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Midkine promotes perineural invasion in human pancreatic cancer

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World Journal of Gastroenterology 2014年第11期20卷 3018-3024页

作者： Jun Yao Wen-Yao Li Shuo-Guo Li xiao-shan feng She-Gan Gao Department of Oncology First Affiliated HospitalHenan University of Science and Technology

AIM: To investigate midkine (MK) and syndecan-3 protein expression in pancreatic cancer by immunohistochemistry, and to analyze their correlation with clinicopathological features, perineural invasion, and prognosis.

关键词： Midkine Syndecan-3 Pancreatic cancer Neurite growth Perineural invasion

Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis

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World Journal of Gastroenterology 2014年第22期20卷 6906-6911页

作者： Shi-Yong Xin xiao-shan feng Li-Qing Zhou Jun-Jun Sun xiao-Le Gao Guo-Liang Yao Department of Urology First Affiliated Hospital of Henan University of Science and Technology Department of Surgical Oncology First Affiliated Hospital of Henan University of Science and Technology Department of Rheumatism Immunity Branch First Affiliated Hospital of Henan University of Science and Technology Department of General Surgery First Affiliated Hospital of Henan University of Science and Technology

AIM:To investigate the expression of microRNA-218(miR-218)in serum from gastric cancer patients and its relationship with clinicopathological ***:A total of 68 patients with pathologically diagnosed gastric cancer and 56 healthy individuals were recruited to this *** expression of miR-218was detected in the serum of gastric cancer patients and healthy individuals by quantitative real-time polymerase chain *** clinical data were collectedand analyzed by statistical ***:miR-218 was reduced significantly in the serum of gastric cancer patients compared to healthy individuals(1.15±0.08 vs 0.37±0.023;P=0.026).In the gastric cancer group,serum expression of miR-218was lower in patients with metastasis and poorly differentiated cancer compared with non-metastatic and well-differentiated cancer(0.19±0.011 vs 0.45±0.021,P=0.031 and 0.21±0.019 vs 0.49±0.021,P=0.025).Serum miR-218 was found to be significantly associated with gastric cancer metastasis(P=0.003),tumor T stage(P=0.018)and tumor grade(P=0.012).Low serum expression of miR-218 was related to an increase in the stage of gastric *** expression level of miR-218 in the serum was correlated with the3-year ***-seven percent of patients with a high level of miR-218 expression survived for 3 years,while only 54%of those with low miR-218 expression ***:miR-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage,grade and *** expression of miR-218 may be a prognostic marker.

关键词： Gastric cancer microRNA-218 Invasion Prognosis

Effect of different fertilizers on methane emission from a paddy field of Zhejiang, China

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Journal of Environmental Sciences 1999年第4期11卷 457-461页

作者： Ibrahim Traore, SHEN Dong\|sheng, MIN Hang, CHEN Mei\|ci, feng xiao\|shan (Department of Environmental Sciences, Zhejiang University,Hangzhou 310029, China) 浙江大学环境保护系浙江杭州浙江农业大学环境保护系浙江杭州

Methane emissions from Chinese paddy soil (Zhejiang Province) were measured over the rice growing seasons. Different fertilizers (organic and chemical) were applied, emissions of methane were high during two periods(5 days after peak tillering and 7 days after heading flowering stage) and significant effect of fertilizers was observed. Methanogenic activities in soils treated with organic manures were obviously higher than those with chemical fertilizers. Among the organic manured fields the maximum methane emission from green manure, biogas residue and beef manure treatment were 52, 20 and 19 times respectively of that given by control, and among chemical fertilizers it was NH\-4HCO\-3>CO(NH 2) 2>(NH 4) 2SO 4>NH 4Cl>NaNO 3 with 2\^4, 2, 1\^5,1\^3 and 0\^2 times respectively of that from control.

关键词： methane emission field methanogenic flora flooded rice organic and chemical fertilizer

Botulinum toxin A inhibits salivary secretion of rabbit submandibular gland

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International Journal of Oral Science 2013年第4期5卷 217-223页

作者： xiao-feng shan Hui Xu Zhi-Gang Cai Li-Ling Wu Guang-Yan Yu Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Department of Physiology and Pathophysiology Peking University Health Science Center

Botulinum toxin A （BTXA） has been used in several clinical trials to treat excessive glandular secretion; however, the precise mechanism of its action on the secretory function of salivary gland has not been fully elucidated. In this study, we aimed to investigate the effect of BTXA on secretion of submandibular gland in rabbits and to identify its mechanism of action on the secretory function of salivary gland. At 12 weeks after injection with 5 units of BTXA, we found a significant decrease in the saliva flow from submandibular glands, while the salivary amylase concentration increased. Morphological analysis revealed reduction in the size of acinar cells with intracellular accumulation of secretory granules that coalesced to form a large ovoid structure. Expression of M3-muscarinic acetylcholine receptor （M3 receptor） and aquaporin-5 （AQP5） mRNA decreased after BTXA treatment, and distribution of AQP5 in the apical membrane was reduced at 1, 2 and 4 weeks after BTXA injection. Furthermore, BTXA injection was found to induce apoptosis of acini. These results indicate that BTXA decreases the fluid secretion of submandibular glands and increases the concentration of amylase in saliva. Decreased expression of M3 receptor and AQP5, inhibition of AQP5 translocation, and cell apoptosis might involve in BTXA-reduced fluid secretion of submandibular lands.

关键词： aquaporin-5 apoptosis botulinum toxin A M3-muscarinic acetylcholine receptor submandibular gland

Therapeutic effects of combined oxaliplatin and S-1 in older patients with advanced gastric cardiac adenocarcinoma

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World Journal of Gastroenterology 2011年第47期17卷 5221-5226页

作者： She-Gan Gao Rui-Nuo Jia xiao-shan feng Xuan-Hu Xie Tan-You shan Li-Xian Pan Na-Sha Song Yu-feng Wang Kai-Li Ding Li-Dong Wang Department of Oncology First-Affiliated HospitalCancer Institute Henan University of Science and TechnologyLuoyang 471003 Henan Province China Henan Key Laboratory for Esophageal Can-cer Laboratory for Cancer Research Basic Medical CollegeZhengzhou University Zhengzhou 450052 Henan ProvinceChina

AIM:To evaluate the effects and safety of combination chemotherapy with oxaliplatin (L-OHP) and S-1 (SOX regimen) in older patients with advanced gastric cardiac adenocarcinoma (GCA). METHODS: Seventy patients with advanced GCA were classified according to age into an older group (≥ 75 years) and a control group ( 0.05). CONCLUSION: The SOX regimen is an effective, safe and well-tolerated regimen for older patients with advanced GCA.

关键词： Gastric cardiac adenocarcinoma Oxalipla-tin S-1 Treatment effect

Precise Mandibular Reconstruction with the Iliac Flap Using Series of Digital Surgical Guides

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Precise Mandibular Reconstruction with the Iliac Flap Using ...

Laparoscopic Partial Nephrectomy by Diode Laser with Highly Selective Clamping of Segmental Renal Arterial

2019第一届全国口腔颌面-头颈肿瘤学术大会——聚合引领、协同发展

作者：康一帆 xiao feng shan LEI Zhang ZHI GangCai Peking University School and Hospital of Stomatology Department of Oral and Maxillofacial Surgery

Objective: Evaluate the accuracy of the iliac flap in reconstructing mandibular defects under the guidance of a series of digital surgical *** and Methods: a retrospective review of 7 patients with mandibular defects reconstructed with an iliac flap under the guidance of a series of digital surgical guides at the Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology from September 2017 to June 2018. The virtual surgical planning(VSP) was done pre-operatively. A resin stereo model was printed for pre-bending the titanium plate. The pre-bent titanium plate and the stereo model were three-dimensional(3D) scanned to obtain the relative positions of the titanium plate and the mandible. Based on the above information, design the series of surgical guide for the osteotomy and shaping to accurately transfer the information of VSP to the surgery. Deviation distribution after 3D comparison was used to evaluate the accuracy of the surgery.

关键词： Precise Mandibular Reconstruction with the Iliac Flap Using Series of Digital Surgical Guides VSP

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Chinese Medical Journal 2015年第16期128卷 2262-2264页

作者： xiao-feng Zhou Zhen-shan Ding Jian-feng Wang Xing Chen Zi-Lin Fang Nai-Bo Liu Guan Zhang Pei-Yu Zhao Department of Urology China-Japan Friendship Hospital Beijing 100029 China

INTRODUCTION The treatment of small renal masses has shifted from radical nephrectomy to partial nephrectomy, in particular, laparoscopic partial nephrectomy. Renal artery clamping is often necessary to minimize hemorrhage during resection in cases of partial nephrectomy. However, renal artery clamping may lead to greater incidence of renal malfunction after partial nephrectomy. Therefore, novel techniques which could both avoid renal artery occlusion and achieve adequate hemostasis are urgently required. Selective renal segmental artery clamping was one of several common methods that could achieve ＂zero ischemia.＂ At the same time, a number of reports about laser-assisted partial nephrectomy on humans using multiple kinds of outstanding coagulative specialties of lasers were published.

关键词： Diode Laser Highly Selective Clamping Partial Nephrectomy

Histochemical studies on intestinal metaplasia adjacent to gastric cardia adenocarcinoma in subjects at high-incidence area in Henan, north China

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World Journal of Gastroenterology 2005年第30期11卷 4634-4637页

作者： She-Gan Gao Li-Dong Wang Zong-Min Fan Ji-Lin Li Xin He Rui-feng Guo Dong-Ling Xie Xin-Wei He shan-shan Gao Hua-Qin Guo Jun-Kuan Wang xiao-shan feng Bao-Gen Ma Laboratory for Cancer Research College of Medicine Zhengzhou University Zhengzhou 450052 Henan Province China Department of Pathology Linzhou Esophageal Cancer Hospital Linzhou Henan Province China Dep-artment of Clinical Oncology The First Affiliated Hospital of Henan Science and Technology University Luoyang 471001 Henan Province China Department of Oncology Henan Tumor Hospital Zhengzhou 450003 Henan Province China

AIM： To characterize the histochemical type and pattern of intestinal metaplasia （IM） adjacent to gastric cardia adenocarcinoma （GCA） and distal gastric cancer （GC） in Unzhou, Henan Province, China. METHODS： Alcian-blue-periodic acid Schiff and high iron diamine-Alcian blue histochemical methods were performed on 142 cases of IM, including 49 cases of GCA and 93 cases of GC. All the patients were from Linzhou, Henan Province, China, the highest incidence area for both GCA and squamous cell carcinoma. Radio- or chemotherapy was not applied to these patients before surgery. RESULTS： The detection rate of IM in tissues adjacent to GCA tissues was 44.9%, which was significantly lower than that in GC tissues （80.64%, P〈0.01）. The rates of both incomplete small intestinal and colonic IM types identified by histochemistry in GCA tissues （31.82% and 63.64%, respectively） were significantly higher than those in GC （5.33% and 21.33%, respectively, P〈0.01）. CONCLUSION： IM in GCA and GC should be considered as a separate entity. Further research is needed to evaluate whether neoplastic progression of IM is related to its mucin profile in GCA.

关键词： Gastric cardia Intestinal metaplasia Histochemistry

氧化铜-过氧化聚吡咯-还原氧化石墨烯复合膜修饰电极非酶检测葡萄糖

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分析测试学报 2017年第8期36卷 969-974页

作者：于浩陈小霞冯晓王姗姗金君延安大学化学与化工学院延安市分析技术与检测重点实验室陕西延安716000

先以氧化石墨烯(Graphen oxide,GO)为阴离子掺杂剂,采用电化学聚合法制备了聚吡咯-氧化石墨烯复合膜(PPy-GO)。分别在0.10 mol/L Na Cl和0.10 mol/L NaOH溶液中对其进行还原和过氧化处理,制得过氧化聚吡咯-还原氧化石墨烯复合膜(OPPy-ER... 详细信息

先以氧化石墨烯(Graphen oxide,GO)为阴离子掺杂剂,采用电化学聚合法制备了聚吡咯-氧化石墨烯复合膜(PPy-GO)。分别在0.10 mol/L Na Cl和0.10 mol/L NaOH溶液中对其进行还原和过氧化处理,制得过氧化聚吡咯-还原氧化石墨烯复合膜(OPPy-ERGO)。再以此OPPy-ERGO复合膜为载体,采用电化学沉积法制备了氧化铜-过氧化聚吡咯-还原氧化石墨烯复合膜修饰电极(CuO-OPPy-ERGO/CCE)。通过扫描电镜和电化学方法对此电极进行表征,研究了葡萄糖在此修饰电极上的电化学行为。结果表明,此电极对葡萄糖的电氧化过程表现出高的催化活性和良好的抗干扰能力。在0.20 mol/L NaOH溶液中,安培法检测葡萄糖的线性范围为5.0×10^(-7)~1.0×10^(-3)mol/L,检出限(3Sb)为2.0×10^(-7)mol/L,灵敏度为121.8μA/(mmol·L^(-1))。该电极用于血清中葡萄糖含量的测定,加标回收率为96.0%~110.1%。

关键词：氧化铜过氧化聚吡咯还原氧化石墨烯葡萄糖电催化