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TRIANGLE operation,combined with adequate adjuvant chemotherapy,can improve the prognosis of pancreatic head cancer:A retrospective study

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1773-1786页

作者： Jia-Hao Chen Li-Yong Zhu Zhi-Wei Cai xiao Hu Abousalam Abdoulkader Ahmed Jie-Qiong Ge xiao-yan tang Chun-Jing Li Yun-Long Pu Chong-Yi Jiang Department of Hepato-Biliary-Pancreatic Surgery Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China Shanghai Key Laboratory of Clinical Geriatric Medicine Fudan UniversityShanghai 200040China Department of Nursing Huadong Hospital Affiliated to Fudan UniversityShanghai 200040China

BACKGROUND The TRIANGLE operation involves the removal of all tissues within the triangle bounded by the portal vein-superior mesenteric vein,celiac axis-common hepatic artery,and superior mesenteric artery to improve patient *** previously promising in patients with locally advanced pancreatic ductal adenocarcinoma(PDAC),data are limited regarding the long-term oncological outcomes of the TRIANGLE operation among resectable PDAC patients undergoing pancreaticoduodenectomy(PD).AIM To evaluate the safety of the TRIANGLE operation during PD and the prognosis in patients with resectable *** This retrospective cohort study included patients who underwent PD for pancreatic head cancer between January 2017 and April 2023,with or without the TRIANGLE *** were divided into the PD_(TRIANGLE)and PD_(non-TRIANGLE)*** and survival outcomes were compared between the two *** adjuvant chemotherapy was defined as adjuvant chemotherapy≥6 *** The PD_(TRIANGLE)and PD_(non-TRIANGLE) groups included 52 and 55 patients,*** were no significant differences in the baseline characteristics or perioperative indexes between the two ***,the recurrence rate was lower in the PD_(TRIANGLE) group than in the PD_(non-TRIANGLE) group(48.1%vs 81.8%,P<0.001),and the local recurrence rate of PDAC decreased from 37.8%to 16.0%.Multivariate Cox regression analysis revealed that PD_(TRIANGLE)(HR=0.424;95%CI:0.256-0.702;P=0.001),adequate adjuvant chemotherapy≥6 months(HR=0.370;95%CI:0.222-0.618;P<0.001)and margin status(HR=2.255;95%CI:1.252-4.064;P=0.007)were found to be independent factors for the recurrence *** The TRIANGLE operation is safe for PDAC patients undergoing ***,it reduces the local recurrence rate of PDAC and may improve survival in patients who receive adequate adjuvant chemotherapy.

关键词： TRIANGLE operation Pancreatic ductal adenocarcinoma Heidelberg triangle Adjuvant chemotherapy Prognosis Pancreaticoduodenectomy

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Determination of the Amplification Factor for 2-Hydroxy-ethylperoxy Radicals in PERCA

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Chinese Chemical Letters 2006年第7期17卷 957-960页

作者： Bin QI yan MA xiao Qian LI xiao yan tang School of Chemistry and Material Sciences Shaanxi Normal University Xian 710062 College of Environmental Sciences Peking University Beijing 100871

A new method is proposed to determine the amplification factor for 2-hydroxy ethylperoxy radicals （HOC2H4O2·） in chemical amplifier. The radical source comes from the reaction of excess ethene with HO· radicals generated in the photolysis of water vapor at the wave length of 185 nm in air in a flow tube. This produces a radical source which contains equal amount of HO2·and HOC2H4O2·. The amplification factor is derived from the slopes of the lines between produced NO2 in chemical amplifier and total initial radical concentrations measured for the source of HO2· and that of the same amount of HO2· and HOC2H4O2· respectively. The amplification factor of HOC2H4O2· was similar to that of HO2·, indicating that HOC2H4O2· can be measured with the same sensitivity as HO2· by chemical amplifier.

关键词： 2-Hydroxy ethylperoxy radical amplification factor chemical amplification.

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Infinitely many nonlocal symmetries and nonlocal conservation laws of the integrable modified KdV-sine-Gordon equation

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Communications in Theoretical Physics 2021年第5期73卷 18-24页

作者： Zu-feng Liang xiao-yan tang Wei Ding Department of Physics Hangzhou Normal UniversityHangzhou 10036China School of Mathematical Sciences Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai 200062China School of Computer Science and Technology Shanghai Normal UniversityShanghai 200234China

Nonlocal symmetries related to the B?cklund transformation(BT)for the modified KdV-sine-Gordon(mKdV-SG)equation are obtained by requiring the mKdV-SG equation and its BT form invariant under the infinitesimal *** through the parameter expansion procedure,an infinite number of new nonlocal symmetries and new nonlocal conservation laws related to the nonlocal symmetries are ***,several new finite and infinite dimensional nonlinear systems are presented by applying the nonlocal symmetries as symmetry constraint conditions on the BT.

关键词： Nonlocal conservation law The modified KdV-sine-Gordon equation Nonlocal symmetry

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Reduction of Precursors of Chlorination By-products in Drinking Water Using Fluidized-bed Biofilm Reactor at Low Temperature

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Biomedical and Environmental Sciences 2006年第5期19卷 360-366页

作者： SHU-GUANG XIE DONG-HUI WEN DONG-WEN SHI xiao-yan tang Department of Environmental Sciences College of Environmental Sciences Peking University Beijing 100871 China School of Environmental Science and Engineering Donghua University Shanghai 200051 China

Objective To investigate the reduction of chlorination by-products （CBPs） precursors using the fluidized-bed biofdm reactor （FBBR）. Methods Reduction of total organic carbon （TOC）, ultraviolet absorbance （UV254）, tfihalomethane （THM） formation potential （THMFP）, haloacetic acid （HAA） formation potential （HAAFP）, and ammonia in FBBR were evaluated in detail. Results The reduction of TOC or UV254 was low, on average 12.6% and 4.7%, respectively, while the reduction of THMFP and HAAFP was significant. The reduction of ammonia was 30%-40% even below 3℃, however, it could quickly rise to over 50% above 3℃. Conclusions The FBBR effectively reduces CBPs and ammonia in drinking water even at low temperature and seems to be a very promising and competitive drinking water reactor for polluted surface source waters, especially in China.

关键词： Chlorination by-products Low temperature Drinking water Fluidized-bed biofilm reactor

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The clinical phenotype and genotype of NLRP12-autoinflammatory disease: a Chinese case series with literature review

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World Journal of Pediatrics 2020年第5期16卷 514-519页

作者： Wei Wang Yu Zhou Lin-Qing Zhong Zhuo Li Shan Jian xiao-yan tang Hong-Mei Song Department of Pediatrics Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina School of Medicine Tsinghua UniversityBeijingChina

Background The nucleotide-binding oligomerization domain-like receptor protein 12(NLRP12)-autoinflammatory disorder(NLRP12-AD)is a rare autoinflammatory disease characterized by recurrent fever,rash as well as musculoskeletal symptoms,which is rarely reported in Asian *** Three cases of NLRP12-AD presented to our hospital were studied after parental consents were *** presentations were recorded on a standardized case report *** of NLRP12 were detected by primary immunodeficiency disease panels and further examined by Sanger *** literature search for relevant studies of systemic autoinflammatory disorders,especially NLRP12-AD between January,2000 and January,2019 was carried and the clinical data were *** were made between groups in terms of onset age and of *** All our patients presented with fever,rash and arthritis/arthralgia,and sensorineural as well as sensorineural deafness(1/3),uveitis(1/3),abdominal pain(1/3),and myalgia(1/3).Two novel mutation variations,p.W581X and p.L558R,are reported *** addition,we also found that two patients inherited the mutated alleles from their healthy parents,and this may be evidence of *** Although the genotypes are similar,the clinical manifestations between Chinese patients and Western patients vary thus highlighting the possible influence of ethnic and environmental *** the other hand,some genetic mutations may lead to specific phenotype,as we have found a high prevalence of sensorineural hearing loss among p.R284X patients.

关键词： Autoinflammatory disease NLRP12-AD Recurrent fever

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Temperature-Dependent Effect of Near-Interface Traps on SiC MOS Capacitance

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Chinese Physics Letters 2018年第10期35卷 77-80页

作者： yan-Jing He xiao-yan tang Yi-Fan Jia Ci-Qi Zhou Yu-Ming Zhang Microelectronics Institute Xidian University

A two-dimensional electrical SiC MOS interface model including interface and near-interface traps is established based on the relevant tunneling and interface Shockley–Read–Hall model. The consistency between simulation results and measured data in the different temperatures shows that this interface model can accurately describe the capture and emission performance for near-interface oxide traps, and can well explain the hysteresis-voltage response with increasing temperature, which is intensified by the interaction between deep oxide traps and shallow oxide traps. This also indicates that the near-interface traps result in an increase of threshold-voltage shift in SiC MOSFET with increasing temperature.

关键词： MOS Temperature-Dependent Effect of Near-Interface Traps on SiC MOS Capacitance SiC

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Human organoids in basic research and clinical applications

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Signal Transduction and Targeted Therapy 2022年第6期7卷 2010-2026页

作者： xiao-yan tang Shanshan Wu Da Wang Chu Chu Yuan Hong Mengdan Tao Hao Hu Min Xu Xing Guo yan Liu Institute for Stem Cell and Neural Regeneration School of PharmacyState Key Laboratory of Reproductive MedicineKey Laboratory of Targeted Intervention of Cardiovascular DiseaseCollaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjingChina Department of Neurobiology School of Basic Medical SciencesNanjing Medical UniversityNanjingChina

Organoids are three-dimensional(3D)miniature structures cultured in vitro produced from either human pluripotent stem cells(hPSCs)or adult stem cells(AdSCs)derived from healthy individuals or patients that recapitulate the cellular heterogeneity,structure,and functions of human *** advent of human 3D organoid systems is now possible to allow remarkably detailed observation of stem cell morphogens,maintenance and differentiation resemble primary tissues,enhancing the potential to study both human physiology and developmental *** they are similar to their original organs and carry human genetic information,organoids derived from patient hold great promise for biomedical research and preclinical drug testing and is currently used for personalized,regenerative medicine,gene repair and transplantation *** recent decades,researchers have succeeded in generating various types of organoids mimicking in vivo ***,we provide an update on current in vitro differentiation technologies of brain,retinal,kidney,liver,lung,gastrointestinal,cardiac,vascularized and multi-lineage organoids,discuss the differences between PSC-and AdSC-derived organoids,summarize the potential applications of stem cell-derived organoids systems in the laboratory and clinic,and outline the current challenges for the application of organoids,which would deepen the understanding of mechanisms of human development and enhance further utility of organoids in basic research and clinical studies.

关键词： organs clinical generating

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Temperature-dependent chloride-mediated access to atom-precise silver thiolate nanoclusters

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Science China Chemistry 2022年第6期65卷 1094-1099页

作者： Ling yang Xin-Yao Wang xiao-yan tang Meng-Yi Wang Chun-yan Ni Hong Yu Ying-Lin Song Brendan F.Abrahams Jian-Ping Lang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China School of Materials Engineering Changshu Institute of TechnologyChangshu215500China School of Physical Science and Technology Soochow UniversitySuzhou215006China School of Chemistry University of MelbourneParkvilleVictoria3010Australia

By using a unique temperature-dependent,chloride-mediated approach,two atom-precise silver nanoclusters[Cl@Ag_(14)(Tab)_(12)-(C_(5)H_(4)NCl)_(12)](PF_(6))_(13)(Cl@Ag_(14))and[Cl_(3)@Ag_(24)(Tab)_(20)(C_(5)H_(4)NCl)_(11)]Cl(PF_(6))_(20)(Cl_(3)@Ag_(24))(Tab=4-(trimethylammonio)benzenethiolate,C_(5)H_(4)NCl=3-chloropyridine)were obtained ***,the number of chloride ions encapsulated inside the Ag-S shell could be regulated by the slow dissolution of almost insoluble KCl at various *** inclusion of additional core chloride ions results in the expansion of the surrounding Ag-S *** article provides a promising synthetic approach for controlling the number of Ag atoms that form a shell around the anionic core,in addition to offering a potential pathway for the introduction of other inorganic anions into silver *** broadly,through the use of related ligands,the synthetic strategy offers scope for generating new families of silver thiolate clusters of varying size and composition.

关键词： temperature-dependent chloride-mediated core expansion silver thiolate nanocluster transformation

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Hysteresis effect in current–voltage characteristics of Ni/n-type 4H-SiC Schottky structure

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Chinese Physics B 2019年第11期28卷 316-321页

作者： Hao Yuan Qing-Wen Song Chao Han xiao-yan tang xiao-Ning He Yu-Ming Zhang Yi-Men Zhang School of Microelectronics Xidian UniversityXi’an 710071China

Hysteresis current–voltage(Ⅰ–Ⅴ) characteristics are often observed in a highly non-ideal(n > 2) as-deposited nickel(Ni)/4 H-SiC Schottky contact. However, we find that this kind of hysteresis effect also exists in an as-deposited Ni/n-type4 H-SiC Schottky structure even if the ideality factor(n) is less than 1.2. The hysteresis Ⅰ–Ⅴ characteristics is studied in detail in this paper by using the various measurements including the hysteresis Ⅰ–Ⅴ, sequentialⅠ–Ⅴ sweeping, cycle Ⅰ–Ⅴ,constant reverse voltage stress(CRVS). The results show that the hysteresis Ⅰ–Ⅴ characteristics are strongly dependent on the sweeping voltage and post-deposition annealing(PDA). The high temperature PDA(800℃) can completely eliminate this hysteresis. Meanwhile, the magnitude of the hysteresis effect is shown to decrease in the sequential Ⅰ–Ⅴ sweeping measurement, which is attributed to the fact that the electrons tunnel from the 4 H-SiC to the localized states at the Ni/ntype 4 H-SiC interface. It is found that the application of the reverse bias stress has little effect on the emission of those trapped electrons. And a fraction of the trapped electrons will be gradually released with the time under the condition of air and with no bias. The possible physical charging mechanism of the interface traps is discussed on the basis of the experimental findings.

关键词： 4H-SiC Schottky hysteresis Ⅰ–Ⅴ Schottky barrier height

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Simulation of SiC radiation detector degradation

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Chinese Physics B 2019年第1期28卷 300-305页

作者： Hai-Li Huang xiao-yan tang Hui Guo Yi-Men Zhang Yu-Tian Wang Yu-Ming Zhang School of Microelectronics Xidian University Key Laboratory of Wide Band-Gap Semiconductor Materials and Devices Xidian University

Simulation on the degradation of 4H-SiC Schottky detector was carried out using ISE TCAD, and the limit of the driftdiffusion analytical model was discussed. Two independent defect levels, rather than a pair of specific carrier lifetime, were induced to describe Z1/2 defects in simulation to calculate the charge collection efficiency versus bias voltage. Comparison between our calculation and the reported experimental results shows that an acceptable agreement was achieved, proving the feasibility of regarding Z1/2 defect as two individual defect levels. Such a treatment can simplify the simulation and may help to further investigate the detector degradation.

关键词： 4H-SiC detector degradation simulation Z1/2 defect

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