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Brain structure underlying the empathizing–systemizing difference in children with autism spectrum disorder

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World Journal of Pediatrics 2023年第8期19卷 782-792页

作者： Ning Pan Li-Zi Lin Xin Wang Lei Shi xiao-Yu Xu Yu-Ying Jin Si Tan xiao-jing song Jin jing Xiu-Hong Li Department of Maternal and Child Health School of Public HealthSun Yat-Sen UniversityNo.74 Zhongshan Road 2Yuexiu DistrictGuangzhou510080China Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment Department of Occupational and Environmental HealthSchool of Public HealthSun Yat-Sen UniversityGuangzhou510080China Key Laboratory of Brain Cognition and Education ScienceMinistry of EducationGuangzhouChina Institute for Brain Research and Rehabilitation and Guangdong Key Laboratory of Mental Health and Cognitive ScienceSouth China Normal UniversityGuangzhou510631China JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research College of PharmacyJinan UniversityGuangzhou510632China Chinese Institute for Brain Research Beijing102206China

Background Behavioral research has shown that children with autism spectrum disorder(ASD)have a higher empathizing–systemizing difference(D score)than normal ***,there is no research about the neuroanatomical mechanisms of the empathizing–systemizing difference in children with *** Participants comprised 41 children with ASD and 39 typically developing(TD)children aged 6‒12 ***–systemizing difference was estimated using the D score from the Chinese version of Children’s Empathy Quotient and Systemizing *** quantified brain morphometry,including global and regional brain volumes and surface-based cortical measures(cortical thickness,surface area,and gyrification)via structural magnetic resonance *** We found that the D score was significantly negatively associated with amygdala gray matter volume[β=−0.16;95%confidence interval(CI):−0.30,−0.02;P value=0.030]in children with *** was a significantly negative association between D score and gyrification in the left lateral occipital cortex(LOC)in children with ASD(B=−0.10;SE=0.03;cluster-wise P value=0.006)and a significantly positive association between D score and gyrification in the right fusiform in TD children(B=0.10;SE=0.03;cluster-wise P value=0.022).Moderation analyses demonstrated significant interactions between D score and diagnosed group in amygdala gray matter volume(β=0.19;95%CI 0.04,0.35;P value=0.013)and left LOC gyrification(β=0.11;95%CI 0.05,0.17;P value=0.001)but not in right fusiform gyrification(β=0.08;95%CI−0.02,0.17;P value=0.105).Conclusions Neuroanatomical variation in amygdala volume and gyrification of LOC could be potential biomarkers for the empathizing–systemizing difference in children with ASD but not in TD ***-scale neuroimaging studies are necessary to test the replicability of our findings.

关键词： Autism spectrum disorder Empathy Structural magnetic resonance imaging Systemizing

Development of a scintillation detector for real-time measurement of space proton effective dose

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Nuclear Science and Techniques 2019年第5期30卷 48-58页

作者： Shou-Jie Zhang Xin-Biao Jiang Da Li xiao-Ren Yu Liang-Liang Miao xiao-jing song Yan Ma Northwest Institute of Nuclear Technology State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Xi'an Jiaotong University

In this study, a scintillation detector was developed to measure the space proton effective dose for astronauts based on the proton effective dose conversion coefficients provided by International Commission on Radiological Protection Report No. 116. In the Monte Carlo N-Particle Transport Code X(version 2.6.0) simulation process, by modulating the depth and solid angle of truncated conical holes in an iron shell from lower-energy protons to higher-energy protons, the energy deposited in the scintillator by isotropic protons was nearly proportional to the corresponding effective dose, with a maximum relative deviation of 13.28% at thirteen energy points in the energy range of 10–400 MeV. Therefore, the detector can monitor proton effective dose indirectly in real time by measuring the deposited energy. We calibrated the photoelectric conversion efficiency of the detector at the cobalt source, tested the response of the detector in the energy range of 30–100 MeV in unidirectional proton field, and validated the simulation with the experimental results.

关键词： Effective dose Space proton Scintillation detector ICRP Report No. 116 Deposited energy

Role of intestinal flora in primary sclerosing cholangitis and its potential therapeutic value

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World Journal of Gastroenterology 2022年第44期28卷 6213-6229页

作者： Zhen-Jiao Li Hong-Zhong Gou Yu-Lin Zhang xiao-jing song Lei Zhang The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina

Primary sclerosing cholangitis(PSC)is an autoimmune disease characterized by chronic cholestasis,a persistent inflammation of the bile ducts that leads to sclerotic occlusion and *** microbes,consisting of microorganisms colonized in the human gut,play an important role in nutrient intake,metabolic homeostasis,immune regulation,and immune regulation;however,their presence might aid PSC *** have found that gut-liver axis interactions also play an important role in the pathogenesis of *** with PSC have considerably reduced intestinal flora diversity and increased abundance of potentially pathogenic *** of the intestinal flora leads to increased intestinal permeability,homing of intestinal lymphocytes,entry of bacteria and their associated metabolites,such as bile acids,into the liver,stimulation of hepatic immune activation,and promotion of ***,PSC effective treatment is ***,a number of studies have recently investigated the targeted modulation of gut microbes for the treatment of various liver diseases(alcoholic liver disease,metabolic fatty liver,cirrhosis,and autoimmune liver disease).In addition,antibiotics,fecal microbiota transplantation,and probiotics have been reported as successful PSC therapies as well as for the treatment of gut dysbiosis,suggesting their effectiveness for PSC ***,this review briefly summarizes the role of intestinal flora in PSC with the aim of providing new insights into PSC treatment.

关键词： Primary sclerosing cholangitis Intestinal flora Antibiotics Fecal microbiota transplantation Probiotics Bile acids

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu jing Zhang jing Yang jinghui Chen Xingyue xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Solid-State Batteries

Very high baseline HIV viremia impairs efficacy of non-nucleoside reverse transcriptase inhibitor-based ART:a longterm observation in treatment-naïve patients

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Infectious Diseases of Poverty 2020年第3期9卷 144-145页

作者： Shuai Chen Yang Han xiao-jing song Yan-ling Li Ting Zhu Hong-Zhou Lu xiao-Ping Tang Tong Zhang Min Zhao Yun He Sheng-Hua He Min Wang Yong-Zhen Li Shao-Biao Huang Yong Li jing Liu Wei Cao Tai-Sheng Li Department of Infectious Diseases Peking Union Medical College HospitalChinese Academy of Medical SciencesNo.1 ShuaifuyuanWangfujing StreetBeijing 100730China 不详

Background:It is not completely clear whether a very high pre-therapy viral load(≥500000 copies/ml)can impair the virological *** aim of this study was to examine the influence of very high baseline HIV-RNA levels on long-term virological responses under one type of ***:A retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009,and from May 2013 to December *** HIV infected adults between 18 and 65 years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based *** patients had baseline HIV-RNA levels over 500 copies/ml,good adherence,and were followed for at least 24 *** suppression was defined as the first HIV-RNA<50 copies/*** failure was defined as any of incomplete viral suppression(HIV-RNA≥200 copies/ml without virological suppression within 24 weeks of treatment)and viral rebound(confirmed HIV-RNA level≥50 copies/ml after virological suppression).Chi-square test,Kaplan–Meier analysis,Cox proportional hazards model and Logistic regression were used to compare virological response between each pretreated viral load ***:A total of 758 treatment-naïve HIV patients in China were *** follow-up time(IQR)was 144(108–276)*** week 48,rates of virological suppression in three groups(<100000,100000–500000 and≥500000 copies/ml)were 94.1,85.0,and 63.8%,respectively(P<0.001).Very high baseline HIV viremia over 500000 copies/ml were found to be associated with delayed virological suppression(≥500000 vs<100000,adjusted relative hazard=0.455,95%CI:0.32–0.65;P<0.001)as well as incomplete viral suppression(≥500000 vs<100000,adjusted odds ratio[aOR]=6.084,95%CI:2.761–13.407;P<0.001)and viral rebound(≥50000 vs<100000,aOR=3.671,95%CI:1.009–13.355,P=0.048).Conclusions:Very high levels of pre-treatment HIV-RNA were related with delayed efficacy of NNRTI-based ART and increased risk of treatment failure.

