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Intracardiac,pulmonary cement embolism in a 67-year-old female after cement-augmented pedicle screw instrumentation:A case report and review of literature

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World Journal of Clinical Cases 2021年第13期9卷 3120-3129页

作者： Tong-Zhou Liang Hai-Peng Zhu Bo gao Yan Peng Wen-Jie gao Department of Orthopedics Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510289Guangdong ProvinceChina Department of Orthopedics Guangdong Women and Children HospitalGuangzhou 511400Guangdong ProvinceChina

BACKGROUND We report a case of Intracardiac,pulmonary,and intravenous cement embolism after cement-augmented pedicle screw instrumentation in treating spondylolisthesis underlying osteoporotic bone,which was successfully managed by conservative *** describe the treatment and outcome of the patient,hoping to shed light on the management of bone cement *** SUMMARY A 67-year-old female suffered from progressive low back pain and numbness in lower extremities for 30 *** was diagnosed with L4 and L5 spondylolisthesis,spinal stenosis,and *** patient underwent spinal canal decompression,an interbody fusion of L4/5 and L5/S1,cement-augmented pedicle screw instrumentation in L4-L5 segments,and regular pedicle screw in S1 *** days postoperatively,a sudden drop in oxygen saturation *** tomography scan confirmed Intracardiac,pulmonary,and intravenous *** patient was treated conservatively by continuous low-flow oxygen inhalation,anti-coagulation,and antibiotic therapy for 1 mo and continued anticoagulation treatment for 6 *** patient showed no further symptoms in a 30-mo *** Intracardiac,pulmonary cement embolism after cement-augmented pedicle screw instrumentation is extremely *** clinical and radiographic evaluation is required in multiple sites of bone cement *** treatment may be a primary consideration in scattered emboli without life-threatening conditions,but a clinical decision should be made on an individualized basis.

关键词： Osteoporosis Polymethyl methacrylate cement Pulmonary embolism Cement-augmented pedicle screw instrumentation Conservative treatment Case report

Research on dynamic response characteristics of CFRP/Al HC SPs subjected to high-velocity impact

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Defence Technology（防务技术） 2018年第5期14卷 503-512页

作者： Guo-wen gao En-ling Tang Min-hui Feng Ya-fei Han Yue Li Mei Liu Ying-liang Xu Li Wang xiao-chu Lin Rui-zhi Wang Yi-guang Cheng Liang-liang Zhao Zhi-qiang Liang Jun-ru Wang Guan-jie Zhao Qing gao Tian-zhi Zheng School of Equipment Engineering Shenyang Ligong University

CFRP/Al HC SPs(Carbon Fiber Reinforced Plastic/Aluminum Honeycomb Sandwich Panels)composite structures are widely used in the aerospace and many other fields due to their excellent performances. In order to reveal profoundly the dynamic response characteristics of CFRP/Al HC SPs composite structure under high-velocity impact loading, the experiments about aluminum honeycomb core and CFRP/Al HC SPs composite structure impacted by high-velocity projectiles have been performed by using a one-stage light gas gun loading and a high-speed camera systems, respectively. The whole physical process of collision is analyzed by using TEMA software which is provided by high-speed camera's manufacturer,and the pictures and related physical parameters of the projectile passing through the different layers at the key moments are extracted based on the set frame rate of the video. Meanwhile, the ABAQUS/Explicit module was used to conduct numerical simulation under the same conditions as the experiments, and extracting the pictures and related physical parameters during the projectile penetrating through aluminum honeycomb core and the sandwich panels at the different key moments. The results show that the durations of action for the projectile impacting the Al HC core and the CFRP/Al HC SPs at the velocity about 280 m/s were 86 μs and 240 μs in experiments, respectively, and the durations of action were 90.7μs and 236.2 μs at the same experimental conditions in numerical simulation, which were basically consistent comparing the experimental to simulated results. Moreover, more than 70% for the kinetic energy of the projectile consumed by the sandwich panels was attributed to the front panel and the aluminum honeycomb core during the entire impact process, and all these have verified the reliability of the numerical simulation.

关键词： ABAQUS/Explicit Duration of action between projectile and target Energy absorption

利用MODIS C6数据分析中国西北地区气溶胶光学厚度时空变化特征

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环境科学 2017年第7期38卷 2637-2646页

作者：赵仕伟高晓清中国科学院寒旱区陆面过程与气候变化重点实验室兰州730000 中国科学院西北生态环境资源研究院兰州730000 中国科学院大学

通过与AERONET太阳光度计站点数据进行对比验证,确认了MODIS C6 AOD融合产品在西北地区的适用性.利用2006~2015年MODIS/AQUA C6 MYD08-M3产品分析中国西北地区气溶胶光学厚度的时空变化特征和形成原因.结果表明:(1)从空间分布特征来看,... 详细信息

