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Ovarian Damages Produced by Aerosolized Fine Particulate Matter （PM2.5） Pollution in Mice： Possible Protective Medications and Mechanisms

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Chinese Medical Journal 2017年第12期130卷 1400-1410页

作者： Hui-Fang Gai Jian-Xiong An xiao-yan qian Yong-Jie Wei John P Williams Guo-Lan Gao Department of Clinical Medicine Weifang Medical University Weifang Shandong 261000 China Department of Obstetrics and Gynecology Aviation General Hospital of China Medical University and Beijing Institute of Translational Medicine Chinese Academy of Sciences Beijing 100012 China Department of Anesthesiology Pain Medicine and Critical Care Medicine Aviation General Hospital of China Medical University and Beijing Translational Medicine Chinese Academy of Sciences Beijing 100012 China Laboratory of Environmental Criteria and Risk Assessment and Environmental Standards Institute Chinese Research Academy of Environmental Sciences Beijing 100012 China Department of Anesthesiology University of Pittsburgh School of Medicine Pittsburgh PA 15213 USA

Background： Ambient aerosol fine particulate matter （PM2.5） is associated with male reproductive toxicity in experiments and may have adverse effects in the female. However, studies evaluating the protective effects and precise mechanisms of aspirin, Vitamin C, Vitamin E, or ozone against toxic effects of PM2.5 are sparse. This study was conducted to investigate the possible protective effects and mechanisms of aspirin, Vitamin C, Vitamin E, or ozone on fertility in female mice treated with PM2.5, Methods： Eighty-four ICR mice were divided into six groups： control group, PM2.5 group, PM2.5 ＋ aspirin group, PM2.5 ＋ Vitamin C group, PM2.5 ＋ Vitamin E group, and PM2.5 ＋ ozone group. PM2.5 was given by intratracheal instillation every 2 days for 3 weeks. Aspirin, Vitamin C, and Vitamin E were given once a day by oral gavage for 3 weeks, and ozone was administered by intraperitoneal injection once a day for 3 weeks. The levels ofanti-Mullerian honnone （AMH）, interleukin-6 （IL-6）, tumor necrosis factor-alpha （TNF-α）, and 8-hydroxy-2＇-deoxyguanosine （8-OHdG） were measured using enzyme-linked immunosorbent assay. Western blotting analysis was used to analyze the expressions ofBcl-2, Bax, and caspase-3 in ovaries. Changes in histological structure were examined by light microscope and electron microscopy was used to detect ultramicrostructure. Results： The results demonstrated that PM2.5 decreased AMH levels （P 〈 0.001）; however, aspirin （P 〈 0.001）, Vitamin C （P 〈 0.001）, Vitamin E （P = 0.001）, and ozone （P = 0.002） alleviated the decrease. Changes of IL-6, TNF-α, 8-OHdG, Bax/Bcl-2, and caspase-3 in PM2.5 group were increased compared to control group （P 〈 0.001）, while in PM2.5 ＋ aspirin, PM2.5 ＋ Vitamin C, PM2.5 ＋ Vitamin E, and PM2.5 ＋ ozone groups, they were statistically decreased compared to PM2.5 group （P 〈 0.001 or P 〈 0.05）. Conclusions： PM2.5 cause the damage of ovaries, and aspirin, Vitamin C, Vitamin E, and ozone antagonizes the damage. The protective mechanism

关键词： Aspirin Fine Particulate Matter Ozone Reproductive Toxicity Vitamin C Vitamin E

Curation,nomenclature,and topological classification of receptor-like kinases from 528 plant species for novel domain discovery and functional inference

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Molecular Plant 2024年第4期17卷 658-671页

作者： qian Liu Qiong Fu Yujie yan qian Jiang Longfei Mao Long Wang Feng Yu Heping Zheng State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University College of BiologyChangshaHunan 410082China Bioinformatics Center Hunan University College of BiologyChangshaHunan 410082China

