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Chinese Journal of Chemistry 2019年第1期37卷 63-70页

作者： Bao-Le Li Wei-Yang Gao han Li Shuo-qing Zhang xiao-qing han Jun Lu Ren-xiao Liang Xin Hong Yi-Xia Jia College of Chemical Engineering State Key Laboratory Breeding Base of Green-Chemical Synthesis TechnologyZhejiang University of TechnologyHangzhouZhejiang 310014China Department of Chemistry Zhejiang UniversityHangzhouZhejiang 310027China Shanghai Key Laboratory for Molecular Engineering of Chlral Drugs Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

Summary of main observation and conclusion An enantioselective desymmetric nucleophilic α-addition of cyclohexanone to propiolamide has been developed through a 6-exo-dig cyclization *** employing simple and readily available L-proline sodium salt as a bifunctional catalyst,a series of chiral 6,6-bicyclic bridged products bearing morphan scaffold have been isolated in good yields and excellent *** functional theory (DFT)calculations elucidated the origins of the enantioselectivity and regioselectivity of this transformation.A salt bridge that links the amide carbonyl group with proline carboxylate in the transition state was proven to be the driving force for the induction of excellent enantioselectivity.

关键词： enantioselective scaffold group

LINC00511 promotes gastric cancer cell growth by acting as a ceRNA

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World Journal of Gastrointestinal Oncology 2020年第4期12卷 394-404页

作者： Chong-Bing Sun Hong-Yi Wang xiao-qing han Yong-Ning Liu Meng-Chun Wang Hong-Xia Zhang You-Feng Gu xiao-Gang Leng Department of General Surgery Weifang People's HospitalWeifang 261041Shandong ProvinceChina Department of Anorectal Surgery Weifang People's HospitalWeifang 261041Shandong ProvinceChina Department of Spine Surgery Weifang People's HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most aggressive malignancies,with a high incidence and poor prognosis ***,accumulating evidence has illustrated that long noncoding RNAs(lnc RNAs)play pivotal roles in many *** has been reported that LINC00511 contributes to tumorigenesis in various ***,the role of LINC00511 in GC cell growth remains mostly *** To determine whether the lnc RNA LINC00511 exerted its carcinogenic function in GC via the miR-124-3 p/PDK4 *** Cell culture and transfection,RNA extraction and quantitative real-time PCR,CCK-8 assay,Colony formation assay,Luciferase reporter assay,RIP assay,RNA pull-down assay,and Western blot analysis were used to show expression and mechanisms of LINC00511 in GC progression and *** assays were performed to verify the relationships among LINC00511,miR-124-3 p and PDK4 *** The expression of LINC00511 was remarkably upregulated in GC cells compared to that in corresponding normal cell *** to the controls,cell proliferation was inhibited,and cell apoptosis was increased upon LINC00511knockdown,demonstrating that LINC00511 influenced GC cell *** exploration of the molecular mechanism revealed that LINC00511 functioned as a molecular sponge of miR-124-3 p and that PDK4 was a downstream target of miR-124-3 p in *** assays showed that the overexpression of PDK4 could partly restore the inhibitory function of si-LINC00511 in *** These data demonstrate that LINC00511 promotes gastric cancer cell growth by acting as a ce RNA to regulate the miR-124-3 p/PDK4 axis,which may be a promising therapeutic target for GC.

关键词： LINC00511 miR-124-3p PDK4 Long noncoding RNAs Gastric cancer

Effect of two surgical approaches on the lung function and prognosis of patients with combined esophagogastric cancer

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World Journal of Gastrointestinal Surgery 2023年第9期15卷 1986-1994页

作者： Chong-Bing Sun xiao-qing han Hao Wang Yi-Xuan Zhang Meng-Chun Wang Yong-Ning Liu Department of General Surgery Weifang People's HospitalWeifang 261041Shandong ProvinceChina Department of Spinal Surgery Weifang People's HospitalWeifang 261041Shandong ProvinceChina Department of Medical Weifang People's HospitalWeifang 261041Shandong ProvinceChina

BACKGROUND Adenocarcinoma of the esophagogastric junction has a center of origin within 5 cm of the esophagogastric *** resection remains the main treatment.A transthoracic approach is recommended for Siewert I adenocarcinoma of the esophagogastric junction and a transabdominal approach is recommended for Siewert III adenocarcinoma of the esophagogastric ***,there is a need to determine the optimal surgical approach for Siewert II adenocarcinoma of the esophagogastric junction to improve lung function and the prognosis of *** To investigate and compare the surgical effects,postoperative changes in pulmonary function,and prognoses of two approaches to treating combined esophagogastric *** One hundred and thirty-eight patients with combined esophagogastric cancer treated by general and thoracic surgeries in our hospital were *** were divided into group A comprising 70 patients(transabdominal approach)and group B comprising 68 patients(transthoracic approach)based on the surgical *** indexes related to surgical trauma,number of removed lymph nodes,indexes of lung function before and after surgery,survival rate,and survival duration of the two groups were compared 3 years after *** The duration of surgery,length of hospital stay,and postoperative drainage duration of the patients in group A were shorter than those of the patients in group B,and the volume of blood loss caused by surgery was lower for group A than for group B(Phan for group B(Phan those in group B on re-evaluation at 3 mo postoperatively(Phan that of patients in group B,which was 23.53%(P<0.05)

关键词： Transabdominal approach Transthoracic approach Esophagogastric Junction cancer Pulmonary function Prognosis Adenocarcinoma

Expression of annexin A5 in serum and tumor tissue of patients with colon cancer and its clinical significance

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World Journal of Gastroenterology 2017年第39期23卷 7168-7173页

