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Interactions between mycoplasma lipid-associated membrane proteins and the host cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第5期7卷 342-350页

作者： YOU xiao-xing ZENG yan-hua WU Yi-mou Institute of Pathogenic Biology School of Medicine Nanhua University Hengyang 421001 China

Mycoplamas are a group of wall-less prokaryotes widely distributed in nature, some of which are pathogenic for humans and animals. There are many lipoproteins anchored on the outer face of the plasma membrane, called lipid-associated membrane proteins (LAMPs). LAMPs are highly antigenic and could undergo phase and size variation, and are recognized by the innate immune system through Toll-like receptors (TLR) 2 and 6. LAMPs can modulate the immune system, and could induce immune cells apoptosis or death. In addition, they may associate with malignant transformation of host cells and are also con-sidered to be cofactors in the progression of AIDS.

关键词： Mycoplasma Lipid-associated membrane proteins (LAMPs) Toll-like receptor (TLR) Immunomodulin

Troglitazone, a peroxisome proliferator-activated receptor γ ligand, induces growth inhibition and apoptosis of HepG2 human liver cancer cells

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World Journal of Gastroenterology 2008年第14期14卷 2168-2173页

作者： yan-Ming Zhou Yin-Hao Wen xiao-yan Kang Hai-hua Qian Jia-Mei yang Zheng-Feng Yin Department of Molecular Oncology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

AIM: To examine the effect of troglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) ligand, on the proliferation and apoptosis of human liver cancer cells. METHODS: Liver cancer cell line HepG2 was cultured and treated with troglitazone. Cell proliferation was detected by 3-(4-,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay; apoptosis was detected by flow cytometry and terminal deoxynucleotidyl transferase- mediated nick end labeling of DNA fragmentation sites (TUNEL) assay; and apoptosis-related protein was detected by immunocytochemistry and Western blotting. RESULTS: Troglitazone inhibited growth and induced apoptosis of HepG2 cells in a dose-dependent manner, and induced activation of caspase-3 expression. Troglitazone not only drove apoptosis-inhibiting factor survivin to translocate incompletely from the nucleus to the cytoplasm, but also inhibited expression of survivin, while it did not affect expression of apoptosis-promoting factor Bax. CONCLUSION: PPARγ ligands inhibit growth and induce apoptosis of liver cancer cells, and may have applications for the prevention and treatment of liver cancer.

关键词： Peroxisome proliferator-activated receptor γ Troglitazone Liver neoplasms Apoptosis

Baicalin protects neonatal rat brains against hypoxicischemic injury by upregulating glutamate transporter 1 via the phosphoinositide 3-kinase/protein kinase B signaling pathway

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Neural Regeneration Research 2017年第10期12卷 1625-1631页

作者： Zhi-qing Zhou Yong-liang Li Zhen-bo Ao Zhi-li Wen Qi-wen Chen Zheng-gang huang Bing xiao xiao-hua yan Department of Pediatrics the Second People's Hospital of Huaihua CityHuaihuaHunan ProvinceChina Department of Ontology the Second People's Hospital of Huaihua CityHuaihuaHunan ProvinceChina Department of Gastroenterology'the Second Affiliated Hospital of Nanchang University NanchangJiangxi ProvinceChina Department of Pediatrics the First Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Department of Neurosurgery the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

Baicalin is a flavonoid compound extracted from Scutellaria baicalensis *** evidence indicates that baicalin is neuroprotective in models of ischemic ***,we investigate the neuroprotective effect of baicalin in a neonatal rat model of hypoxic-ischemic ***-day-old pups underwent left common carotid artery ligation followed by hypoxia（8% oxygen at 37°C） for 2 hours,before being injected with baicalin（120 mg/kg intraperitoneally） and examined 24 hours *** effectively reduced cerebral infarct volume and neuronal loss,inhibited apoptosis,and upregulated the expression of p-Akt and glutamate transporter *** injection of the phosphoinositide 3-kinase/protein kinase B（PI3 K/Akt） inhibitor LY294002 30 minutes before injury blocked the effect of baicalin on p-Akt and glutamate transporter 1,and weakened the associated neuroprotective *** findings provide the first evidence,to our knowledge that baicalin can protect neonatal rat brains against hypoxic-ischemic injury by upregulating glutamate transporter 1 via the PI3 K/Akt signaling pathway.

关键词： nerve regeneration baicalin hypoxia ischemia PI3K/Akt signaling pathway glutamate transporter 1 excitotoxicity neonatal rats apoptosis neural regeneration

Coupling effect between film boiling heat transfer and evaporation drag around a hot-particle in cold liquid

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Nuclear Science and Techniques 2003年第3期14卷 206-211页

作者： LI xiao-yan, yanG yan-hua, XU Ji-Jun(Department of Nuclear Science and System Engineering, School of Mechanics and Power Engineering, Shanghai Jiaotong University, Shanghai 200030) Department of Nuclear Science and System Engineering School of Mechanics and Power Engineering Shanghai Jiaotong University 上海 200030

Extremely rapid evaporation could occur when high-temperature particles contact withlow-temperature liquid. This kind of phenomenon is associated with the engineering safety and the problems inhigh-transient multi-phase fluid and heat transfer. The aim of our study was to design and build an observable ex-periment facility. The first series of experiments were performed by pouring one or six high-temperature particles intoa low saturated temperature liquid pool. The particle's falling-down speed was recorded by a high-speed camera, thuswe can find the special resistant feature of the moving high-temperature particles, which is induced by the high-speedevaporation surrounding the particles. The study has experimentally verified the theory of evaporation drag model.

