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Growth and structural characteristics of metastableβ-In2Se3 thin films on H-terminated Si(111)substrates by molecular beam epitaxy

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Chinese Physics B 2020年第5期29卷 429-434页

作者： Yi-Fan Shen Xi-Bo Yin Chao-Fan Xu Jing He Jun-Ye Li Han-Dong Li xiao-Hong Zhu xiao-bin niu College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 610054China

Epitaxial growth and structural characteristics of metastableβ-In2Se3 thin films on H-terminated Si(111)substrates are *** In2Se3 thin films grown below theβ-to-αphase transition temperature(453 K)are characterized to be strainedβ-In2Se3 mixed with significantγ-In2Se3 *** pure-phased single-crystallineβ-In2Se3 can be reproducibly achieved by in situ annealing the as-deposited poly-crystalline In2Se3 within the phase equilibrium temperature window ofβ-*** is suggeted that the observedγ-to-βphase transition triggered by quite a low annealing temperature should be a rather lowered phase transition barrier of the epitaxy-stabilized In2Se3 thin-film system at a state far from thermodynamic equilibrium.

关键词： In2Se3 molecular beam epitaxy single-crystalline annealing and quench phase transition

血清MMP-8/TIMP-1水平与ACS患者心功能及预后的相关性分析

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中国现代医学杂志 2019年第2期29卷 76-81页

作者：苏佳牛小斌李永伟河南省中医院检验科河南郑州450003

目的探讨血清基质金属蛋白酶-8(MMP-8)/基质金属蛋白酶抑制剂-1(TIMP-1)与急性冠状动脉综合征(ACS)心功能及其预后的相关性。方法选取行冠状动脉造影检查者160例,其中105例确诊ACS患者作为ACS组,其余55例健康者作为对照组。比较两组血清... 详细信息

目的探讨血清基质金属蛋白酶-8(MMP-8)/基质金属蛋白酶抑制剂-1(TIMP-1)与急性冠状动脉综合征(ACS)心功能及其预后的相关性。方法选取行冠状动脉造影检查者160例,其中105例确诊ACS患者作为ACS组,其余55例健康者作为对照组。比较两组血清MMP-8、TIMP-1及左室射血分数(LVEF)。ACS组行常规治疗,PCI术后7 d再次检测血清MMP-8、TIMP-1、MMP-8/TIMP-1及LVEF,出院后随访≥1年,统计ACS组支架血栓发生率和生存率。分析ACS患者血清MMP-8/TIMP-1与LVEF、支架血栓发生率及1年生存率的关系及其预后的价值。结果与对照组比较,ACS组MMP-8、TIMP-1及MMP-8/TIMP-1水平升高,LVEF降低(P<0.05)。与术前比较,ACS组术后7 d MMP-8、TIMP-1及MMP-8/TIMP-1降低,LVEF升高(P <0.05)。ACS组随访1年支架血栓发生率和生存率分别为8.57%和85.71%。与存活患者比较,ACS组死亡患者围手术期MMP-8/TIMP-1升高,LVEF降低(P <0.05)。与无支架血栓患者比较,有支架血栓患者术期血清MMP-8/TIMP-1水平升高,LVEF降低(P <0.05)。ACS患者血清MMP-8/TIMP-1水平与LVEF和1年生存率均呈负相关(P<0.05),与其支架血栓发生率则呈正相关(P<0.05)。结论血清MMP-8/TIMP-1水平与ACS患者LVEF、支架血栓和生存预后均密切相关,可作为其病情和预后评估的参考指标。

关键词：急性冠状动脉综合征/冠状动脉疾病基质金属蛋白酶-8/肽水解酶类基质金属蛋白酶抑制剂-1/酶抑制剂心房动能心室动能预后

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu xiaojian Xu Fei niu Xinlong Dong bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

深圳市不同主要活动场所男男性行为者艾滋病高危行为特点

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热带医学杂志 2017年第10期17卷 1402-1406页

