检索结果-南通市图书馆

The anti-Temperature-vibration properties of viscoelastic anticorrosive tape

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2022年第5期19卷 2413-2419页

作者： Hai-Liang Nie wei-Feng Ma xiao-wei hu wei Dang Jun-Jie Ren Ke Wang Jun Cao Tian Yao xiao-Bin Liang Institute of Safety Assessment and Integrity State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment MaterialsCNPC Tubular Goods Research InstituteXi'an710077China No.2 Oil Extraction Plant Changqing Oilfield BranchPetroChinaGansu745100China

Viscoelastic anticorrosive tape is extensively used for repairing anticorrosive layers on compressor outlet pipelines in the oil and gas ***,there is no relevant research on the coupling effect of temperature and vibration on the performance of viscoelastic anticorrosive *** this paper,acceleration tests of temperature and vibration coupling conditions were conducted to investigate the performance of viscoelastic anticorrosive *** temperature and vibration treatment,the specimens showed wide variance in thickness,and the adhesion and chemical soaking resistance of the tape was ***,the viscoelastic anticorrosive tape still showed high *** to theoretical calculations,the tested viscoelastic body can repair pipes with a maximum diameter of 903 ***,this viscoelastic anticorrosive tape is suitable for the compressor outlets of buried pipelines with diameters smaller than 903 *** research in this paper provides a method and basis for the selection of repairing materials for the anticorrosion coatings of compressor outlet pipelines.

关键词： Station Compressor outlet Anticorrosive coating Viscoelastic anticorrosive tape

Synthesis and anti-inflammatory-analgesic activity of 2',4'-difluoro-3-(carbamoyl)biphenyl-4-yl benzoates

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2008年第12期19卷 1419-1422页

作者： Guang Xiang Zhong Lu Lu Chen Jian Li wei xiao hu Min You Qi College of Pharmaceutical Science Zhejiang University of Technology Hangzhou 310032 PR China

Eighteen 2′,4′-difluoro-3-（carbamoyl）biphenyl-4-yl benzoates were synthesized from diflunisal in three steps with total yields from 72% to 86%. All compounds were identified by IR, 1^H NMR, MS and elemental analysis. The anti-inflammatory activity and analgesic activity for 18 compounds were evaluated. The preliminary assay results showed that compounds 4a and 4p exhibited potent anti-inflammatory-analgesic activity.

关键词： 2′,4′-Difluoro-3-(carbamoyl)biphenyl-4-yl benzoate Anti-inflammatory activity Analgesic activity Diflunisal

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng Song Ihar Razanau Juanxiu xiao wei xiao Di hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Methane Electrochemical conversion Reaction mechanism Catalyst design Electrode Electrocatalysis

Interactions Between Effects of Estrogen Receptor Gene Polymorphisms on BMD and Experiences of the First Spermorrhea in Chinese Han Boys

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2008年第2期21卷 129-136页

作者： JING YIN QIAN ZHANG xiao-QI hu wei-JING DU AI-LING LIU xiao-YAN WANG ZHI-QIN TONG GUAN-SHENG MA National Institute for Nutrition and Food Safety Chinese Center for Disease Control and Prevention 29 Nanwei Road Beijing 100050 China

Objective To study the interaction between polymorphisms of estrogen receptor （ER） gene and puberty on bone mineral density （BMD）. Methods One hundred and forty-six boys aged 13-17 years were divided into two groups according to their first sperrnorrhea. DNA was analyzed for Xba I and Pvu 1/genotypes by PCR-RFLP. BMD of the total body, forearm and lumbar spine was measured by dual-energy X-ray absorptiometry （DXA）. The relationship between polymorphisms of ER gene and BMD in these two groups was analyzed. Results The BMD at all sites in the sperrnorrhea group was significantly higher than that in the un-sperrnorrhea group. The independent contribution of ER genotypes to BMD at two pubertal stages was analyzed after adjusting co-variables. In the un-sperrnorrhea group, the BMD at distal 1/10 and 1/3 forearm of those carrying pp genotype was significantly higher than that of the non-carries, whereas in the sperrnorrhea group BMD in those carrying the same genotype was significantly lower than that in the non-carriers. Similar results were obtained by haplotype analysis. Multiple stepwise regression analysis showed that body weight, age and the first sperrnorrehea were the dominant determinants for BMD. BMD at forearm might be influenced by interaction between ER genotype and the first spermorrehea. Conclusion The polymorphisms of ER gene play a different role in BMD influenced by the first spermorrhea. Chinese boys carrying p or x allele should pay more attention to their bone mass.

