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Colorectal cancer’s burden attributable to a diet high in processed meat in the Belt and Road Initiative countries

World Journal of Gastrointestinal Oncology 2024年第1期16卷 182-196页

作者： Gu liu Chang-Min li Fei Xie Qi-Lai li liang-Yan liao Wen-Jun Jiang xiao-pan li Guan-Ming Lu Department of Gastrointestinal Surgery The First Affiliated HospitalJinan UniversityGuangzhou 510630Guangdong ProvinceChina Department of Gastrointestinal Surgery Chenzhou Third People’s HospitalChenzhou 423000Hunan ProvinceChina Department of Gastrointestinal Surgery Chenzhou First People’s Hospital and the First Affiliated Hospital of Xiangnan UniversityChenzhou423000 Hunan ProvinceChina Department of Breast and Thyroid Surgery the Affiliated Hospital of Youjiang Medical University for NationalitiesBaise 533000Guangxi Zhuang Autonomous RegionChina Department of Health Management Center Zhongshan HospitalShanghai Medical College of Fudan UniversityShanghai 200032China

BACKGROUND Colorectal cancer(CRC)plays a significant role in morbidity,mortality,and economic cost in the Belt and Road Initiative(“B and R”)*** addition,these countries have a substantial consumption of processed ***,the burden and trend of CRC in relation to the consumption of a diet high in processed meat(DHPM-CRC)in these“B and R”countries remain *** To analyze the burden and trend of DHPM-CRC in the“B and R”countries from 1990 to *** We used the 2019 Global Burden of Disease Study to collate information regarding the burden of *** and age-standardized rates(ASRs)of deaths along with the disability-adjusted life years(DALYs)were determined among the“B and R”countries in 1990 and *** joinpoint regression analysis,the average annual percent change(AAPC)was used to analyze the temporal trends of age-standardized DALYs rate(ASDALR)from 1990 to 2019 and in the final decade(2010–2019).RESULTS We found geographical differences in the burden of DHPM-CRC among“B and R”countries,with the three highest-ranking countries being the Russian Federation,China,and Ukraine in 1990,and China,the Russian Federation,and Poland in *** burden of DHPM-CRC generally increased in most member countries from 1990 to 2019(all Pline was observed in Kyrgyzstan,Central Asia,with an AAPC value of-2.05%(95%CI:-2.37%to-1.73%).A substantial upward trend in ASR of mortality,years lived with disability,years of life lost,and DALYs from DHPM-CRC changes in 1990-2019 and the final de

关键词： Belt and Road Initiative countries Colorectal cancer Burden of disease Dietary risk factors Processed meat Disability-adjusted life years Trend analysis

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Understanding the discrepancy between the quality and yield in the synthesis of carbon nanotubes

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Nano Research 2015年第1期8卷 296-302页

作者： xiao Zhang pan li Hongbo Zhang Jie liu Department of Chemistry Duke University Durham North Carolina 27708 United States

High-quality carbon nanotubes （CNTs） are promising materials in many applications. However, current chemical vapor deposition （CVD） methods for CNT synthesis suffer from the discrepancy between the quality and yield of CNTs： Low-quality CNTs can be synthesized with high yield, while high-quality CNTs can only be synthesized with low yield. Here a CVD method has been designed to synthesize both high-quality and low-quality CNTs using the same combination of catalyst and precursor. As a result, we were able to understand the reasons for the low yield in high-quality CNT synthesis and a method was derived to improve their yield. This understanding is an important step towards high- yield synthesis of high-quality CNTs.

关键词： carbon nanotubes chemical vapor deposition high quality high yield catalyst lifetime

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USP10 Alleviates Palmitic Acid-induced Steatosis through Autophagy in HepG2 Cells

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 45-57页

作者： Sheng-liang Xin xiao-li pan xiao-Yuan Xu Yan-Yan Yu Department of Infectious Diseases Peking University First HospitalBeijingChina Division of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina

Background and Aims:Nonalcoholic fatty liver disease(NAFLD)is a common chronic liver disease caused by *** autophagy is closely related to NAFLD ***,ubiquitin-specific peptidase-10(USP10)was reported to ameliorate hepatic steatosis,but the underlying mechanism is still *** view of the potential effects of USP10 on autophagy,we investigated whether USP10 alleviated steatosis through ***:HepG2 cells were treated with palmitic acid(PA)to model NAFLD in *** was used to regulate USP10 level in *** regulators were used to autophagic progression in *** blotting,real-time fluorescence quantitative polymerase chain reaction,lipid drop staining and immunofluorescent staining were performed to determine the effect of USP10 on lipid ***’s t-test and Tukey’s post hoc test were used to compare the means among ***:PA induced cellular steatosis with dependance on ***10 overexpression alleviated PA-induced steatosis,restored autophagic activity,promoted autophagic flux,including synthesis and degradation of autophagosomes,and lipid-targeted *** the presence of autophagy inhibitors,the protective effectiveness of USP10 on steatosis ***,the specific inhibitor to C-jun N-terminal protein kinase-1(JNK1),DB07268,abolished USP10-induced ***,during early stage inhibition of JNK1,compensatory expression of tuberous sclerosis complex-2(TSC2)maintained *** degree of TSC2-to-JNK1 compensation was positively associated with USP10 ***,JNK1 and TSC2 were involved in the lipid-lowering effect of ***:USP10 alleviated hepatocellular steatosis in autophagy-dependent ***1/TSC2 signaling pathways were required for USP10-induced autophagy.

关键词： Autophagy Nonalcoholic fatty liver disease Steatosis Ubiquitinspecific peptidase-10 C-jun N-terminal protein kinase-1 Tuberous sclerosis complex-2

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Development of the Embedded Protective Device Based on ARM

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Journal of China University of Mining and Technology 2005年第4期15卷 344-347页

作者： liU xiao-wen li Na pan Chun-de School of Information ＆ Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

An embedded protective device for 35kV power line is worked out based on Philips’ LPC2292 ARM MCU. Several aspects such as embedded design technique adopted in the system framework, application of adaptive theory in data acquisition, Board Support Packet (BSP) developing and task dispatching related to operating system are discussed. Both hardware and software framework of the system are given. Advanced hardware platform and software development environment is applied in design of the system, with the advanced co-design technology.

关键词： microcomputer protective device ARM embedded operating system adaptive theory BSP

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Benfotiamine prevents increased β-amyloid production in HEK cells induced by high glucose

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Neuroscience Bulletin 2012年第5期28卷 561-566页

作者： xiao-Jing Sun Lei Zhao Na Zhao xiao-li pan Guo-Qiang Fei li-Rong Jin Chun-Jiu Zhong Department of Neurology Zhongshan Hospital & Shanghai Medical College Fudan University Shanghai 200032 China State Key Laboratory of Medical Neurobiology Institute of Brain Science Fudan University Shanghai 200032 China

Objective To determine whether high glucose enhances β-amyloid （Aβ） production in HEK293 Swedish mutant （APPsw） cells with Aβ precursor protein （APP） overexpression, and whether under this condition benfotiamine reduces the increased Aβ production. Methods HEK293 APPsw cells were cultured with different concentrations of glucose for different times. TheAβ content in the supernatant was determined by EliSA. To investigate the mechanism by which benfotiamine reduced Aβ production, glycogen synthase kinase-3 （GSK-3） activity and expression were measured after the cells were cultured with 5.5 g/L glucose for 12 h. Results With 1.0, 3.0, 4.5, 5.5, 6.5, 7.5, 8.5, or 10.5 g/L glucose, Aβ production by HEK293 APPsw cells was highest in the presence of 5.5 g/L glucose for 6 and 12 h. The difference in Aβ content between 5.5 and 1.0 g/L was most marked after incubation for 12 h. Benfotiamine at 20 and 40 μg/mL significantly reduced Aβ production in cells incubated with 5.5 g/L glucose for 12 h. Moreover, 40 μg/mL benfotiamine significantly enhanced the ratio of phosphorylated GSK-3 to total GSK-3, together with consistent down-regulation of GSK-3 activity. Conclusion High glucose increases Aβ production by HEK293 APPsw cells while benfotiamine prevents this increase. This is correlated with the modulation of GSK-3 activity.

关键词： Alzheimer’s disease β-amyloid high glucose benfotiamine glycogen synthase kinase

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A Generalized MSST Algorithm for Counting Points of Elliptic Curves over F_(p)^(n)

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Journal of Systems Science & Complexity 2024年第4期37卷 1738-1754页

作者： li xiao LV Chang pan Zhizhong Key Laboratory of Cyberspace Security Defense Institute of Information EngineeringChinese Academy of SciencesBeijing 100085China School of Cyber Security University of Chinese Academy of SciencesBeijing 100085China Huawei Technologies Co. Ltd.Shenzhen 518129China

Elliptic curve cryptography is an important part of nowaday's public key *** points of elliptic curves over finite fields is of great significance to the selection of safety *** present,there are many p-adic algorithms,such as SST algorithm,generalized AGM algorithm,Kedlaya algorithm,etc.,which can deal with the situation of finite fields of small *** this paper,the authors generalize the MSST algorithm of characteristic 2 to general fields of odd characteristic,and propose the generalized MSST *** generalized MSST algorithm is achieved by combining the advantages of the SST algorithm and the generalized AGM *** the time complexity of the multiplication of two n-bit numbers is denoted as O((n)^(μ)),then the time complexity of the generalized MSST algorithm is O(n^(2μ+1/1+μ)),which is the same as the improved SST *** practical experiments,the running time of the generalized MSST algorithm is less than that of the improved SST algorithm.

