PID) controller is ubiquitous in engineering systems that are typically nonlinear with various uncertainties, including random noise. However, most of the literature on PID control focused on linear deterministic systems. Thus, a theory that explains the rationale of the linear PID when dealing with nonlinear uncertain stochastic systems and a concrete design method that can provide explicit formulas for PID parameters are required. Recently, we have demonstrated that the PID controller can globally stabilize a class of second-order nonlinear uncertain stochastic systems, where the derivative of the system output is assumed to be obtainable, which is generally unrealistic in practical applications. This has motivated us to present some theoretical results on PID control with a state observer for nonlinear uncertain stochastic systems. Specifically, a five-dimensional parameter manifold can be explicitly constructed, within which the three PID parameters and two observer gain parameters can be arbitrarily selected to globally stabilize nonlinear uncertain stochastic systems, as long as some knowledge about the unknown nonlinear drift and diffusion terms is available.

关键词： PID controller system uncertainty nonlinear stochastic systems global stability state observer

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Discussion on the Mechanism of Source Integration between Solar Energy and Biomass Energy with Similar Grades

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Journal of Thermal Science 2021年第5期30卷 1607-1613页

作者： zhao Li SU Dandan Key Laboratory of Efficient Utilization of Low and Medium Grade Energy(Tianjin University) Ministry of Education of ChinaTianjin300350China

The clean transformation of the China’s energy structure is related to the establishment of China as an energy power in the new world *** multi-energy systems based on renewable energy,especially solar energy and biomass energy,have become a popular energy supply ***,there is no clear theoretical guidance for the quantitative source integration of these two types of clean ***,whether the source grades of solar energy and biomass energy are similar in different solar energy modes has not been considered *** at this problem,based on the theory of space-time unity of the special theory of relativity,a new principle of source integration is proposed,and the corresponding mathematical model is *** theoretical calculation of the combination of solar energy and different types of biomass energy is carried *** the premise of the similarity between the source grades of different biomass energy and solar energy,the specific solar energy concentration ratio is *** to this principle,the matching efficiency of the multi-energy integration for rice and corn plants can be increased by 39.2%and 36.2%,respectively.

关键词： special theory of relativity solar energy biomass energy source integration grade

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BRAF^(V600E) vs. TIRADS in predicting papillary thyroid cancers in Bethesda system Ⅰ, Ⅲ, and Ⅴ nodules

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Cancer Biology & Medicine 2019年第1期16卷 131-138页

作者： Ya Wu Ting Xu Xingyue Cao Xin zhao Hongyan Deng Jianxiang Wang xiao Li Qing Yao Xinhua Ye Meiping Shen xiaohong Wu Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University Department of Endocrinology Jiangsu Province Official Hospital Department of Ultrasound The First Affiliated Hospital of Nanjing Medical University Department of Pathology The First Affiliated Hospital of Nanjing Medical University Department of General Surgery The First Affiliated Hospital of Nanjing Medical University

Objective: Bethesda System for Reporting Thyroid Cytopathology(BSRTC) categories Ⅰ, Ⅲ, and Ⅴaccount for a significant proportion of fine needle aspiration cytology(FNAC) diagnoses. This study aimed to compare the diagnostic efficacy of BRAF^(V600E) mutation and the Thyroid Imaging Reporting and Data System(TIRADS) classification in differentiating papillary thyroid cancers(PTCs) from benign lesions among BSRTC I, III, and V ***: A total of 472 patients with 479 nodules were enrolled in this prospective study. Ultrasound, BRAF^(V600E) mutation testing, and FNAC were performed in each nodule, followed by surgery or regular ultrasound ***: In the BSRTC I category, BRAF^(V600E) showed similar sensitivity, higher specificity, and lower accuracy when compared with TIRADS. In the BSRTC III/V category, the sensitivity, specificity, and accuracy of BRAF^(V600E) were similar to those of TIRADS. In comparison to BRAF^(V600E) alone, the combination of the two methods significantly improved sensitivity(BSRTC Ⅰ:93.6% vs. 67.7%, P < 0.01; BSRTC Ⅲ: 93.8% vs. 75.0%, P < 0.01; BSRTC V: 96.0% vs. 85.3%, P < 0.001). When compared with TIRADS alone, the combination improved sensitivity in BSRTC Ⅰ nodules(93.6% vs. 74.2%, P < 0.05), increased sensitivity and decreased accuracy in BSRTC III nodules(93.8% vs. 75.0%, P < 0.01, 91.0% vs. 93.6%, P < 0.01), and improved both sensitivity and accuracy in BSRTC V nodules(96.0% vs. 82.0%, P < 0.001; 94.2% vs. 81.3%, P < 0.001).Conclusions: BRAF^(V600E) exhibited higher specificity and lower accuracy compared with TIRADS in BSRTC Ⅰ nodules, while the two methods showed similar diagnostic value in BSRTC Ⅲ/Ⅴ nodules. The combination of the two methods distinctly improved sensitivity in the diagnosis of PTCs in BSRTC Ⅰ, Ⅲ, and Ⅴ nodules.

关键词： Papillary thyroid carcinoma fine-needle aspiration cytology(FNAC) BRAFV600E thyroid imaging reporting and data system(TIRADS) Bethesda classification

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Variable stars in the field of open cluster NGC 2126

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Research in Astronomy and Astrophysics 2009年第7期9卷 791-802页

作者： Shun-Fang Liu Zhen-Yu Wu xiao-Bin Zhang Jiang-Hua Wu Jun Ma zhao-Ji Jiang Jian-Sheng Chen Xu Zhou National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China Graduate University of Chinese Academy of Sciences Beijing 100049 China

We report the results of a time-series CCD photometric survey of variable stars in the field of open cluster NGC 2126. In about a one square degree field covering the cluster, a total of 21 variable candidates are detected during this survey, of which 16 are newly found. The periods, classifications and spectral types of 14 newly discovered variables are discussed, which consist of six eclipsing binary systems, three pulsating variable stars, three long period variables, one RS CVn star, and one W UMa or δ Scuff star. In addition, there are two variable candidates, the properties of which cannot be determined. By a method based on fitting observed spectral energy distributions of stars with theoretical ones, the membership probabilities and the fundamental parameters of this cluster are determined. As a result, five variables are probably members of NGC 2126. The fundamental parameters of this cluster are determined as： metallicity to be 0.008 Z, age log（t） = 8.95, distance modulus （m - M）0 = 10.34 and reddening value E（B - V） = 0.55 mag.

关键词： open clusters: individual (NGC 2126) - stars: variables (general) - bina- ties: general

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New construction of highly nonlinear resilient S-boxes via linear codes

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Frontiers of Computer Science 2022年第3期16卷 175-181页

作者： Haixia zhao Yongzhuang WEI Ministry of Education Key Laboratory of Cognitive Radio and Information Processing Guilin University of Electronic TechnologyGuilin 541004China School of Mathematics and Computing Science Guilin University of Electronic TechnologyGuilin 541004China Guangxi Key Laboratory of Cryptography and Information Security Guilin University of Electronic TechnologyGuilin 541004China

Highly nonlinear resilient functions play a crucial role in nonlinear combiners which are usual hardware oriented stream *** the past three decades,the main idea of construction of highly nonlinear resilient functions are benefited from concatenating a large number of affine ***,these resilient functions as core component of ciphers usually suffered from the guess and determine attack or algebraic attack since the n-variable nonlinear Boolean functions can be easily given rise to partial linear relations by fixing at most nil variables of *** to design highly nonlinear resilient functions(S-boxes)without concatenating a large number of nil variables affine subfunctions appears to be an important *** this article,a new construction of highly nonlinear resilient functions is *** functions consist of two classes *** specially,the first class(nonlinear part)contains both the bent functions with 2k variables and some affine subfUnctions with n/2-k variables which are attained by using[n/2-k,m,d]disjoint linear *** second class(linear part)includes some linear subfunctions with nil variables which are attained by using[n/2,m,d]disjoint linear *** is illustrated that these resilient functions have high nonlinearity and high algebraic *** particular,It is different from previous well-known resilient S-boxes,these new S-boxes cannot be directly decomposed into some affine subftinctions with nil variables by fixing at most nil *** means that the S-boxes(vectorial Boolean functions)which use these resilient functions as component functions have more favourable cryptography properties against the guess and determine attack or algebraic attacks.

关键词： stream cipher S-box disjoint linear codes resiliency nonlinearity

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The expression,function,and coding potential of circular RNA circEDC3 in chicken skeletal muscle development

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Journal of Integrative Agriculture 2022年第5期21卷 1444-1456页

作者： WEI Yuan-hang zhao Xi-yu SHEN xiao-xu YE Lin ZHANG Yao WANG Yan LI Di-yan ZHU Qing YIN Hua-dong Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130P.R.China

As an emerging class of non-coding transcripts,circular RNAs(circRNAs)are proved to participate in the complex process of myogenesis in diverse species.A previous study has identified circular RNA EDC3(circEDC3)as a typical covalently closed circular RNA abundant in chicken skeletal *** study found that circEDC3 is a conservative circular RNA and performed functional analysis to investigate the role of circEDC3 in chicken muscle *** results indicated that circEDC3 could inhibit(P<0.05)chicken skeletal muscle satellite cells(SMSCs)proliferation and differentiation but had no significant influence on SMSCs ***,bioinformatics analysis showed that circEDC3 had promising coding *** open reading frames(ORF)were found in circEDC3 in this ***,this study predicted that circEDC3 had internal ribosome entry sites(IRES)and N6-methyladenosine(m6A)motifs in different species,implying that circEDC3 might be *** study revealed that circEDC3 might be a negative regulator in chicken muscle development and suggested it has protein-coding potential in different species.

关键词： circEDC3 chicken SMSCs myogenesis coding potential

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Spatial distribution of heavy metals(Cu, Pb, Zn, and Cd)in sediments of a coastal wetlands in eastern Fujian, China

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Journal of Forestry Research 2015年第3期26卷 703-710页

作者： Lili zhao Weibin You Haiqing Hu Wei Hong xiaojuan LIAO Shihong xiao Ren Wang Jinbiao Cai Xuncheng Fan Yong Tan Dongjin He Fujian Agriculture and Forestry University Northeast Forestry University Forestry Bureau of Fuding Forestry Bureau of Xiapu

We investigated the spatial distribution （horizontal and vertical concentrations） of copper （Cu）, lead （Pb）, zinc （Zn）, and cadmium （Cd） in five wetland types （mudflat, aquaculture wetland, water area, farmland wetland and mangrove） from three areas （Ningde, Fuding, and Xiapu）, China. Cu concentrations in five wetland types descended in the order： farm wetland, mudflat, aquaculture, water area and mangrove. Pb concentrations decreased in the order： aquaculture, mangrove, farm wetland, mudflat, and water area. Zn content decreased in the order： farm wetland, water area, aquaculture, mudflat and mangrove, and Cd content decreased as follows： mangrove, aquacul- ture, water area, rnudflat, and farm wetland. Comparison of the concentrations of the same heavy metals in different areas showed that the highest Cu （63.75 mg kg-1） and Zn （152.32mgkg-1） concentrations occurred in Ningdecoastal wetlands; Pb （110.58 mg kg-1） and Cd （2.81 mg kg-1） contents were highest in Fuding wetlands, and the average contents of all heavy metals were very low in Xiapu wetlands. Examination of the vertical distribution showed that the Cu content was high in all mudflat layers; Pb and Cd concentrations were highest in aquaculture and mangrove wetlands, respectively, and Zn content was highest in farm wetlands. The spatial distribution of Cu and Zn contents for different areas decreased as follows： Ningde 〉 Fuding 〉 Xiapu, for Pb and Cd were most concentrated in Fuding coastal wetlands. Concentrations of Zn and Cu were highly correlated, while Zn and Cu were not significantly correlated with Pb.

关键词： Coastal wetland Heavy metal Spatialdistribution Eastem Fujian Ningde City

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