作者：刘莹刘小敏舒彬牛姬飞深圳市福田区疾病预防控制中心广东深圳518040

目的了解深圳市男男性接触者(MSM)不同主要活动场所高危行为特征,为MSM行为干预工作提供依据。方法对MSM进行问卷调查和病毒抗体检测。结果本次调查共发放问卷1 200份,收回有效问卷1 166份,有效率为97.17%。根据主要活动场所将1 166名MS... 详细信息

目的了解深圳市男男性接触者(MSM)不同主要活动场所高危行为特征,为MSM行为干预工作提供依据。方法对MSM进行问卷调查和病毒抗体检测。结果本次调查共发放问卷1 200份,收回有效问卷1 166份,有效率为97.17%。根据主要活动场所将1 166名MSM分为3组:酒吧/会所组481人,桑拿/按摩组227人,互联网组458人。互联网组家乡在城市,大学及以上学历,高收入构成比高于其他两组(P<0.05),桑拿/按摩组的在婚/同居构成比最高(P<0.05)。桑拿/按摩组跟男性发生肛交及群交时使用安全套每次都用比率最高(P<0.05),分别是68.16%和74.03%,互联网组在跟男性口交,跟确立关系男友肛交,跟一夜情男性性伴肛交和口交以及跟女友性行为时使用安全套每次都用频率最高(P<0.05)。酒吧/会所组,桑拿/按摩组,互联网组艾滋病知识知晓率分别是76.92%,79.83%,83.38%,互联网组知晓率最高(P<0.05)。结论不同主要活动场所的MSM具有不同的艾滋病高危行为,需针对不同人群采取相应的艾滋病干预策略。

关键词：男男性接触者艾滋病高危行为

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河溪近自然治理的基本模式与应用界限

水土保持学报 2002年第6期16卷 84-87,91页

作者：高甲荣肖斌牛健植北京林业大学水土保持与荒漠化教育部重点实验室北京100083 西北农林科技大学林学院陕西杨陵712100

河溪系统是流域管理中最基本和最重要的单元。在分析传统河溪治理的基础上,简要地介绍了河溪近自然治理的概念、发展和特征,提出了河溪近自然治理的原则,并对河溪近自然治理的基本模式进行了探讨。

关键词：河溪近自然治理基本模式应用界限

Burden of mental disorders and risk factors in the Western Pacific region from 1990 to 2021

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World Journal of Psychiatry 2025年第1期15卷 93-105页

作者： Ya-Xin Xu xiao-Xuan niu Wen-Chang Jia Jing Wen Xue-Lin Cheng Yan Han Ming-Hui Peng Jing Zhou Yao Liu Sun-Fang Jiang xiao-Pan Li Department of Health Management Centre Zhongshan HospitalFudan UniversityShanghai 200030China Department of General Practice Zhongshan HospitalFudan UniversityShanghai 200030China Department of Nutrition Zhongshan HospitalFudan UniversityShanghai 200032China School of Public Health Fudan UniversityShanghai 200032China

BACKGROUND The burden of mental disorders(MD)in the Western Pacific Region(WPR)re-mains a critical public health concern,with substantial variations across demogra-phics and *** To analyze the burden of MD in the WPR from 1990 to 2021,along with associated risk factors,to reveal changing trends and emerging *** We used data from the Global Burden of Disease 2021,analyzing prevalence,incidence,and disability-adjusted life years(DALYs)of MD from 1990 to *** methods included age-standardisation and uncertainty analysis to address variations in population structure and data *** Between 1990 and 2021,the prevalence of MD rose from 174.40 million cases[95%uncertainty interval(UI):160.17-189.84]to 234.90 million cases(95%UI:219.04-252.50),with corresponding DALYs increasing from 22.8 million(95%UI:17.22-28.79)to 32.07 million(95%UI:24.50-40.68).During this period,the burden of MD shifted towards older age *** and anxiety disorders were predominant,with females showing higher DALYs for depressive and anxiety disorders,and males more affected by conduct disorders,attention-deficit hyperactivity disorder,and autism spectrum ***,New Zealand,and Malaysia reported the highest burdens,whereas Vietnam,China,and Brunei Darussalam reported the ***,childhood sexual abuse and bullying,and intimate partner violence emerged as significant risk *** This study highlights the significant burden of MD in the WPR,with variations by age,gender,and *** coronavirus disease 2019 pandemic has exacerbated the situation,emphasizing the need for a coordinated response.

