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Retinal vascular morphological characteristics in diabetic retinopathy: an artificial intelligence study using a transfer learning system to analyze ultra-wide field images

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1001-1006页

作者： Xin-Yi Deng Hui Liu Zheng-Xi Zhang Han-xiao Li Jun Wang Yi-Qi Chen Jian-Bo Mao Ming-zhai Sun Li-Jun Shen Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina Department of Precision Machinery and Instrumentation University of Science and Technology of ChinaHefei 230026Anhui ProvinceChina Department of Retina Eye Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To investigate the morphological characteristics of retinal vessels in patients with different severity of diabetic retinopathy(DR)and in patients with or without diabetic macular edema(DME).METHODS:The 239 eyes of DR patients and 100 eyes of healthy individuals were recruited for the *** severity of DR patients was graded as mild,moderate and severe non-proliferative diabetic retinopathy(NPDR)according to the international clinical diabetic retinopathy(ICDR)disease severity scale classification,and retinal vascular morphology was quantitatively analyzed in ultra-wide field images using RU-net and transfer learning *** presence of DME was determined by optical coherence tomography(OCT),and differences in vascular morphological characteristics were compared between patients with and without ***:Retinal vessel segmentation using RU-net and transfer learning system had an accuracy of 99%and a Dice metric of *** with the healthy group,the DR group had smaller vessel angles(33.68±3.01 vs 37.78±1.60),smaller fractal dimension(Df)values(1.33±0.05 vs 1.41±0.03),less vessel density(1.12±0.44 vs 2.09±0.36)and fewer vascular branches(206.1±88.8 vs 396.5±91.3),all P<*** the severity of DR increased,Df values decreased,P=*** significant difference between the DME and non-DME groups were observed in vascular morphological ***:In this study,an artificial intelligence retinal vessel segmentation system is used with 99%accuracy,thus providing with relatively satisfactory performance in the evaluation of quantitative vascular *** patients have a tendency of vascular occlusion and *** presence of DME does not compromise the integral retinal vascular pattern.

关键词： diabetic retinopathy vascular morphology deep learning ultra-wide field imaging diabetic macular edema

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Programmable silicon-photonic quantum simulator based on a linear combination of unitaries

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Photonics Research 2024年第8期12卷 1760-1767页

作者： YUE YU YULIN CHI CHONGHAO zhai JIESHAN HUANG QIHUANG GONG JIANWEI WANG State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Frontiers Science Center for Nano-optoelectronics&Collaborative Innovation Center of Quantum Matter Peking UniversityBeijing 100871China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Yangtze Delta Institute of Optoelectronics Peking UniversityNantong 226010China Hefei National Laboratory Hefei 230088China Department of Electrical and Computer Engineering University of WashingtonSeattleWashington 98195USA China Mobile Research Institute Beijing 100053China

Simulating the dynamic evolution of physical and molecular systems in a quantum computer is of fundamental interest in many *** implementation of dynamics simulation requires efficient quantum *** Lie-Trotter-Suzuki approximation algorithm,also known as the Trotterization,is basic in Hamiltonian dynamics simulation.A multi-product algorithm that is a linear combination of multiple Trotterizations has been proposed to improve the approximation ***,implementing such multiproduct Trotterization in quantum computers remains challenging due to the requirements of highly controllable and precise quantum entangling operations with high success ***,we report a programmable integrated-photonic quantum simulator based on a linear combination of unitaries,which can be tailored for implementing the linearly combined multiple Trotterizations,and on the simulator we benchmark quantum simulation of Hamiltonian *** modify the multi-product algorithm by integrating it with oblivious amplitude amplification to simultaneously reach high simulation precision and high success *** quantum simulator is devised and fabricated on a large-scale silicon-photonic quantum chip,which allows the initialization,manipulation,and measurement of arbitrary four-qubit states and linearly combined unitary *** an example,the quantum simulator is reprogrammed to emulate the dynamics of an electron spin and nuclear spin coupled *** work promises the practical dynamics simulations of real-world physical and molecular systems in future large-scale quantum computers.

关键词： quantum Hamiltonian linearly

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Incorporating Lasso Regression to Physics-Informed Neural Network for Inverse PDE Problem

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 385-399页

作者： Meng Ma Liu Fu Xu Guo Zhi zhai National Key Lab of Aerospace Power System and Plasma Technology Xi’an Jiaotong UniversityXi’an710049China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an710049China Department of Electrical and Computer Engineering University of Massachusetts LowellLowellMA 01854USA

Partial Differential Equation(PDE)is among the most fundamental tools employed to model dynamic *** PDE modeling methods are typically derived from established knowledge and known phenomena,which are time-consuming and ***,discovering governing PDEs from collected actual data via Physics Informed Neural Networks(PINNs)provides a more efficient way to analyze fresh dynamic systems and establish *** study proposes Sequentially Threshold Least Squares-Lasso(STLasso),a module constructed by incorporating Lasso regression into the Sequentially Threshold Least Squares(STLS)algorithm,which can complete sparse regression of PDE coefficients with the constraints of l0 *** further introduces PINN-STLasso,a physics informed neural network combined with Lasso sparse regression,able to find underlying PDEs from data with reduced data requirements and better *** addition,this research conducts experiments on canonical inverse PDE problems and compares the results to several recent *** results demonstrated that the proposed PINN-STLasso outperforms other methods,achieving lower error rates even with less data.

关键词： Physics-informed neural network inverse partial differential equation Lasso regression scientific machine learning

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Dendritic tip selection during solidification of alloys:Insights from phase-field simulations

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Chinese Physics B 2024年第9期33卷 467-472页

作者： Qingjie Zhang Hui Xing Lingjie Wang Wei zhai School of Physical Science and Technology Northwestern Polytechnical UniversityXi’an710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518063China

The effect of undercooling DT and the interface energy anisotropy parameter e4 on the shape of the equiaxed dendritic tip has been investigated by using a quantitative phase-field model for solidification of binary *** was found that the tip radius r increases and the tip shape amplitude coefficient A4 decreases with the increase of the fitting range for all *** dendrite tip shape selection parameter sdecreases and then stabilizes with the increase of the fitting range,and sincreases with the increase of *** relationship between sand e4 follows a power-law function sµea 4,and a is independent of DT but dependent on the fitting *** results demonstrate that the predicted sis consistent with the curve of microscopic solvability theory(MST)for e4<0.02,and sobtained from our phase-field simulations is sensitive to the undercooling when e4 is fixed.

关键词： phase-field simulations dendritic structure interface energy anisotropy tip shape selection parameter

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基于四甲基联苯胺和吖啶橙间荧光共振能量转移的比率型荧光测定左氧氟沙星

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光谱学与光谱分析 2024年第2期44卷 426-433页

作者：翟好英赵文林周文俊内江师范学院化学化工学院沱江流域特色农业资源四川省科技资源共享服务平台果类废弃物资源化四川省高等学校重点实验室四川内江641100

基于3,3’,5,5’(四甲基联苯胺(3,3’,5,5’-tetramethylbenzidine,TMB)和吖啶橙(AO)之间荧光共振能量转移(FRET),建立了一种快速、低背景干扰、高灵敏度测定盐酸左氧氟沙星(LVF)的新型比率型荧光探针。在pH 5.0 NaAc-HCl缓冲溶液中,在3... 详细信息

基于3,3’,5,5’(四甲基联苯胺(3,3’,5,5’-tetramethylbenzidine,TMB)和吖啶橙(AO)之间荧光共振能量转移(FRET),建立了一种快速、低背景干扰、高灵敏度测定盐酸左氧氟沙星(LVF)的新型比率型荧光探针。在pH 5.0 NaAc-HCl缓冲溶液中,在310 nm的光激发下,TMB在350~500 nm处的荧光光谱和AO的吸收光谱重叠。以TMB作为能量供体,AO作为能量受体,构建了FRET体系。根据能量转移理论,该体系的荧光共振能量转移效率为62.5%,供体-受体间距离为2.17 nm,进一步说明TMB和AO之间发生了FRET。当在体系中加入LVF后,TMB将荧光能量转移给LVF,LVF又作为供体将能量转移给AO。LVF在TMB和AO之间起到桥梁作用,LVF将吸收的TMB荧光能量转移给AO,使得TMB荧光强度明显降低,AO的荧光强度则显著增加,从而提高了体系的FRET效率。在最优实验条件下,F546 nm与F402 nm之比与LVF浓度(2~80μmol·L^(-1))之间存在良好的线性关系,线性回归方程为F_(546 nm)/F_(402 nm)=87.916c+3.108,线性相关系数为0.9993,检出限(LOD)为15.7 nmol·L^(-1)。一些常见的阳离子(K^(+),Mg^(2+),Ca^(2+),Cu^(2+),Mn^(2+),Zn^(2+),Co^(2+),Ni^(2+),Cr^(3+)等)、阴离子(F^(-),Br^(-),NO_(3)^(-),IO_(3)^(-),CO_(3)^(2-),SO_(4)^(2-)等)、糖类(葡萄糖,蔗糖和淀粉)、药物(谷胱甘肽,抗坏血酸和异烟肼)和几种氨基酸(甘氨酸,亮氨酸,半胱氨酸等)均不干扰LVF的测定,表明该比率型荧光探针对LVF具有高选择性。该方法用于商用药物制剂中LVF含量的测定,加标回收率在93%~97%之间。该比率型荧光探针在临床研究中对LVF的检测具有较大的应用潜力,为开发一种简便、选择性和灵敏的检测药物制剂中LVF含量的传感器提供了较好的理论依据,同时为提高LVF临床用药的安全性与合理性水平提供了一定的方法。

关键词： 3,3’,5,5’-四甲基联苯胺吖啶橙左氧氟沙星荧光共振能量转移比率型荧光探针

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Integration of bio-inspired limb-like structure damping into motor suspension of high-speed trains to enhance bogie hunting stability

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Railway Engineering Science 2024年第3期32卷 324-343页

作者： Heng Zhang Liang Ling Sebastian Stichel Wanming zhai State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu 610031China Department of Engineering Mechanics KTH Royal Institute of TechnologyStockholmSweden

Hunting stability is an important performance criterion in railway *** study proposes an incorporation of a bio-inspired limb-like structure(LLS)-based nonlinear damping into the motor suspension system for traction units to improve the nonlinear critical speed and hunting stability of high-speed trains(HSTs).Initially,a vibration transmission analysis is conducted on a HST vehicle and a metro vehicle that suffered from hunting motion to explore the effect of different motor suspension systems from on-track ***,a simplified lateral dynamics model of an HST bogie is established to investigate the influence of the motor suspension on the bogie hunting *** bifurcation analysis is applied to optimize the motor suspension parameters for high critical ***,the nonlinear damping of the bio-inspired LLS,which has a positive correlation with the relative displacement,can further improve the modal damping of hunting motion and nonlinear critical speed compared with the linear motor suspension ***,a comprehensive numerical model of a high-speed train,considering all nonlinearities,is established to investigate the influence of different types of motor *** simulation results are well consistent with the theoretical *** benefits of employing nonlinear damping of the bio-inspired LLS into the motor suspension of HSTs to enhance bogie hunting stability are thoroughly validated.

关键词： High-speed train Hunting stability Bio-inspired limb-like structure Motor suspension Nonlinear damping

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Achieving laparoscopic anatomic resection for hepatocellular carcinoma by fluorescence guided positive staining of hepatic cone unit

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 406-411页

作者： Jun-Fang Deng Chuan-Hui Peng Yu Zhang xiao-Feng Xu Rong-Liang Tong Zheng-Long zhai Di-Yu Chen Cheng Zhang Li-Ming Wu Jian Wu Division of Hepatobiliary Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Laparoscopic anatomical liver resection has been increasingly reported worldwide,but how to demarcate the resection planes is technically challenging[1].Positive staining technique with intraoperative indocyanine green(ICG)-fluorescence imaging has been introduced as an effective tool for real-time intraoperative guidance[2].Liver anatomy is ***,liver is composed of 9 segments,each is composed of two to three subsegments,and each subsegment contains several hepatic cone units.A hepatic cone unit is dominated by a tertiary or quaternary hepatic pedicles[3].

关键词： hepatic resection anatomy

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Single-cell transcriptomic landscape of peripheral blood cells provides insights into adaptation of red-eared sliders(Trachemys scripta elegans)

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Integrative Zoology 2024年第3期19卷 468-479页

作者： Rui GUO Guangwei MA xiaofei zhai Haitao SHI Jichao WANG Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikouChina

Red-eared sliders(Trachemys scripta elegans),as one of the 100 most threatening aliens,have stronger immunity than the native species in response to environmental *** cells are an important component of immunity in the ***,the blood cell researches of turtle are still in the traditional blood cell classification and morphological structure ***,turtle granulocytes cannot be accurately identified using traditional ***-cell RNA sequencing techniques have been successfully implemented to study cells based on the mRNA expression patterns of each *** present study profiled the transcriptomes of peripheral blood cells in red-eared sliders to construct a single-cell transcriptional landscape of the different cell types and explored environmental adaptation mechanism from the perspective of *** 14 transcriptionally distinct clusters(platelets,erythrocytes1,erythrocytes2,CSF1R monocytes,POF1B monocytes,neutrophils,GATA2high basophils,GATA2low basophils,CD4 T cells,CD7 T cells,B cells,ACKR4 cells,serotriflin cells,and ficolin cells)were identified in the peripheral blood cells of the red-eared *** particular,a subtype of erythrocytes(erythrocytes1)that expressed immune signals was *** blood cells were grouped into three lineages:platelet,erythroid/lymphoid,and myeloid cell ***,based on differentiation trajectory and up-regulated gene expression,ACKR4 cells were newly identified as lymphocytes,and serotriflin and ficolin cells as *** single-cell transcriptional atlas of the peripheral blood cells in red-eared sliders provided in the present study will offer a comprehensive transcriptome reference for the exploration of physiological and pathological hematology in this species.

关键词： blood cells single-cell RNA-seq Trachemys scripta elegans

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The Limit Distribution of Stochastic Evolution Equations Driven by-Stable Non-Gaussian Noise

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应用数学 2024年第4期37卷 1180-1194页

作者： zhai Likai FU Hongbo School of Mathematical and Physical Sciences Wuhan Textile UniversityWuhan 430073China

We study the distribution limit of a class of stochastic evolution equation driven by an additive-stable Non-Gaussian process in the case of α∈(1,2).We prove that,under suitable conditions,the law of the solution co... 详细信息

关键词： Stochastic evolution equation α-stable Non-Gaussian process Distribution

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Cucurbit[8]uril-regulated face-to-face dimerization assembly enhanced photosensitization and photocatalysis

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Science China Chemistry 2024年第5期67卷 1605-1612页

作者： Haigen Nie Die Hu Zhiyao Zeng Yan Fan Yaxin zhai Xin-Long Ni Key Laboratory of Chemical Biology and Traditional Chinese Medicine Ministry of Educational of ChinaKey Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China

In water, N,N′-diarylpyridinium thiazolo[5,4-d]thiazole guests(G1–G3) were encapsulated by cucurbit[8]uril(Q[8]) to construct Q[8]_(3)/G_(2) complexes, in which the encapsulated G molecules exist as an exact face-to-face dimer. These complexation behaviors have been indicated by proton nuclear magnetic resonance(~1H NMR) spectroscopy and isothermal titration calorimetry(ITC),and have been confirmed by X-ray single crystal structural analysis of Q[8]_(3)/G2_(2). While free guests G1–G3 have no ability to sensitize singlet oxygen, they all become effective singlet oxygen sensitizers when complexed with Q[8]. By irradiation of white light, Q[8]_(3)/G_(2) complexes induced selective oxidation of aryl sulfide to aryl sulfoxide in good yields and selective oxidation of dimethyl sulfide(DMS) to dimethyl sulfoxide(DMSO) in excellent yields without over-oxidation to dimethyl sulfone(DMSO_(2))even for elongated irradiation. High-yield photo-oxidation of DMS to DMSO_(2) was only achieved by irradiation of blue light in the presence of Q[8]_(3)/G1_(2), which was also effective in photobleaching of Rhodamine B in water. The higher photo-oxidation power of Q[8]_(3)/G1_(2) has been ascribed to an additional generation of reactive oxygen species besides singlet oxygen.

关键词： host-guest interaction dimerization macrocycles photosensitization

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