通过与AERONET太阳光度计站点数据进行对比验证,确认了MODIS C6 AOD融合产品在西北地区的适用性.利用2006~2015年MODIS/AQUA C6 MYD08-M3产品分析中国西北地区气溶胶光学厚度的时空变化特征和形成原因.结果表明:(1)从空间分布特征来看,塔里木盆地和关中盆地是高值区,青海南部、甘肃西南部是低值区;准噶尔盆地是前后5年年均AOD对比增量区,柴达木盆地和河套地区是对比减量区.(2)从时间变化特征来看,近10年西北地区年均AOD变化范围为0.18~0.22,2011年起呈缓慢下降趋势,平均年降幅约为0.32%;南疆地区呈现较为明显的年际变化特征,与沙尘天气强弱、频次的年份分布直接相关;东部地区在2011~2015年,下降趋势显著,平均年降幅达到1.1%;北疆和青藏地区年均AOD整体保持平稳;西北地区不同区域AOD季节变化均呈现从春季至秋季逐步下降,冬季再次回升的相同关系.

关键词： MODIS 气溶胶光学厚度 AERONET 时空特征西北地区

Molecular characterization and efficacy evaluation of a transgenic corn event for insect resistance and glyphosate tolerance

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2018年第8期19卷 610-619页

作者： Miao-miao LIU xiao-jing ZHANG Yan gao Zhi-cheng SHEN Chao-yang LIN Institute of Insect Science Department of Plant Protection Zhejiang University

A transgenic maize event ZD12-6 expressing a Bacillus thuringiensis （Bt） fusion protein CrylAb/Cry2Aj and a modified 5-enolpyruvylshikimate-3-phosphate synthase （EPSPS） protein G10 was characterized and evaluated. Southern blot analysis indicated that ZD12-6 is a single copy integration event. The insert site was determined to be at chromosome 1 by border sequence analysis. Expression analyses of Bt fusion protein CrylAb/Cry2Aj and the EPSPS protein G10 suggested that they are both expressed stably in different generations. Insect bioassays demonstrated that the transgenic plants are highly resistant to Asian corn borer （Ostnnia furnacalis）, cotton boll worm （Helicoverpa armigera）, and armyworm （Mythimna separata）. This study suggested that ZD12-6 has the potential to be developed into a commercial transgenic line.

关键词： Transgenic maize Bacillus thuringiensis (Bt) Insect resistance Glyphosate tolerance

Mechanism Underlying Antitumor Effects of Sinomenine

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Chinese Journal of Integrative Medicine 2019年第11期25卷 873-878页

作者： gao Le-nyu ZHONG Bing WANG Yong Department of Traditional Chinese Medicine Southwest Hospital the Third Military Medical University (Army Military Medical University)

Sinomenine(SIN) is a bioactive alkaloid compound extracted from a Chinese medicinal plant Sinomenium acutum. It is a multitarget antitumor natural substance. Various mechanisms have been proposed for the antitumor effects of SIN, such as direct cytotoxicity, induction of apoptosis, sensitization attenuating radiotherapy and chemotherapy, reversal of drug resistance, resistance to distant metastasis, and antiangiogenesis. SIN can be used as a tumor cell killer and an adjuvant to radiotherapy and chemotherapy. However, recent studies are mostly limited to the basic experimental stage; no systematic clinical studies have yet been reported. Therefore, this paper aimed to review the mechanism underlying the antitumor effects of SIN by consulting relevant domestic and foreign studies and to provide a relevant reference for further development, use, and exploration of SIN.

关键词： antitumor mechanism pharmacology sinomenine Chinese medicine

含苯并咪唑结构的薁类衍生物的设计合成及抗炎活性研究

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有机化学 2023年第9期43卷 3246-3256页

作者：肖梦佳高希珂四川师范大学化学与材料科学学院成都610066 中国科学院上海有机化学研究所、中国科学院有机功能分子合成与组装化学重点实验室上海200032

苯并咪唑(BI)结构广泛存在于多种生物活性化合物中, 在药物合成领域受到越来越多的关注. 薁类衍生物是一类可从药用植物中获得的天然产物, 具有抗炎、抗氧化及低毒等特点. 以薁类衍生物与BI为原料, 通过Buchwald- Hartwig偶联得到了14... 详细信息

苯并咪唑(BI)结构广泛存在于多种生物活性化合物中, 在药物合成领域受到越来越多的关注. 薁类衍生物是一类可从药用植物中获得的天然产物, 具有抗炎、抗氧化及低毒等特点. 以薁类衍生物与BI为原料, 通过Buchwald- Hartwig偶联得到了14个含苯并咪唑结构的薁类衍生物, 并研究了其抗炎活性和构效关系. 结果表明, 这些化合物能有效抑制脂多糖(LPS)诱导的巨噬细胞中NO的产生, 具有比愈创木薁磺酸钠(GAS-Na)更好的抗炎活性. 其中有三个薁类衍生物具有低毒性和高抗炎效果, 酶联免疫吸附测定法(ELISA)表明其以浓度依赖性的方式抑制LPS诱导的肿瘤坏死因子α (TNF-α)和白细胞介素6 (IL-6)的释放. 研究表明1-愈创木薁-苯并咪唑(GABI-1)具有高抗炎活性(给药浓度为20 μmol/L时的NO抑制率为33.69%)和低细胞毒性, 有望成为新型抗炎药候选分子.

关键词：薁愈创木薁苯并咪唑愈创木薁磺酸钠抗炎活性

Surface-patterned chalcogenide glasses with high-aspect-ratio microstructures for long-wave infrared metalenses

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Opto-Electronic Science 2024年第10期3卷 1-13页

作者： Zhaofeng Gu Yixiao gao Kongsi Zhou Junyang Ge Chen Xu Lei Xu Mohsen Rahmani ran Jiang Yimin Chen Zijun Liu Chenjie Gu Yaoguang Ma Jianrong Qiu Xiang Shen Laboratory of Infrared Materials and Devices Research Institute of Advanced TechnologiesNingbo UniversityNingbo 315211China Zhejiang Key Laboratory of Advanced Optical Functional Materials and Devices Ningbo 315211China Advanced Optics&Photonics Laboratory Department of EngineeringSchool of Science and TechnologyNottingham Trent UniversityNottingham NG118NSUnited Kingdom Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational ResearchCenter for Advanced PhotonicsZhejiang UniversityHangzhou 310027China Ningbo Institute of Oceanography Ningbo 315832China

Multidimensional-engineering chalcogenide glasses is widely explored to construct various infrared photonic devices,with their surface as a key dimension for wavefront ***,we demonstrate direct patterning high-aspect-ratio microstructures on the surface of chalcogenide glasses offers an efficient and robust method to manipulate longwave infrared *** chalcogenide glass being considered soft in terms of its mechanical properties,we successfully fabricate high-aspect-ratio micropillars with a height of 8μm using optimized deep etching process,and we demonstrate a 2-mm-diameter all-chalcogenide metalens with a numerical aperture of 0.45 on the surface of a 1.5-mm-thick As2Se3 *** the exceptional longwave infrared(LWIR)transparency and moderate refractive index of As2Se3 glass,the all-chalcogenide metalens produces a focal spot size of~1.39λ0 with a focusing efficiency of 47%at the wavelength of 9.78μm,while also exhibiting high-resolution imaging *** work provides a promising route to realize easy-to-fabricate,mass-producible planar infrared optics for compact,light-weight LWIR imaging systems.

关键词： chalcogenide glasses long wave infrared metalens

Dust collector localization in trouble of moving freight car detection system

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Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第2期14卷 98-106页

作者： Fu-qiang ZHOU Rong ZOU He gao School of Instrumentation Science and Optoelectronics Engineering Beihang University

For a long time,trouble detection and maintenance of freight cars have been completed manually by *** realize the transition from manual to computer-based detection and maintenance,we focus on dust collector localization under complex conditions in the trouble of moving freight car detection *** mid-level features which are also named flexible edge arrangement(FEA) features,we first build the edge-based 2D model of the dust collectors,and then match target objects by a weighted Hausdorff distance *** difference is that the constructed weighting function is generated by the FEA features other than specified subjectively,which can truly reflect the most basic property regions of the 3D *** results indicate that the proposed algorithm has better robustness to variable lighting,different viewing angle,and complex texture,and it shows a stronger adaptive *** localization correct rate of the target object is over 90%,which completely meets the need of practical applications.

关键词： Hausdorff distance Weighting function Trouble detection Rail transportation

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单机多目标火力/电子战攻击综合决策

系统工程与电子技术 2008年第5期30卷 872-875页

作者：李波高晓光西北工业大学电子信息学院陕西西安710072

针对单机多目标攻击时的火力/电子战综合决策,提出了一种考虑电子干扰效果的火力打击目标排序算法。该算法根据目标雷达辐射源对载机的威胁程度,建立了机载有源压制干扰的能量分配方法,利用有源压制干扰对目标雷达的压制距离引入距离削... 详细信息

针对单机多目标攻击时的火力/电子战综合决策,提出了一种考虑电子干扰效果的火力打击目标排序算法。该算法根据目标雷达辐射源对载机的威胁程度,建立了机载有源压制干扰的能量分配方法,利用有源压制干扰对目标雷达的压制距离引入距离削弱因子,可获得有源干扰效果对目标威胁级别的影响程度,改进只考虑敌我双方火力威胁程度时的目标打击排序结果。给出了该算法的具体步骤,通过仿真实验证明了该算法的有效性。仿真结果表明,考虑有源干扰效果后的火力攻击目标排序,可以使飞行员首先攻击毁伤概率最大的目标,提高整体的作战效能。

关键词：决策理论协同作战目标排序火力打击电子战