关键词： Mental disorders Western pacific region Global Burden of Disease Risk factors Disability-adjusted life years

种植密度及行距配置对直播油菜农艺性状和产量品质的影响

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四川农业大学学报 2017年第2期35卷 167-171页

作者：段秋宇廖方全刘士山蒲晓斌牛应泽吴永成四川农业大学农学院四川温江611130 广汉市农业局四川广汉618300 四川省农业科学院作物研究所成都610066

【目的】旨在构建四川盆地直播油菜适宜机收的高产群体结构。【方法】于2013/2014、2014/2015年选用中熟杂交油菜品种川油36,在成都平原区系统研究了不同种植密度(15×104~60×104株/hm2)及行距配置(20 cm、30 cm、40cm、40 cm+20 cm)... 详细信息

【目的】旨在构建四川盆地直播油菜适宜机收的高产群体结构。【方法】于2013/2014、2014/2015年选用中熟杂交油菜品种川油36,在成都平原区系统研究了不同种植密度(15×104~60×104株/hm2)及行距配置(20 cm、30 cm、40cm、40 cm+20 cm)对直播油菜农艺性状和产量品质的影响。【结果】种植密度对直播油菜农艺性状有重要影响,增密处理(30~60万株/hm2)可提高主序角果所占比例。随种植密度的加大(15~60万株/hm2),籽粒产量呈先升、后降趋势,密度在30万株/hm2时产量最高,继续增加密度,籽粒产量则显著降低。种植密度对籽粒品质的影响不显著。相同密度(30~36万株/hm2)下,不同行距配置(20 cm、30 cm、40 cm、40 cm+20 cm)对直播油菜农艺性状和籽粒产量均无显著影响,但较宽的行距配置(30 cm、40 cm)的主序角果数和产量均高于窄行距(20 cm),籽粒含油率则显著高于窄行距(20 cm)。【结论】在充足施肥条件下,直播油菜适宜机收和高产的种植密度为30~36万株/hm2,行距配置以等行距30~40 cm为宜,或采用宽窄行40 cm+20 cm。

关键词：直播油菜种植密度行距配置农艺性状产量品质

C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway as a therapeutic target and regulatory mechanism for spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2231-2244页

作者： Xiangzi Wang xiaofei niu Yingkai Wang Yang Liu Cheng Yang Xuyi Chen Zhongquan Qi School of Medicine Guangxi UniversityNanningGuangxi Zhuang Autonomous RegionChina Graduate School of Tianjin University of Traditional Chinese Medicine TianjinChina Characteristic Medical Center of People’s Armed Police Forces TianjinChina Fujian Maternity and Child Health Hospital FuzhouFujian ProvinceChina

Spinal cord injury involves non-reversible damage to the central nervous system that is characterized by limited regenerative capacity and secondary inflammatory *** expression of the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis exhibits significant differences before and after *** studies have revealed that the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis is closely associated with secondary inflammatory responses and the recruitment of immune cells following spinal cord injury,suggesting that this axis is a novel target and regulatory control point for *** review comprehensively examines the therapeutic strategies targeting the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis,along with the regenerative and repair mechanisms linking the axis to spinal cord ***,we summarize the upstream and downstream inflammatory signaling pathways associated with spinal cord injury and the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review primarily elaborates on therapeutic strategies that target the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the latest progress of research on antagonistic drugs,along with the approaches used to exploit new therapeutic targets within the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 axis and the development of targeted ***,there are presently no clinical studies relating to spinal cord injury that are focusing on the C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 *** review aims to provide new ideas and therapeutic strategies for the future treatment of spinal cord injury.

关键词： apoptosis C-C motif chemokine ligand 2/C-C motif chemokine receptor 2 pathway C-C motif chemokine receptor 2 antagonists chemokine ligand 2 chemokine receptor 2 inflammation macrophage microglia spinal cord injury therapeutic method

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin niu Jiafeng Fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry