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Magnetic resonance imaging focused on the ferritin heavy chain 1 reporter gene detects neuronal differentiation in stem cells

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Neural Regeneration Research 2023年第7期18卷 1563-1569页

作者： xiao-Ya He Yi-rui Zhou Tong mu Yi-Fan Liao Li Jiang Yong Qin Jin-Hua Cai Department of Radiology Children’s Hospital of Chongqing Medical UniversityNational Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChongqing Key Laboratory of PediatricsChongqingChina Department of Endocrinology and Metabolism West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Nuclear Medicine The Second Hospital of the Army Medical UniversityChongqingChina Department of Neurology Children’s Hospital of Chongqing Medical UniversityChongqingChina

The neuronal differentiation of mesenchymal stem cells offers a new strategy for the treatment of neurological ***,there is a need to identify a noninvasive and sensitive in vivo imaging approach for real-time monitoring of transplanted stem *** previous study confirmed that magnetic resonance imaging,with a focus on the ferritin heavy chain 1 reporter gene,could track the proliferation and differentiation of bone marrow mesenchymal stem cells that had been transduced with lentivirus carrying the ferritin heavy chain 1 reporter ***,we could not determine whether or when bone marrow mesenchymal stem cells had undergone neuronal differentiation based on changes in the magnetic resonance imaging *** solve this problem,we identified a neuron-specific enolase that can be differentially expressed before and after neuronal differentiation in stem *** this study,we successfully constructed a lentivirus carrying the neuron-specific enolase promoter and expressing the ferritin heavy chain 1 reporter gene;we used this lentivirus to transduce bone marrow mesenchymal stem *** and animal studies showed that the neuron-specific enolase promoter effectively drove the expression of ferritin heavy chain 1 after neuronal differentiation of bone marrow mesenchymal stem cells;this led to intracellular accumulation of iron and corresponding changes in the magnetic resonance imaging *** summary,we established an innovative magnetic resonance imaging approach focused on the induction of reporter gene expression by a neuron-specific *** imaging method can be used to noninvasively and sensitively detect neuronal differentiation in stem cells,which may be useful in stem cell-based therapies.

关键词： ferric ammonium citrate ferritin heavy chain 1 gene magnetic resonance imaging mesenchymal stem cells molecular imaging neuronal differentiation neuron-like cells neurons neuron-specific enolase promoter

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An artificial neural network model for multi-flexoelectric actuation of Plates

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International Journal of Smart and Nano Materials 2022年第4期13卷 713-734页

作者： mu Fan Pengcheng Yu Zhongmin xiao State Key Laboratory of Mechanics and Control of Mechanical Structures Nanjing University of Aeronautics and AstronauticsNanjingChina Interdisciplinary Research Institute of Aeronautics and Astronautics College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjingChina School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore

Flexoelectric effect can be used to design actuators to control engi-neering structures including beams,plates,and *** flexo-electric actuators method has the advantage of less stress concentration and better control effect,but the mode-dependent optimal actuator locations could influence the flexoelectric actuation effect *** this work,a neural network model is established to study the optimal combinations of multiple flexoelectric actuators on a rectangular *** the physical model,an atomic force micro-scope(AFM)probe was employed to generate an electric field gradient in the flexoelectric patch,so that flexoelectric control force and moment can be *** flexoelectric actuators on the plate was *** studies showed that the flexoelectricity induced stress mainly concentrate near the probe,the size and shape of the flexoelectric patch have limited effect on the actuation,hence,only the actuator positions were choosing as the input of the ANN *** the prediction of the neural network model,the driving effect of a large number of actuators at different positions can be quickly obtained,and the optimal position of the actuator can be analyzed more accurately.

关键词： smart structure flexoelectric effect vibration of thin plate Artificial neural network

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Finely Tuned Electron/Hole Transport Preference of Thiazoloisoindigo-based Conjugated Polymers by Incorporation of Heavy Chalcogenophenes

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Chinese Journal of Polymer Science 2021年第7期39卷 838-848页

作者： Chen-Chen Li Miao Xiong Jia-Wei Peng Jie-Yu Wang Huan-rui Zhang You-Bing mu Jian Pei xiao-Bo Wan Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationSchool of Chemical&Environmental EngineeringJianghan UniversityWuhan 430056China Beijing National Laboratory for Molecular Sciences the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Qingdao Institute of Bioenergy&Bioprocess Technology Chinese Academy of SciencesQingdao 266101China

A series of copolymers of thiazoloisoindigo (Tzll) with different chalcogenophene trimers were synthesized to systematicllyinvestigate the chalcogen effect on their charge transport *** only the middlethiophene ring of terthiphene(T-T-T)is replaced byheavier chalcogenophenes,a preference(expressed by the ratio of μe/μh)towards electron transport was observed descending from T-T-Tto T-Se-Tthen to T-Te-T(Se and Te stand for selenophene and tellurophene,respectively).On the other hand,with the increased number of heavierchalcogenophenes,a preference toward hole transport was observed descending from Se-T-Se to Se-Se-se then to *** phenomenon iswellexplained by the balance between the aromatic resonance energy of the chalcogenophenes and the electronegativity of the ***,P(TZll-T-Se-T)displayed relatively balanced ambipolar property(μh^(max)andμe^(max) of 3.77 and 1.59 cm^(2)·v^(-1)·s^(-1)with aμe/μh of 0.42).while P(Tll-Se-Te-Se)exhibited the best preference to hole transfer with a u.u,of 0.09.P(Tzll-T-Te-T)exhibited the best preference to electrontransfer with aμe/μl,of 16 and theμe^(max)of 0.64 cm^(2)·v^(-).s^(-1)which is the highest electron mobility among the known conjugated polymerscontaining tellurophenes.

关键词： Thiazoloisoindigo Copolymers Charge transport properties Chalcogenophene trimers

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黑死病与奥斯曼帝国的兴起(1347-1453)

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古代文明（中英文） 2025年第1期19卷 50-58,M0004,M0005页

作者：母仕洪西南大学历史文化学院、伊朗研究中心重庆400715

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧... 详细信息

14世纪中叶以降,黑死病在东地中海地区反复暴发,对当地的国家造成严重冲击,尤其是使日渐衰微的拜占庭帝国遭受严重的人口衰减与社会瓦解。然而,此间征服事业方兴未艾的奥斯曼帝国不仅躲过黑死病致命侵袭,反而借助黑死病对敌对政权的摧残加速了对外扩张进程,实现了国力的持续提升。黑死病之所以对奥斯曼帝国与敌对政权的冲击效应大相径庭,主要缘于帝国位居内陆的地理位置、游牧社会组织形式以及相对有效的防疫举措。总之,黑死病肆虐对以拜占庭帝国为主的东地中海诸政权产生了严重负面效应,一定程度上为奥斯曼早期扩张铺平了道路,成为促进帝国兴起不可忽视的重要因素。

关键词：黑死病奥斯曼帝国拜占庭帝国瘟疫大流行

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Inhibition of proliferation of prostate cancer cell line, PC-3, in vitro and in vivo using （-）-gossypol

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Asian Journal of Andrology 2010年第3期12卷 390-399,I0011页

作者： Xian-Qing Zhang xiao-Feng Huang Shi-Jie mu Qun-Xing An Ai-Jun Xia rui Chen Dao-Cheng Wu The Key Laboratory of Biomedical Information Engineering of Ministry of Education Xi ＇an Jiaotong University Xi ＇an 710038 China Department of Blood Transfusion Xij＇ing Hospital Xi ＇an 710032 China Central Laboratory Fourth Military Medical University Xi＇an 710032 China

We investigated the antiproliferative activity of （-）-gossypol on the human prostate cancer cell line PC3 in vitro and in vivo to elucidate its potential molecular mechanisms. Cell growth and viability were evaluated using the 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide （MTT） assay, and cell apoptosis was detected by flow cytometry, terminal deoxynucleotidyl transferase dUTP nick end labelling （TUNEL） and electron microscopy. Expression of proliferating cell nuclear antigen （PCNA）, Bcl-2, CD31, caspase-3 and caspase-8 in tumour tissue was determined by immunohistochemistry. The drug concentration that yielded 50% cell inhibition （IC50 value） was 4.74 μg mL-1. In the PC-3 tumour xenograft study, （-）-gossypol （〉 5 mg kg-1） given once a day for 7 days significantly inhibited tumour growth in a dose-dependent manner. Immunohistochemical analysis revealed that （-）-gossypol enhanced caspase-3 and caspase-8 expression and decreased the expression of PCNA, Bcl-2 and CD31 in tumour tissues. It suggested that cell apoptosis and inhibition of angiogenesis might contribute to the anticancer action of （-）-gossypol.

关键词： apoptosis electron microscopy flow cytometry (-)-gossypol immunohistochemistry prostate cancer

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Syntheses and Crystal Structures of Functionalized Tetramethyl Resorcinarenes

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Chemical Research in Chinese Universities 2015年第6期31卷 925-929页

作者： mu Huarong ZHOU rui SUN Jing YAN Chaoguo College of Chemical Engineering Yangzhou Polytechnic Institute Yangzhou 225127 P. R. China College of Chemistry & Chemical Engineering Yangzhou University Yangzhou 225002 P. R. China

Tetramethyl resorcinarene, which was obtained by acidic condensation of resorcinol with paraacetoalde- hyde, was chemically modified to the functionalized O-acyl, O-tosyl and O-acetate derivatives by corresponding acylation, p-toluenesulfonylation and alkylation reactions. The single crystal structures of these functionalized resor- cinarenes and the complex of tetramethyl resorcinarene with 2,2＇-hipyridine were determined by X-ray diffraction method. All these resorcinarenes adopt the all-cis configuration with four methyl groups stretching to the down rim and form 1D or 2D structures through H-bonds.

关键词： Resorcinarene Macrocycle Chemical modification Configuration Crystal structure

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Co-Estimation of State of Charge and Capacity for Lithium-Ion Batteries with multi-Stage Model Fusion Method

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Engineering 2021年第10期7卷 1469-1482页

作者： rui Xiong Ju Wang Weixiang Shen Jinpeng Tian Hao mu Department of Vehicle Engineering School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081China Faculty of Science Engineering and TechnologySwinburne University of TechnologyHawthornVIC 3122Australia

Lithium-ion batteries(LIBs)have emerged as the preferred energy storage systems for various types of electric transports,including electric vehicles,electric boats,electric trains,and electric *** energy management of LIBs in electric transports for all-climate and long-life operation requires the accurate estimation of state of charge(SOC)and capacity in *** study proposes a multistage model fusion algorithm to co-estimate SOC and ***,based on the assumption of a normal distribution,the mean and variance of the residual error from the model at different ageing levels are used to calculate the weight for the establishment of a fusion model with stable ***,a differential error gain with forward-looking ability is introduced into a proportional–integral observer(PIO)to accelerate convergence ***,a fusion algorithm is developed by combining a multistage model and proportional–integral–differential observer(PIDO)to co-estimate SOC and capacity under a complex application ***,the convergence and anti-noise performance of the fusion algorithm are ***,the hardware-in-the-loop platform is set up to verify the performance of the fusion *** validation results of different aged LIBs over a wide range of temperature show that the presented fusion algorithm can realize a high-accuracy estimation of SOC and capacity with the relative errors within 2%and 3.3%,respectively.

