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Artful union of a zirconium-porphyrin MOF/GO composite for fabricating an aptamer-based electrochemical sensor with superb detecting performance

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Chinese Chemical Letters 2021年第9期32卷 2851-2855页

作者： Hong-Kai Li Hai-Lin Ye xiao-xue zhao xiao-Long Sun Qian-Qian Zhu Zhang-Ye Han Rongrong Yuan Hongming He Tianjin Key Laboratory of Structure and Performance for Functional Molecules College of ChemistryTianjin Normal UniversityTianjin 300387China Department of Materials Science and Engineering Jilin Jianzhu UniversityChangchun 130118China

More and more attentions have been focused on design and synthesis of novel metal-organic framework/graphene oxide(MOF/GO)composites with unique ***-porphyrin MOF(PCN-222)is in-situ synthesis with the existence of GO with-COOH group to artfully fabricate a PCN-222/GO *** composite can be employed as functional material to modify the working *** to excellent electrical conductivity of GO,abundant mesoporous channels and numerous Zr(Ⅳ)metal sites of PCN-222,this composite can immobilize a large amount of aptamer through strongπ-πstacking interaction and high affinity between phosphate group of aptamer and Zr(Ⅳ)site of PCN-222 ***,an ultra-sensitive electrochemical aptasensor based on PCN-222/GO composite can quantificationally detect trace chloramphenicol with limit of detection of 7.04 pg/m L(21.79 pmol/L)from 0.01 ng/m L to 50 ng/m L by electrochemical impedance spectroscopy even in real ***,this fabricated aptasensor reveals good repeatability,outstanding selectivity and preferable long-term *** research provides a useful approach to construct MOF/GO composites for fabricating electrochemical aptasensors in the electrochemical detection field.

关键词： PCN-222/GO composite Aptamer Electrochemical aptasensor Chloramphenicol Electrochemical impedance spectroscopy

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磷烯的制备、结构、性质及器件应用

物理化学学报 2017年第11期33卷 2153-2172页

作者：朱晋潇刘晓东薛敏钊陈长鑫上海交通大学化学工程系和微纳电子学系上海200240

磷烯是继石墨烯之后一种新型的二维材料,具有优异的物理、化学和机械性能,在各类器件中具有大的应用潜力。目前对磷烯的最新制备方法、特性调控和应用的系统总结较少。本文对磷烯的制备、结构、性质、改性方法及其器件应用进行了系统的... 详细信息

磷烯是继石墨烯之后一种新型的二维材料,具有优异的物理、化学和机械性能,在各类器件中具有大的应用潜力。目前对磷烯的最新制备方法、特性调控和应用的系统总结较少。本文对磷烯的制备、结构、性质、改性方法及其器件应用进行了系统的综述。首先概括了磷烯"自上而下"和"自下而上"的制备方法,对其结构和性质进行了总结,同时讨论了磷烯的修饰改性方法,最后对磷烯的器件应用进行了较详细的介绍,并在此基础上对磷烯的研究方向和前景进行了展望。

关键词：磷烯材料制备结构表征器件应用

Quinidine/Quinine:Stereospecific blockade of HERG in Xenopus oocytes and in mammalian cells

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Quinidine/Quinine:Stereospecific blockade of HERG in Xenopus...

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

2006第六届中国药学会学术年会

作者： Li Bao-xin, zhao Wen-xiao, zhao xue-ling, Yang Baofeng Department of Pharmacology, Harbin Medical University, Harbin 150086, China

＜正＞Aim: Quinidine and quinine are diastereoisomers. Quinidine prolonged action potential duration in vitro and repolarization time in vivo significantly more than quinine. In humans, quinidine prolongs the QT inter... 详细信息

关键词： HERG channel quinidine quinine

来源： cnki会议评论

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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1991年高考考生须知250题

ZnO-Bi_2O_3系压敏陶瓷缺陷弛豫特性的研究进展

1991年

作者：辽宁省高等学校招生委员会办公室编 LIAO NING SHENG GAO DENG xue JIAO zhao SHENG WEI YUAN HUI BAN GONG SHI BIAN LIAO NING SHENG GAO DENG xue xiao zhao SHENG WEI YUAN HUI BAN GONG SHI BIAN

来源：汇雅图书（南通市图书馆... 评论

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汇雅图书（南通市图书馆）

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物理学报 2017年第2期66卷 11-24页

作者：赵小强赵学童许超李巍巍任路路廖瑞金李建英重庆大学电气工程学院输变电装备及系统安全与新技术国家重点实验室重庆400044 重庆大学计算机学院重庆400044 国网四川省电力公司电力科学研究院成都610072 西安交通大学电气工程学院电力设备电气绝缘国家重点实验室西安710049

由于具有良好的非欧姆特性,ZnO压敏陶瓷被广泛用于电子线路和电力系统的浪涌吸收和瞬态过电压抑制,因此,ZnO压敏陶瓷材料的发展一直备受国内外学者和业界的关注.然而,ZnO压敏陶瓷内部的缺陷结构及其引起的弛豫过程与ZnO压敏陶瓷电性能... 详细信息

由于具有良好的非欧姆特性,ZnO压敏陶瓷被广泛用于电子线路和电力系统的浪涌吸收和瞬态过电压抑制,因此,ZnO压敏陶瓷材料的发展一直备受国内外学者和业界的关注.然而,ZnO压敏陶瓷内部的缺陷结构及其引起的弛豫过程与ZnO压敏陶瓷电性能之间的关联还不清楚,一直是研发新型ZnO压敏陶瓷所要面临的挑战.本文综述了ZnO压敏陶瓷的缺陷类型、理论计算,着重分析了不同缺陷的相应弛豫表征方法,并对ZnO压敏陶瓷的缺陷弛豫机理及其与电老化特性的关联等方面进行了评述.

