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Combination of oridonin and TRAIL induces apoptosis in uveal melanoma cells by upregulating DR5

International Journal of Ophthalmology(English edition) 2021年第12期14卷 1834-1842页

作者： Xin Hua peng Wu Guo-Sheng Gao xiao-Lei Ye Department of Clinical Laboratory Hwa Mei HospitalUniversity of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Ningbo Institute of Life and Health Industry University of Chinese Academy of SciencesNingbo 315010Zhejiang ProvinceChina Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina College of Life Sciences China West Normal UniversityNanchong 637009Sichuan ProvinceChina

AIM:To investigate the inhibitory effect of the combined use of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and oridonin on choroidal melanoma cell lines,and to explore its underlying ***:MUM-2B and C918 cells were treated with different concentrations of TRAIL and oridonin,and MTT assay used to evaluate the inhibition rate of the two compounds on ***,the cell cycle distribution and apoptosis were detected by flow cytometry,and changes in apoptosis-related proteins such as death receptor 5(DR5),a-caspase-3,and x-linked inhibitor of apoptosis protein(XIAP)were detected by Western ***-2B cells were transfected with si-DR5,which interfered with the expression of the DR5 *** and Western blot assay were used to detect cell activity and apoptosis-related ***:When TRAIL and oridonin were simultaneously administered to the MUM-2B cells,the apoptosis rate was significantly higher than that by the two drugs ***,the effect of combined use of TRAIL and oridonin on C918 cells was not significantly different from that used *** cycle analysis showed that TRAIL and oridonin could induce G2/M arrest in MUM-2B *** Western blot results showed that the protein expression levels of the DR5,a-caspase-3,and BAX increased,while the expression levels of the anti-apoptosis-related proteins XIAP and BCL-2 were suppressed when TRAIL and oridonin simultaneously administered to MUM-2B *** the expression of DR5 gene in MUM-2B cells could reverse the inhibitory effect of oridonin and TRAIL on the proliferation and apoptosis induction of MUM-2B ***:The inhibitory effects of oridonin and TRAIL on MUM-2B cells are significantly enhanced when they were administered as a combined treatment,which may ascribe to up-regulation of DR5.

关键词： tumor necrosis factor-related apoptosisinducing ligand oridonin apoptosis choroidal melanoma

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Short-pulse high-power microwave breakdown at high pressures

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Chinese Physics B 2015年第2期24卷 282-286页

作者：赵朋程廖成冯菊 Institute of Electromagnetics Southwest Jiaotong University School of Physics and Optoelectronic Engineering Xidian University

The fluid model is proposed to investigate the gas breakdown driven by a short-pulse（such as a Gaussian pulse） highpower microwave at high ***,the fluid model requires specification of the electron energy distribution function（EEDF）;the common assumption of a Maxwellian EEDF can result in the inaccurate breakdown prediction when the electrons are not in *** confirm that the influence of the incident pulse shape on the EEDF is tiny at high pressures by using the particle-in-cell Monte Carlo collision（PIC-MCC） *** a result,the EEDF for a rectangular microwave pulse directly derived from the Boltzmann equation solver Bolsig＋ is introduced into the fluid model for predicting the breakdown threshold of the non-rectangular pulse over a wide range of pressures,and the obtained results are very well matched with those of the PIC-MCC *** time evolution of a non-rectangular pulse breakdown in gas,obtained by the fluid model with the EEDF from Bolsig＋,is presented and analyzed at different *** addition,the effect of the incident pulse shape on the gas breakdown is discussed.

关键词： fluid model electron energy distribution function gas breakdown short-pulse high-power microwave

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Gas emission and dynamics in the infrared dark cloud G31.23＋0.05

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Research in Astronomy and Astrophysics 2017年第4期17卷 35-48页

作者： xiao-Lan Liu Jun-Jie Wang Jin-Long Xu Chuan-peng Zhang National Astronomical Observatories Chinese Academy of SciencesBeijing 100012China NAOC-TU Joint Center for Astrophysics Lhasa 850000China

We performed a multiwavelength study towards the infrared dark cloud （IRDC） G31.23＋0.05 with new CO observations from Purple Mountain Observatory and archival data （the GLIMPSE, MIPSGAL, HERSCHEL, ATLASGAL, BGPS and NVSS surveys）. From these observations, we iden- tified three IRDCs with systemic velocities of 108.36 ± 0.06 （cloud A）, 104.22 ± 0.11 （cloud B） and 75.73 ± 0.07 km s-1 （cloud C） in the line of sight towards IRDC G31.23. Analyses of the molecular and dust emission suggest that cloud A is a filamentary structure containing a young stellar object; clouds B and C both include a starless core. Clouds A and B are gravitationally bound and have a chance to form stars. In addition, the velocity information and the position-velocity diagram suggest that clouds A and B are adjacent in space and provide a clue hinting at a possible cloud-cloud collision. Additionally, the distribution of dust temperature shows a temperature bubble. The compact core in cloud A is associated with an UCHII region, an IRAS source, H20 masers, CH3OH masers and OH masers, suggesting that massive star formation is active there. We estimate the age of the HII region to be （0.03-0.09）Myr, indicating that the star inside is young.