关键词： State of charge Capacity estimation Model fusion Proportional-integral-differential observer Hardware-in-the-loop

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铈掺杂纳米氧化锌光催化降解水中抗生素研究

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哈尔滨商业大学学报（自然科学版） 2018年第2期34卷 166-169页

作者：杨威孙晓蕊穆德颖李若菡许静东刘昊哈尔滨商业大学食品工程学院哈尔滨150076 哈尔滨商业大学生命科学与环境科学研究中心哈尔滨150076

以铈掺杂纳米氧化锌为催化剂,在不同条件下对抗生素头孢呋辛钠进行光催化降解,探究其最优的降解方案.结果表明,铈的掺杂量,光催化剂的投加量,抗生素的质量浓度,p H值等对降解效率均有显著的影响.通过对催化剂的重复利用,证明催化剂在光... 详细信息

以铈掺杂纳米氧化锌为催化剂,在不同条件下对抗生素头孢呋辛钠进行光催化降解,探究其最优的降解方案.结果表明,铈的掺杂量,光催化剂的投加量,抗生素的质量浓度,p H值等对降解效率均有显著的影响.通过对催化剂的重复利用,证明催化剂在光催化降解反应中可循环使用,并且仍拥有良好的降解效果.

关键词：铈掺杂纳米氧化锌光催化抗生素

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Embedding aligned nanofibrous architectures within 3D-printed polycaprolactone scaffolds for directed cellular infiltration and tissue regeneration

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International Journal of Extreme Manufacturing 2023年第2期5卷 190-206页

作者： Zijie Meng Xingdou mu Jiankang He Juliang Zhang rui Ling Dichen Li State Key Laboratory for Manufacturing Systems Engineering Xi an Jiaotong UniversityXi an 710049People's Republic of China NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices Xi'an Jiaotong UniversityXi'an 710049People's Republic of China Department of Vascular and Endocrine Surgery Xijing HospitalThe Air Force Medical UniversityXi'an 710049People's Republic of China

Three-dimensional(3D) printing provides a promising way to fabricate biodegradable scaffolds with designer architectures for the regeneration of various ***,the existing3D-printed scaffolds commonly suffer from weak cell-scaffold interactions and insufficient cell organizations due to the limited resolution of the 3D-printed ***,composite scaffolds with mechanically-robust frameworks and aligned nanofibrous architectures are presented and hybrid manufactured by combining techniques of 3D printing,electrospinning,and unidirectional *** was found that the composite scaffolds provided volume-stable environments and enabled directed cellular infiltration for tissue *** particular,the nanofibrous architectures with aligned micropores served as artificial extracellular matrix materials and improved the attachment,proliferation,and infiltration of *** proposed scaffolds can also support the adipogenic maturation of adipose-derived stem cells(ADSCs)in ***,the composite scaffolds were found to guide directed tissue infiltration and promote nearby neovascularization when implanted into a subcutaneous model of rats,and the addition of ADSCs further enhanced their adipogenic *** presented hybrid manufacturing strategy might provide a promising way to produce additional topological cues within 3D-printed scaffolds for better tissue regeneration.

关键词： hybrid manufacturing 3D printing unidirectional freeze-casting nanofibrous architectures tissue regeneration

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Using FEM to predict tree motion in a wind field

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第7期9卷 907-915页

作者： xiao-yi HU Wei-ming TAO Yi-mu GUO Department of Mechanical Engineering Zhejiang University Hangzhou 310027 China School of Engineering Zhejiang Forestry University Hangzhou 311300 China

In this paper we propose a finite element(FE) simulation method to predict tree motion in a wind field. Two FE tree models were investigated:One model was generated based on a realistic nature-looking geometric tree model,and the other was a symmetric model to investigate the influence of asymmetric material properties on tree motion. The vortex-induced vibration(VIV) theory is introduced to estimate the fluctuating wind force being exerted on tree stems and the fluid-structure interaction(FSI) analysis is also included in the simulation. The results indicate that asymmetric material properties result in the crosswind displacement of the investigated node and the main swaying direction deviation. The simulation reveals that under wind loading,a tree with leaves has much larger swaying amplitude along the wind direction and longer swaying period than a tree without leaves. However,the crosswind swaying amplitude is mainly due to branch interaction. The numerical simulation proved that the inter-action of tree branches can prevent dangerous swaying motion developing.

关键词： Finite element method (FEM) Fluid-structure interaction (FSI) Vortex-induced vibration (VIV) Asymmetric Wind field

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