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World Journal of Clinical Cases 2024年第18期12卷 3629-3635页

作者： Wei-Jie He Wen-Xing Xu Xu-Dong Zhang Yue Chen Shu-Ying He Xian-Qin Wei xiao-lan huang Department of Anesthesiology Liuzhou People's Hospital affiliated to Guangxi Medical UniversityLiuzhou 545000Guangxi Zhuang Autonomous RegionChina Department of Ultrasound Medicine Liuzhou People's Hospital affiliated to Guangxi Medical UniversityLiuzhou 545000Guangxi Zhuang Autonomous RegionChina

BACKGROUND The midpoint transverse process to pleura(MTP)block,a novel technique for thoracic paravertebral block(TPVB),was first employed in laparoscopic renal cyst *** SUMMARY Thoracic paravertebral nerve block is frequently employed for perioperative analgesia during laparoscopic cyst *** address safety concerns associated with TPVBs,we administered MTP blocks in two patients prior to administering general anesthesia for laparoscopic cyst *** MTP block was performed at the T9 level under ultrasound guidance,with 20 mL of 0.5%ropivacaine *** sensation to cold and pinprick was observed from the T8 to T11 dermatome *** postoperative Numeric Pain Rating Scale scores were 0/10 at rest and on movement,with none exceeding a mean 24 h numeric rating scale>*** MTP block was effective technique for providing postoperative analgesia for patients undergoing laparoscopic renal cyst decortication.

关键词： Midpoint transverse process to pleura block Laparoscopic renal cyst decortication Pain Analgesia Case report

WNT7A promotes tumorigenesis of head and neck squamous cell carcinoma via activating FZD7/JAK1/STAT3 signaling

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International Journal of Oral Science 2024年第1期16卷 85-96页

作者： Qingling huang Yi xiao Ting lan Youguang Lu Li huang Dali Zheng Department of Biochemistry and Molecular Biology School of Basic Medical SciencesFujian Medical UniversityFuzhouChina Fujian Key Laboratory of Oral Diseases School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Preventive Dentistry School and Hospital of StomatologyFujian Medical UniversityFuzhouChina Department of Dentistry The First Affiliated Hospital of Fujian Medical UniversityFuzhouChina

Wnt signaling are critical pathway involved in organ development, tumorigenesis, and cancer progression. WNT7A, a member of the Wnt family, remains poorly understood in terms of its role and the underlying molecular mechanisms it entails in head and neck squamous cell carcinoma (HNSCC). According to the Cancer Genome Atlas (TCGA), transcriptome sequencing data of HNSCC, the expression level of WNT7A in tumors was found to be higher than in adjacent normal tissues, which was validated using Real-time RT-PCR and immunohistochemistry. Unexpectedly, overexpression of WNT7A did not activate the canonical Wnt-β-catenin pathway in HNSCC. Instead, our findings suggested that WNT7A potentially activated the FZD7/JAK1/STAT3 signaling pathway, leading to enhanced cell proliferation, self-renewal, and resistance to apoptosis. Furthermore, in a patient-derived xenograft (PDX) tumor model, high expression of WNT7A and phosphorylated STAT3 was observed, which positively correlated with tumor *** findings underscore the significance of WNT7A in HNSCC progression and propose the targeting of key molecules within the FZD7/JAK1/STAT3 pathway as a promising strategy for precise treatment of HNSCC.

关键词： WNT squamous tumorigenesis

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi huang xiao-xiao Liu lan-Wei Li Guang-Ming huang Zhao-Xia huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

Unveiling inverse vulcanized polymers as metal-free,visible-light-driven photocatalysts for cross-coupling reactions

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Chinese Chemical Letters 2024年第4期35卷 142-146页

作者： lang Gao Cen Zhou Rui Wang Feng lan Bohang An xiaozhou huang xiao Zhang Fujian Key Laboratory of Polymer Science Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical EngineeringCollege of Chemistry and Materials ScienceFujian Normal UniversityFuzhou 350007China Fujian Engineering and Research Center of New Chinese Lacquer Materials College of Materials and Chemical EngineeringMinjiang UniversityFuzhou 350108China

Inverse vulcanized polymers(IVPs) that generated from elemental sulfur and smaller amounts of alkenes have found broad promising applications such as cathode materials for Li-S batteries, dynamic and repairable materials, optics applications, and metal sorption. However, their exploration in organic synthesis is still unprecedented. Here we first report the application of inverse vulcanized polymers in catalysis for organic transformations. A biomass-derived inverse vulcanized polymer(IVP-EAE) is found to be capable of catalyzing cross-coupling reactions in a transition-metal-free fashion under visible *** method allows the direct C–H functionalization of pyrroles and N-arylacrylamides with(hetero)aryl halides, respectively, leading to the formation of two sets of structurally important scaffolds including pyrrole-containing biaryls and 3,3-disubstituted oxindoles with high selectivity. We anticipate this study will not only unveil the new potential of IVPs, but also offer a distinct type of catalysts for organic transformations.

关键词： Cross coupling Inverse vulcanized polymers Metal free Photocatalyst Visible light

Myeloperoxidase: a new target for the treatment of stroke?

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Neural Regeneration Research 2022年第8期17卷 1711-1716页

作者： Yun-Chang Wang Yu-Bao Lu xiao-lan huang Yong-Feng Lao Lu Zhang Jun Yang Mei Shi Hai-Long Ma Ya-Wen Pan Yi-Nian Zhang The Second Clinical Medical School Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Lanzhou University Second HospitalLanzhouGansu ProvinceChina Xiangya Hospital Central South UniversityChangshaHunan ProvinceChina Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina University of Chinese Academy of Sciences BeijingChina

Myeloperoxidase is an important inflammatory factor in the myeloid system,primarily expressed in neutrophils and *** and its active products participate in the occurrence and development of hemorrhagic and ischemic stroke,including damage to the blood-brain barrier and *** a specific inflammatory marker,myeloperoxidase can be used in the evaluation of vascular disease occurrence and development in stroke,and a large amount of experimental and clinical data has indicated that the inhibition or lack of myeloperoxidase has positive impacts on stroke *** studies have also shown that there is a correlation between the overexpression of myeloperoxidase and the risk of *** occurrence of stroke not only refers to the first occurrence but also includes ***,myeloperoxidase is significant for the clinical evaluation and prognosis of *** paper reviews the potential role played by myeloperoxidase in the development of vascular injury and secondary brain injury after stroke and explores the effects of inhibiting myeloperoxidase on stroke *** paper also analyzes the significance of myeloperoxidase etiology in the occurrence and development of stroke and discusses whether myeloperoxidase can be used as a target for the treatment and prediction of stroke.

关键词： blood-brain barrier hemorrhagic stroke inflammation ischemic stroke microglia myeloperoxidase neutrophils secondary brain injury stroke

Nanoparticle targeting cGAS-STING signaling in disease therapy

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Nano Research 2024年第8期17卷 7315-7336页

作者： lan Zhou Yu huang Yuzhang Wu Shupei Tang Frontier Medical Training Brigade Third Military Medical UniversityHutubi 831200China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy

Role of biochar in raising blue carbon stock capacity of salt marshes

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Pedosphere 2024年第1期34卷 19-22页

作者： Yuzhou huang Xi xiao Ocean College Zhejiang UniversityZhoushan 316021China Key Laboratory of Marine Ecological Monitoring and Restoration Technologies of the Ministry of Natural Resources of China Shanghai 201306China Donghai Laboratory Zhoushan 316021China Ocean Academy Zhejiang UniversityZhoushan 316021China Key Laboratory of Watershed Non-point Source Pollution Control and Water Eco-security of Ministry of Water Resources College of Environmental and Resources SciencesZhejiang UniversityHangzhou 310058China

Salt marshes are an important blue carbon ecosystem, with surprisingly fast carbon accumulation rates that are 40 times higher than those of terrestrial forests. In recent decades, salt marshes have suffered great degradation and loss all over the world. The idea to enhance carbon stock in salt marshes(so-called blue carbon) using biochar (so-called black carbon) has recently been proposed. Although experiments and observations remain limited, significant enhancements in soil organic carbon and plant growth have been documented in most case studies. However, due to the limited number of observations and their relatively short time window ranging from months to less than one year, there still exists a knowledge gap regarding the process, mechanism, and effect of biochar in enhancing carbon stock in salt marshes. Future research is urgently needed in the following perspectives:1) exploring the relationship between carbon stock enhancement efficiency and biochar properties, 2) optimizing the physical and chemical properties of biochar to boost its efficiency, and 3)studying the in-situ responses of complex carbon pools to biochar addition, especially under tidal conditions and over a longer period of time.

