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Chemical Research in Chinese Universities 2024年第6期40卷 1023-1032页

作者： TANG Zeng LAI Yue lu Hao XIA Yi JIANG Xue xiong xiaoli xiao Ting College of Chemistry and Material Science Key Laboratory of the Evaluation and Monitoring of Southwest Land ResourcesMinistry of EducationSichuan Normal UniversityChengdu 610068P.R.China

Prussian blue nanoparticles (PB NPs) have exhibited favorable anti-inflammatory effects in animal models,and have been proved to mimic three antioxidant enzymes: peroxidase,catalase,and superoxide *** the oxidase-like activity of PB NPs has not been *** this work,PB NPs with outstanding oxidase-like activity were demonstrated by virtue of the colorimetric substrate o-phenylenediamine (OPD).Interestingly,based on the oxidase-like activity,PB NPs can also catalytically oxidize vitamin B1 (VB1) to strongly fluorescent product in the physiological environment without the addition of other *** that VB1 has no toxicity and carcinogenicity comparing with OPD,a novel PB NPs-VB1 fluorescent sensor was further developed for simple,nontoxic,and rapid detection of ascorbic acid (AA) in foods and alkaline phosphatase (ALP) in human serum samples by taking advantage of the reduction of PB NPs to Prussian White by AA or enzymatic hydrolysate of ALP and ascorbic acid 2-phosphate (AA2P);leading to the decrease of fluorescence *** extremely low detection limits of 44 nmol/L for AA and 72 mU/L for ALP as well as the excellent applicability in real samples were both ***,we envision that such a novel fluorescent probe would be potentially applied in the food analysis and clinic diagnosis fields.

关键词： Prussian blue nanoparticles Oxidase-like activity Fluorescence probe Ascorbic acid Alkaline phosphatase

Seizures in posterior reversible encephalopathy syndrome:blood pressure management in normotensive patients

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Acta Epileptologica 2021年第1期3卷 214-219页

作者： lu lu Weixi xiong Yingying Zhang Yingfeng xiao Dong Zhou Department of Neurology West China HospitalSichuan UniversityChengdu 610041SichuanChina

Posterior reversible encephalopathy syndrome(PRES)is a rare clinical disease that refers to the subcortical vasogenic edema involving bilateral parieto-occipital regions,with a usually reversible syndrome when causes are eliminated or *** or blood pressure fluctuations are most common causes of PRES,but other contributors like chemotherapy and autoimmune disorders have also been *** has rapid onset of ***,it is of major importance to determine whether blood pressure management plays an important role in *** presented two PRES patients who developed non-convulsive seizure but had normal baseline blood pressure at the time of presence of *** diagnosis of PRES was made by *** patients had no history of seizure or hypertension,but during the disease course they presented with temporal elevation of blood pressure with different *** second patients without instant blood pressure control developed residual symptoms of seizure at 90-and 120-day *** the exact pathophysiology of PRES remains to be fully understood,primary and secondary prolonged blood pressure fluctuations may be associated with the prognosis of this *** blood pressure management would be critical to favorable outcome.

关键词： patients diagnosis chemotherapy

Application of laparoscopic total mesorectal excision combined with sphincter-preserving surgery in low or ultralow rectal cancer

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 8-14页

作者： Yan Liu xiao-Ming lu Yan-Feng Niu Kai-xiong Tao Guo-Bin Wang Department of Gastrointestinal Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 P.R.China

