Myeloperoxidase: a new target for the treatment of stroke?

作     者：Yun-Chang Wang Yu-Bao Lu Xiao-Lan Huang Yong-Feng Lao Lu Zhang Jun Yang Mei Shi Hai-Long Ma Ya-Wen Pan Yi-Nian Zhang Yun-Chang Wang;Yu-Bao Lu;Xiao-Lan Huang;Yong-Feng Lao;Lu Zhang;Jun Yang;Mei Shi;Hai-Long Ma;Ya-Wen Pan;Yi-Nian Zhang

作者机构：The Second Clinical Medical SchoolLanzhou UniversityLanzhouGansu ProvinceChina Department of NeurosurgeryLanzhou University Second HospitalLanzhouGansu ProvinceChina Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Department of Spine SurgeryThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina University of Chinese Academy of SciencesBeijingChina 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第8期

页      面：1711-1716页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China,No.81771297(to YNZ) CuiYing Scientific and Technological Innovation Program of Lanzhou University Second Hospital of China,No.CY2017-MS04(to YNZ) Hui-Chun Chin and Tsung-Dao Lee Chinese Undergraduate Research Endowment of China,No.LZU-JZH2224(to YCW) National Innovation and Entrepreneurship Training Program for Undergraduate of China,No.201910730212(to YCW) CuiYing Scientific Training Program for Undergraduates of Lanzhou University Second Hospital of China,No.CYXZ2019-06(to YCW) 

主　　题：blood-brain barrier hemorrhagic stroke inflammation ischemic stroke microglia myeloperoxidase neutrophils secondary brain injury stroke 

摘      要：Myeloperoxidase is an important inflammatory factor in the myeloid system,primarily expressed in neutrophils and *** and its active products participate in the occurrence and development of hemorrhagic and ischemic stroke,including damage to the blood-brain barrier and *** a specific inflammatory marker,myeloperoxidase can be used in the evaluation of vascular disease occurrence and development in stroke,and a large amount of experimental and clinical data has indicated that the inhibition or lack of myeloperoxidase has positive impacts on stroke *** studies have also shown that there is a correlation between the overexpression of myeloperoxidase and the risk of *** occurrence of stroke not only refers to the first occurrence but also includes ***,myeloperoxidase is significant for the clinical evaluation and prognosis of *** paper reviews the potential role played by myeloperoxidase in the development of vascular injury and secondary brain injury after stroke and explores the effects of inhibiting myeloperoxidase on stroke *** paper also analyzes the significance of myeloperoxidase etiology in the occurrence and development of stroke and discusses whether myeloperoxidase can be used as a target for the treatment and prediction of stroke.