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Discordance analysis for apolipoprotein and lipid measures for predicting myocardial infarction in statin-treated patients with coronary artery disease:a cohort study

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Journal of Geriatric Cardiology 2023年第12期20卷 845-854页

作者： Tian-Yu LI Pei ZHU Ying SONG xiao-fang tang Zhan GAO Run-Lin GAO Jin-Qing YUAN National Clinical Research Center for Cardiovascular Diseases National Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The optimal apolipoprotein or lipid measures for identifying statin-treated patients with coronary artery disease(CAD)at residual cardiovascular risk remain *** study aimed to compare the predictive powers of apolipoprotein B(apoB),non-high-density lipoprotein cholesterol(non-HDL-C),low-density lipoprotein cholesterol(LDL-C),apoB/apolipoprotein A-1(apoA-1)and non-HDL-C/HDL-C for myocardial infarction(MI)in CAD patients treated with statins in the setting of secondary *** The study included 9191 statin-treated CAD patients with a five-year median *** measures were anal-yzed as continuous variables and concordance/discordance groups by *** hazard ratio(HR)with 95%CI was estimated by Cox proportional hazards *** were classified by the clinical presentation of CAD for further *** The high-apoB-low-LDL-C and the high-non-HDL-C-low-LDL-C categories yielded HR of 1.40(95%CI:1.04–1.88)and 1.51(95%CI:1.07–2.13)for MI,respectively,whereas discordant high LDL-C with low apoB or non-HDL-C was not associa-ted with the risk of *** association of MI with discordant apoB versus non-HDL-C,apoB/apoA-1 versus apoB,non-HDL-C/HDL-C versus non-HDL-C,or apoB/apoA-1 versus non-HDL-C/HDL-C was *** patterns were found in patients with acute coronary *** contrast,no association was observed between any concordance/discordance category and the risk of MI in patients with chronic coronary *** ApoB and non-HDL-C better predict MI in statin-treated CAD patients than LDL-C,especially in patients with acute coronary ***/apoA-1 and non-HDL-C/HDL-C show no superiority to apoB and non-HDL-C for predict-ing MI.

关键词： patients coronary infarction

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Effects of starvation and hormones on DNA synthesis in silk gland cells of the silkworm, Bombyx moil

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Insect Science 2016年第4期23卷 569-578页

作者： Yao-Feng Li Xiang-Yun Chen Chun-Dong Zhang xiao-fang tang La Wang Tai-Hang Liu Min-Hui Pan Cheng Lu State Key Laboratory of Silkworm Genome Biology Southwest University Key Laboratory for Sericulture Functional Genomics and Biotechnology of Agricultural Ministry Southwest University Chongqing Department of Biochemistry and Molecular Biology Chongqing Medical University Chongqing China

Silk gland cells of silkworm larvae undergo multiple cycles of endomitosis for the synthesis of silk proteins during the spinning phase. In this paper, we analyzed the endomitotic DNA synthesis of silk gland cells during larval development, and found that it was a periodic fluctuation, increasing during the vigorous feeding phase and being gradually inhibited in the next molting phase. That means it might be activated by a self- regulating process after molting. The expression levels of cyclin E, cdtl and pcna were consistent with these developmental changes. Moreover, we further examined whether these changes in endomitotic DNA synthesis resulted from feeding or hormonal stimulation. The results showed that DNA synthesis could be inhibited by starvation and re-activated by re-feeding, and therefore appears to be dependent on nutrition. DNA synthesis was suppressed by in vivo treatment with 20-hydroxyecdysone （20E）. However, there was no effect on DNA synthesis by in vitro 20E treatment or by either in vivo or in vitro juvenile hormone treatment. The levels of Akt and 4E-BP phosphorylation in the silk glands were also reduced by starvation and in vivo treatment with 20E. These results indicate that the activation of endomitotic DNA synthesis during the intermolt stages is related to feeding and DNA synthesis is inhibited indirectly by 20E.

