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FUZZY SYNTHETIC EVAluATION ON RESIDENT'S PERCEPTIONS OF TOURISM IMPACTS——Case of Jiuzhaigou National Park, Sichuan Province, China

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Chinese Geographical Science 2006年第1期16卷 87-94页

作者： lu xiao-li WU Chun-you xiao Gui-rong School of Management Dalian University of Technology Dalian 116024 P.R.China Eaculty of Geography Environmental Studies University of Waterlao Ontaria Canada N2L 3G1

Tourism can have both positive and negative outcomes for residents in tourism destinations, It is a good method to analyze the status of tourism impact by means of investigating residents＇ perceptions of it. Various methods have been used in previous authoritative studies. However, owing to inherent imprecision, difficulties always exist in some conventional methodologies when describing the interpretation of linguistic or measured uncertainties for real-world randoln phenomena. The purpose of this research is to present the fuzzy synthetic evaluation method to investigate residents＇ perceptions of tourisln impacts. At first, basic attributes and a hierarchical framework of tourism impacts are defined and formed. Secondly, the weighted vectors are determined according to the knowledge and experience of experts. Thirdly, the weighted evaluation matrices are aggregated to get the fuzzy sets of tourism impacts. In the last stage, the final fuzzy sets are defuzzified to get the rank of the residents＇ perceptions of tourism impacts. A case study in Jiuzhaigou National Park of China is provided to demonstrate the application of this method.

关键词： residents' perceptions tourism impacts fuzzy synthetic evaluation Jiuzhaigou National Park

Congenital hepatic fibrosis in a young boy with congenital hypothyroidism:A case report

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World Journal of Clinical Cases 2021年第6期9卷 1475-1482页

作者： Fang-Fei xiao Yi-Zhong Wang Fang Dong xiao-lu li Ting Zhang Department of Gastroenterology Hepatology and NutritionShanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China

BACKGROUND Congenital hepatic fibrosis(CHF)is a rare autosomal recessive disorder characterized by variable degrees of periportal fibrosis and malformation of bile *** is generally accompanied by a variety of conditions or syndromes with other organ *** SUMMARY We report a 5-year-4-month-old Chinese boy with congenital hypothyroidism(CH)diagnosed with *** patient was diagnosed with CH by a newborn screening test and has since been taking *** has developed normally without neurocognitive *** liver function was observed in the patient at the age of 4 years and 11 mo,and elevated levels of liver function indices were persistent for 5 *** imaging indicated hepatosplenomegaly without narrowing of the portal vein but dilated splenic vein.A liver biopsy confirmed the pathological features of *** testing revealed two novel homozygous mutations,namely,c.2141-3T>C variant in PKHD1 related to CHF and c.2921G>A(p.R974H)in DUOX2 related to *** patient was treated with compound glycyrrhizin tablet,ursodeoxycholic acid,and levothyroxine after *** patient achieved a favorable clinical outcome during a follow-up period of over 2 *** Herein,we report the first case of a Chinese boy with comorbidity of CHF and CH,carrying both PKHD1 gene and DUOX2 gene novel *** biopsy and genetic testing should be considered for the diagnosis of coexistent liver disease in CH patients with unexplained abnormal liver function.

关键词： Congenital hepatic fibrosis Congenital hypothyroidism liver biopsy PKHD1 DUOX2 Case report Genetic testing

MATERIAL ELECTROMAGNETIC PARAMETERS EXTRACTION USING SVM METHOD

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Journal of Electronics(China) 2010年第4期27卷 544-547页

作者： xiao Huaibao lu guizhen li Yanfei Communication University of China Beijing 100024 China

The method extracting the electromagnetic parameters from scattering coefficients was studied in this paper. The Support Vector Machine (SVM) method is used to solve the inverse problem of parameters extraction. The mapping relationship is set up by calculating a large number of S pa-rameters from the samples with different permittivity by using transmission line theory. The simulated data set is used as training data set for SVM. After the training, the SVM is used to predict the permittivity of material from the scattering coefficients.

关键词： Support Vector Machine (SVM) Permittivity Parameters extraction Scattering parameters

Synthesis of (S)-N-(2-Ethyl-6-methylphenyl) alanine by Enzyme-catalyzed Resolution and Chemical Racemization

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Chemical Research in Chinese Universities 2009年第6期25卷 836-840页

作者： ZHENG liang-yu ZHANG Suo-qin lu xiao-li CAO Shu-gui Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education College of Chemistry Stomatological Hospital Jilin University Changchun 130021 P. R. China

A practical synthesis of （S）-N-（2-ethyl-6-methylphenyl）alanine, a key intermediate for （S）-metolachlor, was completed by means of lipase-catalyzed hydrolytic kinetic resolution and chemical racemization of the remaining ester. The effects of operating temperature and enzyme concentration on the activity and enantioselectivity of enzyme were initially studied, and it was found that the enantioselectivity of CAL-B towards the resolution was not high enough to obtain enantiomerically pure compound（E=12.1）. When diethyl ether（15%, volume fraction） was added in the reaction medium, the lipase gave an excellent enantioselectivity（E=117.8）, which is about 9.7-fold that in pure buffered aqueous solution. For overcoming the limitation of a maximum theoretical yield of 50%, the acid product was separated from the remaining ester by a simple extraction procedure and the remaining ester was racemized with aldehyde and acetic acid under microwave irradiation or conventional heating condition, The results show the microwave irradiation was more effective than the conventional heating method and gave the desired （R,S）-N-（2- ethyl-6-methylphenyl）alanine methyl ester a high yield（92%） with R/S=50/50 in 1 h.

关键词： Candida antarctica lipase B Resolution (S)-N-(2-Ethyl-6-methylphenyl)alanine Racemization

Tocilizumab promotes corneal allograft survival in rats by modulating Treg-Th17 balance

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International Journal of Ophthalmology(English edition) 2019年第12期12卷 1823-1831页

作者： xiao-Song Wu xiao-li lu Jing Wu Ming Ma Jian Yu Zhen-Yu Zhang Dpartment of Ophthalmology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Huiqiao Building Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Guangdong Women And Children Hospital Guangzhou 511400Guangdong ProvinceChina

AIM: To examine the therapeutic effects of tocilizumab on experimental corneal transplantation and its effect on Treg/Th17 balance. METHODS: Allograft corneal graft was performed between host Sprague Dawley and Wistar donor *** rats were randomly divided into four groups: normal,autograft, allograft, and allograft treated with ***-Meier was performed to draw the survival *** protein levels of interleukin-17A(IL-17A), vascular endothelial growth factor(VEGF), and forkhead box protein3(Foxp3) were measured by *** mRNA levels of IL-17A, VEGF, retinoid-related orphan receptor gammat(RORγt), interleukin-6(IL-6) and Foxp3 were detected by reverse transcription real-time polymerase chain reaction(RT-PCR). The Treg and Th17 cells were investigated by flow cytometry. RESULTS: The survival time of tocilizumab group was(24±1.27 d) longer than that of allograft group(10±0.55 d).Moreover, immunohistochemical examination revealed that IL-17A and VEGF protein levels in the allograft group were significantly higher than that of tocilizumab group(Plizumab treated group(Plizumab group(Plizumab group(Plizumab treated group was significantly higher than other groups(PluSION: These findings suggest that tocilizumab may promote corneal allograft survival, possibly by modulating Treg-Th17 balance.

关键词： tocilizumab corneal transplantation Th17/Treg rats

Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang lu Zhao-li Ding Rui Mao Gui-Gang Zhao Yu-Qi He xiao-lu li Jiang liu Department of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

Safety of fecal microbiota transplantation in Chinese children: A single-center retrospective study

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World Journal of Clinical Cases 2018年第16期6卷 1121-1127页

作者： Xin-Yue Zhang Yi-Zhong Wang xiao-lu li Hui Hu Hai-Feng liu Dan li Yong-Mei xiao Ting Zhang Department of Gastroenterology Hepatology and Nutrition Shanghai Children's Hospital Shanghai Jiao Tong University

BACKGROUND Fecal microbiota transplantation(FMT) is the administration of fecal bacterial liquid from healthy donors to a recipient's digestive tract, which is recommended as a therapeutic method for recurrent Clostridium difficile infection(CDI). Many clinical trials focusing on different diseases are in progress. To date, scarce research and long-term follow-up have been conducted on FMT in children or on the proper guidelines. Our center first performed FMT to treat a 13-month-old boy with severe CDI in 2013. Until February 2018, our center had performed 114 pediatric FMT procedures in 49 subjects. AIM To investigate the safety of FMT in children. METHODS A retrospective study was conducted on 49 patientswho underwent 114 FMT treatments at our hospital. All FMT processes followed uniform standards. Adverse events(AEs) related to FMT were divided into shortterm(48 h post-FMT) and long-term(3 mo). All potential influencing factors for AEs, such as gender, age, time of FMT infusion, route of administration, disease type, immune function state, and donor relative genetic background, were analyzed as independent factors. The significant independent factors and risk ratio with 95% confidence interval(CI) were assessed by multivariate logistic regression *** Forty-nine patients(mean age 68.1 mo, range 4 to 193 mo) were recruited. Their average follow-up time after the first FMT was 23.1 mo. The incidence of short-term AEs was 26.32%(30/114). The most common shortterm AEs were abdominal pain, diarrhea, fever, and vomiting, which were all self-limited and symptom-free within 48 h. Two severe AEs occurred, and one patient died in the fourth week after FMT. All-cause mortality was 2.04%. As independent factors, age(P = 0.006) and immune state(P = 0.002) had significant effects. Age greater than 72 mo seemed to be correlated with more AEs than age 13 to 36 mo(P = 0.04). In multivariate logistic regression analysis, immune state was an independent risk factor for

