检索结果-南通市图书馆

World Journal of Diabetes 2024年第2期15卷 170-185页

作者： Han Chen Guo-Xin Zhang xiao-ying zhou Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210003Jiangsu ProvinceChina Department of Gastroenterology Jiangsu Province HospitalNanjing 210029Jiangsu ProvinceChina

BACKGROUND Helicobacter pylori(***)infection is related to various extragastric diseases including type 2 diabetes mellitus(T2DM).However,the possible mechanisms connecting *** infection and T2DM remain *** To explore potential molecular connections between *** infection and *** We extracted gene expression arrays from three online datasets(GSE60427,GSE27411 and GSE115601).Differentially expressed genes(DEGs)commonly present in patients with *** infection and T2DM were *** genes were validated using human gastric biopsy *** between hub genes and immune cell infiltration,miRNAs,and transcription factors(TFs)were further *** A total of 67 DEGs were commonly presented in patients with *** infection and *** significantly upregulated hub genes,including TLR4,ITGAM,C5AR1,FCER1G,and FCGR2A,were finally identified,all of which are closely related to immune cell *** gene-miRNA analysis detected 13 miRNAs with at least two gene ***-gene interaction networks showed that TLR4 was coregulated by 26 TFs,the largest number of TFs among the 5 hub *** We identified five hub genes that may have molecular connections between *** infection and *** study provides new insights into the pathogenesis of ***-induced onset of T2DM.

关键词： Helicobacter pylori Type 2 diabetes mellitus Bioinformatics analysis Differentially expressed genes Hub genes

A STUDY ON TRANSIENT FLUID FLOW OF HORIZONTAL WELLS IN DUAL-PERMEABILITY MEDIA

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2010年第1期22卷 44-50页

作者： WANG xiao-dong zhou ying-fang LUO Wan-jing School of Energy Resources China University of Geosciences Beijing 100083 China

To adopt horizontal wells in dual media reservoirs, a good understanding of the related fluid flows is necessary. Most of the recent studies focus on dual porosity media instead of dual permeability media. In this article, through both integral transformation and sink-source superposition, a new Laplace-domain solution is obtained for the slightly-compressible fluid flow in the 3-D dual-permeability media in which the horizontal well is operating in a constant rate of production. Major asymptotic characteristics of diagnosis curves of dimensionless downhole pressure are analyzed by the limited analysis. Effects of parameters of dual-permeability media including mobility ratio k, storativity ratio ω and inter-porosity flow parameter k on the downhote pressure are studied by using the Laplace numerical inversion. The new solution obtained in this article includes and improves the previous results and then can be used as a basis for either pressure transient analysis or formation behavior evaluation for the typical reservoir with horizontal wells.

关键词： horizontal well dual-permeability media fluid flow in 3-D porous media transient pressure analysis Laplacetransformation

维普期刊数据库

Association between Helicobacter pylori infection and migraine: A meta-analysis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第40期20卷 14965-14972页

作者： Jing Su xiao-ying zhou Guo-Xin Zhang Department of Gastroenterology The First Affiliated Hospital of Nanjing Medical University First Clinical Medical College of Nanjing Medical University

AIM: To quantify the association between Helicobacter pylori (H. pylori) infection and migraine.

关键词： Helicobacter pylori Migraine Meta-analysis Odds ratio Subgroup analysis

A quantitative study of disruptive technology policy texts:An example of China’s artificial intelligence policy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Data and Information Science 2024年第3期9卷 155-180页

作者： ying zhou Linzhi Yan xiao Liu School of Management Anhui UniversityHefei 230601China

