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SH2B1 Tunes Hippocampal ERK Signaling to Influence Fluid Intelligence in Humans and Mice

Research 2024年第3期2023卷 369-389页

作者： Xiujuan Du yuhua Yan Juehua yu Tailin Zhu Chu-Chung Huang Lingli Zhang Xingyue Shan Ren Li yuan dai Hui LV xiao-Yong Zhang Jianfeng Feng Wei-Guang Li Qiang Luo Fei Li Developmental and Behavioral Pediatric Department Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research and Ministry of Education-Shanghai Key Laboratory for Children's Environmental HealthXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Developmental and Behavioral Pediatric Department Shanghai Xinhua Children's HospitalShanghai 200092China National Clinical Research Center for Aging and Medicine at Huashan Hospital Institute of Science and Technology for Brain-lnspired IntelligenceMinistry of Education-Key Laboratory of Computational Neuroscience and Brain-lnspired IntelligenceFudan UniversityShanghai 200433China State Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain Science Institutes of Brain Science and Human Phenom InstituteFudan UniversityShanghai 200032China Shanghai Key Laboratory of Brain Functional Genomics(Ministry of Education) School of Life SciencesEast China Normal UniversityShanghai 200062China Department of Rehabilitation Medicine Huashan HospitalInstitute for Translational Brain ResearchState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceFudan UniversityShanghai 200032China Center for Experimental Studies and Research The First Affliated Hospital of Kunming Medical UniversityKunming 650032China Shanghai Research Center for Brain Science and Brain-lnspired Intelligence Shanghai201210China Institute of Cognitive Neuroscience School of Psychology and Cognitive ScienceEast China Normal UniversityShanghai 200062China.

Fluid intelligence is a cognitive domain that encompasses general reasoning, pattern recognition, and problem-solving abilities independent of task-specific experience. Understanding its genetic and neural underpinnings is critical yet challenging for predicting human development, lifelong health, and well-being. One approach to address this challenge is to map the network of correlations between intelligence and other constructs. In the current study, we performed a genome-wide association study using fluid intelligence quotient scores from the UK Biobank to explore the genetic architecture of the associations between obesity risk and fluid intelligence. Our results revealed novel common genetic loci (SH2B1, TUFM, ATP2A1, and FOXO3) underlying the association between fluid intelligence and body metabolism. Surprisingly, we demonstrated that SH2B1 variation influenced fluid intelligence independently of its effects on metabolism but partially mediated its association with bilateral hippocampal volume. Consistently, selective genetic ablation of Sh2b1 in the mouse hippocampus, particularly in inhibitory neurons, but not in excitatory neurons, significantly impaired working memory, short-term novel object recognition memory, and behavioral flexibility, but not spatial learning and memory, mirroring the human intellectual performance. Single-cell genetic profiling of Sh2B1-regulated molecular pathways revealed that Sh2b1 deletion resulted in aberrantly enhanced extracellular signal-regulated kinase (ERK) signaling, whereas pharmacological inhibition of ERK signaling reversed the associated behavioral impairment. Our cross-species study thus provides unprecedented insight into the role of SH2B1 in fluid intelligence and has implications for understanding the genetic and neural underpinnings of lifelong mental health and well-being.

关键词： metabolism impaired reversed

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Designing Symmetric Gradient Honeycomb Structures with Carbon‑Coated Iron‑Based Composites for High‑Efficiency Microwave Absorption

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Nano-Micro Letters 2024年第11期16卷 224-241页

作者： yu Zhang Shu‑Hao Yang yue Xin Bo Cai Peng‑Fei Hu Hai‑Yang dai Chen‑Ming Liang yun‑Tong Meng Ji‑Hao Su xiao‑Juan Zhang Min Lu Guang‑Sheng Wang School of Chemistry Beihang UniversityBeijing 100191People’s Republic of China School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002People’s Republic of China School of Chemical Engineering Northeast Electric Power UniversityJilin 132000People’s Republic of China College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048People’s Republic of China

