Values of debulking surgery for unresectable well-differentiated metastatic pancreatic neuroendocrine tumors:a comparative study

作     者：Xi-Tai Huang Jin-Zhao Xie Liu-Hua Chen Jian-Peng Cai Wei Chen Li-Jian Liang Ning Zhang Xiao-Yu Yin 

作者机构：Department of Pancreato-Biliary SurgeryThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of GastroenterologyThe First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China 

出 版 物：《Gastroenterology Report》 (胃肠病学报道（英文）)

年 卷 期：2023年第11卷第1期

页      面：247-253页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：pancreatic neuroendocrine tumor metastasis debulking surgery prognosis 

摘      要：Background and objective:The value of debulking surgery for unresectable well-differentiated metastatic pancreatic neuroendocrine tumor(m-PNET)remains poorly *** study aimed to evaluate the outcomes of m-PNET following debulking surgery in our ***:Patients with well-differentiated m-PNET in our hospital between February 2014 and March 2022 were *** and long-term outcomes of patients treated with radical resection,debulking surgery,and conservative therapy were compared ***:Fifty-three patients with well-differentiated m-PNET were reviewed,including 47 patients with unresectable m-PNET(debulking surgery,25;conservative therapy,22)and 6 patients with resectable m-PNET(radical resection).Patients undergoing debulking surgery had a post-operative Clavien–DindoIII complication rate of 16.0%without *** 5-year overall survival(OS)rate of patients treated with debulking surgery was significantly higher than that of those treated with conservative therapy alone(87.5%vs 37.8%,log-rank P=0.022).Besides,the 5-year OS rate of patients treated with debulking surgery was comparable to that of patients with resectable m-PNET undergoing radical resection(87.5%vs 100%,log-rank P=0.724).Conclusions:Patients with unresectable well-differentiated m-PNET who underwent resection had better long-term outcomes than those who received conservative therapy *** 5-year OS of patients undergoing debulking surgery and radical resection were *** surgery could be considered for patients with unresectable well-differentiated m-PNET if no contraindication exists.