Purpose:The transformative impact of disruptive technologies on the restructuring of the times has attracted widespread global *** study aims to analyze the characteristics and shortcomings of China’s artificial intelligence(AI)disruptive technology policy,and to put forward suggestions for optimizing China’s AI disruptive technology ***/methodology/approach:Develop a three-dimensional analytical framework for“policy tools-policy actors-policy themes”and apply policy tools,social network analysis,and LDA topic model to conduct a comprehensive analysis of the utilization of policy tools,cooperative relationships among policy actors,and the trends in policy theme settings within China’s innovative AI technology ***:We find that the collaborative relationship among the policy actors of AI disruptive technology in China is insufficiently *** subjects exhibit low participation in the cooperation network and overly rely on central subjects,forming a“center-periphery”network *** tool usage is predominantly focused on supply and environmental types,with a severe inadequacy in demand-side policy tool *** themes are diverse,encompassing topics such as“Intelligent Services”“Talent Cultivation”“Information Security”and“Technological Innovation”,which will remain focal *** the themes of“Intelligent Services”and“Intelligent Governance”,policy tool usage is relatively balanced,with close collaboration among policy ***,the theme of“AI Theoretical System”lacks a comprehensive understanding of tool usage and necessitates enhanced cooperation with other policy *** limitations:The data sources and experimental scope are subject to certain limitations,potentially introducing biases and imperfections into the research results,necessitating further validation and *** implications:The study introduces a three-dimensional analysis framework for disruptive technology p

关键词： Disruptive technologies Artificial intelligence Synergies Policy tools Thematic evolution

Effects of dietary intervention on human diseases:molecular mechanisms and therapeutic potential

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1389-1422页

作者： Yu-Ling xiao Yue Gong ying-Jia Qi Zhi-Ming Shao Yi-zhou Jiang Key Laboratory of Breast Cancer in Shanghai Department of Breast SurgeryFudan University Shanghai Cancer CenterShanghaiChina Department of Oncology Shanghai Medical CollegeFudanUniversityShanghai200032China

Diet,serving as a vital source of nutrients,exerts a profound influence on human health and disease ***,dietary interventions have emerged as promising adjunctive treatment strategies not only for cancer but also for neurodegenerative diseases,autoimmune diseases,cardiovascular diseases,and metabolic *** interventions have demonstrated substantial potential in modulating metabolism,disease trajectory,and therapeutic *** reprogramming is a hallmark of malignant progression,and a deeper understanding of this phenomenon in tumors and its effects on immune regulation is a significant challenge that impedes cancer *** intake,as a key environmental factor,can influence tumor *** evidence indicates that dietary interventions might affect the nutrient availability in tumors,thereby increasing the efficacy of cancer ***,the intricate interplay between dietary interventions and the pathogenesis of cancer and other diseases is *** encouraging results,the mechanisms underlying diet-based therapeutic strategies remain largely unexplored,often resulting in underutilization in disease *** this review,we aim to illuminate the potential effects of various dietary interventions,including calorie restriction,fasting-mimicking diet,ketogenic diet,protein restriction diet,high-salt diet,high-fat diet,and high-fiber diet,on cancer and the aforementioned *** explore the multifaceted impacts of these dietary interventions,encompassing their immunomodulatory effects,other biological impacts,and underlying molecular *** review offers valuable insights into the potential application of these dietary interventions as adjunctive therapies in disease management.

关键词： diseases metabolism potential

An improved installation of 2-hydroxy-4-methoxybenzyl(iHmb)method for chemical protein synthesis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 145-150页

作者： ying Li Long-Jie Wang Yong-Kang zhou Jun Liang Bin xiao Ji-Shen Zheng The First Affiliated Hospital of USTC MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Chemistry University of Science and Technology of ChinaHefei 230027China

The 2-hydroxy-4-methoxybenzyl(Hmb)backbone modification can prevent amide bond-mediated sidereactions(e.g.,aspartimide formation,peptide aggregation)by installing the removable Hmb group into a peptide bond,thus improving the synthesis of long and challenging peptides and ***,its use is largely precluded by the limited Hmb’s installation *** this report,an improved installation of Hmb(iHmb)method was developed to achieve the flexible installation and the convenient removal of *** iHmb method involves two critical steps:(1)oxidative diazotization of the readily installed 2-hydroxy-4-methoxy-5-amino-benzyl(Hmab)to give 2-hydroxy-4-methoxy-5-diazonium-benzyl(Hmdab)by combining soamyl nitrite(IAN)/HBF_(4),and(2)reductive elimination of Hmdab to give the desired Hmb by 1,2-ethanedithiol(EDT).The iHmb method enables the installation of Hmb at any primary amino acid including the highly sterically hindered amino acids(e.g.,valine and isoleucine).The practicality and utility of the iHmb method was demonstrated by one-shot solid-phase synthesis of a challenging aspartimide-prone peptide,the mirror-image version of a hydrophobic peptide and a long-chain peptide up to ***,the iHmb method can be utilized to facilitate chemical protein ligation,as exemplified by the synthesis of the single-spanning membrane protein *** iHmb method expands the toolkit for peptide synthesis and ligation and facilitates the preparation of peptides/proteins.

关键词： Chemical protein synthesis Solid-phase peptide synthesis Removable backbone modification 2-Hydroxy-4-methoxybenzyl(Hmb)group Aspartimide-prone peptides Difficult peptides Membrane proteins

维普期刊数据库

Oat arabinoxylan promoted Lactobacillus gasseri to alleviate metabolic disorders in high-fat diet-induced obese mice

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： ying Zhang Ming zhou Yaqin zhou xiao Guan School of Health Science and Engineering， University of Shanghai for Science and Technology National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center MDO Smarter Grain Technology Co.， Ltd.

Arabinoxylan (AX) has been found to improve an imbalanced gut microbiota. Lactobacillus gasseri is a beneficial endogenous bacterium that has been shown to have several health benefits in the human gut， particularly its lipid-lowering activity. However， it is not known whether AX can promote the action of L. gasseri. The results of in vitro experiments showed that AX promoted biofilm formation in L. gasseri， its acid and bile salt resistance could be enhanced， and enabled better colonization of L. gasseri in the intestinal tract of mice. In vivo experiments showed that the AX+ L. gasseri group could effectively ameliorate weight gain and fat accumulation in high-fat diet-induced obese mice， and the L. gasseri group or AX+L. gasseri alleviated liver injury in mice. 16S rRNA sequencing showed that L. gasseri can colonize the mice intestine and AX+L. gasseri can ameliorate gut microbiota dysbiosis in obese mice by increasing Lactobacillus spp. and Coriobacteriaceae＿UCG-002 and decreasing Peptococcaceae. In addition， metabolomics results indicated that the L. gasseri group and the AX+L. gasseri group could alleviate metabolic disorders by decreasing the levels of L-phenylalanine， L-tyrosine， kynurenine acid， and arachidonic acid in obese mice. The effect of AX+L. gasseri group was better than that of the L. gasseri group， suggesting that AX promotes the lipid-lowering activity of L. gasseri， and the mechanism may be due to the activation of retrograde endocannabinoid signaling. AX can be used as a functional food ingredient to potentially alleviate obesity and metabolic syndrome.

关键词：

Catechins promoted Enterococcus faecalis to alleviate related indices of nonalcoholic steatohepatitis mice induced by high-fat diet

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： ying Zhang Yaqin zhou Ming zhou xiao Guan School of Health Science and Engineering， University of Shanghai for Science and Technology National Grain Industry (Urban Grain and Oil Security) Technology Innovation Center MDO Smarter Grain Technology Co.， Ltd.

This study provides different opinion for exploring the mechanism of catechin (CAT) relieving nonalcoholic steatohepatitis (NASH)， it is more innovative to explore from the perspective of intestinal microorganism. Through in vitro fermentation experiments， CAT could improve the abundance of Enterococcus， and Enterococcus faecalis (EF) accounts for the vast majority of Enterococcus in human gut. The experimental results in vivo showed that EF group and CAT+EF group could reduce the body weight， liver weight and epididymal fat weight of NASH mice， and improve the changes of serum and liver indexes. HE staining observation showed that these two groups have greatly improved the fatty degeneration， balloon degeneration and necrotic focus caused by NASH. The alleviation of CAT+EF group was more obvious. Results of targeted metabonomics showed that CAT could promote EF to produce more methyl palmitate (MP， C16:0)， which plays a great role in relieving NASH. Our results indicated that EF could alleviate NASH and CAT+EF group had better alleviation may due to more production of MP by EF. This study provides a new idea for CAT to alleviate NASH.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Heavy Metal Toxicity

中国药理学与毒理学杂志 2006年第3期 177-178页

作者： Seiichoro Himeno Mao-Xiang Zhu Zhi-Hua Yang Zhen-Shan Cao Xiu-Jie Pan Shi Yu xiao-ying zhou Ping-Kun zhou Yoshito Kumagai xiao-Jiang Tang xiao-Jun Yang Jing-Hui Guo Wen-Liang zhou

S6-1 Novel cadmium transport systems found in metallothionein-null cadmium-resistant cellsSeiichoro HIMENO (JST)S6-2 Harmful effects of depleted uranium aerosol and the protective role of DMSO ZHU Mao-Xiang, YANG Zhi-Hua, CAO Zhen-Shan, PAN Xiu-Jie, YU Shi, zhou xiao-ying, zhou Ping-Kun(Department of Radiation Toxicology and Oncology, Beijing Institute of Radiation Medicine, Beijing 100850, China)Abstract:The aim is to investigate the health effects of depleted uranium(DU) material and the protective role of DMSO. Exposure model of rat was established by inhaling DU aerosol. The amount of DU aerosol inhalation in rats was calculated through measuring the DU concentration and its inhalational fraction (about 130 mg DU/rat) or determining DU contents in lung tissue (12.68±3.31) mg DU/rat or (65.43±11.72) mg DU·kg -1 BW. At a given time after DU aerosol inhalation, a series end-points of biological effects were detected in the exposed rats: ① lung was the organ with the highest level of remaining U. The half time of clearance was more than 100 d. With the time extending, U can be transported through body fluid to many organs or tissues, including liver, kidney, brain, heart, spleen, thymus, bones, etc; ② weight gaining of rats was lower than that of normal group in a dose- and time-dependent manner; ③ the counts of WBC and differential leukocytes including lymphocytes and monocytes in peripheral blood were reduced in dose and time dependent manner.

关键词： JST ATPase TMT

Misdiagnosis of synovial sarcoma-cellular myofibroma with SRFRELA gene fusion:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第7期12卷 1326-1332页

作者： ying zhou Yi-Wen Sun xiao-Yang Liu Dan-Hua Shen Department of Pathology Peking University People’s HospitalBeijing 100044China

BACKGROUND Cellular myofibroma is a rare subtype of myofibroma that was first described in *** diagnosis is often challenging because of its relative rarity,lack of known genetic abnormalities,and expression of muscle markers that can be confused with sarcomas that have myogenic ***,scholars have limited knowledge of this disease,and published cases are *** accumulation of diagnostic and treatment experiences is *** SUMMARY A 16-year-old girl experienced left upper limb swelling for 3 *** sought medical attention at a local hospital 10 months ago,where magnetic resonance imaging revealed a 5-cm soft tissue *** biopsy performed at a local hospital resulted in the diagnosis of a spindle cell soft tissue *** patient was referred to our hospital for limb salvage surgery with endoprosthetic *** was initially diagnosed with a synovial ***,clinical management with chemotherapy was continued for the malignant *** pathology department also performed fluorescence in situ hybridization for result validation,which returned negative for SS18 gene breaks,indicating that it was not a synovial ***-generation sequencing was used to identify the SRF-RELA *** final pathological diagnosis was a cellular/myofibroblastic neoplasm with an SRF-RELA gene *** patient had initially received two courses of chemotherapy;however,chemotherapy was discontinued after the final *** This case was misdiagnosed because of its rare occurrence,benign biological behavior,and pathological similarity to soft tissue sarcoma.

关键词： Cellular myofibroma SRF RELA Fusion Pathology Case report