Discordance analysis for apolipoprotein and lipid measures for predicting myocardial infarction in statin-treated patients with coronary artery disease:a cohort study

作     者：Tian-Yu LI Pei ZHU Ying SONG Xiao-Fang TANG Zhan GAO Run-Lin GAO Jin-Qing YUAN Tian-Yu LI;Pei ZHU;Ying SONG;Xiao-Fang TANG;Zhan GAO;Run-Lin GAO;Jin-Qing YUAN

作者机构：National Clinical Research Center for Cardiovascular DiseasesNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina 

出 版 物：《Journal of Geriatric Cardiology》 (老年心脏病学杂志（英文版）)

年 卷 期：2023年第20卷第12期

页      面：845-854页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the China National Key R&D Program during the 13th Five-year Plan Period,China(2016YFC1301301) the CAMS Innovation Fund for Medical Sciences,China(2020-I2 M-C&T-B-049) the National Clinical Research Center for Cardiovascular Diseases,Fuwai Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China(NCRC2020013) 

主　　题：patients coronary infarction 

摘      要：BACKGROUND The optimal apolipoprotein or lipid measures for identifying statin-treated patients with coronary artery disease(CAD)at residual cardiovascular risk remain *** study aimed to compare the predictive powers of apolipoprotein B(apoB),non-high-density lipoprotein cholesterol(non-HDL-C),low-density lipoprotein cholesterol(LDL-C),apoB/apolipoprotein A-1(apoA-1)and non-HDL-C/HDL-C for myocardial infarction(MI)in CAD patients treated with statins in the setting of secondary *** The study included 9191 statin-treated CAD patients with a five-year median *** measures were anal-yzed as continuous variables and concordance/discordance groups by *** hazard ratio(HR)with 95%CI was estimated by Cox proportional hazards *** were classified by the clinical presentation of CAD for further *** The high-apoB-low-LDL-C and the high-non-HDL-C-low-LDL-C categories yielded HR of 1.40(95%CI:1.04–1.88)and 1.51(95%CI:1.07–2.13)for MI,respectively,whereas discordant high LDL-C with low apoB or non-HDL-C was not associa-ted with the risk of *** association of MI with discordant apoB versus non-HDL-C,apoB/apoA-1 versus apoB,non-HDL-C/HDL-C versus non-HDL-C,or apoB/apoA-1 versus non-HDL-C/HDL-C was *** patterns were found in patients with acute coronary *** contrast,no association was observed between any concordance/discordance category and the risk of MI in patients with chronic coronary *** ApoB and non-HDL-C better predict MI in statin-treated CAD patients than LDL-C,especially in patients with acute coronary ***/apoA-1 and non-HDL-C/HDL-C show no superiority to apoB and non-HDL-C for predict-ing MI.