关键词： Bombyx mori DNA synthesis endomitosis silk gland starvation 20-hydroxyecdysone

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Performance of iron-air battery with iron nanoparticle-encapsulated C-N composite electrode

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Frontiers in Energy 2024年第1期18卷 42-53页

作者： Can fang Xiangmei tang Jiaoyan WANG Qingfeng YI School of Chemistry and Chemical Engineering Hunan University of Science and TechnologyXiangtan 411201China Hunan Provincial Key Laboratory of Advanced Materials for New Energy Storage and Conversion Xiangtan 411201China

Highly efficient and stable iron electrodes are of great significant to the development of iron-air battery(IAB).In this paper,iron nanoparticle-encapsulated C–N composite(NanoFe@CN)was synthesized by pyrolysis using polyaniline as the C–N *** performance of the NanoFe@CN in different electrolytes(alkaline,neutral,and quasi-neutral)was investigated via cyclic voltammetry(CV).The IAB was assembled with NanoFe@CN as the anode and IrO_(2)+Pt/C as the *** effects of different discharging/charging current densities and electrolytes on the battery performance were also *** K_(2)SO_(4)electrolyte can effectively suppress the passivation of iron electrode,and the battery showed a good cycling stability during 180 charging/discharging *** to the pure nano-iron(NanoFe)battery,the NanoFe@CN battery has a more stable cycling stability either in KOH or NH_(4)Cl+KCl electrolyte.

关键词： energy storage and conversion metallic composites nanocomposites iron-air battery iron anode

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Investigation of Adhesive Perception Based on Friction and Brain Activation

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Journal of Bionic Engineering 2024年第4期21卷 1862-1877页

作者： Xingxing fang Wei tang Shousheng Zhang Tengfei Zhuang School of Mechatronic Engineering China University of Mining and TechnologyXuzhou221116JiangsuChina

The enhancement of adhesive perception is crucial to maintaining a stable and comfortable grip of the skin-touch *** study the tactile perception of adhesive surfaces,subjective evaluation,skin friction and vibrations,and neurophysiological response of the brain activity were investigated *** materials,which are commonly used for bionic materials and skin-touch products,were chosen for the tactile *** results showed that with the increasing of surface adhesion,the dominant friction transferred from a combination of adhesive friction and deformation friction to adhesive *** friction coefficient and vibration amplitude had strong correlations with the perceived adhesion of *** parietal lobe and occipital lobe were involved in adhesive perceptions,and the area and intensity of brain activation increased with the increasing surface *** with larger adhesion tended to excite a high P300 amplitude and short latency,indicating that the judgment was faster and that more attentional resources were involved in adhesive ***,the electroencephalograph signals of the adhesive perception were simulated by the neural mass *** demonstrated that the excitability and intensity of brain activity,and the connectivity strength between two neural masses increased with the increasing surface *** study is meaningful to understand the role of surface adhesion in tactile friction and the cognitive mechanism in adhesive perception to improve the tactile experience of adhesive materials.

关键词： Surface adhesion Tactile perception Friction Brain activation Neural mass model

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Effects of chronic obstructive pulmonary disease on longterm prognosis of patients with coronary heart disease postpercutaneous coronary intervention

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Journal of Geriatric Cardiology 2022年第6期19卷 428-434页

作者： Yi YAO Pei ZHU Na XU Lin JIANG xiao-fang tang Ying SONG Xue-Yan ZHAO Shu-Bin QIAO Yue-Jin YANG Jin-Qing YUAN Run-Lin GAO Center for Coronary Heart Disease National Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND Chronic obstructive pulmonary disease(COPD)and cardiovascular diseases are often comorbid conditions,their co-occurrence yields worse outcomes than either condition *** study aimed to investigate COPD impacts on the five-year prognosis of patients with coronary heart disease(CHD)after percutaneous coronary intervention(PCI).METHODS Patients with CHD who underwent PCI in 2013 were recruited,and divided into COPD group and non-COPD *** events occurring among those groups were recorded during the five-year follow-up period after PCI,including all-cause death and cardiogenic death,myocardial infarction,repeated revascularization,as well as stroke and bleeding *** adverse cardiac and cerebral events were a composite of all-cause death,myocardial infarction,repeated revascularization and *** A total of 9843 patients were consecutively enrolled,of which 229 patients(2.3%)had *** to non-COPD patients,COPD patients were older,along with poorer estimated glomerular filtration rate and lower left ventricular ejection ***-year follow-up results showed that incidences of all-cause death and cardiogenic death,as well as major adverse cardiac and cerebral events,for the COPD group were significantly higher than for non-COPD group(10.5%vs.3.9%,7.4%vs.2.3%,and 30.1%vs.22.6%,respectively).COPD was found under multivariate Cox regression analysis,adjusted for confounding factors,to be an independent predictor of all-cause death[odds ratio(OR)=1.76,95%CI:1.15-2.70,P=0.009]and cardiogenic death(OR=2.02,95%CI:1.21-3.39,P=0.007).CONCLUSIONS COPD is an independent predictive factor for clinical mortality,in which CHD patients with COPD are associated with worse prognosis than CHD patients with non-COPD.

关键词： patients coronary prognosis

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A Numerical Calculation Algorithm of the Inclination Function Based on the Representation of SO(3) Group

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Acta Mathematicae Applicatae Sinica 2024年第1期40卷 137-148页

作者： Yu-xiao Wei Wen-lin tang Department of Geophysics School of Geology Engineering and GeomaticsChang’An UniversityXi’an710064China Key Laboratory of Electronics and Information Technology for Space Systems National Space Science CenterChinese Academy of SciencesBeijing100190China

In the determination of the Earth gravity field in satellite geodesy, the inclination functions represent the projection of data observed along the orbital plane of a satellite orbit into the sphere in the terrestial reference frame. The inclination functions in this work is studied from a group theoretical perspective. The inclination functions are proved to generate a representation of the SO(3) group. An orthogonal relation of the inclination functions is derived and some recurrence relations for the inclination functions are given, based on which an algorithm to calculate the inclination functions is proposed.

关键词： SO(3)group inclination function satellite geodesy representation of SO(3)

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Cnoidal waves and their soliton limits in single mode fiber lasers

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Photonics Research 2024年第3期12卷 543-551页

作者： xiao HU TUPEI CHEN SEONGWOO YOO DINGYUAN tang Julong College Shenzhen Technology UniversityShenzhen 518118China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

Cnoidal waves are a type of nonlinear periodic wave solutions of the nonlinear dynamic *** are well known in fluid dynamics,but it is not the case in *** this paper we show both experimentally and numerically that cnoidal waves could be formed in a fiber laser either in the net normal or net anomalous cavity dispersion regime,especially because,as the pump power is increased,the formed cnoidal waves could eventually evolve into a train of bright(in the net anomalous cavity dispersion regime)or dark(in the net normal cavity dispersion regime)*** simulations of the laser operation based on the extended nonlinear Schrödinger equation(NLSE)have well reproduced the experimental *** result not only explains why solitons can still be formed in a fiber laser even without mode locking but also suggests a new effective way of automatic stable periodic pulse train generation in lasers with a nonlinear cavity.

关键词： fiber pump mode

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Experimental distillation of tripartite quantum steering with an optimal local filtering operation

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Photonics Research 2024年第3期12卷 552-562页

作者： QIAN-XI ZHANG xiao-XU fang HE LU School of Physics State Key Laboratory of Crystal MaterialsShandong UniversityJinan 250100China Shenzhen Research Institute of Shandong University Shenzhen 518057China

Multipartite Einstein-Podolsky-Rosen(EPR)steering admits multipartite entanglement in the presence of uncharacterized verifiers,enabling practical applications in semi-device-independent *** applications generally require stronger steerability,while the unavoidable noise weakens steerability and consequently degrades the performance of quantum information ***,we propose the local filtering operation that can maximally distill genuine tripartite EPR steering from N copies of three-qubit generalized Greenberger-Horne-Zeilinger states,in the context of two semi-device-independent *** optimal filtering operation is determined by the maximization of assemblage *** and numerical results indicate the advantage of the proposed filtering operation when N is finite and the steerability of initial assemblages is ***,a proof-of-principle demonstration of two-copy distillation is realized with the optical *** advantage of the optimal local filtering operation is confirmed by the distilled assemblage in terms of higher assemblage fidelity with perfectly genuine tripartite steerable assemblages,as well as the greater violation of the inequality to witness genuine tripartite steerable *** results benefit the distillation of multipartite EPR steering in practice,where the number of copies of initial assemblages is generally finite.

关键词： filtering distillation optimal

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Impact of Proton-pump Inhibitors on the Pharmacodynamic Effect and Clinical Outcomes in Patients Receiving Dual Antiplatelet Therapy after Percutaneous Coronary Intervention： A Propensity Score Analysis

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Chinese Medical Journal 2017年第24期130卷 2899-2905页

作者： Pei Zhu Zhan Gao xiao-fang tang Jing-Jing Xu Yin Zhang Li-Jian Gao Jue Chen Shu-Bin Qiao Yue-Jin Yang Run-Lin Gao Bo Xu Jin-Qing Yuan Department of Cardiology Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China

Background：Prior studies have reported controversial conclusions regarding the risk of adverse cardiovascular events in patients using proton-pump inhibitors （PPIs） combined with clopidogrel therapy,causing much uncertainty in clinical *** sought to evaluate the safety of PPIs use among high-risk cardiovascular patients who underwent percutaneous coronary intervention （PCI） in a long-term follow-up ***：A total of 7868 consecutive patients who had undergone PCI and received dual antiplatelet therapy （DAPT） at a single center from January 2013 to December 2013 were *** diphosphate （ADP）-induced platelet aggregation inhibition was measured by modified thromboelastography （mTEG） in 5042 *** score matching （PSM） was applied to control differing baseline *** proportional hazards regression was used to evaluate the 2-year major adverse cardiovascular and cerebrovascular events （MACCEs）,as well as individual events,including all-cause death,myocardial infarction,unplanned target vessel revascularization,stent thrombosis,and ***：Among the whole cohort,27.2% were prescribed *** ADP-induced platelet aggregation inhibition by mTEG was significantly lower in PPI users than that in non-PPI users （42.0 ± 30.9% vs.46.4 ± 31.4%,t =4.435,P 〈 0.001）.Concomitant PPI use was not associated with increased MACCE through 2-year follow-up （12.7% vs.12.5%,x2 =0.086,P =0.769）.Other endpoints showed no significant differences after multivariate adjustment,regardless of ***：In this large cohort of real-world patients,the combination of PPIs with DAPT was not associated with increased risk of MACCE in patients who underwent PCI at up to 2 years of follow-up.

关键词： Clopidogrel Drug Interactions Percutaneous Coronary Intervention Proton-pump lnhibitors

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Endoscopic-ultrasound-guided biliary drainage with placement of electrocautery-enhanced lumen-apposing metal stent for palliation of malignant biliary obstruction:Updated meta-analysis

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 907-920页

作者： Zu-Xiang Peng fang-fang Chen Wen tang Xu Zeng Hong-Juan Du Ru-Xian Pi Hong-Ming Liu xiao-xiao Lu Department of Hepatobiliary Surgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Oncology Chongqing General HospitalChongqing UniversityChongqing 401147China Department of Gastroenterology and Hepatobiliary Surgery People’s Hospital of Fenggang CountyGuizhou 564200Guizhou ProvinceChina Hepatobiliary and Pancreatic Tumor Center Chongqing University Cancer HospitalChongqing 400030China

BACKGROUND Endoscopic ultrasound-guided biliary drainage using electrocautery-enhanced(ECE)delivery of lumen-apposing metal stent(LAMS)is gradually being re-cognized as a viable palliative technique for malignant biliary obstruction after endoscopic retrograde cholangiopancreatography(ERCP)***,most of the studies that have assessed its efficacy and safety were small and *** meta-analyses of six or fewer studies that were published 2 years ago were therefore underpowered to yield convincing *** To update the efficacy and safety of ECE-LAMS for treatment of biliary ob-struction after ERCP *** We searched PubMed,EMBASE,and Scopus databases from the inception of the ECE technique to May 13,*** outcome measure was pooled technical success rate,and secondary outcomes were pooled rates of clinical success,re-intervention,and adverse ***-analysis was performed using a random-effects model following Freeman-Tukey double-arcsine transformation in R soft-ware(version 4.1.3).RESULTS Fourteen eligible studies involving 620 participants were ultimately *** pooled rate of technical success was 96.7%,and clinical success was 91.0%.Adverse events were reported in 17.5%of *** reinter-vention rate was 7.3%.Subgroup analyses showed results were generally *** ECE-LAMS has favorable success with acceptable adverse events in relieving biliary obstruction when ERCP is *** consistency of results across most subgroups suggested that this is a generalizable approach.

关键词： Biliary obstruction Biliary drainage Electrocautery-enhanced lumen-apposing metal stents Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography failure

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