关键词： BMD Puberty Hormones and receptors Polymorphism Boys

Intensified Antiplatelet Treatment Reduces Major Cardiac Events in Patients with Clopidogrel Low Response： A Meta-analysis of Randomized Controlled Trials

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2016年第8期129卷 984-991页

作者： Lei Xu xiao-wei hu Shu-hua Zhang Ji-Min Li hui Zhu Ke Xu Jun Chen Chun-Jian Li Department of Cardiology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210000 China Department of Cardiology Sir Yifu Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 211166 China Coronary Artery Disease Center First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210000 China Department of Cardiology People's Hospital of Maanshan City Maanshan Anhui 243000 China

Background：Clopidogrel low response （CLR） is an independent risk factor of adverse outcomes in patients undergoing percutaneous coronary intervention （PCI）,and intensified antiplatelet treatments （IAT） guided by platelet function assays might overcome laboratory ***,whether IAT improves clinical outcomes is ***：Relevant trials were identified in PubMed,the Cochrane Library,and the Chinese Medical Journal Network databases from their establishment to September 9,*** were screened using predefined inclusion *** meta-analysis and cumulative meta-analysis were performed using the Review Manager 5.0 and STATA 12.0 software ***：Thirteen randomized controlled trials involving 5111 patients with CLR were *** a follow-up period of 1-12 months,the incidences of cardiovascular （CV） death,nonfatal myocardial infarction （MI）,and stent thrombosis were significantly lower in the IAT arm than in the conventional antiplatelet treatment arm （relative risk [RR] =0.45,95% confidence interval [CI]：0.36-0.57,P 〈 0.000,01）,whereas bleeding was similar between the two arms （RR =1.05,95% CI：0.86-1.27,P =0.65）.Conclusions：IAT guided by platelet function assays reduces the risk of CV death,nonfatal MI,and stent thrombosis （ST） without an increased risk of bleeding in patients undergoing PCI and with CLR.

关键词： Coronary Artery Disease Individualized Medicine Platelet Aggregation Inhibitor Platelet Function Test

Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第26期15卷 3240-3245页

作者： Ji-Hong Yao Xue-Song Zhang Shu-Sen Zheng Ying-hua Li Li-Ming Wang Zhen-Zhen Wang Liang Chu xiao-wei hu Ke-Xin Liu xiao-Feng Tian Department of Pharmacology Dalian Medical University Dalian 116044 Liaoning Province China Department of Heneral Surgery Second Affiliated Hospital of Dalian Medical University Dalian 116023 LiaoningProvince China Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University Schoolof Medicine Hangzhou 310003 Zhejiang Province China

AIM： To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion （I/R）. METHODS： Rats were divided randomly into three experimental groups： sham, intestinal I/R and carnosol treatment （n = 18 each）. The intestinal I/R model was established by clamping the superior mesenteric artery for 1 h. In the carnosol treatment group, surgery was performed as in the intestinal I/R group, with intraperitoneal administration of 3 mg/kg carnosol 1 h before the operation. At 2, 4 and 6 h after reperfusion, rats were killed and blood, intestine and liver tissue samples were obtained. Intestine and liver histology was investigated. Serum levels of aspartate aminotransferase （AST）, alanine aminotransferase （ALT） and interleukin （IL）-6 were measured. Liver tissue superoxide dismutase （SOD） and myeloperoxidase （IvIPO） activity were assayed. The liver intercellular adhesion molecule-1 （ICAM-1） and nuclear factor κB （NF-κB） were determined by immunohistochemical analysis and western blot analysis. RESULTS： Intestinal I/R induced intestine and liver injury, characterized by histological changes, as well as a significant increase in serum AST and ALT levels. The activity of SOD in the liver tissue decreased after I/R, which was enhanced by carnosol pretreatment. In addition, compared with the control group, carnosol markedly reduced liver tissue MPO activity and serum IL-6 level, which was in parallel with the decreased level of liver ICAI-1 and NF-κB expression. CONCLUSION： Our results indicate that carnosol pretreatment attenuates liver injury induced by intestinal I/R, attributable to the antioxidant effect and inhibition of the NF-κB pathway.