The impedance matching of absorbers is a vital factor affecting their microwave absorption(MA)*** this work,we controllably synthesized Material of Institute Lavoisier 88C(MIL-88C)with varying aspect ratios(AR)as a precursor by regulating oil bath conditions,followed by one-step thermal decomposition to obtain carbon-coated iron-based *** the precursor MIL-88C(Fe)preparation conditions,such as the molar ratio between metal ions and organic ligands(M/O),oil bath temperature,and oil bath time,influenced the phases,graphitization degree,and AR of the derivatives,enabling low filler loading,achieving well-matched impedance,and ensuring outstanding MA *** MOF-derivatives 2(MD_(2))/polyvinylidene Difluoride(PVDF),MD_(3)/PVDF,and MD4/PVDF absorbers all exhibited excellent MA properties with optimal filler loadings below 20 wt%and as low as 5 wt%.The MD_(2)/PVDF(5 wt%)achieved a maximum effective absorption bandwidth(EAB)of 5.52 GHz(1.90 mm).The MD_(3)/PVDF(10 wt%)possessed a minimum reflection loss(RL_(min))value of−67.4 at 12.56 GHz(2.13 mm).A symmetric gradient honeycomb structure(SGHS)was constructed utilizing the high-frequency structure simulator(HFSS)to further extend the EAB,achieving an EAB of 14.6 GHz and a RL_(min) of−59.0 *** research offers a viable inspiration to creating structures or materials with high-efficiency MA properties.

关键词： MIL-88C(Fe) Fe/Fe_(3)O_(4)/Fe_(3)C@C Controllable preparation Symmetric gradient honeycomb structure Microwave absorbing

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Accurate diagnosis of severe coronary stenosis based on resting magnetocardiography: a prospective, single-center, cross-sectional analysis

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Journal of Geriatric Cardiology 2024年第4期21卷 407-420页

作者： Jian-Guo CUI Feng TIAN yu-Hao MIAO Qin-Hua JIN Ya-Jun SHI Li LI Meng-Jun SHEN xiao-Ming XIE Shu-Lin ZHANG yun-dai CHEN School of Medicine Nankai UniversityTianjinChina Senior Department of Cardiology the Sixth Medical CenterChinese PLA General HospitalBeijingChina Joint Laboratory of Bioimaging Technology and Applications SAS-SIM-IT&MEDIShanghaiChina Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghaiChina

OBJECTIVE To evalu ate the role of resting magnetocardiography in identifying seve re coronary artery stenosis in patients with suspected coronary artery *** A total of 513 patients with angina symptoms were included and divided into two groups based on the extent of coronary artery disease determined by angiography:the non-severe coronary stenusis group(<70% stenosis) and the severe coronary stenosis group(≥70% stenosis).The diagnostic model was constructed using magnetic field map(MFM) parameters,either individually or in combination with clinical *** performance of the models was evaluated using receiver operating characteristic curves,accuracy,sensitivity,specificity,positive predictive value(PPV) and ne gative predictive value(NPV).Calibration plots and decision curve analysis were performed to investigate the clinical utility and performance of the models,*** In the severe coronary stenosis group,QR_MCTDd,S_MDp,and TT_(MA)C_(50) were significantly higher than those in the non-severe coronary stenosis group(10,46±10.66 vs,5.11±6.07,P <0.001;7.2±8.64 vs.4.68±6.95,P=0.003;0.32±57.29 vs.0.26±57.29,P <0.001).While,QR_MV_(amp),R_(MA),and T_(MA) in the severe coronary stenosis group were lower(0.23±0.16 vs.0.28±0.16,P<0.001;55.06±48.68 vs.59.24±53.01,P<0.001;51.67±39.32 vs. 60.45±51.33,P <0.001).Seven MFM parameters were integrated into the model,resulting in an area under the curve of 0.810(95% CI:0.765-0.855).The sensitivity,specificity,PPV,NPV,and accurecy were 71.7%,80.4%,93.3%,42.8 %,and 73.5%;*** combined model exhibited an area under the curve of 0.845(95% CI:0.798-0.892).The sensitivity,specificity,PPV,NPV,and accuracy were 84.3%,73.8%,92.6%,54.6%,and 82.1%;*** curves demonstrate d excellent agreement between the nomogram prediction and actual *** decision curve analysis showed that the c ombine d model provided greater net benefit compared to the magnetocardingraphy model.C