关键词： Elliptic curve generalized AGM algorithm generalized MSST algorithm SST algorithm

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Long-term optical color behavior of a sample of blazars

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Research in Astronomy and Astrophysics 2018年第12期18卷 67-74页

作者： xiao-pan li Yu-Hui Luo Hai-Tao Yang Hai-Yan Yang Cheng Yang Yan Cai College of Physics and Information Engineering Zhaotong University College of Photoelectron and Communication Engineering Yunnan Open University

We report on the optical color variability of a sample of 24 blazars, consisting of nine flat spectrum radio quasars(FSRQs) and 15 BL Lacertae objects(BL Lacs), on timescales of years using simultaneous V-and R-band observations observed by the Kanata telescope at Higashi-Hiroshima *** correlations between color indices V-R and magnitudes reveal that 11 BL Lacs and one FSRQ exhibited significant(i.e., r > 0.2 and P lity that the BWB chromatic trend is dominant for BL Lacs and the RWB trend is especially found in FSRQs, which has been presented occasionally in different samples of *** superpositions of the red emission component from the Doppler-boosted relativistic jet and the blue component arising from the accretion disk might be a possible interpretation for the long-term color behaviors.

关键词： galaxies:active BL Lacertae objects:general quasars:general methods:statistical

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Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-Ming Yin li-li Wu Shu-Sheng li xiao-Na pan xiao-li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

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Cancer incidence and patient survival rates among the residents in the Pudong New Area of Shanghai between 2002 and 2006

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Chinese Journal of Cancer 2013年第9期32卷 512-519页

作者： xiao-pan li Guang-Wen Cao Qiao Sun Chen Yang Bei Yan Mei-Yu Zhang Yi-Fei Fu li-Ming Yang Department of Tumors and Injury Prevention Center for Disease Control and Prevention Department of Epidemiology Second Military Medical University

With the growing threat of malignancy to health,it is necessary to analyze cancer incidence and patient survival rates among the residents in Pudong New Area of Shanghai to formulate better cancer prevention strategies.A total of 43,613 cancer patients diagnosed between 2002 and 2006 were recruited from the Pudong New Area Cancer *** incidence,observed survival rate,and relative survival rate of patients grouped by sex,age,geographic area,and TNM stage were calculated using the Kaplan-Meier,life table,and Ederer II methods,*** 2002 and 2006,cancer incidence in Pudong New Area was 349.99 per 100,000 person-years,and the 10 most frequently diseased sites were the lung,stomach,colon and rectum,liver,breast,esophagus,pancreas,brain and central nervous system,thyroid,and *** patients with cancers of the colon and rectum,breast,thyroid,brain and central nervous system,and bladder,the 5-year relative survival rate was greater than 40%,whereas patients with cancers of the liver and pancreas had a 5-year relative survival rate of less than 10%.The 1-year to 5-year survival rates for patients grouped by sex,age,geographic area,and TNM stage differed significantly(all P<0.001).Our results indicate that cancer incidence and patient survival in Pudong New Area vary by tumor type,sex,age,geographic area,and TNM stage.

关键词：上海浦东新区癌症发病率癌症患者存活率居民中枢神经系统地理区域甲状腺癌

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Meta-analysis of moxibustion in the management of functional dyspepsia

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 140-144页

作者： Yong-li HAN Hong-xing ZHANG xiao-li pan Song CHEN College of Acupuncture and Orthopedics Hubei University of Traditional Chinese Medicine Wuhan Hubei Province 430065 China Wuhan municipal health and Family Planning Commission Wuhan 430065 Hubei Province China

Objective:To analyze the efficacy and safety of moxibustion(A kind of complementary and alternative methods of traditional Chinese medicine)for the Functional dyspepsia(FD).Methods:Six electronic databases were searched for randomized controlled trials investigating the efficacy of moxibustion in the treatment of *** search period was from inception to February 25,*** reports of RCT on the moxibustion compare with medication were ***'s quality was evaluated with the Cochrane Risk Bias Tool in the Cochrane Handbook by two independent *** Review Manager 5.3 was used to evaluate the publication ***:Eleven eligible reports comprising a total of 870 participants were *** risk of bias was generally *** the primary outcome,compared with medications,moxibustion significantly alleviated overall FD symptoms but there was a moderate inconsistency among studies(11 RCTs,RR=1.27,95% CI[1.20,1.36]).Moxibustion appears to be associated with few adverse events but the evidence is limited due to poor report ***:Moxibustion showed greater improvement in terms of clinical efficacy in the treatment of FD than pharmacological medications,and although it was not possible to draw a definitive conclusion due to the small sample size,high risk of bias,and low quality of the *** multi-center and long-term high-quality randomized control trials are needed.

关键词： Functional dyspepsia Moxibustion Meta-analysis

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