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福州地区不同年龄牙龈炎人群口腔健康宣教途径及策略分析

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中国医药指南 2024年第9期22卷 117-120页

作者：许雯静陈守芳林倩倩辛勇蔡盛岳曾友胜胡泽凯肖鹏辉黄永玲福建中医药大学附属人民医院口腔科福州350000 福建医科大学口腔医学院附属口腔医院福州350000

目的调查福州地区不同年龄段牙龈炎人群口腔健康知识来源途径差异,初步分析宣传策略,为有针对性地开展的口腔健康宣教提供依据。方法采用单纯随机抽样的方式,收集于2021年6月至2021年10月就诊的420例慢性牙龈炎患者进行问卷调查,按年龄... 详细信息

目的调查福州地区不同年龄段牙龈炎人群口腔健康知识来源途径差异,初步分析宣传策略,为有针对性地开展的口腔健康宣教提供依据。方法采用单纯随机抽样的方式,收集于2021年6月至2021年10月就诊的420例慢性牙龈炎患者进行问卷调查,按年龄分为两组:18~35岁组,36~65岁组。结果网络为18~35岁组获取口腔健康知识的主要途径,而36~65岁组主要途径为网络与医疗机构,且两者效应叠加后占绝对优势。全年龄人群最主要传播途径为网络。结论充分发挥网络宣传的同时,加强医疗机构网络公众号建设,将网络及医疗机构宣传途径叠加,可获取更广传播效果。

关键词：口腔卫生宣教牙龈炎保健知识口腔健康途径

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新型前列环素类似物曲前列尼尔

中国新药杂志 2014年第22期23卷 2585-2588,2592页

作者：顾智淳刘晓琰沈节艳蔡宗烨上海交通大学医学院附属仁济医院药剂科上海200127 上海交通大学医学院附属仁济医院心内科上海200127

肺动脉高压(PAH)是以肺血管阻力增加导致右心衰和死亡的一类进展性和致死性疾病。曲前列尼尔是一个稳定的前列环素类似物,用于治疗PAH。该药的主要药理作用包括舒张肺血管,抑制血小板聚集及平滑肌细胞增生,可通过皮下、静脉、吸入和口... 详细信息

肺动脉高压(PAH)是以肺血管阻力增加导致右心衰和死亡的一类进展性和致死性疾病。曲前列尼尔是一个稳定的前列环素类似物,用于治疗PAH。该药的主要药理作用包括舒张肺血管,抑制血小板聚集及平滑肌细胞增生,可通过皮下、静脉、吸入和口服给药。临床研究表明,曲前列尼尔能够改善PAH患者临床症状和活动耐量,提高生活质量。常见的不良反应(AEs)包括头痛、皮肤潮红、颌痛、腹泻等;皮下给药时注射部位反应较常见。本文就曲前列尼尔的药理作用、药动学、临床研究及安全性作一阐述。

关键词：曲前列尼尔前列环素类似物肺动脉高压

Endoscopic Surgery versus External Ventricular Drainage Surgery for Severe Intraventricular Hemorrhage

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Current Medical Science 2018年第5期38卷 880-887页

作者： Ping SONG Fa-liang DUAN Qiang cai Jing-lei WU xiao-bin CHEN Yuan WANG Cong-gang HUANG Ji-qiang LI Zhu-qiang HE Qiao-chun HUANG Mei LIU Yan-gao ZHANG Ming LUO Department of Neurosurgery the First Hospital of WuhanWuhan 430022China Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhan 430060China Intensive Care Unit the First Hospital of WuhanWuhan 430022China

The efficacy and applied value of endoscopic hematoma evacuation vs. external ventricular drainage (EVD) in the treatment of severe ventficular hemorrhage (IVH) were explored and *** Jan.2015 to Dec.2016,the clinical data of 42 cases of IVH were retrospectively analyzed,including 18 patients undergoing endoscopic hematoma evacuation (group A),and 24patients receiving EVD (group B).The hematoma clearance rate was calculated by 3D Slicer software,and complications and outcomes were compared between the two *** were no significant differences in age,sex and Graeb score between groups A and B (P>0.05).The hematoma clearance rate was 70.81%±27.64% in group A and 48.72%±36.58% in group B with a statistically significant difference (P<0.05).The operative time in groups A and B was 72.45±25.26 min and 28.54±15.27min,respectively (P<0.05).The Glasgow Coma Scale (GCS) score increased from 9.28±2.72 at baseline to 11.83±2.91 at 1 week postoperatively in group A,and from 8.25±2.62 at baseline to 10.79±4.12 at 1 week postoperatively in group B (P<0.05).The length of hospital stay was 12.67±5.97 days in group A and 17.33±8.91 days in group B with a statistically significant difference (P<0.05).The GOS scores at 6 months after surgery were 3.83±1.12 in group A,and 2.75±1.23 in group B (P<0.05). These results suggested that endoscopic hematoma evacuation has an advantage of a higher hematoma clearance rate,fewer complications and better outcomes in the treatment of severe IVH,indicating it is a safe,effective and promising approach for severe IVH.

关键词： endoscopic surgery severe intraventricular hemorrhage external ventricular drainage

基于SC-LDGM码的随机混合业务传输方案

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电子学报 2022年第10期50卷 2305-2310页

作者：王翌昕蔡穗华马啸中山大学计算机学院广东广州510006

本文研究了一种适用于随机混合业务的传输方案,其可以对随机到达的不同业务实现不等差错保护,从而满足不同业务对于传输质量的不同需求.该方案的主要优势是,利用一套编译码器满足不同业务基本的质量要求;而对于要求较高的业务,则采用级... 详细信息

本文研究了一种适用于随机混合业务的传输方案,其可以对随机到达的不同业务实现不等差错保护,从而满足不同业务对于传输质量的不同需求.该方案的主要优势是,利用一套编译码器满足不同业务基本的质量要求;而对于要求较高的业务,则采用级联外码的技术.另一个有别于传统方法的创新点是,该方案采用叠加的方式实现业务类型标识比特的传输,既不消耗额外的带宽,也不消耗额外的传输能量.仿真结果表明,本文所提出的编译码方案能高效准确地对业务类型进行识别,从而有效地实现随机混合业务的不等保护.

关键词：随机混合业务传输不等差错保护系统卷积低密度生成矩阵码业务类型辨识

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GPS在列车完整性检查中的应用研究

北京交通大学学报 2006年第2期30卷 69-71,75页

作者：陈晓乾王剑蔡伯根北京交通大学电子信息工程学院北京100044

研究利用GPS进行列车完整性检查的方法,通过试验结果来验证这种方法的有效性及准确度,并对报警门限和报警方式进行了研究.

关键词：全球卫星定位系统列车完整性检查列尾装置

Detection of RASSF1A promoter hypermethylation in serum from gastric and colorectal adenocarcinoma patients

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World Journal of Gastroenterology 2008年第19期14卷 3074-3080页

作者： Yu-cai Wang Zheng-HongYu Chang Liu Li-Zhi Xu Wen Yu Jia Lu Ren-Min Zhu guo-Li Li Xin-Yi Xia xiao-Wei Wei Hong-Zan Ji Heng Lu Yong Gao Wei-Min Gao Long-Bang Chen Department of Medical Oncology Jinling Hospital Nanjing 210002 Jiangsu Province China Medical School of Nanjing University Nanjing 210093 Jiangsu Province China Department of Experimental Radiation Oncology The University of Texas M.D. Anderson Cancer Center The University of Texas Graduate School of Biomedical Sciences at Houston Houston TX 77030 United States Department of Molecular Pathology The University of Texas M. D. Anderson Cancer Center Houston TX 77030 United States Department of Gastroenterology Jinling Hospital Nanjing 210002 Jiangsu Province China Institute of General Surgery Jinling Hospital Nanjing 210002 Jiangsu Province China Institute of Laboratory Medicine Jinling Hospital Nanjing 210002 Jiangsu Province China Department of Environmental Toxicology The Institute of Environmental and Human Health Texas Tech University Lubbock TX 79409 United States

AIM：To evaluate the diagnostic role of serum RASSF1A promoter hypermethylation in gastric and colorectal adenocarcinoma. METHODS：Methylation-specific polymerase chain reaction （MSPCR） was used to examine the promoter methylation status of the serum RASSF1A gene in 47 gastric adenocarcinoma patients, 45 colorectal adenocarcinoma patients, 60 patients with benign gastrointestinal disease （30 with benign gastric disease and 30 with benign colorectal disease）, and 30 healthy donor controls. Apaired study of RASSF1A promoter methylation status in primary tumor, adjacent normal tissue, and postopertive serum were conducted in 25 gastric and colorectal adenocarcinoma patients who later were underwent surgical therapy. RESULTS：The frequencies of detection of serum RASSF1A promoter hypermethylation in gastric （34.0%） and colorectal （28.9%） adenocarcinoma patients were significantly higher than those in patients with benign gastric （3.3%） or colorectal （6.7%） disease or in healthy donors （0%）（P 〈 0.01）. The methylation status of RASSF1A promoter in serum samples was consistent with that in paired primary tumors, and the MSPCR results for RASSF1A promoter methylation status in paired preoperative samples were consistent with those in postoperative serum samples. The serum RASSF1A promoter hypermethylation did not correlate with patient sex, age, tumor differentiation grade, surgical therapy, or serum carcinoembryonic antigen level. Although the serum RASSF1A promoter hypermethylation frequency tended to be higher in patients with distant metastases, there was no correlation between methylation status and metastasis. CONCLUSION：Aberrant CpG island methylation within the promoter region of RASSF1A is a promising biomarker for gastric and colorectal cancer.

关键词： Gastric cancer Colorectal cancer Genemethylation RASSFIA

Chronic kidney disease: an independent risk factor of all-cause mortality for elderly Chinese patients with chronic heart failure

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Journal of Geriatric Cardiology 2012年第4期9卷 355��-360页

作者： Shi-Hui Fu Bing Zhu Yu-xiao Zhang Shuang-Yan Yi Yuan Liu Tie-Hui xiao Liang Wang Yong-Yi Bai cai-Yi Lu Ping Ye Lei-Ming Luo Department of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China Institute of Geriatric Cardiology Chinese PLA General Hospital Beijing 100853 China

Objective To evaluate the prognostic value of chronic kidney disease (CKD) in elderly Chinese patients with chronic heart failure (CHF). Methods The study consisted of 327 elderly patients with CHF. All-cause mortality was chosen as an endpoint over the median follow-up period of 345 days. Cox regression analysis was used to identify the risk factors of mortality. Results The median age of the entire cohort was 85 years (60��100 years). The mortality for 168 elderly patients with CHF and CKD (51.4% of entire cohort) was 39.9% (67 deaths), which was higher than the mortality for CHF patientswithout CKD [25.2% (40/159 deaths)] and the mortality for entire cohort with CHF [32.7% (107/327 deaths)]. The Cox regression analysis showed that old age [hazard ratio (HR): 1.033; 95% confidence interval (95%CI): 1.004��1.064], CKD(HR: 1.705; 95%CI: 1.132��2.567), CHF New York HeartAssociation (NYHA) class IV (HR: 1.913; 95% CI: 1.284��2.851), acute myocardial infarction (AMI) (HR: 1.696; 95% CI: 1.036��2.777), elevated resting heart rate (HR: 1.021; 95% CI: 1.009��1.033), and decreased plasma albumin (HR: 0.883; 95% CI: 0.843��0.925) were independent risk factors of mortality for elderly patientswith CHF. Conclusions CKDwas an independent risk factor of mortality for elderly Chinese patientswith CHF.

关键词： Chronic heart failure Chronic kidney disease Risk factor The aged

Investigation of porous negative electrode for lithium-oxygen battery

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Investigation of porous negative electrode for lithium-oxyge...

磺酸功能化离子液体的合成及催化制备生物柴油应用

中国化学会第30届学术年会-第三十分会：化学电源

作者： Kedi cai Yao xiao Rui yang xiaoshi Lang Tieshi He Liaoning Engineering Technology Research Center of Supercapacitor University of Bohai

Lithium-oxygen battery has been attracted great attention in recent years for their high theoretical specific energy, high theoretical specific capacity, safety and good compatibility with the environment. In this study, we presented the novel lithium-oxygen battery with porous negative electrode. The battery consisted of porous lithium metal negative electrode, organic electrolyte, and porous carbon positive electrode. From Fig.1, it can be seen that the negative electrode and positive electrode fed with nitrogen gas and oxygen gas, respectively. Novel battery restrains oxygen gas from positive electrode move to negative electrode at discharge. The performances of specific energy and cycle life for novel lithium-oxygen battery were enhanced due to the restrain the corrosion of lithium metal.

关键词： Lithium/oxygen battery Porous anode

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化工学报 2021年第7期72卷 3601-3612页

作者：蔡东仁詹国武肖静冉邱挺华侨大学化工学院福建厦门361021 福州大学石油化工学院福建福州350108

基于4-甲基噻唑,采用两步法合成4种不同阴离子的磺酸功能化离子液体用于催化无患子油与甲醇酯交换反应制备生物柴油。傅里叶红外光谱、核磁共振和热重分析结果表明,离子液体被成功制备并且具备高热稳定性。其中,3-(3-磺酸基)丙基-4-甲... 详细信息

基于4-甲基噻唑,采用两步法合成4种不同阴离子的磺酸功能化离子液体用于催化无患子油与甲醇酯交换反应制备生物柴油。傅里叶红外光谱、核磁共振和热重分析结果表明,离子液体被成功制备并且具备高热稳定性。其中,3-(3-磺酸基)丙基-4-甲基噻唑三氟甲烷磺酸盐([Ps-MTH][CF3SO3])在所制备的离子液体中表现出最高的催化活性。以[Ps-MTH][CF3SO3]为催化剂,无患子油与甲醇酯交换反应的最佳操作条件为反应温度128℃、醇油摩尔比28.10∶1、催化剂用量0.62 mmol/g(基于油的质量)、反应时间8 h,生物柴油收率高达92.78%±0.47%。此外,[Ps-MTH][CF3SO3]具备良好的重复使用性,在不同酯交换反应中也表现出良好的催化活性。该研究为离子液体催化无患子油制备生物柴油的工业化生产提供了基础数据。

关键词：生物柴油 4-甲基噻唑离子液体无患子油酯交换