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Chinese Chemical Letters 2024年第7期35卷 247-252页

作者： xiao xiao Biao Chen jia-Wei Li Jun-Bo Zheng Xu Wang Hang Zhao Fen-Er Chen Institute of Pharmaceutical Science and Technology Collaborative Innovation Center of Yangtze River Delta Region Green PharmaceuticalsZhejiang University of TechnologyHangzhou 310014China College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China

A highly efficient and concise bromocyclization has been successfully achieved,in which tryptamine/tryptophol derivates can be transformed to valuable HPI/TFI scaffolds with economic and green ***,a controllable cascade transformation of bromocyclization and aromatic bromination has also been smoothly achieved to form dibrominated HPIs and *** could be successfully scaled up under both the batch process and a continuous flow *** most remarkable peculiarity of our process over all previous methods is that the generated water is the major ***,successful application of this new protocol has been demonstrated by the pharmaceutical and natural products syntheses.

关键词： Tryptamines and tryptophols Nitrite Economic and sustainable bromocyclization HPI and TFI structures Bath and flow

Variational Neural Inference Enhanced Text Semantic Communication System

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China Communications 2024年第7期21卷 50-64页

作者： Zhang Xi Zhang Yiqian Li Congduan ma xiao School of Electronics and Communication Engineering Sun Yat-Sen UniversityShenzhen 518107China Guizhou University State Key Laboratory of Public Big Data Guiyang 550025China Shenzhen Key Laboratory of Navigation and Communication Integration Shenzhen 518107China School of Computer Science and Engineering Sun Yat-Sen UniversityGuangzhou 510006China

Recently,deep learning-based semantic communication has garnered widespread attention,with numerous systems designed for transmitting diverse data sources,including text,image,and speech,*** efforts have been directed toward improving system performance,many studies have concentrated on enhancing the structure of the encoder and ***,this often overlooks the resulting increase in model complexity,imposing additional storage and computational burdens on smart ***,existing work tends to prioritize explicit semantics,neglecting the potential of implicit *** paper aims to easily and effectively enhance the receiver's decoding capability without modifying the encoder and decoder *** propose a novel semantic communication system with variational neural inference for text ***,we introduce a simple but effective variational neural inferer at the receiver to infer the latent semantic information within the received *** information is then utilized to assist in the decoding *** simulation results show a significant enhancement in system performance and improved robustness.

关键词： deep learning semantic communication variational neural inference

Designing ABC-6 family small pore zeolites by epitaxial growth approach

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Chinese Chemical Letters 2024年第3期35卷 508-512页

作者： xiaohui Cui jia Lv Chao ma Yujiao Wang Zhenghao jia Daliang Zhang Peng Guo Zhongmin Liu Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450001China National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Multi-scale Porous materials Center Institute of Advanced Interdisciplinary Studies&School of Chemistry EngineeringChongqing UniversityChongqing 400044China University of Chinese Academy of Sciences Beijing 100049China Division of Energy Research Resources Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Aluminosilicate small pore zeolites belonging to ABC-6 family play crucially important roles in the high methanol conversion with the high selectivity of light olefins,gas separation and storage,and selective catalytic reduction of NO_(x).In this work,we report a general method,called the epitaxial growth approach,for designing ABC-6 family small pore *** is mainly realized through the epitaxial growth on the nonporous SOD-type zeolite in the presence of inorganic cations(Na^(+)and K^(+))combined with a variety of organic structure directing agents(OSDAs).In this case,a series of ABC-6 family small pore zeolites such as ERI-,SWY-,LEV-,AFX-,and PTT-type zeolites have been successfully synthesized within a few *** importantly,the advanced focused ion beam(FIB)and the low-dose high-resolution transmission electron microscopy(HRTEM)imaging technique have been utilized for unraveling the zeolite heterojunction at the atomic level during the epitaxial growth *** turns out(222)crystallographic planes of the SOD-type zeolite substrate provide unique pre-building units,which facilitate the growth of targeted ABC-6 family small pore zeolites along its ***,the morphologies of ERI-type zeolite can also be tuned through the epitaxial growth approach,achieving a longer lifetime in the methanol conversion.

关键词： Zeolite structure Zeolite synthesis Structural characterizations Low-dose imaging Focused ion beam

Isocyanide-Based One-Pot Cascade Synthesis of 3-Acyl Isoindolinones

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Chinese Journal of Chemistry 2024年第3期42卷 259-263页

作者： jia Liu Yi-Ming Zhu xiao-Ping Xu Shun-Jun Ji Key Laboratory of Organic Synthesis of jiangsu Province College of ChemistryChemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouJiangsu215123 China Suzhou Baolidi Functional materials Research Institute SuzhouJiangsu215144 China

A series of 3-acyl-substituted isoindolinone derivatives were synthesized in a one-pot manner via the reaction of o-bromobenzaldehydes,isocyanides,and carboxylic acids in the presence of palladium catalyst and base. The reaction employing easily available starting materials features simple operation and high efficiency. The mechanistic study showed that the reaction might undergo 1) Pd-catalyzed [3+2] cyclization of o-bromobenzaldehyde with isocyanide and the re-insertion of another molecule of isocyanide,2) addition of carboxylic acid to in situ formed ketenimine followed by a rearrangement relay to give 3,3-diacyl-substituted isoindolinone derivative. Further transformations of the obtained products through decarbonylation could also be realized.

关键词： One-pot reaction Isocyanide Pd catalysis Rearrangement reaction Isoindolinone

Construction of biomimetic proton transport channels in metal-organic framework

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Chinese Chemical Letters 2024年第3期35卷 513-517页

作者： xiao-Min Li Junchao jia Danting Yang jiali Jin Junkuo Gao School of materials Science and Engineering Institute of Functional Porous MaterialsZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Key Laboratory of Pathophysiology School of Public HealthSchool of MedicineNingbo UniversityNingbo 315211China

Construction of proton transport channels in metal-organic frameworks(MOFs)with simple synthesis processes,high proton conductivities and good performance stabilities has been of great interest for proton exchange membrane fuel cell(PEMFC).Herein,we mimic the proton transport behavior of amino acid residues in bacteriorhodopsin,select UiO-66-COOH as the host,glycine and aspartic acid as the functional guest molecules,and then functionalize the MOF framework with amino acids to obtain biomimetic proton transport *** strategy endows UiO-66-COOH-Asp a high proton conductivity of 1.19×10^(-2)S/cm at 70℃and 98%RH,excellent cycle stability of performances and performance durability,which can be comparable to the reported MOFs-based proton ***,the proton conduction mechanism in UiO-66-COOH-Asp is elaborated in detail due to its visual structure,which is also one of the advantages of adopting MOFs as research platform,making it possible to optimize the structure-activity relationship of advanced ***,this strategy has clear objectives and simple synthesis,which has made certain contributions to both theoretical research and future industrial production of proton conductors.

关键词： MOF Amino acids Biomimetic proton transport channels Synergistic effect Proton conduction mechanism

Progress in the treatment of advanced hepatocellular carcinoma with immune combination therapy

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 273-286页

作者： Di Pan Hao-Nan Liu Peng-Fei Qu xiao ma Lu-Yao ma xiao-xiao Chen Yu-Qin Wang xiao-Bing Qin Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Department of General Surgery The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

Advanced hepatocellular carcinoma(HCC)is a severe malignancy that poses a serious threat to human *** to challenges in early diagnosis,most patients lose the opportunity for radical treatment when ***,recent advancements in cancer immunotherapy provide new directions for the treatment of *** instance,monoclonal antibodies against immune check-point inhibitors(ICIs)such as programmed cell death protein 1/death ligand-1 inhibitors and cytotoxic t-lymphocyte associated antigen-4 significantly improved the prognosis of patients with ***,tumor cells can evade the immune system through various *** the rapid development of genetic engineering and molecular biology,various new immunotherapies have been used to treat HCC,including ICIs,chimeric antigen receptor T cells,engineered cytokines,and certain cancer *** review summarizes the current status,research progress,and future directions of different immunotherapy strategies in the treatment of HCC.