关键词：耦合效应薄膜状沸腾热传导蒸汽爆炸工程安全

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关于藏边盐井村的宗教与现状考察

中国藏学 2009年第4期 41-46页

作者：颜小华广西师范大学历史文化与旅游学院

盐井村隶属于西藏芒康县盐井纳西民族自治乡,当地聚居着部分藏族和纳西族群众,亦有少量汉族。历史上他们信奉藏传佛教、东巴教或天主教,形成了目前多元宗教并存的局面,为我们今天构建和谐社会背景下的宗教文化提供了一幅真实的画卷。

关键词：藏边盐井多元和谐

甘青地貌、族群、文化与宗教——来华传教士笔下的甘青社会

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兰州大学学报（社会科学版） 2010年第6期38卷 57-64页

作者：颜小华广西师范大学历史文化与旅游学院广西桂林541004

来华传教士是中西文化交往中不可忽视的一个群体,明清之际至清末民国时期有部分传教士进入甘青地区,并对当地社会风貌,包括族群、文化和宗教进行了描绘和记载,从一个有别于国人的角度来看待和分析地方社会情状,呈现出早期甘青地区中西... 详细信息

来华传教士是中西文化交往中不可忽视的一个群体,明清之际至清末民国时期有部分传教士进入甘青地区,并对当地社会风貌,包括族群、文化和宗教进行了描绘和记载,从一个有别于国人的角度来看待和分析地方社会情状,呈现出早期甘青地区中西交往的图景。

关键词：甘肃青海传教士地方社会

HYPERFINE INTERACTIONS IN CRYOGENIC NON-MAGNETIC AUSTENIC STEEL 30Mn23A14Cr5

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Chinese Science Bulletin 1989年第17期34卷 1486-1488页

作者：鄢晓华陈义龙 Department of Physics Wuhan University Wuhan Department of PhysicsBeijing Normal UniversityBeijing Department of Physics Wuhan University Wuhan

The cryogenic non-magnetic austenic steel 30Mn23Al4Cr5 with outstanding lowtemperature physical features may be used within a large temperature range and thus has wide applied prospects, but most of the studies on this steel focused on its macro properties.M(?)ssbauer spectroscopy is a useful tool for investigating the hyperfine interactions

关键词： Mssbauer spectrum hyperfine interaction electronic spin relaxation

企业职工基本养老保险基金中央调剂制度的政策效应

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上海经济研究 2019年第9期31卷 80-90页

作者：肖严华上海社会科学院经济研究所

本文构建了企业职工基本养老保险中央调剂基金的模型,就各省的人口变量、工资变量、政策变量(即上解比例)对该省调剂率的影响进行了数理推论,并对上解比例为3%和3.5%的两种情景进行了模拟测算和相关指标比较。结果发现,某一省份"净接受"... 详细信息

本文构建了企业职工基本养老保险中央调剂基金的模型,就各省的人口变量、工资变量、政策变量(即上解比例)对该省调剂率的影响进行了数理推论,并对上解比例为3%和3.5%的两种情景进行了模拟测算和相关指标比较。结果发现,某一省份"净接受"或"净贡献"的中央调剂金占中央调剂金总规模之比,即调剂率的方向和比率值的大小,取决于该省的人口变量和工资变量,而与上解比例无关。提高上解比例,并不影响各省份调剂率的方向与比率值的大小,但却提高中央调剂金总规模和各省份的净拨付额,均衡各省份当期养老基金净收入额的分布和累计结余基金的分布(大幅降低某些省份累计结余的赤字额,但对累计结余较多的省份的影响并不大),从而有效均衡了全国各省份养老保险负担,在全国各省份之间实现了有效调剂。本文建议确定中央调剂金的最适度上解比例。

关键词：基本养老中央调剂模型构建上解比例调剂率

社保减免政策对上海养老保险基金的影响及政策选择

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上海经济研究 2020年第7期32卷 58-65页

作者：肖严华上海社会科学院经济研究所 200020

本文在梳理社保减免政策的基础上,估算该减免政策对上海养老保险基金收入的影响,结果显示该影响的最低值约为580亿元,基于官方预测的估算约为800亿元。基于该估算结果,本文对上海养老保险基金的可持续性进行分析,最后提出在经济增速下... 详细信息

本文在梳理社保减免政策的基础上,估算该减免政策对上海养老保险基金收入的影响,结果显示该影响的最低值约为580亿元,基于官方预测的估算约为800亿元。基于该估算结果,本文对上海养老保险基金的可持续性进行分析,最后提出在经济增速下行周期以更大的政策力度进一步完善养老保险的相关政策建议,包括将国资划转给全国社保基金的比例由10%提高到20%,由全国社保基金最终承担影响;试点非缴费型的零支柱养老金,提高低收入群体的获得感;加快第一支柱基础养老金的全国统筹,提高对企业的激励;扩大第二支柱的个人账户占比,提高对劳动者的激励。

关键词：社保减免养老保险影响估算政策选择