关键词： HIV Viral load Baseline RNA Antiretroviral therapy Treatment outcome Virologic response

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风力机叶片的红外热成像无损检测的数值研究

北京工业大学学报 2006年第1期32卷 48-52,66页

作者：肖劲松严天鹏北京工业大学环境与能源工程学院传热强化与过程节能教育部重点实验室北京100022

针对大型风力机叶片的典型材料中可能存在的典型缺陷,以脉冲红外热成像法检测风力机叶片的内部气孔为例,建立了轴对称非稳态导热模型,应用ANSYS软件,进行计算机模拟计算,得到模型在脉冲加热-冷却阶段任一时刻的温度场和热流场以及有缺... 详细信息

针对大型风力机叶片的典型材料中可能存在的典型缺陷,以脉冲红外热成像法检测风力机叶片的内部气孔为例,建立了轴对称非稳态导热模型,应用ANSYS软件,进行计算机模拟计算,得到模型在脉冲加热-冷却阶段任一时刻的温度场和热流场以及有缺陷区及无缺陷区对应表面温度及温差的变化趋势,从理论计算的角度揭示了红外热成像检测材料内部缺陷的机理,同时验证了应用红外热成像技术无损检测材料内部缺陷的可能性．

关键词：风力机叶片红外热成像无损检测数值研究

Domain generalization with semi-supervised learning for people-centric activity recognition

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Science China(Information Sciences) 2025年第1期68卷 171-188页

作者： jing LIU Wei ZHU Di LI Xing HU Liang song Academy for Engineering & Technology Fudan University Shanghai East-bund Research Institute on Networking Systems of AI School of Optoelectronic Information and Computer Engineering University of Shanghai for Science & Technology

People-centric activity recognition is one of the most critical technologies in a wide range of real-world applications,including intelligent transportation systems, healthcare services, and brain-computer interfaces. Large-scale data collection and annotation make the application of machine learning algorithms prohibitively expensive when adapting to new tasks. One way of circumventing this limitation is to train the model in a semi-supervised learning manner that utilizes a percentage of unlabeled data to reduce the labeling burden in prediction tasks. Despite their appeal, these models often assume that labeled and unlabeled data come from similar distributions, which leads to the domain shift problem caused by the presence of distribution gaps. To address these limitations, we propose herein a novel method for people-centric activity recognition,called domain generalization with semi-supervised learning(DGSSL), that effectively enhances the representation learning and domain alignment capabilities of a model. We first design a new autoregressive discriminator for adversarial training between unlabeled and labeled source domains, extracting domain-specific features to reduce the distribution gaps. Second, we introduce two reconstruction tasks to capture the task-specific features to avoid losing information related to representation learning while maintaining task-specific consistency. Finally, benefiting from the collaborative optimization of these two tasks, the model can accurately predict both the domain and category labels of the source domains for the classification task. We conduct extensive experiments on three real-world sensing datasets. The experimental results show that DGSSL surpasses the three state-of-the-art methods with better performance and generalization.