作者： Chong-Bing Sun Ai-Yan Zhao Shuai Ji xiao-qing han Zuo-Cheng Sun Meng-Chun Wang Fu-Chang Zheng Department of General Surgery Weifang People’s Hospital Department of Anorectal Surgery Linqu People’s Hospital

AIM To investigate the expression of annexin A5 in serum and tumor tissue of patients with colon cancer and to analyze its clinical *** Ninety-three patients with colon cancer treated at our hospital between February 2013 and March 2016 were included in an observation group, and 40 healthy individuals were included in a control group. Enzyme-linked immunosorbent assay was performed to determine the serum level of annexin A5, while immunohistochemistry was performed to determine the expression of annexin A5 in cancer *** The serum level of annexin A5 was 0.184 ± 0.043 ng/m L in the observation group, which was significantly higher than that in the control group(P han that in patients without lymph node metastasis(P han that in patients with stage Ⅰ to Ⅱ disease(P han that in patients whose tumors were negative for annexin A5 expression(P 0.148 ng/m L for serum level of annexin A5 was used in the diagnosis of colon cancer, the sensitivity was 83.90%, and the specificity was 57.50%.CONCLUSION For patients with colon cancer, annexin A5 expression in cancer tissues is related to lymph node metastasis and tumor grade. Serum level of annexin A5 is related to annexin A5 expression in cancer tissues and is of diagnostic relevance.

关键词： Immunohistochemistry Annexin A5 Colon cancer Serum

Spatial modulation for electronic speckle patterns and its demodulation

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Optoelectronics Letters 2005年第2期1卷 141-143页

作者： SUN Ping TAO Chun-xian ZhanG Li WANG xiao-feng han qing College of Physics and Electronics Shondong Normal University Jinan 250014 China

A spatial modulation method for electronic speckle patterns is *** fringes are produced by object tilting and the phase field of deformation is demodulated by Fourier *** principle is *** system and some typical experimental results are *** results prove that by using object tilting method speckle patterns can be modulated very well and the out-of displacement of an object can be obtained effectively.

关键词：空间调制电子模式傅立叶传递相位测量干涉图

改进的ViBe算法及其在交通视频处理中的应用

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光学精密工程 2017年第3期25卷 806-811页

作者：闵卫东郭晓光韩清南昌大学信息工程学院南昌330031 天津工业大学计算机科学与软件学院天津300387

基于ViBe算法的运动目标检测具有很高的处理效率,但在复杂背景下也存在缺陷,比如不能有效抑制运动目标的残影和鬼影区域、易受噪音干扰,在交通视频的处理中更为明显。鉴于ViBe算法的这些不足,本文对ViBe原算法提出了改进,结合像素生命... 详细信息

基于ViBe算法的运动目标检测具有很高的处理效率,但在复杂背景下也存在缺陷,比如不能有效抑制运动目标的残影和鬼影区域、易受噪音干扰,在交通视频的处理中更为明显。鉴于ViBe算法的这些不足,本文对ViBe原算法提出了改进,结合像素生命长度对鬼影或残影像素进行判断,利用二次更新策略提高消除速度。根据像素值变化引入最大类间方差法,将原有的固定像素阈值变为动态阈值,以提高交通视频中车辆目标检测的抗干扰能力。实验结果表明,在3组不同交通场景视频中,改进算法能够在较少帧数内消除目标的残影或者鬼影。对结果的量化分析也证明了改进算法由于应用了动态阈值,使目标检测的精准度和整体性都有所提高。

关键词：运动目标检测 ViBe算法改进视频处理动态噪音抑制动态阈值

Optimization of PID Parameters Based on Genetic Algorithm and Interval Algorithm

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Optimization of PID Parameters Based on Genetic Algorithm an...

Study of preparation of BG/HA gradient coating on titanium alloy by electrophoretic deposition method

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作者： SHAO xiao-gen,xiao Li-qing,han Cheng-chun Xuzhou Institute of Technology,Xuzhou 221008,China

To overcome simple genetic algorithm’s defects of worse local searching ability and premature convergence,a hybrid algorithm of genetic algorithm and interval algorithm was proposed,and applied to parameters optimization of PID controller by employing interval algorithm in population initialization of genetic *** simulation and experimental results show that the new algorithm is better than simple genetic algorithm,which can improve the convergence speed,overcome the premature convergence phenomena,reduce the influence of random initial population, improve the convergence precision,and has excellent convergence performance and optimization ability.

关键词： Genetic Algorithm Interval Algorithm PID Controller Simulation

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Chinese Journal of Biomedical Engineering(English Edition) 2001年第1期10卷 13-19页

作者： CHEN xiao-ming, han qing-rong, LI Shi-pu, XU Chuan-bo Biomedical Materials and Engineering Center of Wuhan University of Technology, Wuhan 430070,China Biomedical Materials and Engineering Center of Wuhan University of Technology Wuhan 430070China

In this paper, a gradient bioactive coating made from modified bioglass(BG) and hydroxyapatite(HA) was prepared by electrophoretic deposition method(EPD)on the surface of titanium alloy. Strong bonding between the matrix and BG/HA gradient coating was got by sintering. Crystal composition of the coating was analyzed by XRD. The characteristics of surface and cross section of the coating were observed by SEM. Adhesive strength of the coating was tested by pull method. The optimizing technological parameters were determined.

关键词： BG/HA gradient coating, electrophoretic deposition (EPD), titanium alloy

Spatial modulation for electronic speckle patterns and its demodulation

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Optoelectronics Letters 2005年第2期 65-67页

作者： SUN Ping-*, TAO Chun-xian, ZhanG Li, WANG xiao-feng, and han qing College of Physics and Electronics,Shandong Normal University,Jinan 250014,China

关键词： ESPI

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai xiao-Yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan xiao-Yan Sun Xu-Fang Ying Zhi-qing Ben Min han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin