Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis

作     者：Shi-Yong Xin Xiao-Shan Feng Li-Qing Zhou Jun-Jun Sun Xiao-Le Gao Guo-Liang Yao 

作者机构：Department of UrologyFirst Affiliated Hospital of Henan University of Science and Technology Department of Surgical OncologyFirst Affiliated Hospital of Henan University of Science and Technology Department of Rheumatism Immunity BranchFirst Affiliated Hospital of Henan University of Science and Technology Department of General SurgeryFirst Affiliated Hospital of Henan University of Science and Technology 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2014年第20卷第22期

页      面：6906-6911页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by A grant from Liaoning Provincial Science and Technology Plan Foundation No.2011225013 

主　　题：Gastric cancer microRNA-218 Invasion Prognosis 

摘      要：AIM:To investigate the expression of microRNA-218(miR-218)in serum from gastric cancer patients and its relationship with clinicopathological ***:A total of 68 patients with pathologically diagnosed gastric cancer and 56 healthy individuals were recruited to this *** expression of miR-218was detected in the serum of gastric cancer patients and healthy individuals by quantitative real-time polymerase chain *** clinical data were collectedand analyzed by statistical ***:miR-218 was reduced significantly in the serum of gastric cancer patients compared to healthy individuals(1.15±0.08 vs 0.37±0.023;P=0.026).In the gastric cancer group,serum expression of miR-218was lower in patients with metastasis and poorly differentiated cancer compared with non-metastatic and well-differentiated cancer(0.19±0.011 vs 0.45±0.021,P=0.031 and 0.21±0.019 vs 0.49±0.021,P=0.025).Serum miR-218 was found to be significantly associated with gastric cancer metastasis(P=0.003),tumor T stage(P=0.018)and tumor grade(P=0.012).Low serum expression of miR-218 was related to an increase in the stage of gastric *** expression level of miR-218 in the serum was correlated with the3-year ***-seven percent of patients with a high level of miR-218 expression survived for 3 years,while only 54%of those with low miR-218 expression ***:miR-218 is deregulated in gastric cancer patients and is strongly correlated with tumor stage,grade and *** expression of miR-218 may be a prognostic marker.