关键词： coronary stenosis specificity

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Refractory autoimmune hemolytic anemia in a patient with systemic lupus erythematosus and ulcerative colitis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2286-2292页

作者： dai-Xing Chen yue Wu Sui-Feng Zhang xiao-Jun Yang Department of Digestive System Chongqing Traditional Chinese Medicine HospitalChongqing 400021China

BACKGROUND Ulcerative colitis(UC)and systemic lupus erythematosus(SLE)are both systemic immunoreactive diseases,and their pathogenesis depends on the interaction between genes and environmental *** are no reports of UC with SLE in China,but six cases of SLE with UC have been reported in *** combination of these two diseases has distinct effects on the pathogenesis of both *** SUMMARY A female patient(30 years old)came to our hospital due to dull umbilical pain,diarrhea and mucous bloody stool in August 2018 and was diagnosed with *** symptoms were relieved after oral administration of mesalazine(1 g po tid)or folic acid(5 mg po qd),and the patient were fed a control *** June 24,2019,the patient was admitted for treatment due to anemia and *** hospitalization,the patient had repeated low-grade fever and a progressively decreased Hb *** tests revealed positive antinuclear antibody test,positive anti-dsDNA antibody,0.24 g/L C3(0.9-1.8 g/L),0.04 g/L C4(0.1-0.4 g/L),32.37 g/L immunoglobulin(8-17 g/L),and 31568.1 mg/24 h total 24-h urine protein(0-150 mg/24 h).The patient was diagnosed with SLE involving the joints,kidneys and blood *** reported cases of SLE were retrieved from PubMed to characterize clinicopathological features and identify prognostic factors for *** The patient was discharged in remission after a series of treatments,such as intravenous methylprednisolone sodium succinate,intravenous human immunoglobulin,cyclophosphamide injection,and plasma *** discharge,the patient took oral prednisone acetate tablets,cyclosporine capsules,hydroxychloroquine sulfate tablets and other treatments for symptoms and was followed up regularly for 1 month,after which the patient's condition continued to improve and stabilize.

关键词： Plasma exchange Autoimmune hemolytic anemia Systemic lupus erythematosus Ulcerative colitis Case report

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Identification and functional analysis of CG3526 in spermatogenesis of Drosophila melanogaster

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Insect Science 2024年第1期31卷 79-90页

作者： Qihao Hu Yanhong xiao Runnan Wei Ting Tang Liang Wen yuzhen Lu xiao-Qiang yu Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Guangzhou Key Laboratory of Insect Development Regulation and Application ResearchInstitute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou510631 China

Spermatogenesis is a critical part of reproduction in insects;however,its molecular mechanism is still largely *** this study,we identified a testis-specific gene CG3526 in Drosophila *** analysis showed that CG3526 contains a zinc binding domain and 2 C2H2 type zinc fingers,and it is clustered to the vertebrate really interesting new gene(RING)family E3 ubiquitin-protein *** CG3526 was knocked down by RNA interference(RNAi),the testis became much smaller in size,and the apical tip exhibited a sharp and thin end instead of the blunt and round shape in the control *** importantly,compared to the control flies,only a few mature sperm were present in the seminal vesicle of C587-Gal4>CG3526 RNAi *** staining of the testis from CG3526 RNAi flies showed that the homeostasis of testis stem cell niche was disrupted,cell distribution in the apical tip was scattered,and the process of spermatogenesis was not ***,we found that the phenotype of CG3526 RNAi flies’testis was similar to that of testis of Stat92E RNAi flies,the expression level of CG3526 was significantly downregulated in the Stat92EF06346 mutant flies,and the promoter activity of CG3526 was upregulated by *** together,our results indicated that CG3526 is a downstream effector gene in the JAK-STAT signaling pathway that plays a key role in the spermatogenesis of Drosophila.