This study aimed to investigate the influence of laparoscopic total mesorectal excision combined with sphincter-preserving surgery on the postoperative defecation function,urinary function and sexual function in low or ultralow rectal cancer.A retrospective study was undertaken on 107 patients(65 laparoscopic resection and 42 laparoctomic resection)with rectal cancer undergoing laparoscopic or open laparoscopic total mesorectal excision combined with sph incter-preserving surgery from April 2009 to April *** quality of life outcomes of all patients,including defection,urinary and sexual function,were assessed at 6,12 and 24 months after *** quality of life index(GQOLI)was used to evaluate the fecal incont inence and bowel *** and sexual functions were studied by means of questionnaires on the basis of the international prostatic symptom score(IPSS)and international index of erectile function(IEF),*** laparoscopic surgery group,there were two cases of anastomotic leakage,three cases of anast omotic strict ure,seven cases of local recurrence,ten cases of hepatic metastasis and five cases of lung *** satisfaction rates of patients about their defe-cation function reached 60.3%(35/58,84.5%(49/58)and 913%(53/58)at6,12,and 24 months follow-up,*** assessment after one year showed that the overall incidence of uri-nary dysfunction was 10.7%(7/65);Among male patients,18.4%(7/36)sufered from erectile dysfunction and 27.8%(10/36)sufered from ejaculatory dysfunction;65.5%(19/29)female patients investigated were satisfied with their postoperative sexual *** open surgery group,there were two cases of anastomotic leakage,two cases of anastomotic stricture,nine cases of local recurrence,ten cases of hepatic metastasis and seven cases of kung *** satisfaction rates of patients about their defecation function were 56.4%(22/39),82.1%(32/39)and 94.8%(37/39)at 6,12,and 24 months follow-up,resp

关键词： Rectal cancer laparoscope sphincter-preserving surgery quality of life.

Knowledge-oriented modeling for influencing factors of battle damage in military industrial logistics:An integrated method

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Defence Technology（防务技术） 2020年第3期16卷 571-587页

作者： xiong Li xiao-dong Zhao Wei Pu Military Exercise and Training Center Army Academy of Armored ForcesBeijing 100072China

Modeling influencing factors of battle damage is one of essential works in implementing military industrial logistics simulation to explore battle damage laws ***,one of key challenges in designing the simulation system could be how to reasonably determine simulation model input and build a bridge to link battle damage model and battle damage laws *** this paper,we propose a novel knowledge-oriented modeling method for influencing factors of battle damage in military industrial logistics,integrating conceptual analysis,conceptual modeling,quantitative modeling and simulation *** conceptualize influencing factors of battle damage by using the principle of hierarchical decomposition,thus classifying the related battle damage knowledge ***,we construct the conceptual model of influencing factors of battle damage by using Entity-Relations hip approach,thus describing their interactions ***,we extract the important influencing factors by using social network analysis,thus evaluating their importance quantitatively and further clarifying the elements of ***,we develop an agent-based military industry logistics simulation system by taking the modeling results on influencing factors of battle damage as simulation model input,and obtain simulation model output,i.e.,new battle damage laws knowledge,thus verifying feasibility and effectiveness of the proposed *** results show that this method can be used to support human decision-making and action.

关键词： Battle damage Industrial logistics Entity-relationship approach Social network analysis Agent-based simulation

An approach for predicting digital material consumption in electronic warfare

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Defence Technology（防务技术） 2020年第1期16卷 263-273页

作者： xiong Li xiao-dong Zhao Wei Pu Military Exercise and Training Center Army Academy of Armored ForcesBeijing 100072China

Electronic warfare is a modern combat mode,in which predicting digital material consumption is a key for material requirements planning(MRP).In this paper,we introduce an insensitive loss function(ε) and propose a ε-SVR-based prediction ***,we quantify values of influencing factors of digital equipments in electronic warfare and a small-sample data on real consumption to form a real combat data set,and preprocess it to construct the sample ***,we establish the ε-SVR-based prediction model based on "wartime influencing factors-material consumption" and perform model *** case study,we give 8 historical battle events with battle damage data and predict 3 representative kinds of digital materials by using the proposed *** results illustrate its higher accuracy and more convenience compared with other current *** data acquisition controller prediction as an example,our model has better prediction performance(RMSE=0.575 7,MAPE(%)=12.037 6 and R^2=0.996 0) compared with BP neural network model(RMSE=1.272 9,MAPE(%)=23.577 5 and R^2=0.980 3) and GM(1,1) model(RMSE=2.095 0,MAPE(%)=24.188 0 and R^2=0.946 6).The fact shows that the approach can be used to support decision-making for MRP in electronic warfare.

关键词： Electronic warfare Support vector regression(SVR) Prediction model Decision-making

海南省163例汉族HCV慢性感染者中的基因型分布

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中国热带医学 2016年第9期16卷 873-876页

作者：吴涛王家健许小珍熊璐王姣王福利林锋海南省人民医院感染科海南海口570311 海南金域医学检验中心海南海口570311 海南省人民医院医疗保健中心海南海口570311 海南省人民医院热带病实验室海南海口570311

目的了解丙型肝炎病毒(HCV)在海南省汉族HCV慢性感染者中的基因型分布特点。方法选择在海南省人民医院就诊的176份汉族本土HCV慢性感染者(HCV-Ab和HCV RNA均阳性)血清标本,通过提取HCV-RNA,然后使用RT-PCR、巢式PCR(Nested-PCR)方法来扩... 详细信息

目的了解丙型肝炎病毒(HCV)在海南省汉族HCV慢性感染者中的基因型分布特点。方法选择在海南省人民医院就诊的176份汉族本土HCV慢性感染者(HCV-Ab和HCV RNA均阳性)血清标本,通过提取HCV-RNA,然后使用RT-PCR、巢式PCR(Nested-PCR)方法来扩增Core-E1区并测定其核苷酸序列,最后与已知HCV基因型序列构建系统发育树分析、确定其基因亚型及分布。结果成功提取HCV-RNA和测序的海南省汉族HCV慢性感染者标本为163例,检出阳性率为92.6%,其基因型分布和比率如下:1a型占3.1%(5/163),1b型占33.1%(54/163),2a型占6.7%(11/163),3a型占8.6%(14/163),3b型占14.7%(24/163),6a型占33.7%(55/163)。结论海南省汉族HCV慢性感染者中基因型分布与全国的HCV基因型分布一样,基因型为1a、1b、2a、3a、3b和6a。海南省汉族同属我国汉族HCV传播圈,本研究发现6a是海南省汉族HCV慢性感染者中最主要的基因亚型,提示6a可能在海南省汉族人群中发生迅速传播。

关键词：丙型病毒性肝炎基因型分布海南省汉族

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Construction of enantioenriched eight-membered lactones via Pd-catalyzed asymmetric(6+2)dipolar annulation

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Science China Chemistry 2022年第12期65卷 2437-2443页

作者： Bao-Cheng Wang Yi Wei Feng-Ya xiong Bao-Le Qu Wen-Jing xiao Liang-Qiu lu Key Laboratory of Pesticide&Chemical Biology Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan430079China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai200032China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang453007China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou730000China

Concise synthesis of eight-membered lactones,a kind of medium-sized heterocycles widespread in many bioactive natural products,is highly ***,it still remains a challenge due to unfavorable entropic factor and transannular ***,we disclose an enantioselective synthesis of eight-membered lactones through a Pd-catalyzed asymmetric(6+2)dipolar annulation of vinyl oxetanes andα-diazo ketones(20 examples,up to 93%yield and 95:5 er).This reaction features simple operation,mild conditions and good enantiocontrol,especially the challenging chiral all-carbon quaternary stereocenter.A newly developed chiral hybrid P,S ligand and the in-situ photo-generation of ketene dipolarophiles are crucial to this success.

关键词： asymmetric catalysis dipolar annulation eight-membered lactone ketene palladium

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Long non-coding RNAs with essential roles in neurodegenerative disorders

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Neural Regeneration Research 2024年第6期19卷 1212-1220页

作者： Wandi xiong Lin lu Jiali Li Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences&Yunnan Province Kunming Institute of Zoologythe Chinese Academy of SciencesKunmingYunnan ProvinceChina Tsinghua-Peking Center for Life Sciences BeijingChina National Institute on Drug Dependence Peking UniversityBeijingChina PKU/McGovern Institute for Brain Research Peking UniversityBeijingChina Institute of Mental Health National Clinical Research Center for Mental DisordersKey Laboratory of Mental Health and Peking University Sixth HospitalPeking UniversityBeijingChina