关键词： activity recognition deep learning domain generalization semi-supervised learning adversarial training

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Longitudinal directional movement of Alcian blue in Gephyrocharax Melanocheir fish: Revealing interstitial flow and related structure

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World Journal of Acupuncture-Moxibustion 2019年第2期29卷 127-132页

作者： Wei-bo ZHANG xiao-jing song Ze WANG Guang-jun WANG Shu-yong JIA Yu-ying TIAN Hong-yan LI Department of biomedical engineering Institute of Acupuncture &Moxibustion China Academy of Chinese Medical Sciences Beijing 100700 China Department of Endocrinology Guang'anmen Hospital China Academy of Chinese Medical Sciences Beijing 100053 China

Background:Observing interstitial fluid(ISF)is very difficult because interstitial structure collapses and ISF disappears after tissue ***,ISF is colorless,and interstitial flow is weak in *** order to view the interstitial flow,special dye and animal model was chosen to explore the movement characteristic of interstitial flow and related ***:The Gephyrocharax Melanocheir(GM)fish,a special animal with translucent body,were placed into 0.03 g/L tricain solution for anesthesia.20-25μL Alcian blue(AB)solution which can stain acid mucopolysaccharide immobilized by the collagen net in connective tissue was injected into each fish at a single point with a rate of 2 μL/min via a micro-injection *** process of infusion and the movement of the AB in fish were record by a digital ***(fresh)frozen sections of AB tracks tissue were performed to observe the morphological ***:Several blue tracks were observed which were formed by longitudinal directional movements of AB *** back lateral track,the velocity and length of the movements were significantly fast and longer on the direction toward head than that toward tail(P<0.01).For lateral middle track,the result was opposite,namely toward tail(P<0.01).This phenomenon indicated an inherent ISF flow according to Darcy's *** study showed these tracks were just in septa composed by connective *** stained blue septa formed various shapes as interstitial space for ISF flow and connected with one another like a *** finding can help us to understand the essence of meridian in traditional Chinese medicine(TCM).Conclusions:The dynamic asymmetry of the AB tracks revealed interstitial flow in the GM fish *** implied an inherent interstitial flow along particular pathway formed by septa which may be a key to understand the nature and value of meridians and collaterals in health care.

关键词： Interstitial fluid Interstitial flow Meridians and collaterals Alcian blue Gephyrocharax Melanocheir fish

Electrochemical conversion of methane to bridge the gap in the artificial carbon cycle

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Journal of Energy Chemistry 2025年第1期100卷 286-308页

作者： Yuhao Peng Yuefeng song Ihar Razanau Juanxiu xiao Wei xiao Di Hu Guoxiong Wang College of Chemistry and Molecular Sciences Hubei Key Laboratory of Electrochemical Power Sources Wuhan University State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Dalian Institute of Chemical Physics Chinese Academy of Sciences Laboratory of Physical-Chemical Technologies SSPA Scientific and Practical Materials Research Centre of NAS of Belarus State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University Department of Chemical and Environmental Engineering University of Nottingham Ningbo China

Methane, an abundant one-carbon（C1） resource, is extensively used in the industrial production of vital fuels and value-added chemicals. However, current industrial methane conversion technologies are energy-and carbon-intensive, mainly due to the high activation energy required to break the inert C–H bond, low selectivity, and problematic side reactions, including CO2emissions and coke deposition. Electrochemical conversion of methane（ECM） using intermittent renewable energy offers an attractive solution, due to its modular reactor design and operational flexibility across a broad spectrum of temperatures and pressures. This review emphasizes conversion pathways of methane in various reaction systems, highlighting the significance and advantages of ECM in facilitating a sustainable artificial carbon cycle. This work provides a comprehensive overview of conventional methane activation mechanisms and delineates the complete pathways of methane conversion in electrolysis contexts. Based on surface/interface chemistry, this work systematically analyzes proposed reaction pathways and corresponding strategies to enhance ECM efficiency towards various target products, including syngas, hydrocarbons, oxygenates, and advanced carbon materials. The discussion also encompasses opportunities and challenges for the ECM process, including insights into ECM pathways, rational electrocatalyst design, establishment of benchmarking protocols, electrolyte engineering, enhancement of CH4conversion rates, and minimization of CO2emission.

关键词： Activation energy