关键词： CG3526 JAK-STAT spermatogenesis STAT92E testis

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Rapid report of the December 18,2023 M_(S)6.2 Jishishan earthquake,Gansu,China

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Earthquake Research Advances 2024年第2期4卷 14-21页

作者： Guangjie Han Danqing dai yu Li Nan Xi Li Sun China Earthquake Networks Center Beijing100045China

On December 18,2023,the Jishishan area in Gansu Province was jolted by a M_(S) 6.2 earthquake,which is the most powerful seismic event that occurred throughout the year in *** earthquake occurred along the NWtrending Lajishan fault(LJSF),a large tectonic transformation *** this event,China Earthquake Networks Center(CENC)has timely published several reports about seismic sources for emergency *** earthquake early warning system issued the first alert 4.9 s after the earthquake occurrence,providing prompt notification that effectively mitigated panics,injuries,and deaths of *** near real-time focal mechanism solution indicates that this earthquake is associated with a thrust *** distribution of aftershocks,the rupture process,and the recorded amplitudes from seismic monitoring and GNSS stations,all suggest that the mainshock rupture predominately propagates to the northwest *** duration of the rupture process is~12 s,and the largest slip is located at approximately 6.3 km to the NNW from the epicenter,with a peak slip of 0.12 m at~8 km *** station N0028 recorded the highest instrumental intensity,which is 9.4 on the Mercalli *** estimated intensity map shows a seismic intensity reaching up to IX near the rupture area,consistent with field survey *** aftershocks(up to December 22,2023)are mostly distributed in the northwest direction within~20 km of the *** earthquake caused serious casualties and house collapses,which requires further investigations into the impact of this earthquake.

关键词： Earthquake early warning Focal mechanism Rupture process Real-time intensity Coseismic deformation

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Topological Confinement in Reversibly Interlocked Polymer Networks

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Chinese Journal of Polymer Science 2024年第2期42卷 133-140,I0004页

作者： Wan-Ting dai Zhen-Hua Xie yu-Bin Ke Yang You Min-Zhi Rong Ming-Qiu Zhang Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GD HPPC LabIGCMESchool of ChemistrySun Yat-sen UniversityGuangzhou510275China Spallation Neutron Source Science Center China Spallation Neutron SourceDongguan523803China Institute of High Energy Physics Chinese Academy of SciencesBeijing100049China College of Materials and Metallurgy Guizhou UniversityGuiyang550025China

Recently, we reported a series of reversibly interlocked polymer networks(RILNs), whose mechanical robustness and functionalities improvement was believed to be derived from topological interlocking of two sub-networks, although the direct evidence for the deduction is still lacking. Herein, a specially-designed RILNs system, in which the inter-component hydrogen bonds can be shielded as needed, was prepared and used to study the micro-structures of RILNs, aiming to verify the existence of mechanical interlocking in RILNs. By changing the pH of the swelling solvent, the effect exerted by the inter-component non-covalent bonds was eliminated, so detailed information of the networks structure was exposed. The small angle X-ray scattering(SAXS) and small-angle neutron scattering(SANS) results indicated that swelling-induced structural evolution of the two sub-networks mutually affected each other, even when the inter-component hydrogen bonds were absent, proving the presence of topological interlocking. The findings may help to draw a more accurate physical image and reveal the detailed structureproperty relationship of RILNs.

关键词： Reversibly interlocked polymer networks Small angle X-ray scattering Small-angle neutron scattering Topological confinement

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Quantum support vector machine for multi classification

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Communications in Theoretical Physics 2024年第7期76卷 57-62页

作者： Li Xu xiao-yu Zhang Ming Li Shu-qian Shen College of Science China University of PetroleumQingdao 266580China

Classical machine learning algorithms seem to be totally incapable of processing tremendous data,while quantum machine learning algorithms could deal with big data unhurriedly and provide exponential acceleration over classical *** this paper,we propose two quantum support vector machine algorithms for multi *** is the quantum version of the directed acyclic graph support vector *** other one is to use the Grover search algorithm before measurement,which amplifies the amplitude of the phase storing of the classification *** k classification,the former provides quadratic reduction in computational complexity when *** latter accelerates the training speed significantly and more importantly,the classification result can be read out with a probability of at least 50%using only one *** conduct numerical simulations on two algorithms,and their classification success rates are 96%and 88.7%,respectively.

关键词： quantum support vector machine quantum feature mapping Grover search algorithm

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Local environment regulation of transition metal dichalcogenide-based single-atom catalysts

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Rare Metals 2024年第9期43卷 4019-4037页

作者： Ming-Hui Li Jing Li xiao-yu Zheng Yao Zhou Advanced Research Institute of Multidisciplinary Science andSchool of Chemistry and Chemical Engineering Beijing Institute of Technology Laser Micro/Nano Fabrication Laboratory School of Mechanical Engineering Beijing Institute of Technology

Single-atom catalysts have risen significant attention in the realm of green electrocatalytic energy conversion to address energy and environmental sustainability challenges. Transition metal dichalcogenide（TMD）-based single-atom catalysts are considered highly effective in electrocatalysis due to the TMDs' notable specific surface area, tunable elemental species and efficient utilization of single atoms. In order to enhance electrocatalytic performance, it is imperative to elaborately engineer the local environment surrounding the active sites of single atoms within TMDs. In this review, we initially explore the effects of synthesis methods on single-atom active sites and the influence of loading of single atoms on catalytic performance for TMDs. The modulation strategies of the local environment surrounding single-atom sites in TMDs are elaborated, including substitution engineering,surface adsorption, vacancies, spatial confinement and dual-atom site strategies. For each modulation strategy, the effects of diverse local environments on various electrocatalytic applications are presented, such as the oxygen evolution reaction, oxygen reduction reaction, nitrogen reduction reaction, CO2reduction reaction and CO oxidation. Ultimately, this study presents a comprehensive overview of the challenges encountered and the potential directions for the advancement of single-atom catalysts based on TMDs in the realm of electrocatalysis.

关键词： Electrocatalysis

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A new fabrication method for enhancing the yield of linear micromirror arrays assisted by temporary anchors

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Microsystems & Nanoengineering 2024年第3期10卷 169-180页

作者： Xingchen xiao Ting Mao Yingchao Shi Kui Zhou Jia Hao Yiting yu Ningbo Institute of Northwestern Polytechnical University College of Mechanical EngineeringNorthwestern Polytechnical University710072 Xi’anChina Key Laboratory of Micro/Nano Systems for Aerospace(Ministry of Education) Shaanxi Province Key Laboratory of Micro and Nanoelectromechanical SystemsNorthwestern Polytechnical University710072 Xi’anChina

As one of the most common spatial light modulators,linear micromirror arrays(MMAs)based on microelectromechanical system(MEMS)processes are currently utilized in many ***,two crucial challenges exist in the fabrication of such devices:the adhesion of silicon microstructures caused by anodic bonding and the destruction of the suspended silicon film due to residual *** solve these issues,an innovative processing method assisted by temporary anchors is *** approach effectively reduces the span of silicon microstructures and improves the Euler buckling limit of the silicon ***,these temporary anchors are strategically placed within the primary etching areas,enabling easy removal without additional processing *** a result,we successfully achieved wafer-level,high-yield manufacturing of linear MMAs with a filling factor as high as 95.1%.Demonstrating superior capabilities to those of original MMAs,our enhanced version boasts a total of 60 linear micromirror elements,each featuring a length-to-width ratio of 52.6,and the entire optical aperture measures 5 mm×6 *** linear MMA exhibits an optical deflection angle of 20.4°at 110 Vdc while maintaining exceptional deflection flatness and *** study offers a viable approach for the design and fabrication of thin-film MEMS devices with high yields,and the proposed MMA is promising as a replacement for digital micromirror devices(DMDs,by TI Corp.)in fields such as spectral imaging and optical communication.

关键词： mirror exceptional anodic

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