关键词： ZnO压敏陶瓷缺陷结构弛豫机理电性能

针刺坐骨神经干治疗腰椎间盘突出症所致坐骨神经痛的疗效观察

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针刺研究 2016年第5期41卷 447-450,473页

作者：邱玲胡小丽赵学宇郑旭张吉张敏何流成都市第一人民医院疼痛科成都610041 成都中医药大学针灸推拿学院成都610072

目的:观察以针刺坐骨神经干为主治疗腰椎间盘突出症所致坐骨神经痛的疗效,并与常规针刺组进行比较,探讨腰椎间盘突出症所致坐骨神经痛的更佳治疗方案。方法:将腰椎间盘突出症所致坐骨神经痛患者随机分为神经干刺激组和常规针刺组,每组3... 详细信息

目的:观察以针刺坐骨神经干为主治疗腰椎间盘突出症所致坐骨神经痛的疗效,并与常规针刺组进行比较,探讨腰椎间盘突出症所致坐骨神经痛的更佳治疗方案。方法:将腰椎间盘突出症所致坐骨神经痛患者随机分为神经干刺激组和常规针刺组,每组30例。常规针刺组选取阿是穴、腰夹脊、大肠俞穴,并结合辨证取穴针刺;神经干刺激组采用坐骨神经干刺激法,针刺环跳、环中,并配合常规针刺的方法进行治疗。两组均每天治疗1次,5次为1个疗程,每个疗程间休息2d,共治疗4个疗程。采用简化McGill疼痛量表(SFMPQ)进行临床疗效评价。结果:神经干刺激组愈显率为83.3%(25/30),明显优于常规针刺组的60.0%(18/30,P<0.05)。治疗后两组疼痛分级指数、视觉疼痛模拟评分、现有疼痛强度评分较治疗前均明显降低(P<0.01),神经干刺激组较常规针刺组改善更为明显(P<0.01)。结论:在治疗腰椎间盘突出症所致坐骨神经痛方面,针刺坐骨神经干与常规针刺方法均安全有效,在改善患者疼痛方面,针刺坐骨神经干治疗优于常规针刺。

关键词：针刺腰椎间盘突出症坐骨神经痛坐骨神经干刺激

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思政理论课实践教学模式构建与应用创新

高等财经教育研究 2018年第1期21卷 50-55页

作者：马晓亮赵雪照李捷山西能源学院思政部山西晋中030600

思想政治理论课实践教学模式的构建和应用是关乎实践教学质量的关键因素,目前各高校对此存在概念认识不清、构建实施不力、应用效果不显的弊病。围绕实践教学概念这一核心,将实施机制、保障机制、中期测评机制和结果评价机制有机组合,... 详细信息

思想政治理论课实践教学模式的构建和应用是关乎实践教学质量的关键因素,目前各高校对此存在概念认识不清、构建实施不力、应用效果不显的弊病。围绕实践教学概念这一核心,将实施机制、保障机制、中期测评机制和结果评价机制有机组合,建立相对稳定的实践教学体系是解决该问题的有效途径。同时,我们还应注重理论建设,重视学生获得感,切合社会主流价值导向,紧跟时代发展潮流。

关键词：思想政治理论课实践教学模式应用创新

Unlocking the stable interface in aqueous zinc-ion battery with multifunctional xylose-based electrolyte additives

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Journal of Energy Chemistry 2025年第1期100卷 770-778页

作者： xiaoqin Li Jian Xiang Lu Qiu xiaohan Chen Yinkun zhao Yujue Wang Qu Yue Taotao Gao Wenlong Liu Dan xiao zhaoyu Jin Panpan Li Institute for Advanced Study Chengdu University School of Mechanical Engineering Chengdu University College of Food and Biological Engineering Chengdu University Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of China College of Materials Science and Engineering Sichuan University

The growth of dendrites and the side reactions occurring at the Zn anode pose significant challenges to the commercialization of aqueous Zn-ion batteries（AZIBs）. These challenges arise from the inherent conflict between mass transfer and electrochemical kinetics. In this study, we propose the use of a multifunctional electrolyte additive based on the xylose（Xylo） molecule to address these issues by modulating the solvation structure and electrode/electrolyte interface, thereby stabilizing the Zn anode. The introduction of the additive alters the solvation structure, creating steric hindrance that impedes charge transfer and then reduces electrochemical kinetics. Furthermore, in-situ analyses demonstrate that the reconstructed electrode/electrolyte interface facilitates stable and rapid Zn2+ion migration and suppresses corrosion and hydrogen evolution reactions. As a result, symmetric cells incorporating the Xylo additive exhibit significantly enhanced reversibility during the Zn plating/stripping process, with an impressively long lifespan of up to 1986 h, compared to cells using pure ZnSO4electrolyte. When combined with a polyaniline cathode, the full cells demonstrate improved capacity and long-term cyclic stability. This work offers an effective direction for improving the stability of Zn anode via electrolyte design, as well as highperformance AZIBs.

关键词： Solvation