关键词： Hepatocellular carcinoma Immunotherapies Immune checkpoint inhibitor Clinical efficacy Adverse reactions

Data driven analysis reveals prognostic genes and immunological targets in human sepsis-associated acute kidney injury

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World Journal of Emergency Medicine 2024年第2期15卷 91-97页

作者： Qing Zhao Jinfu ma jianguo xiao Zhe Feng Hui Liu Department of Diagnosis and Treatment of Cadres the First Medical CenterChinese PLA General HospitalBeijing 100853China Intensive Care Unit the 305th Hospital of Chinese PLABeijing 100032China Department of Critical Care Medicine the First Medical CenterChinese PLA General HospitalBeijing 100853China Nephrology Department the First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND:The molecular mechanism of sepsis-associated acute kidney injury(SA-AKI)is *** analyzed co-differentially expressed genes(co-DEGs)to elucidate the underlying mechanism and intervention targets of ***:The microarray datasets GSE65682,GSE30718,and GSE174220 were downloaded from the Gene Expression Omnibus(GEO)*** identified the co-DEGs and constructed a gene co-expression network to screen the hub *** analyzed immune correlations and disease correlations and performed functional annotation of the hub *** also performed single-cell and microenvironment analyses and investigated the enrichment pathways and the main transcription ***,we conducted a correlation analysis to evaluate the role of the hub ***:Interleukin 32(IL32)was identified as the hub gene in SA-AKI,and the main enriched signaling pathways were associated with hemopoiesis,cellular response to cytokine stimulus,inflammatory response,and regulation of kidney ***,IL32 was significantly associated with mortality in SA-AKI ***,macrophages,T cells,and NK cells were closely related to IL32 and were involved in the immune microenvironment in SA-AKI ***32 expression increased significantly in the kidney of septic ***-like receptor 2(TLR2)was significantly and negatively correlated with ***:IL32 is the key gene involved in SA-AKI and is significantly associated with ***2 and relevant immune cells are closely related to key genes.

关键词： Sepsis Acute kidney injury Interleukin 32 Toll-like receptor 2 Bioinformatics analysis

Experimental study of the damage characteristics of rocks containing non-penetrating cracks under cyclic loading

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International Journal of Mining Science and Technology 2024年第2期34卷 197-210页

作者： Jun Xu xiaochun xiao Lu ma Sen Luo jiaxu Jin Baijian Wu School of Mechanics and Engineering Liaoning Technical UniversityFuxin 123000China School of Civil Engineering Liaoning Technical UniversityFuxin 123000China Department of Engineering Mechanics Southeast UniversityNanjing 211189China

The damage evolution process of non-penetrating cracks often causes some unexpected engineering *** specimens containing non-penetrating crack(s)are used to study the damage evolution and characteristics under cyclic *** results show that under cyclic loading,the relationship between the number of non-penetrating crack(s)and the characteristic parameters(cyclic number,peak stress,peak strain,failure stress,and failure strain)of the pre-cracked specimens can be represented by a decreasing linear *** damage evolution equation is fitted by calibrating the accumulative plastic strain for each cycle,and the damage constitutive equation is proposed by the concept of effective ***,non-penetrating cracks are more likely to cause uneven stress distribution,damage accumulation,and local failure of *** local failure can change the stress distribution and relieve the inhibition of non-penetrating crack extension and eventually cause a dramatic destruction of the ***,the evolution process caused by non-penetrating cracks can be regarded as one of the important reasons for inducing *** results are expected to improve the understanding of the process of spalling formation and rockburst and can be used to analyze the stability of rocks or rock structures.

