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A PRECISE METHOD FOR SOLVING WAVE PROPAGATION IN HOLLOW SANDWICH CYLINDERS WITH PRISMATIC CORES

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Acta Mechanica Solida Sinica 2015年第4期28卷 360-374页

作者： Junmiao Meng Zichen Deng xiao jian xu Kai Zhang Xiuhui Hou Department of Engineering Mechanics Northwestern Polytechnical University School of Civil Engineering Chang'an University

Wave propagation in infinitely long hollow sandwich cylinders with prismatic cores is analyzed by the extended Wittriek-Williams （W-W） algorithm and the precise integration method （PIM）. The effective elastic constants of prismatic cellular materials are obtained by the homogenization method. By applying the variational principle and introducing the dual variables the canonical equations of Hamiltonian system are constructed. Thereafter, the wave propagation problem is converted to an eigenvalue problem. In numerical examples, the effects of the prismatic cellular topology, the relative density, and the boundary conditions on dispersion relations, respectively, are investigated.

关键词： extended Wittrick-Williams algorithm cellular material Hamiltonian system dispersion relation

Clinical study on the minimally invasive percutaneous nephrolithotomy treatment of upper urinary calculi

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World Journal of Clinical Cases 2022年第4期10卷 1198-1205页

作者： xiao-jian xu Jun Zhang Miao Li jian-Quan Hou Department of Urology The First Affiliated Hospital of Soochow UniversitySuzhou 215006Jiangsu ProvinceChina

BACKGROUND Upper urinary tract stones are very common in my country,with an incidence of 1%to 5%in the North and an even higher incidence of 5%to 10%in the *** incidence rate in the south is higher than that in the north,mainly due to the water quality,climate and eating habits of the *** the perspective of sex,incidence is more likely in males than *** the high-incidence population,young adults are most prone to *** in the age range of 25 to 40 years are more likely to have *** To observe the therapeutic effect of minimally invasive percutaneous nephrolithotomy(mPCNL)on upper urinary tract stones and its influence on the renal function of *** Patients with upper urinary tract stones who were treated in our hospital from February 2017 to March 2018 were selected as research subjects and were divided into the PCNL group and the mPCNL group according to the random number table *** general conditions of the two groups of patients were observed during the perioperative period,and the differences in stone clearance,pain,renal function indicators and complication rates were compared between the two groups to determine which were statistically significant(P<0.05).RESULTS The operation time of the mPCNL group was longer than that of the PCNL group(t=-34.392,P<0.001),and the intraoperative blood loss of the mPCNL group was more than that of the PCNL group(t=34.090,P<0.001).There was no difference in renal function indices between the two groups of patients before treatment,and there was no difference in the levels of serum creatinine,β2 microglobulin or retinol binding protein in the mPCNL group after *** visual analog scale score of patients in the mPCNL group was lower than that of the PCNL group(t=12.191,P<0.001),and there was no significant difference in the stone clearance rate between the two groups(χ2 value=1.013,P=0.314).There was no significant difference in the incidence of urine extravasation,dyspnea

关键词： Percutaneous nephrolithotomy Minimally invasive percutaneous nephrolithotomy Upper urinary calculi Calculi Renal function Complications

Comparative transcriptomic analysis of rat versus mouse cerebral cortex after traumatic brain injury

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维普期刊数据库

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Neural Regeneration Research 2021年第7期16卷 1235-1243页

作者： Meng-Shi Yang xiao-jian xu Bin Zhang Fei Niu Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury and Department of Neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Nerve Injury and Repair Center of Beijing Institute for Brain Disorders BeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

The heterogeneity of traumatic brain injury(TBI)-induced secondary injury has greatly hampered the development of effective treatments for TBI *** common processes across species may be an innovative strategy to combat debilitating *** the present study, a cross-species transcriptome comparison was performed for the first time to determine the fundamental processes of secondary brain injury in Sprague-Dawley rat and C57/BL6 mouse models of TBI, caused by acute controlled cortical *** RNA sequencing data from the mouse model of TBI were downloaded from the Gene Expression Omnibus(ID: GSE79441) at the National Center for Biotechnology *** the rat data, peri-injury cerebral cortex samples were collected for transcriptomic analysis 24 hours after *** expressed gene-based functional analysis revealed that common features between the two species were mainly involved in the regulation and activation of the innate immune response, including complement cascades as well as Toll-like and nucleotide oligomerization domain-like receptor *** findings were further corroborated by gene set enrichment ***, transcription factor analysis revealed that the families of signal transducers and activators of transcription(STAT), basic leucine zipper(BZIP), Rel homology domain(RHD), and interferon regulatory factor(IRF) transcription factors play vital regulatory roles in the pathophysiological processes of TBI, and are also largely associated with *** findings suggest that targeting the common innate immune response might be a promising therapeutic approach for *** animal experimental procedures were approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No.201802001) on June 6, 2018.

关键词： cognitive impairment cross-species comparison gene set enrichment analysis inflammation innate immune neurodegenerative disease secondary injury transcription factor transcriptome traumatic brain injury

Protein profiling identified mitochondrial dysfunction and synaptic abnormalities after dexamethasone intervention in rats with traumatic brain injury

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Neural Regeneration Research 2021年第12期16卷 2438-2445页

作者： Fei Niu Bin Zhang Jie Feng Xiang Mao xiao-jian xu Jin-Qian Dong Bai-Yun Liu Department of Neurotrauma Beijing Key Laboratory of Central Nervous System InjuryBeijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Key Laboratory of Central Nervous System Injury Research Center for Brain TumorBeijing Institute of Brain DisordersBeijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Neurosurgery the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

Dexamethasone has been widely used after various neurosurgical procedures due to its anti-inflammatory property and the abilities to restore vascular permeability,inhibit free radicals,and reduce cerebrospinal fluid *** to the latest guidelines for the treatment of traumatic brain injury in the United States,high-dose glucocorticoids cause neurological *** investigate the reason why high-dose glucocorticoids after traumatic brain injury exhibit harmful effect,rat controlled cortical impact models of traumatic brain injury were *** 1 hour and 2 days after surgery,rat models were intraperitoneally administered dexamethasone 10 mg/*** results revealed that 31 proteins were significantly upregulated and 12 proteins were significantly downregulated in rat models of traumatic brain injury after dexamethasone *** Ingenuity Pathway Analysis results showed that differentially expressed proteins were enriched in the mitochondrial dysfunction pathway and synaptogenesis signaling *** blot analysis and immunohistochemistry results showed that Ndufv2,Maob and Gria3 expression and positive cell count in the dexamethasone-treated group were significantly greater than those in the model *** findings suggest that dexamethasone may promote a compensatory increase in complex I subunits(Ndufs2 and Ndufv2),increase the expression of mitochondrial enzyme Maob,and upregulate synaptic-transmission-related protein *** changes may be caused by nerve injury after traumatic brain injury treatment by *** study was approved by Institutional Ethics Committee of Beijing Neurosurgical Institute(approval No.201802001)on June 6,2018.

关键词： dexamethasone Gria3 Maob mass spectrometry mitochondrial dysfunction Ndufs2 Ndufv2 proteomics synaptic abnormalities traumatic brain injury

Variational principles for buckling and vibration of MWCNTs modeled by strain gradient theory

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Applied Mathematics and Mechanics(English Edition) 2014年第9期35卷 1115-1128页

作者：徐晓建邓子辰 Department of Engineering Mechanics Northwestern Polytechnical University State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology

Variational principles for the buckling and vibration of multi-walled carbon nanotubes （MWCNTs） are established with the aid of the semi-inverse method. They are used to derive the natural and geometric boundary conditions coupled by small scale parameters. Hamilton＇s principle and Rayleigh＇s quotient for the buckling and vibration of the MWCNTs are given. The Rayleigh-Ritz method is used to study the buckling and vibration of the single-walled carbon nanotubes （SWCNTs） and double-walled carbon nanotubes （DWCNTs） with three typical boundary conditions. The numerical results reveal that the small scale parameter, aspect ratio, and boundary conditions have a profound effect on the buckling and vibration of the SWCNTs and DWCNTs.

关键词： variational principle strain gradient theory buckling vibration carbonnanotube

Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury

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Neural Regeneration Research 2022年第2期17卷 386-394页

作者： xiao-jian xu Meng-Shi Yang Bin Zhang Qian-Qian Ge Fei Niu Jin-Qian Dong Yuan Zhuang Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury and Department of Neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Nerve Injury and Repair Center of Beijing Institute for Brain Disorders BeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

Transfer RNA(t RNA)-derived small RNAs(ts RNAs) are a recently established family of regulatory small non-coding RNAs that modulate diverse biological processes. Growing evidence indicates that ts RNAs are involved in neurological disorders and play a role in the pathogenesis of neurodegenerative disease. However, whether ts RNAs are involved in traumatic brain injury-induced secondary injury remains poorly understood. In this study, a mouse controlled cortical impact model of traumatic brain injury was established, and integrated ts RNA and messenger RNA(m RNA) transcriptome sequencing were used. The results revealed that 103 ts RNAs were differentially expressed in the mouse model of traumatic brain injury at 72 hours, of which 56 ts RNAs were upregulated and 47 ts RNAs were downregulated. Based on micro RNA-like seed matching and Pearson correlation analysis, 57 differentially expressed ts RNA-m RNA interaction pairs were identified, including 29 ts RNAs and 26 m RNAs. Moreover, Gene Ontology annotation of target genes revealed that the significantly enriched terms were primarily associated with inflammation and synaptic function. Collectively, our findings suggest that ts RNAs may be associated with traumatic brain injury-induced secondary brain injury, and are thus a potential therapeutic target for traumatic brain injury. The study was approved by the Beijing Neurosurgical Institute Animal Care and Use Committee(approval No. 20190411) on April 11, 2019.

关键词： gene set enrichment analysis inflammation integrated analysis neurodegenerative disease next-generation sequencing secondary injury synaptic function transfer RNA-derived small RNAs transfer RNAs traumatic brain injury

Neutrophil-derived interleukin-17A participates in neuroinflammation induced by traumatic brain injury

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Neural Regeneration Research 2023年第5期18卷 1046-1051页

作者： xiao-jian xu Qian-Qian Ge Meng-Shi Yang Yuan Zhuang Bin Zhang Jin-Qian Dong Fei Niu Hao Li Bai-Yun Liu Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury and Department of Neurosurgery Beijing Neurosurgical Institute and Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Nerve Injury and Repair Center of Beijing Institute for Brain Disorders BeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

After brain injury, infiltration and abnormal activation of neutrophils damages brain tissue and worsens inflammation, but the mediators that connect activated neutrophils with neuroinflammation have not yet been fully clarified. To identify regulators of neutrophil-mediated neuroinflammation after traumatic brain injury, a mouse model of traumatic brain injury was established by controlled cortical impact. At 7 days post-injury(sub-acute phase), genome-wide transcriptomic data showed that interleukin 17 A-associated signaling pathways were markedly upregulated, suggesting that interleukin 17 A may be involved in neuroinflammation. Double immunofluorescence staining showed that interleukin 17 A was largely secreted by neutrophils rather than by glial cells and neurons. Furthermore, nuclear factor-kappaB and Stat3, both of which are important effectors in interleukin 17 A-mediated proinflammatory responses, were significantly activated. Collectively, our findings suggest that neutrophil-derived interleukin 17 A participates in neutrophil-mediated neuroinflammation during the subacute phase of traumatic brain injury. Therefore, interleukin 17 A may be a promising therapeutic target for traumatic brain injury.

关键词： immune infiltration innate immunity interleukin-17A neurodegenerative disease neuroinflammation neutrophils secondary brain injury transcription factor transcriptome traumatic brain injury

Tandem Mass Tag-based proteomics analysis reveals the vital role of inflammation in traumatic brain injury in a mouse model

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Neural Regeneration Research 2023年第1期18卷 155-161页

作者： Jin-Qian Dong Qian-Qian Ge Sheng-Hua Lu Meng-Shi Yang Yuan Zhuang Bin Zhang Fei Niu xiao-jian xu Bai-Yun Liu Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

Proteomics is a powerful tool that can be used to elucidate the underlying mechanisms of diseases and identify new ***,it may also be helpful for understanding the detailed pathological mechanism of traumatic brain injury(TBI).In this study,we performed Tandem Mass Tag-based quantitative analysis of cortical proteome profiles in a mouse model of *** results showed that there were 302 differentially expressed proteins in TBI mice compared with normal mice 7 days after *** Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses showed that these differentially expressed proteins were predominantly involved in inflammatory responses,including complement and coagulation cascades,as well as chemokine signaling *** transcription factor analysis revealed that the inflammation-related transcription factors NF-κB1,RelA,IRF1,STAT1,and Spi1 play pivotal roles in the secondary injury that occurs after TBI,which further corroborates the functional enrichment for inflammatory *** results suggest that inflammation-related proteins and inflammatory responses are promising targets for the treatment of TBI.

关键词： bioinformatics complement cascade mass spectrometry neuroinflammation proteomics secondary injury subacute phase tandem mass tag transcription factor traumatic brain injury

Observation of topological charge transformations in acoustic vortex using passive periodic systems

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 140-147页

作者： Di-Chao Chen Xie Liu Changqing xu Da-jian Wu Ying Cheng xiao-Jun Liu School of Physics and Technology Nanjing Normal University Key Laboratory of Modern Acoustics School of Physics Nanjing University

Vortex transmutation utilizes a periodic system, which not only enables the alteration of the topological charge(TC) of unstable input vortices but also facilitates their transformation into stable structures. This approach is crucial for investigating the characteristics of vortices in various wave systems. Here, we achieve acoustic vortex TC transmutation by employing a welldesigned dual-structured plate external system(DPES). The interactions between the acoustic vortex and the finite-order discrete rotational symmetry lead to the transformation of its topological charge when complete rotational symmetry is broken to Nthorder discrete symmetry. Our results experimentally demonstrate the acoustic vortex TC transmutation based on passive artificial structures, enabling numerous applications in particle manipulation and information multiplexing as well as advancing our understanding and control over free-space acoustic vortices.

关键词： acoustic vortex topological charge transformation artificial structure