关键词： soil stock char

Field-assisted machining of difficult-to-machine materials

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International Journal of Extreme Manufacturing 2024年第3期6卷 39-89页

作者： Jianguo Zhang Zhengding Zheng Kai huang Chuangting Lin Weiqi huang xiao Chen Junfeng xiao Jianfeng Xu State Key Laboratory of Intelligent Manufacturing Equipment and Technology School of Mechanical Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China School of Mechanical Engineering Hubei University of TechnologyWuhan 430068People’s Republic of China

Difficult-to-machine materials (DMMs) are extensively applied in critical fields such as aviation,semiconductor,biomedicine,and other key fields due to their excellent material ***,traditional machining technologies often struggle to achieve ultra-precision with DMMs resulting from poor surface quality and low processing *** recent years,field-assisted machining (FAM) technology has emerged as a new generation of machining technology based on innovative principles such as laser heating,tool vibration,magnetic magnetization,and plasma modification,providing a new solution for improving the machinability of *** technology not only addresses these limitations of traditional machining methods,but also has become a hot topic of research in the domain of ultra-precision machining of *** new methods and principles have been introduced and investigated one after another,yet few studies have presented a comprehensive analysis and *** fill this gap and understand the development trend of FAM,this study provides an important overview of FAM,covering different assisted machining methods,application effects,mechanism analysis,and equipment *** current deficiencies and future challenges of FAM are summarized to lay the foundation for the further development of multi-field hybrid assisted and intelligent FAM technologies.

关键词： field-assisted machining difficult-to-machine materials materials removal mechanism surface integrity

Microwave Through Wall Imaging via An Induced Current Learning Method

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Journal of Beijing Institute of Technology 2024年第3期33卷 248-254页

作者： Pengjin lan Jianguo huang Tianyi Zhou Faculty of Electrical Engineering and Computer Science Ningbo UniversityNingbo 315211China

In this paper,an induced current learning method(ICLM)for microwave through wall imaging(TWI),named as TWI-ICLM,is *** the inversion of induced current,the unknown object along with the enclosed walls are treated as a combination of ***,a non-iterative method called distorted-Born backpropagation(DB-BP)is utilized to generate the initial *** the training stage,several convolutional neural networks(CNNs)are cascaded to improve the estimated induced *** addition,a hybrid loss function consisting of the induced current error and the permittivity error is used to optimize the network ***,the relative permittivity images are conducted analytically using the predicted current based on *** the numerical and experimental TWI tests prove that,the proposed method can achieve better imaging accuracy compared to traditional distorted-Born iterative method(DBIM).

关键词： through wall imaging inverse scattering problem convolutional neural network(CNN)

A Mean-Field Game for a Forward-Backward Stochastic System With Partial Observation and Common Noise

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 746-759页

作者： Pengyan huang Guangchen Wang Shujun Wang Hua xiao the School of Control Science and Engineering Shandong University the School of Statistics and Mathematics Shandong University of Finance and Economics IEEE the School of Management Shandong University the School of Mathematics and Statistics Shandong University

This paper considers a linear-quadratic(LQ) meanfield game governed by a forward-backward stochastic system with partial observation and common noise,where a coupling structure enters state equations,cost functionals and observation ***,to reduce the complexity of solving the meanfield game,a limiting control problem is *** virtue of the decomposition approach,an admissible control set is *** a filter technique and dimensional-expansion technique,a decentralized control strategy and a consistency condition system are derived,and the related solvability is also ***,we discuss an approximate Nash equilibrium property of the decentralized control ***,we work out a financial problem with some numerical simulations.

关键词： Decentralized control strategy ϵ-Nash equilibrium forward-backward stochastic system mean-field game partial observation