关键词： stars formation - ISM HII regions - ISM molecules - ISM individual (IRDCG31.23+0.05) - ISM kinematics and dynamics

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Protection of Two-Qubit Entanglement by the Quantum Erasing Effect

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Chinese Physics Letters 2012年第5期29卷 26-29页

作者： XIANG Shao-Hua DENG xiao-peng SONG Ke-Hui Department of Physics and Information Engineering Huaihua UniversityHuaihua 418008

We present a scheme to save the entanglement of two spatially separated atoms,each located in a leaky cavity,through the quantum erasing *** is shown that no matter whether the two atoms are in the pure or mixed state,one can robustly save their initial entanglement even if the number of erasing events is *** also briefly discuss the challenging aspect of implementing such a scheme.

关键词： method spatially separated

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Biomarker evidence for changes in terrestrial organic matter input into the Yellow Sea mud area during the Holocene

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Science China Earth Sciences 2016年第6期59卷 1216-1224页

作者： WU peng xiao xiaoTong TAO ShuQin YANG ZuoSheng ZHANG HaiLong LI Li ZHAO MeiXuna Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China Key Laboratory of Marine Hydrocarbon Resources and Environmental Geology Ministry of Land and ResourcesQingdao 266071China Third Institute of Oceanography State Oceanic Administration(SOA)Xiamen 361005China College of Marine Geoscience Ocean University of ChinaQingdao 266100China

We present lipid biomarker records of two cores （ZYI and ZY3） from the central South Yellow Sea mud area to investigate the changes in sources and transport processes of the sedimentary organic matter （OM） throughout the Holocene. Based on the analysis of marine biomarker content （EPB （Phytoplankton Biomarker, total content of brassicasterol, dinosterol and C37-alkenones） and crenarchaeol）, and terrestrial biomarkers （En-alkanols and brGDGTs） as well as TMBR＇ and BIT index values, the marine organic matter （MOM） and terrestrial organic matter （TOM） deposition history was reconstructed. Changes in TOM and MOM were related to variations in land vegetation density and marine productivity, as well as transport processes dominated by the oceanic circulation system. The marine biomarker contents from the South Yellow Sea have generally in- creased throughout the Holocene, indicating that the increased MOM contents were mainly controlled by the strengthening of the circulation system. The terrestrial biomarkers, on the other hand, were more variable, indicating more complex influence of TOM burial in the Yellow Sea. During the Early Holocene （7200-6000 cal yr BP）, the moderate TOM input revealed by the terrestrial proxy records may result from abundant land source supply by strong river transport despite the lack of transport via circulation system. The Mid-Holocene （6000-3000 cal yr BP） was characterized by decreased terrestrial biomarker contents. The balance between the decrease in land source supply and increase of transportation by the current system of the TOM resulted in the lower but stable contents of TOM. During the Late Holocene （3000 cal yr BP to present）, the TOM deposition in the South Yellow Sea increased as the current system was further enhanced and thus transported more TOM to the central South Yellow Sea, although the land supply of TOM was further reduced.

关键词： South Yellow Sea Holocene Biomarker Marine organic matter Terrestrial organic matter

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Screening of Substrates of Protein Arginine Methyltransferase 1 in Glioma

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Chinese Medical Sciences Journal 2012年第1期27卷 1-6页

作者： Shan Wang xiao-chao Tan Bin Yang Bin Yin xiao-zhong peng National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100005China

Objective To screen the asymmetric dimethyl arginines (ADMA)-containing proteins which could combine with protein arginine methyltransferase 1 (PRMT1). Methods Western blot was adopted to identify the expression of PRMT1 and the proteins with ADMA in glioma cell lines and normal brain tissues, and then to detect the changes of ADMA level after knock-down of PRMT1 with RNAi transfection in U87MG cells. Co-Immunoprecipitation (Co-IP), western blot, and sliver staining were employed to screen the candidate binding proteins of PRMT1. Then liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify the binding proteins of PRMT1. Results The expression of PRMT1 and some levels of ADMA were higher in glioma cell lines than in normal brain tissues. After knocking down PRMT1, some ADMA levels were found declined. After screening the binding proteins of PRMT1 with Co-IP and LC-MS/MS, 26 candidate binding proteins were identified. Among them, 6 candidate proteins had higher ions scores (>38) and bioinformation analysis predicted that SEC23-IP, ANKHD1-EIF4EBP3 protein, and 1-phosphatidylinositol-3-phosphate 5-kinase isoform 2 had possible methylated aginine sites. Conclusions The high expression of PRMT1 in glioma may induce the change of ADMA levels. Altogether 26 candidate proteins were identified, which contain ADMA and specifically bind with PRMT1.