Recently,with the advent of high-resolution and high-throughput sequencing technologies,an increasing number of long non-coding RNAs(lncRNAs)have been found to be involved in the regulation of neuronal function in the central nervous system with specific spatiotemporal patterns,across different neurodegenerative ***,the underlying mechanisms of lncRNAs during neurodegeneration remain poorly *** review provides an overview of the current knowledge of the biology of lncRNAs and focuses on introducing the latest identified roles,regulatory mechanisms,and research status of lncRNAs in Alzheimer's disease,Parkinson's disease,Huntington's disease,and amyotrophic lateral ***,this review discusses the potential values of lncRNAs as diagnostic biomarkers and therapeutic targets for neurodegenerative diseases,hoping to provide broader implications for developing effective treatments.

关键词： Alzheimer's disease amyotrophic lateral sclerosis biomarker Huntington's disease long non-coding RNAs neurodegenerative diseases Parkinson's disease therapy transcriptional regulation translational regulation

Mussel‑Inspired Redox‑Active and Hydrophilic Conductive Polymer Nanoparticles for Adhesive Hydrogel Bioelectronics

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Nano-Micro Letters 2020年第12期12卷 117-132页

作者： Donglin Gan Tao Shuai xiao Wang Ziqiang Huang Fuzeng Ren Liming Fang Kefeng Wang Chaoming Xie xiong lu Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031People’s Republic of China Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055GuangdongPeople’s Republic of China Department of Polymer Science and Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhouPeople’s Republic of China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064People’s Republic of China

Conductive polymers(CPs)are generally insoluble,and developing hydrophilic CPs is significant to broaden the applications of *** this work,a mussel-inspired strategy was proposed to construct hydrophilic CP nanoparticles(CP NPs),while endowing the CP NPs with redox activity and *** is a universal strategy applicable for a series of CPs,including polyaniline,polypyrrole,and poly(3,4-ethylenedioxythiophene).The catechol/quinone contained sulfonated lignin(LS)was doped into various CPs to form CP/LS NPs with hydrophilicity,conductivity,and redox *** CP/LS NPs were used as versatile nanofillers to prepare the conductive hydrogels with long-term *** CP/LS NPs-incorporated hydrogels have a good conductivity because of the uniform distribution of the hydrophilic NPs in the hydrogel network,forming a well-connected electric *** hydrogel exhibits long-term adhesiveness,which is attributed to the mussel-inspired dynamic redox balance of catechol/quinone groups on the CP/LS *** conductive and adhesive hydrogel shows good electroactivity and biocompatibility and therefore has broad applications in electrostimulation of tissue regeneration and implantable bioelectronics.

关键词： Mussel-inspired Redox-active nanoparticles Conductive polymer Conductive hydrogel Adhesive bioelectronics

Synthesis and Extended 3D Hydrogen-bonded Structure of Complex Tris(violurato-N,O) Cobalt(III) Hexahydrate

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Chinese Journal of Structural Chemistry 2006年第2期25卷 163-167页

作者： xiao Zi-Jing LIU Shi-xiong Central Laboratory Fuzhou University Fuzhou 350002 China College of Materials Science and Engineering Huaqiao University Quanzhou 362011 China State Key Laboratory of Structural Chemistry Fuzhou 350002 China

The cobalt（Ⅲ） violurato complex （[Co（C4H2N3O4）3]·6H2O, Mr = 635.28） has been prepared and structurally characterized. The crystal is of monoclinic, space group P2 1/n with a = 10.176（1）, b = 11.8010（9）, c = 19.706（2） A°, β= 97.382（3）°, V= 2346.9（4）A°^3, Z = 4, Dc= 1.798 g/cm^3, F（000） = 1296, μ = 0.839 mm^-1, R = 0.0482 and wR = 0.1357. The Co atom in the title compound is six- coordinated by three carbonyl O atoms and three oximido N atoms of three violurato ligands, forming an octahedral coordination geometry. The neighboring molecules are connected together by hydrogen bonds of N-H…O, O-H…O and O-H…N, forming an extended three-dimensional supra- molecular architecture.

关键词： Co(Ⅲ) complex violuric acid crystal structure hydrogen bond