关键词： Damage characteristics Constitutive model Fissured rocks Non-penetrating crack Cyclic loading

Ultra-high NA graphene oxide flat lens on a fiber facet with near diffraction-limited focusing

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Photonics Research 2024年第7期12卷 1457-1463页

作者： xiaoKE CHEN LIN ma ZUYUAN HE GUIYUAN CAO HAN LIN BAOHUA jia State Key Laboratory of Advanced Optical Communication Systems and Networks Shanghai Jiao Tong UniversityShanghai 200240China Nanophotonics Research Center Shenzhen Key Laboratory of Micro-Scale Optical Information TechnologyShenzhen UniversityShenzhen 518060China School of Science RMIT UniversityMelbourne VIC 3000Australia The Australian Research Council(ARC)Industrial Transformation Training Centre in Surface Engineering for Advanced materials(SEAM) RMIT UniversityMelbourne VIC 3000Australia

The realization of a high numerical aperture(NA) fiber lens is critical for achieving high imaging resolution in endoscopes, enabling subwavelength operation in optical tweezers and high efficiency coupling between optical fibers and photonic chips. However, it remains challenging with conventional design and fabrication. Here we propose an ultrathin(400 nm) graphene oxide(GO) film lens fabricated in situ on a standard single-mode fiber facet using the femtosecond laser direct writing technique. An extremely high NA of 0.89 is achieved with a near diffraction-limited focal spot(FWHM = 0.68λ), which is verified theoretically and experimentally. The diameter of the fabricated fiber GO lens is as small as 12 μm with no beam expansion structure. The proposed fiber GO lens is promising for applications such as super-resolution imaging, compact optical tweezers, medical endoscopes,and on-chip integration.

关键词： fiber high oxide

Remote sensing and its applications using GNSS reflected signals:advances and prospects

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Satellite Navigation 2024年第1期5卷 10-51页

作者： Shuanggen Jin Adriano Camps Yan jia Feng Wang manuel martin-Neira Feixiong Huang Qingyun Yan Shuangcheng Zhang Zhongyu Li Komi Edokossi Dongkai Yang Zhiyu xiao Zhongmin ma Weihua Bai Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China School of Surveying and Land Information Engineering Henan Polytechnic UniversityJiaozuo454003China Department of Signal Theory and Communications Technical University of CataloniaBarcelona08034Spain Department of Surveying and Geoinformatics Nanjing University of Posts and TelecommunicationsNanjing210023China School of Electronics and Information Engineering Beihang UniversityBeijing100191China European Space Research and Technology Centre(ESTEC) European Space Agency2200-AGNoordwijkThe Netherlands National Space Science Center Chinese Academy of SciencesBeijing100190China School of Remote Sensing and Geomatics Engineering Nanjing University of Information Science and TechnologyNanjing210044China College of Geological Engineering and Geomatics Chang’an UniversityXi’an710054China University of Electronic Science and Technology of China Chengdu611731China

The Global Navigation Satellite Systems(GNSS),including the US’s GPS,China’s BDS,the European Union’s Galileo,and Russia’s GLONASS,offer real-time,all-weather,any-time,anywhere and high precision observations by transmitting L band signals continuously,which have been widely used for positioning,navigation and *** the development of GNSS technology,it has been found that GNSS-reflected signals can be used to detect Earth’s surface characteristics together with other signals of *** this paper,the current status and latest advances are presented on Global Navigation Satellite System-Reflectometry(GNSS-R)in theory,methods,techniques and *** developments and progresses in GNSS-R instruments,theoretical modeling,and signal processing,ground and space-/air-borne experiments,parameters retrieval(*** speed,sea surface height,soil moisture,ice thickness),sea surface altimetry and applications in the atmosphere,oceans,land,vegetation,and cryosphere are given and reviewed in ***,the challenges in the GNSS-R development of each field are also ***,the future applications and prospects of GNSS-R are discussed,including multi-GNSS reflectometry,new GNSS-R receivers,GNSS-R missions,and emerging applications,such as mesoscale ocean eddies,ocean phytoplankton blooms,microplastics detection,target recognition,river flow,desert studies,natural hazards and landslides monitoring.

关键词： GNSS Reflectometry Remote sensing Environmental change