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Mechanical properties and fracture mechanism of Fe/Cu composite sheets with Al interlayer after annealing treatment

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Journal of Iron and Steel Research(International) 2023年第9期30卷 1888-1895页

作者： xiao-wei feng Jia-xin Li Zhi-bin Zheng Bo feng Hao-kun Yang Institute of New Materials Guangdong Academy of SciencesGuangdong Provincial Key Laboratory of Metal Toughening Technology and ApplicationGuangzhou 510000GuangdongChina Smart Manufacturing Division Hong Kong Productivity CouncilHong Kong 999077China

The feasibility of preparing Fe/Cu composite sheet was achieved by introducing submillimeter thickness Al sheet as an interlayer by rolling at room temperature.The shear test of the composite sheet supported that the metallurgical bonding strength between Fe/(Al)/Cu interface was stronger than that of Cu sheet at the initial state.With further 300 or 600℃ annealing treatments,the interlayer subsequently exhibited brittle shear fracture,and the shear strength significantly dropped under the shear test.Furthermore,the tensile test pointed out that the tensile fracture mechanism changed from fracture as a whole structure to interlayer-to-layer delamination mode after annealing treatment.The microstructure and X-ray diffraction observations proved that the formation of Cu–Al intermetallic compounds(IMCs)along the interlayer resulted in brittle fracture,rather than that of Fe–Al IMCs after annealing,especially under 600℃ annealing treatment.The investigation of the effect of the rolling process and annealing treatment on the mechanical properties of the Fe/(Al)/Cu composite sheet shall provide instruction for high-quality composite metallic sheet fabrication.

关键词： Composite sheet Fe/Cu Interlayer Intermetallic compound Fracture

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结构化液体的设计、构筑与应用

高分子学报 2024年第5期55卷 485-508页

作者：封维潇 Thomas P.Russell 史少伟北京化工大学化工资源有效利用国家重点实验室北京软物质科学与工程高精尖创新中心北京100029 Department of Polymer Science and Engineering University of MassachusettsAmherstMassachusetts 01003

结构化液体是近年来基于二元流体体系,利用固体粒子液/液界面自组装和堵塞相变构筑的一类非平衡态软物质材料,兼具固体的结构稳定性和液体的流动性.然而,受限于组装基元和成型方法,制备具有精准结构的智能结构化液体及衍生功能材料仍面... 详细信息

结构化液体是近年来基于二元流体体系,利用固体粒子液/液界面自组装和堵塞相变构筑的一类非平衡态软物质材料,兼具固体的结构稳定性和液体的流动性.然而,受限于组装基元和成型方法,制备具有精准结构的智能结构化液体及衍生功能材料仍面临挑战.我们课题组在该领域开展了大量研究工作,在发展界面调控新机制,制备液体/固体新材料,以及实现材料器件新突破等方面取得了系列创新成果.本专论从固体粒子界面自组装机制出发,重点阐述了一种利用纳米粒子和聚合物液/液界面共组装制备纳米粒子表面活性剂,进而构筑结构化液体的普适策略;总结归纳了结构化液体在响应性调控、高效精准构筑以及功能材料制备等方面的研究进展;并对该领域面临的机遇和挑战做出展望.

关键词：结构化液体纳米粒子表面活性剂液/液界面自组装

Experimental research on HEL and failure properties of alumina under impact loading

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Defence Technology（防务技术） 2016年第3期12卷 272-276页

作者： xiao-wei feng Jing-zhen CHANG Yong-gang LU Institute of Systems Engineering China Academy of Engineering Physics

A series of plate impact experiments on alumina was conducted using a light gas gun in order to further investigate Hugoniot elastic limit(HEL)and failure properties of alumina under shock compression.The velocity interferometer system for any reflector(VISAR)was used to record the rear-free surface velocity histories of the alumina samples.According to the experimental results,the HELs of tested alumina samples with different thicknesses were measured,and the decay phenomenon of elastic wave in shocked alumina was studied.A phenomenological expression between HEL and thickness of sample was presented,and the causes of the decay phenomenon were discussed.The propagation of failure wave in shocked alumina was probed.The velocity and delayed time of failure wave propagation were obtained.The physical mechanism of the generation and propagation of failure was further discussed.

关键词： Plate impact experiment Alumina Hugoniot elastic limit Failure wave

Recent Advancements in Intestinal Microbiota Analyses:A Review for Non-Microbiologists

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Current Medical Science 2018年第6期38卷 949-961页

作者： xiao-wei feng Wen-ping DING Ling-yun XIONG Liang GUO Jia-ming SUN Peng xiao Department of Psychiatry Wuhan Youfu HospitalWuhan 430050China Department of Ultrasound Wuhan Women and Children's Health Care CenterWuhan 430016China Department of Plastic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan 430022China

Microbial constituents naturally inhabiting the gastrointestinal tract may influence the homeostasis of the gut environment.The presence or overabundance of some bacterial taxa has been reported to be associated with complex diseases,and the metabolites of certain bacteria may contribute to diverse disorders by influencing signaling pathways.Therefore,the study of gut microbial population has emerged as a crucial field and a new potential area of clinical significance. Advances in the methods of microbiota analysis have shed light upon the details including species diversity,microfloral activities as well as the entire gut microbiota.Nevertheless,comprehensive reviews on this subject are still limited.For elucidating the appropriate selection strategy of the methods to address a particular research question,we comprehensively reviewed the continuously improving technologies,classical to newly developed,and dissected their relative advantages and drawbacks.In addition,aiming at the rapidly advancing next-generation sequencing,we enumerated the improvements in mainstream platforms and made the horizontal and vertical comparison among them.Additionally,we demonstrated the four main-omics methods,which may provide further mechanistic insights into the role of microbiota,to propel phylotyping analysis to functional analysis.

关键词： gut microbiota methods analysis advantages drawbacks

Microstructure and nanoindentation hardness of shot-peened ultrafine-grained low-alloy steel

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Journal of Iron and Steel Research(International) 2019年第5期26卷 472-482页

作者： xiao-wei feng Juan Xie Wen-ying Xue Yong-feng Shen Hong-bo Wang Zhen-yu Liu Institute of Systems Engineering of China Academy of Engineering Physics Mianyang 621999 Sichuan China Key Laboratory for Anisotropy and Texture of Materials (MOE) School of Materials Science and Engineering Northeastern University Shenyang 110819 Liaoning China The State Key Lab of Rolling and Automation Northeastern University Shenyang 110819 Liaoning China

The effect of shot peening (SP) on microstructure and hardness of ultrafine-grained (UFG) low-alloy steel was investigated. With increasing shot-peening time from 0.5 to 1.5 h, grain size of UFG low-alloy steel decreases from 400 to 280 nm at surface whilst that of the layer with a depth of 160μm decreases from (230 ± 15) to (75 ± 5) nm. Interestingly, nanoindentation shows that hardness increases linearly with increasing the SP duration, reaching a value as high as (7.10 ± 0.1) GPa at the depth of 160 μm after the SP duration of 1.5 h. The thickness of the SP treated layer is measured as^300 μm. The Hall-Petch (H-P) relationship was established for the hardening layer. Correspondingly, abrasion resistance should be ~51% higher than that of as-prepared UFG low-alloy steel. As shown in SP processing, grain refinement is the key factor responsible for the strengthening of the studied steel.

关键词： Low-alloy steel Shot peening Grain refinement Nanoindentation Hardness

Efficacy and safety of itraconazole use in infants

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世界儿科杂志:英文版 2016年第4期12卷 399-407页

作者： Shuang Chen Kai-Yi Sun xiao-wei feng Xin Ran Jebina Lama Yu-Ping Ran Department of Dermatovenereology West China HospitalSichuan UniversityChengdu610041China

Background:Itraconazole has been used to treat fungal infections,in particular invasive fungal infections in infants or neonates in many countries.Data sources:Literature search was conducted through Ovid EMBASE,PubMed,ISI Web of Science,CNKI and Google scholarship using the following key words:“pediatric”or“infant”or“neonate”and“fungal infection”in combination with“itraconazole”.Based on the literature and our clinical experience,we outline the administration of itraconazole in infants in order to develop evidence-based pharmacotherapy.Results:Of 45 articles on the use of itraconazole in infancy,13 are related to superficial fungal infections including tinea capitis,sporotrichosis,mucosal fungal infections and opportunistic infections.The other 32 articles are related to systemic fungal infections including candidiasis,aspergillosis,histoplasmosis,zygomycosis,trichosporonosis and opportunistic infections as caused by Myceliophthora thermophila.Conclusion:Itraconazole is safe and effective at a dose of 5 mg/kg per day in a short duration of therapy for superficial fungal infections and 10 mg/kg per day for systemic fungal infections in infants.With a good compliance,it is cost-effective in treating infantile fungal infections.The profiles of adverse events induced by itraconazole in infants are similar to those in adults and children.

关键词： infant itraconazole prophylaxis superficial fungal infections systemic fungal infections

济南市区典型污染时期大气中醛酮化合物的组分特征及生成机制

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中国环境科学 2024年第1期44卷 72-82页

作者：闫怀忠王杰石敬华曹燕燕由希华魏小锋刘仕杰张桂芹山东建筑大学市政与环境工程学院山东济南250101 山东省生态环境监测中心山东济南250101 山东建筑大学资源与环境创新研究院山东济南250101

利用2,4-二硝基苯肼采样管采样-高效液相色谱仪分析的方法,在济南市夏季典型臭氧污染时期(2022年6月14~22日)对两个不同市区点位(建大和创业园)大气中醛酮化合物开展同步采样分析,利用基于观测的化学箱式模型(OBM)对主要醛酮化合物的光... 详细信息

利用2,4-二硝基苯肼采样管采样-高效液相色谱仪分析的方法,在济南市夏季典型臭氧污染时期(2022年6月14~22日)对两个不同市区点位(建大和创业园)大气中醛酮化合物开展同步采样分析,利用基于观测的化学箱式模型(OBM)对主要醛酮化合物的光化学反应进行模拟,识别主要醛酮化合物的二次生成途径及重要前体物.采样期间醛酮化合物总浓度为(19.78±9.83)×10^(-9),甲醛、乙醛和丙酮贡献率分别为36.75%、21.39%、14.64%,是最主要的醛酮化合物.建大点位甲醛浓度存在午间与夜间双峰高值,创业园点位甲醛浓度存在早晚高峰变化特征,两点位乙醛浓度呈“夜高昼低”日变化特征.两点位甲醛和乙醛特征比值(C1/C2)分别为1.97、1.47,乙醛和丙醛特征比值(C2/C3)分别为9.27、8.76,建大点位C1/C2存在明显的午间峰值.OBM模拟结果显示,甲醛最大生成速率为6.17×10^(-9)h^(-1),乙醛最大生成速率为1.67×10^(-9)h^(-1),丙酮最大生成速率为0.66×10^(-9)h^(-1),烷氧自由基(RO)+O_(2)反应是二次生成的主要途径.结合相对增量反应活性(RIR)结果发现,烯烃对济南市大气中甲醛和乙醛的二次生成有重要影响,乙烯、异戊二烯和丙烯是甲醛的重要前体物,丙烯和2-丁烯是乙醛的重要前体物,对人为烯烃重点排放行业进行科学合理管控将有利于阻抑大气中主要醛酮化合物的二次生成.

关键词：醛酮化合物组分特征光化学反应生成机制 OBM模型臭氧

Geochemical characteristics and growth suitability assessment of Scutellaria baicalensis Georgi in the Earth's critical zone of North China

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Journal of Mountain Science 2022年第5期19卷 1245-1262页

作者： LI Xia wei xiao-feng WU Jin YIN Zhi-qiang WAN Li-qin SUN Hou-yun AN Yong-long College of Water Sciences Beijing Normal UniversityBeijing 100875China China Institute of Geo-Environment Monitoring Beijing 100081China Beijing Institute of Geology for Mineral Resources Beijing 100012China Faculty of Architecture Civil and Transportation EngineeringBeijing University of TechnologyBeijing 100124China School of Water Resources&Environment China University of GeosciencesBeijing 100083China

Geochemical differentiation of soils has a series of consequences on plant and places pressure on the ecological environment.The quantitative evaluation of element migration in the Earth’s critical zone is a challenging task.In this study,two demonstration study areas of Scutellaria baicalensis Georgi were selected,and multiple chemical weathering indexes,chemical loss fraction,mass migration coefficients and biological enrichment coefficient method were used to assess the ecological and geochemical suitability.The results show that for the element of Fe,Zn,Se,Cu,Co,Ni,Mo and Ge,the degree of weathering and soil maturation,were greater in the rhyolitic tuff area than in the Plagioclase gneiss area.In both research sites,the heavy metal level of samples in Scutellaria baicalensis Georgi did not exceed the standard limits.The plagioclase gneiss region’s surface soil environment was more alkaline,and the content of soil organic matter was lower,resulting in a higher bioenrichment intensity of Ge,Co,Cu,and Se elements in Scutellaria baicalensis Georgi than in the rhyolite-tuff area.The elements of Cd,Nb,Mo,Pb and As are considerably enriched in the soil of the plagioclase gneiss area but lost by leaching in the soil of the rhyolite tuff area,which is connected to the interplay of elemental abundance and human impact in the parent materials.This study provides a good example of how to assess growth suitability of Chinese medicinal materials in the Earth’s critical zone.

关键词： Earth’s critical zone Biogeochemistry characteristics Weathering mechanism Element migration Chinese medicinal materials Chengde

Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： feng Li Yuan Yang Hua Yue Shuang Wang xiao Zhang wei wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to tumours.However,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based agents.Herein,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer treatment.Briefly,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading method.Then,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target impacts.The released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its uptake.As a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery