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基于大数据的高校图书馆学科服务平台的构建研究

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情报科学 2017年第6期35卷 34-38页

作者：肖欣伟王晨张凤荣长春理工大学计算机科学技术学院吉林长春130022 长春理工大学马克思主义学院吉林长春130022 东北师范大学马克思主义学部吉林长春130024

【目的/意义】通过构建基于大数据的图书馆学科服务平台,为高校用户提供精准的学科信息服务。【方法/过程】文章在对大数据相关应用分析的基础上,讨论了高校图书馆学科服务模式,研究了大数据相关技术在高校图书馆学科服务应用中的优势,... 详细信息

【目的/意义】通过构建基于大数据的图书馆学科服务平台,为高校用户提供精准的学科信息服务。【方法/过程】文章在对大数据相关应用分析的基础上,讨论了高校图书馆学科服务模式,研究了大数据相关技术在高校图书馆学科服务应用中的优势,并设计出基于大数据的学科服务平台方案。该方案在传统的图书馆服务架构上,通过增加移动通信服务系统和数据采集与处理系统,来方便信息获取。【结果/结论】通过在部分高校图书馆的实施,表明文章提出的学科服务平台具有很好的可用性。

关键词：高校图书馆科学服务平台大数据

A low redox potential and long life organic anode material for sodium-ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 557-564页

作者： Zhi Li Yang wei Kang Zhou xin Huang xing Zhou Jie Xu Taoyi Kong Junwei Lucas Bao xiaoli Dong Yonggang Wang Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy Collaborative Innovation Center of Chemistry for Energy Materials (iChEM) Fudan University Department of Chemistry Boston College School of Materials Science and Engineering Anhui University of Technology

Sodium-ion batteries （SIBs） with organic electrodes are an emerging research direction due to the sustainability of organic materials based on elements like C,H,O,and sodium ***,organic electrode materials for SIBs are mainly used as cathodes because of their relatively high redox potentials（>1 V）.Organic electrodes with low redox potential that can be used as anode are ***,a novel organic anode material （tetrasodium 1,4,5,8-naphthalenetetracarboxylate,Na4TDC） has been developed with low redox potential （<0.7 V） and excellent cyclic *** three-sodium storage mechanism was demonstrated with various in-situ/ex-situ spectroscopy and theoretical calculations,showing a high capacity of 208 mAh/g and an average decay rate of merely 0.022%per ***,the Na4TDC-hard carbon composite can further acquire improved capacity and cycling stability for 1200 cycles even with a high mass loading of up to 20 mg *** pairing with a thick Na3V2（PO4）3cathode (20.6 mg cm-2),the as-fabricated full cell exhibited high operating voltage （2.8 V）,excellent rate performance and cycling stability with a high capacity retention of 88.7% after 200 cycles,well highlighting the Na4TDC anode material for SIBs.

关键词： Organic anode material Low redox potential Composite anode Sodium-ion batteries

Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu xin Shao Qinqin Wang xin Dong Bin Duan Feiyang xing Jun Wu Minmin xiao Fangqing Zhao Jing-Dong J.Han Qi Liu xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

Metal nanoparticles decorated CoFe-(oxy)hydroxysulfides nanosheets fabricated by a general strategy for electrocatalytic water splitting

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Journal of Energy Chemistry 2025年第1期100卷 26-38页

作者： xiaodong Yang Haochen Shen xiaoming xiao Zhichao Li Qi Zhou wei Yang Bin Jiang Yongli Sun Luhong Zhang Zhenhua Yan School of Chemical Engineering and Technology Tianjin University Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University

This study presents a novel method to fabricate metal-decorated,sulfur-doped layered double hydroxides （M/SLDH） through spontaneous redox and sulfurization *** developed Ag/SLDH and Pt/SLDH catalysts with abundant heterogeneous interfaces and hierarchical nanostructures demonstrated outstanding oxygen evolution reaction （OER） and hydrogen evolution reaction （HER） performance,achieving low overpotentials of 212 and 35 mV at 10 mA cm-2in 1 M KOH,*** both anode and cathode in water splitting,they required only 1.47 V to reach 10 mA cm-2and exhibited high structural robustness,maintaining stability at 1000 mA cm-2for 300 ***-situ Raman analysis revealed that the synergistic effects of metal nanoparticles and S doping significantly promote the transformation into the S-Co1-xFexOOH layer,which serves as the active phase for water ***,ultraviolet photoelectron spectroscopy （UPS） and density functional theory （DFT） analyses indicated that incorporating metal nanoparticles and S doping increase electron density near the Fermi level and reduce reaction energy barriers,thus enhancing intrinsic OER and HER *** study provides a scalable strategy for synthesizing high-performance electrocatalysts for water splitting,with promising potential for broader applications.

关键词： LDH Spontaneous reaction Metal nanoparticles Water splitting

经济新常态下煤炭资源型城市发展问题及对策研究

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煤炭经济研究 2014年第11期34卷 71-76页

作者：栗继祖魏晓昕太原理工大学经济管理学院山西太原030024 太原理工大学矿业工程学院山西太原030024

针对我国经济增速回落、大力推动煤炭消费革命、宏观调控摒弃大规模的非常规刺激措施,坚持控制能源消费总量,节能优先,形成集约高效的能源消费方式,抑制不合理能源消费的经济新常态下,从经济新常态的主要特征和煤炭市场变化角度,对山西... 详细信息

针对我国经济增速回落、大力推动煤炭消费革命、宏观调控摒弃大规模的非常规刺激措施,坚持控制能源消费总量,节能优先,形成集约高效的能源消费方式,抑制不合理能源消费的经济新常态下,从经济新常态的主要特征和煤炭市场变化角度,对山西省煤矿、乡村和城镇的协调发展问题进行了分析,通过分析资源型城市系统中的煤炭企业、周边村镇和煤炭城市间的内在联系,为煤炭企业、周边村镇、煤炭城市和谐发展的新路子提出了对策与建议。

关键词：经济新常态协调发展对策

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long xiao Gao Zhengwei Wang Zhizhong Guan xiaolan Qi wei Hong Yan xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai xiao-Yan Bao Lin-Jie Wu Ya-xin Qin xin Tan xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

不同方法制备Al-Zn-Si-RE涂镀层的腐蚀行为和机理对比研究

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现代涂料与涂装 2023年第3期26卷 1-5页

作者：魏小昕蒋穹江苏麟龙新材料股份有限公司江苏无锡214183 盐城工学院材料科学与工程学院江苏盐城224051

采用SEM和EDS等手段对比研究了热浸镀和热喷涂两种方法制备的AI-Zn-Si-RE合金涂层的微观组织,采用电化学测试技术研究了两种涂层在3.5%NaCl溶液中的腐蚀行为,并讨论了涂层腐蚀机制及不同制备工艺对涂层性能的影响。结果表明:1)热喷涂和... 详细信息

采用SEM和EDS等手段对比研究了热浸镀和热喷涂两种方法制备的AI-Zn-Si-RE合金涂层的微观组织,采用电化学测试技术研究了两种涂层在3.5%NaCl溶液中的腐蚀行为,并讨论了涂层腐蚀机制及不同制备工艺对涂层性能的影响。结果表明:1)热喷涂和热浸镀两种合金涂层都拥有牺牲阳极的保护作用,但热喷涂合金涂层的保护效果更显著。2)当热浸镀及热喷涂涂层表面出现致密的腐蚀生成物时,可以很大程度地提高涂层屏蔽作用。3)阻抗谱演化分析发现,热喷涂涂层存在氧化膜点蚀阶段而热浸镀涂层没有此阶段。随着腐蚀进行,热喷涂涂层表面不断生成腐蚀产物,涂层耐腐蚀性能提高,在试验结束时仍然处于前中期,而热浸镀涂层的低频容抗出现Wurburg扩散阻抗特征,随后涂层基本失去防腐蚀能力。

关键词： Al-Zn-Si-RE涂镀层热喷涂热浸镀微观形貌腐蚀行为

AP1000核电站^(106)Ru正常运行源项研究

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核科学与工程 2016年第4期36卷 520-526页

作者：祝兆文方岚刘新华李小龙魏方欣蒋婧环境保护部核与辐射安全中心北京100082 中核核电运行管理有限公司浙江海盐314300

AP1000核电站一回路中^(106)Ru的现实源项远远高于其设计源项,其一回路活度浓度与131I相当,既从理论计算分析不可信,又与电厂实际测量数据不符。一回路^(106)Ru活度浓度过高,使得电厂液态流出物中106Ru及其子体^(106)Rh占到除氚和碳-14... 详细信息

AP1000核电站一回路中^(106)Ru的现实源项远远高于其设计源项,其一回路活度浓度与131I相当,既从理论计算分析不可信,又与电厂实际测量数据不符。一回路^(106)Ru活度浓度过高,使得电厂液态流出物中106Ru及其子体^(106)Rh占到除氚和碳-14外放射性年排放量预期值的一半以上,严重背离电厂运行经验,而且对AP1000电厂流出物监测、环境监测和环境影响评价造成了误导。本文分析了ANSI/ANS-18.1中现实源项计算方法存在的问题,研究提出了从一回路主要核素活度浓度出发计算^(106)Ru现实源项的方法,其计算结果与M310/CPR1000、VVER-1000等国内压水堆电厂的现实源项基本一致,能客观反映压水堆电厂^(106)Ru源项,可供国内AP1000核电厂源项计算时参考。

关键词： AP1000 源项裂变产物 ^106Ru