Receptor-like kinases(RLKs)are the most numerous signal transduction components in plants and play important roles in determining how different plants adapt to their ecological *** on RLKs has focused mainly on a small number of typical RLK members in a few model *** is an urgent need to study the composition,distribution,and evolution of RLKs at the holistic level to increase our understanding of how RLKs assist in the ecological adaptations of different plant *** this study,we collected the genome assemblies of 528 plant species and constructed an RLK *** this dataset,we identified and characterized 524948 RLK family *** member underwent systematic topological classification and was assigned a gene ID based on a unified nomenclature ***,we identified two novel extracellular domains in some RLKs,designated xiao and *** analysis of the RLK family revealed that the RLCK-XVII and RLCK-XII-2 classes were present exclusively in dicots,suggesting that diversification of RLKs between monocots and dicots may have led to differences in downstream cytoplasmic *** also used an interaction proteome to help empower data mining for inference of new RLK functions from a global perspective,with the ultimate goal of understanding how RLKs shape the adaptation of different plants to the environments/*** assembled RLK dataset,together with annotations and analytical tools,forms an integrated foundation of multiomics data that is publicly accessible via the metaRLK web portal(http://***).

关键词： RLK RLCK domain signaling pathway receptor-protein interactions

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基于图像的非真实感艺术绘制技术综述

工程图学学报 2010年第1期31卷 6-12页

作者：钱小燕南京航空航天大学民航学院江苏南京210016

非真实感绘制是计算机图形学和图像处理中一个崭新的课题,属于计算机艺术的范畴,正受到国内外研究者越来越多的重视并取得了一系列的研究成果。首先简要介绍了非真实感绘制的研究意义及其研究范围;然后通过对其中涉及的主要关键算法进... 详细信息

非真实感绘制是计算机图形学和图像处理中一个崭新的课题,属于计算机艺术的范畴,正受到国内外研究者越来越多的重视并取得了一系列的研究成果。首先简要介绍了非真实感绘制的研究意义及其研究范围;然后通过对其中涉及的主要关键算法进行总结分析,并对国内外典型的绘制方法进行比较和分类,阐述了非真实感绘制的主要研究内容;最后对今后的发展方向做出了展望。

关键词：计算机应用非真实感绘制综述颜色传输纹理合成基于画笔的绘制

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引导滤波的红外图像预处理算法

科学技术与工程 2015年第21期35卷 32-37页

作者：钱小燕南京航空航天大学民航学院南京210000

针对红外图像固有噪声和灰度分布非均匀性影响图像质量的问题,提出一种基于引导滤波的红外图像预处理方法。根据引导图的局部信息,在红外图像的不同位置动态生成滤波核函数,从而可以在平滑场景的同时保持甚至增强边缘细节。实验表明,该... 详细信息

针对红外图像固有噪声和灰度分布非均匀性影响图像质量的问题,提出一种基于引导滤波的红外图像预处理方法。根据引导图的局部信息,在红外图像的不同位置动态生成滤波核函数,从而可以在平滑场景的同时保持甚至增强边缘细节。实验表明,该方法可以有效滤除噪声,保持场景强边缘,改善灰度分布非均匀性;且由于引导滤波算法复杂度与滤波半径无关,处理速度快。此外,应用实验表明该方法可以提高融合图像视觉效果,增强目标跟踪的定位精度,在图像增强中能够有效避免伪边缘的产生。

关键词：红外图像去噪引导滤波图像增强图像融合

RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-xiao Li Hong-Nan Mo yan-Tong Zhou Dan Lv Jing-Tong Zhai Hai-Li qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

Micro-sized nanoaggregates:Spray-drying-assisted fabrication and applications

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Particuology 2024年第2期85卷 22-48页

作者： Dan-Lei yang Rong-Kun Liu yan Wei qian Sun Jie-Xin Wang School of Life Sciences and Chemical Engineering Jiangsu Second Normal UniversityNanjing210013China State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology School of Chemistry and Chemical EngineeringGuangxi UniversityNanning530004China

The applications of nanoparticles suffer from their extremely small size and intrinsic trend of *** nanoparticles to form micro-sized nanoaggregates(MNAs)with increased size,ordered structure,as well as controllable size,shape,and morphology is a crucial step in various fields of science and technology to maintain the unique characteristics of nanoparticles while obtaining greatly enhanced or new performance at the *** structure of MNAs prominently affects their functionality,which is determined by the arrangement of nanoparticles and the interaction between primary *** methods have been proposed to prepare the MNAs,in which spray-drying technology stands out considering the feasibility,scalability for industry,cost,and *** assembly of nanoparticles through spray-drying under tunable process parameters yields diverse physical properties and structural arrangements of nanoparticles of the MNAs,they therefore exhibit enormous potential in a wide range of application *** review presents the construction and applications of spray-dried *** factors that influence the size,morphology,and structure of the MNAs are discussed in *** addition,the outstanding application performance resulting from the tightly packed nanoparticles in regular-shaped MNAs obtained by the spray-drying process is illustrated.