关键词： Carnosol Liver injury Ischemia reperfusion Nuclear factor κB

哺乳动物昼夜节律调节的神经基础——昼夜光感受器

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

生物化学与生物物理进展 2003年第5期30卷 694-697页

作者：谌小维胡志安第三军医大学神经生物学教研室重庆400038

哺乳动物昼夜光感受器为一组具有直接感光功能的特殊视网膜神经节细胞 ,其基本感光色素为黑视素 .昼夜光感受器具有直接、广谱和稳定感受昼夜光变化的功能特点 .昼夜光感受器的功能是通过导引作用 ,使下丘脑视交叉上核内的昼夜节律活动... 详细信息

哺乳动物昼夜光感受器为一组具有直接感光功能的特殊视网膜神经节细胞 ,其基本感光色素为黑视素 .昼夜光感受器具有直接、广谱和稳定感受昼夜光变化的功能特点 .昼夜光感受器的功能是通过导引作用 ,使下丘脑视交叉上核内的昼夜节律活动与外界明

关键词：哺乳动物昼夜节律调节神经昼夜光感受器导引作用黑视素隐花色素视网膜节细胞

Tumor inflammation-specific self-amplifying fluorescent molecular probes induce an anti-tumor immune response

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期 273-287页

作者： Shuguang Yang Lijun hu Hong xiao Zecong xiao Xintao Shuai PCFM Lab of Ministry of Education School of Materials Science and Engineering Sun Yat-sen University Department of Ultrasound The Fifth Affiliated Hospital Sun Yat-sen University Department of Medical Ultrasound The Third Affiliated Hospital of Sun Yat-sen University Nanomedicine Research Center The Third Affiliated Hospital of Sun Yat-sen University

Enhancing the concentration of exogenous molecular drugs within the tumor microenvironment through enzyme-catalyzed polymerization presents a novel strategy for cancer therapy. Nonetheless, the optimization of the catalytic efficiency is often impeded by the inefficient expression of enzymes. Herein, we reported a self-amplifying fluorescent molecular probe, Bis-HTPICG, for photodynamic therapy(PDT) and subsequent PDT-induced immunoreaction. The Bis-HTP-ICG probe possesses a noticeable enzyme-catalyzed polymerization facilitated by myeloperoxidase(MPO), a crucial enzyme secreted by neutrophils at inflammation sites. Upon exposure to laser irradiation, Bis-HTP-ICG showed a high PDT efficacy, inducing an acute inflammatory response that stimulates further recruitment of neutrophils and then elevated MPO secretion. The heightened level of MPO enhances the accumulation of the Bis-HTP-ICG via self-polymerization or binding with intratumoral proteins following MPO enzyme catalysis, instigating a self-amplifying chain reaction cycle involving Bis-HTP-ICG, neutrophils and ***, PDT efficiently incites immunogenic cell death(ICD) in tumor cells, initiating an anti-tumor immune response including dendritic cells(DCs) maturation, T cell proliferation and reprogramming of tumor-associated neutrophils(TANs). This work portrays a promising strategy for self-amplification of fluorescent molecular probes through adjustable enzyme levels,potentially offering a unique avenue to enhance the tumor accumulation of molecular drugs for improved tumor therapy.

关键词：

同方期刊数据库

Identification of a Positive Cis-Element Upstream of human NKX3.1 Gene

在线全文

学校读者我要写书评

暂无评论

Acta Biochimica et Biophysica Sinica 2005年第11期37卷 773-778页

作者： An-Li JIANG Peng-Ju ZHANG xiao-Yan hu wei-Wen CHEN Feng KONG Zhi-Fang LIU hui-Qing YUAN Jian-Ye ZHANG Department of Biochemistry,Medical School of Shandong University,Jinan 250012,China DepartmentofBiochemistry MedicalSchoolofShandongUniversityJinan250012China

NKX3.1 is a prostate-specific homeobox gene related to prostate development and *** this work,we aimed to identify precisely the functional cis-element in the 197 bp region(from-1032 to -836 bp)of the NKX3.1 promoter(from -1032 to +8bp),which was previously identified topresent positive regulatory activity on NKX3.1 expression,by deletion mutagenesis analysis and electro-phoretic mobility shift assay(EMSA).A 16 bp positive cis-element located between -920 and -905 bpupstream of the NKX3.1 gene was identified by deletion mutation analysis and proved to be a functionalpositive cis-element by *** will be important to further study the functions and regulatory mechanismsof this positive cis-element in NKX3.1 gene expression.

关键词： human NKX3.1 cis-acting element positive regulation mutagenesis