关键词： protein arginine methyltransferase 1 asymmetric dimethyl arginines liquidchromatography-tandem mass spectrometry

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Effect of suppressing dust by multi-direction whirling air curtain on fully mechanized mining face

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International Journal of Mining Science and Technology 2016年第4期26卷 629-635页

作者： Nie Wen Liu Yanghao Wei Wenle Hu Xiangming Ma xiao peng Huitian State Key Laboratory of Mining Disaster Prevention and Control Co-founded by Shandong Province and the Ministry of Science and Technology Shandong University of Science and Technology Mining and Safety College Shandong University of Science and Technology

A combined method of numerical simulation and field testing was adopted in this study in the interest of solving the problem of hard to control high concentrate dusts on a fully mechanized mining face. In addi- tion, the dust suppression effect of a multi-direction whirling air curtain was studied in this paper. Under the influence of the wall attachment effect, the compressed air which blows out from the two-phase or three-phase radial outlets on the generator of the air curtain can form a multi-direction whirling air curtain, which can cover the whole roadway section of a fully mechanized mining face. The traditional method of controlling dust is a forcing system with exhaust overlap which has the major disadvantage of lacking a jet effect and consequently results in poor dust control. It is difficult to form the air flow field within the range of Lp ≤ 5√S. However, due to the effect of this novel system, the radial airflow can be turned into axial airflow allowing fresh air to flow through the length of the heading. The air flow field which is good at controlling dust diffusion can be formed 12.8 m from the heading face. Furthermore, the field measurement results show that before the application of a multi-direction whirling air curtain, the dust concentration is 348.6 mg/m^3 and 271.4 mg/m^3 respectively at the roadway cross-section measurement points which are 5 m and 10 m from the heading face. However, after the application of the multi-direction whirling air curtain, the dust concentration is only 61.2 mg/m3 and 14.8 mg/m^3, respectively. Therefore, the dust control effect of a multi-direction whirling air curtain is obvious.

关键词： Fully mechanized mining face Compressed air Multi-directional whirling air curtain AirflowDust suppression

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New Facile Synthesis of 2-Aryloxy-5-(2-furfurylidene)- 4H-imidazolin-4-ones

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Chinese Chemical Letters 2002年第10期13卷 942-944页

作者： Ming Wu DING Jing ZHU Su Fang SHI xiao peng LIU Institute of Organic Synthesis Central China Normal UniversityWuhan 430079 Department of Chemistry Central China Normal UniversityWuhan 430079 Center of Analysis and Testing Central China Normal UniversityWuhan 430079

Novel 2-aryloxy-5-(2-furfurylidene)-4H-imidazolin-4-ones 6 were synthesized by aza-Wittig reaction of vinyliminophosphorane 4 with phenyl isocyanate and subsequent condensation with Various substituted phenols in the presence of catalytic amount of potassium carbonate. The products are confirmed by H-1 NMR, MS, IR and elementary analysis.

关键词： 4H-imidazolin-4-one aza-Wittig reaction iminophosphorane synthesis

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Microstructures and mechanical behaviors of CVI-based C/C composites containing h-BN powdered additives

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Journal of Materials Science & Technology 2019年第12期35卷 2824-2831页

作者： peng xiao Zhichao Li Zeyan Liu Zhuan Li Bengu Zhang Jinwei Li Yang Li National Key Laboratory of Science and Technology for National Defence on High-strength Structural Materials Central South UniversityChangsha 410083China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083China

Hexagonal boron nitride(h-BN) powders were introduced into carbon fiber preform by powder addition and subsequent combined with chemical vapor infiltration(CVI) for densification to prepare carbon fiber reinforced/carbon and boron nitride dual matrix composites(C/C-BN). Microstructures and mechanical properties of C/C composites with three different volume contents of h-BN powders were investigated in comparison to pure C/C composites. Results indicated that the introduction of h-BN powders into C/C composites significantly reduced the size of Py C and the anisotropy of thermal contraction in matrix,leading to a gradual disappearance of ring defects as the h-BN content increased. In addition, an enhanced interfacial bonding between fiber and matrix obtained due to higher-textured Py C and rougher fiber surface. Thereby, the flexural strengths and modulus of as-prepared composites decreased firstly and then increased, while the impact toughness presented a decreasing tendency as the content of BN powders increased. Furthermore, with the increasing of h-BN content, anisotropies of compressive properties were weakened, and the compressive strength of C/C-BN composites were always higher than that of pure C/C composit. However, when C/C composites modified by 13.5 vol% content of h-BN, excessive loose BN aggregates appeared in C/C-BN composites, leading to a relatively slight reduction of compressive strength.

关键词： C/C composites h-BN Pyrolytic carbon Interfacial bonding Mechanical properties

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Hybrid Composite of Polyaniline Containing Carbon Nanotube

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Chinese Chemical Letters 2001年第11期12卷 1037-1040页

作者： Jian Guo DENG xiao Bin DING Yu Xing peng Albert SCCHAN chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041 Open Laboratory of Chirotechnology and Department of Applied Biology and Chemical Technology Hong Kong Polytechnic UniversityHong Kong

Carbon nanotube-polyaniline hybrid material was synthesized by emulsion polymerization in-situ. The morphology of hybrid material was studied by TEM and X-ray diffraction. The conductivity of nanocomposite increases with the increasing of carbon nanotube content because of the new conductivity passageways formed by carbon nanotubes.

关键词： carbon nanotube polyaniline hybrid material

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