关键词： Safety Fecal microbiota transplantation Pediatrics Adverse event Immune system diseases Age factors

Comprehensive Analysis of Key mRNAs and lncRNAs in Osteosarcoma Response to Preoperative Chemotherapy with Prognostic Values

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Current Medical Science 2021年第5期41卷 916-929页

作者： Mi li Wei-ting CHENG Hao li Zhi ZHANG xiao-li lu Si-si DENG Jian li Cai-hong YANG Department of Orthopedics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Oncology Department Wuhan No.1 Hospital Wuhan 430030China Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute of Experimental Immunology University Clinic of Rheinische Friedrich-Wilhelms-UniversityBonn D-53127Germany

Objective:Osteosarcoma is one of the most common types of bone sarcoma with a poor ***,identifying the predictive factors that contribute to the response to neoadjuvant chemotherapy remains a significant ***:A public data series(GSE87437)was downloaded to identify differentially expressed genes(DEGs)and differentially expressed lncRNAs(DElncRNAs)between osteosarcoma patients that do and do not respond to preoperative ***,functional analysis of the transcriptome expression profile,regulatory networks of DEGs and DElncRNAs,competing endogenous RNAs(ceRNA)and protein-protein interaction networks were ***,the function,pathway,and survival analysis of hub genes was performed and drug and disease relationship prediction of DElncRNA was carried ***:A total of 626 DEGs,26 DElncRNAs,and 18 hub genes were ***,only one gene and two lncRNAs were found to be suitable as candidate gene and lncRNAs ***:The DEGs,hub genes,candidate gene,and candidate lncRNAs screened out in this context were considered as potential biomarkers for the response to neoadjuvant chemotherapy of osteosarcoma.

关键词： osteosarcoma preoperative chemotherapy competing endogenous RNAs differentially expressed genes survival analysis

Management of venous stenosis in living donor liver transplant recipients

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World Journal of Gastroenterology 2009年第39期15卷 4969-4973页

作者： Jie Yang Ming-Qing Xu lu-Nan Yan Wu-Sheng lu xiao li Zheng-Rong Shi Bo li Tian-Fu Wen Wen-Tao Wang Jia-Ying Yang Department of liver and Vascular Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

AIM:To retrospectively evaluate the management and outcome of venous obstruction after living donor liver transplantation(LDLT).METHODS:From February 1999 to May 2009,1 intraoperative hepatic vein(HV) tension induced HV obstruction and 5 postoperative HV anastomotic stenosis occurred in 6 adult male LDLT *** portal vein(PV) anastomotic stenosis occurred in 1 pediatric left lobe *** ranged in age from 9 to 56 years(median,44 years).An air balloon was used to correct the intraoperative HV *** surgical reoperation,transjugular HV balloon dilatation with stent placement and transfemoral venous HV balloon dilatation was performed for HV stenosis on days 3,15,50,55,and 270 after LDLT,*** dilatation followed with stent placement via superior mesenteric vein was performed for the pediatric PV stenosis 168 d after ***:The intraoperative HV tension was corrected with an air *** recipient who underwent emergent reoperation for hepatic stenosis died of hemorrhagic shock and renal failure 2 d *** balloon dilatation via the transjugular and transfemoral venous approach was technically successful in all *** patient with early-onset HV stenosis receiving transjugular balloon dilatation and stent placement on the 15th postoperative day left hospital 1 wk later and disappeared,while the patient receiving the same interventional procedures on the 50th postoperative day died of graft failure and renal failure 2 wk *** patients with late-onset HV stenosis receiving balloon dilatation have survived for 8 and 4 mo without recurrent stenosis and ascites,*** dilatation and stent placement via the superior mesenteric venous approach was technically successful in the pediatric left lobe LDLT,and this patient has survived for 9 mo without recurrent PV stenosis and ***:Intraoperative balloon placement,emergent reoperation,proper interventional balloon dilatation and

关键词： living donor liver transplantation Venous obstruction Anastomotic stenosis Venoplasty Stent