关键词： Spray-drying Micro-sized nanoaggregates Applications

Demyelinating neuropathy in patients with hepatitis B virus: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1766-1771页

作者： xiao-xiao yan Jin Huang Jing Lin Department of Neurology The Third Affiliated Hospital of Wenzhou Medical UniversityRuian 325000Zhejiang ProvinceChina

BACKGROUND Hepatitis B rarely leads to demyelinating neuropathy,despite peripheral neuropathy being the first symptom of hepatitis B *** SUMMARY A 64-year-old man presented with sensorimotor symptoms in multiple peripheral *** testing showed that these symptoms were due to hepatitis *** undergoing treatment involving intravenous immunoglobulin and an antiviral agent,there was a notable improvement in his *** Although hepatitis B virus(HBV)infection is known to affect hepatocytes,it is crucial to recognize the range of additional manifestations linked to this *** connection between long-term HBV infection and demyelinating neuropathy has seldom been documented;hence,prompt diagnostic and treatment are *** patient's positive reaction to immunoglobulin seems to be associated with production of the antigen-antibody immune complex.

关键词： Hepatitis B virus infection Extrahepatic manifestations Demyelinating neuropathy Intravenous immunoglobulin Electroneuromyography Case report

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Chinese Journal of Integrative Medicine 2024年第8期30卷 684-691页

作者： CAO Wei WANG Lu HOU Ting-hui SHI Yun-zhou ZHENG qian-hua ZHENG Hui ZOU Zi-hao QIN Di yanG qian CHEN Si-jue WANG Hai-yan xiao Xian-jun LI Ying Department of Acupuncture and Moxibustion Chengdu University of Traditional Chinese MedicineChengdu610000China Acupuncture and Moxibustion School of Health Preservation and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu610000China

Objective: To explore the demographic and disease-related factors associated with acupuncture response in patients with chronic tension-type headache(CTTH). Methods: Using data from the randomized clinical trial(218 cases) consisting of 4 weeks of baseline assessment, 8 weeks of treatment, and 24 weeks of follow-up, participants were regrouped into responders(at least a 50% reduction in monthly headache days at week 16 compared with baseline) and non-responders. Twenty-three demographic and disease-related factors associated with acupuncture response in 183 participants were analyzed by multivariable logistic regression. Results: One hundred and nineteen(65.0%) participants were classified as responders. Four factors were significantly independently associated with acupuncture response, including treatment assignment, headache intensity at baseline, and 2 domains [general health(GH) and social functioning(SF)] from the 36-Item Short Form Health Survey quality of life questionnaire. Treatment assignment was associated with nonresponse: participants receiving true acupuncture were 3-time more likely to achieve a CTTH response than those receiving superficial acupuncture [odds ratio(OR) 0.322, 95% confidence interval(CI) 0.162 to 0.625, P=0.001]. Compared with patients with mild-intensity headache, patients with moderate-intensity headache were twice as likely to respond to acupuncture(OR 2.001, 95% CI 1.020 to 4.011, P=0.046). The likelihood of non-response increased by 4.5% with each unit increase in the GH grade(OR 0.955, 95% CI 0.917 to 0.993, P=0.024) while decreased by 3.8% with each unit increase in the SF grade(OR 1.038, 95% CI 1.009 to 1.069, P=0.011). Conclusions: Greater headache intensity, lower GH score, and higher SF score were associated with better acupuncture responses in CTTH patients. These 3 factors require independent validation as predictors of acupuncture effectiveness in CTTH.

关键词： acupuncture chronic tension-type headache logistic regression quality of life Chinese medicine

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： Huang Chen Rui-Ying Jiang Zhan Hua xiao-Wei Wang xiao-Li Shi Ye Wang qian-qian Feng Jie Luo Wu Ning yan-Fen Shi Da-Kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II *** This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis