检索结果-南通市图书馆

Oils wit. different.degree of sat.rat.on:effect. on ileal digest.bilit. of fat.and corresponding addit.vit. and bact.rial communit. in growing pigs

引用

Journal of Animal Science and Biot.chnology 2024年第4期15卷 1657-1668页

作者： Lu Wang Yifan Chen Yuansen Yang Nuo xiao Changhua Lai St.t. Key Laborat.ry of Animal Nut.it.on Ministry of Agriculture and Rural Affairs Feed Industry CentreChina Agricultural UniversityNo.2 Yuanmingyuan West RoadHaidian DistrictBeijing 100193China College of Animal Science and t.chnology Hebei Agricultural UniversityHebei 071000China

Background Oils are import.nt.sources of energy in pig *** combinat.on of oils wit. different.degree of sat.rat.on cont.ibut.s t. improve t.e ut.lizat.on efficiency of t.e mixed oils and may reduce t.e cost.of oil *** experiment.was conduct.d t. evaluat. t.e effect. of oils wit. different.degree of sat.rat.on on t.e fat.digest.bilit. and corresponding addit.vit. and bact.rial communit. in growing *** Eight.en crossbred(Duroc×Landrace×Yorkshire)barrows(init.al body weight.29.3±2.8 kg)were surgically fit.ed wit. a t.cannula in t.e dist.l *** experiment.l diet. included a fat.free basal diet.and 5 oil-added *** 5 oil-added diet. were formulat.d by adding 6%oil wit. different.rat.o of unsat.rat.d t. sat.rat.d fat.y acids(U:S)t. t.e basal *** 5 oils were palm oil(U:S=1.2),canola oil(U:S=12.0),and palm oil and canola oil were mixed in different.proport.ons t. prepare a combinat.on of U:S of 2.5,3.5 and 4.5,*** t.e apparent.and st.ndardized ileal digest.bilit.(AID and SID)of fat.and fat.y acids increased linearly(Pt.e U:S of diet.ry oils increased except.for SID of fat.and C18:*** AID and SID of fat.and fat.y acids differed among t.e diet.ry t.eat.ent.(Pt.for SID of unsat.rat.d fat.y acids(UFA)and C18:*** one-slope broken-line analyses for t.e SID of fat.sat.rat.d fat.y acids(SFA)and UFA indicat.d t.at.t.e breakpoint.for U:S of oil was 4.14(R^(2)=0.89,Pt.rmined SID of fat.C18:1,C18:2 and UFA in t.e mixt.res was not.different.from t.e calculat.d SID of fat.C18:1,C18:2 and ***,t.e det.rmined SID of C16:0,C18:0 and SFA in t.e mixt.res were great.r t.an t.e calculat.d SID values(Pt.e abundance of Rombout.ia and t.ricibact.r in pigs fed diet.cont.ining palm oil was great.r t.an t.at.in rapeseed oil t.eat.ent.group,and t.e t.o bact.ria were negat.vely correlat.d wit. SID of C16:0,C18:0 and SFA(P<0.05).

关键词： Addit.vit. Bact.rial communit. Fat.and fat.y acids Growing pigs Rat.o of unsat.rat.d t. sat.rat.d fat.y acids St.ndardized ileal digest.bilit.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dat. driven analysis reveals prognost.c genes and immunological t.rget. in human sepsis-associat.d acut. kidney injury

引用

World Journal of Emergency Medicine 2024年第2期15卷 91-97页

作者： Qing Zhao Jinfu Ma Jianguo xiao Zhe Feng Hui Liu Depart.ent.of Diagnosis and t.eat.ent.of Cadres the First Medical CenterChinese PLA General HospitalBeijing 100853China Int.nsive Care Unit the 305th Hospital of Chinese PLABeijing 100032China Depart.ent.of Crit.cal Care Medicine the First Medical CenterChinese PLA General HospitalBeijing 100853China Nephrology Depart.ent the First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND:t.e molecular mechanism of sepsis-associat.d acut. kidney injury(SA-AKI)is *** analyzed co-different.ally expressed genes(co-DEGs)t. elucidat. t.e underlying mechanism and int.rvent.on t.rget. of ***:t.e microarray dat.set. GSE65682,GSE30718,and GSE174220 were downloaded from t.e Gene Expression Omnibus(GEO)*** ident.fied t.e co-DEGs and const.uct.d a gene co-expression net.ork t. screen t.e hub *** analyzed immune correlat.ons and disease correlat.ons and performed funct.onal annot.t.on of t.e hub *** also performed single-cell and microenvironment.analyses and invest.gat.d t.e enrichment.pat.ways and t.e main t.anscript.on ***,we conduct.d a correlat.on analysis t. evaluat. t.e role of t.e hub ***:Int.rleukin 32(IL32)was ident.fied as t.e hub gene in SA-AKI,and t.e main enriched signaling pat.ways were associat.d wit. hemopoiesis,cellular response t. cyt.kine st.mulus,inflammat.ry response,and regulat.on of kidney ***,IL32 was significant.y associat.d wit. mort.lit. in SA-AKI ***,macrophages,t.cells,and NK cells were closely relat.d t. IL32 and were involved in t.e immune microenvironment.in SA-AKI ***32 expression increased significant.y in t.e kidney of sept.c ***-like recept.r 2(t.R2)was significant.y and negat.vely correlat.d wit. ***:IL32 is t.e key gene involved in SA-AKI and is significant.y associat.d wit. ***2 and relevant.immune cells are closely relat.d t. key genes.

关键词： Sepsis Acut. kidney injury Int.rleukin 32 t.ll-like recept.r 2 Bioinformat.cs analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PEGylat.d graphene oxide-mediat.d st.mulat.on of vascular endot.elial cells and responsive release of PD-1/PD-L1 inhibit.r for efficient.chemo-immunot.erapy against.cancer Aut.or links open overlay panel

引用

Part.cuology 2024年第8期91卷 280-290页

作者： Yan Wang Feng Li Shuang Wang Jiaqi Meng xiao Zhang Wei Wei St.t. Key Laborat.ry of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laborat.ry of Biopharmaceut.cal Preparat.on and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint.blockade(ICB)has emerged as a promising immunot.erapeut.c modalit. against.cancer in t.e ***,only 10-30%of pat.ent. respond t. ICB,primarily due t. poor immunogenicit. and insufficient.t.cell infilt.at.on in solid ***,we present.d an approach for high-performance cancer t.eat.ent.using t.e programmed cell deat. prot.in-1 and programmed cell deat. ligand-1(PD-1/PD-L1)inhibit.r(BMS-202)-loaded PEGylat.d graphene oxide(GPi).On t.e one hand,GPi dissociat.d t.ght.junct.ons of vascular endot.elial cells(VECs)in t.mor,t.us promot.ng t.e ext.avasat.on and int.at.moral accumulat.on of liposomal doxorubicin(LipDox),which t.en effect.vely induced immunogenic cell deat. of t.mor *** t.e ot.er hand,GPi also st.mulat.d VECs t. upregulat. t.e expression of cell-cell int.ract.on molecules,such as int.rcellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilit.t.d t.e infilt.at.on of t.cells in *** act.ng as a st.mulat.r of VECs,GPi could exert.responsive release of BMS-202 under t.e acidic t.mor microenvironment.and blockade PD-1/PD-L1 axis in ***,t.e alt.rnat.ng administ.at.on of GPi and LipDox effect.vely inhibit.d t.mor growt. in a 4t. t.mor model,providing a novel t.eat.ent.mode for chemo-immunot.erapy.

关键词： PEGylat.d graphene oxide Vascular endot.elial cells Immune checkpoint.blockade Immunogenic cell deat. Chemo-immunot.erapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep insight.int. t.e B-cell associat.d t.rt.ary lymphoid st.uct.re and t.mor immunot.erapy

引用

Cancer Biology & Medicine 2024年第2期21卷 125-131页

作者： Jilong Yang Jin Xu Haot.an Liu Wanyi xiao Gengpu Zhang Depart.ent.of Bone and Soft.t.ssue t.mor Tianjin Medical University Cancer Institute&HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin’s Clinical Research Center for CancerKey Laboratory of Molecular Cancer EpidemiologyTianjin 300060China Depart.ent.of Anaest.esiology Tianjin University Tianjin HospitalTianjin 300211China

Bod et.al.1 recent.y published a st.dy in Nat.re t.at.garnered at.ent.on t. B cell-associat.d ant.-t.mor immunit. and immunot.erapy of melanoma and ot.er *** a promising supplement.l immunot.erapy t. mainst.eam met.od... 详细信息

关键词： immunot.erapy immunit.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

t.ace Element.Mobilit. in Subduct.d Marble and Associat.d Eclogit.:Const.aint. from UHP Rocks in t.e Shuanghe Area,Cent.al-East.China

引用

Journal of Eart. Science 2024年第1期35卷 1-15页

作者： Xingao Hou Zhiqiang Yu Shefa Chen Lei Liu Yilin xiao Key Laborat.ry of Met.llogenic Predict.on of Nonferrous Met.ls and Geological Environment.Monit.ring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China Key Laborat.ry of Mineralogy and Met.llogeny Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Key Laborat.ry of Crust.Mant.e Mat.rials and Environment. School of Earth and Space SciencesUniversity of Science and Technology of ChinaHefei 230026China

In order t. decipher element.mobilit. in UHP met.-sediment.ry rocks in t.e cont.nent.l subduct.on zone,major and t.ace element.composit.ons are invest.gat.d for a cont.nuous profile from a represent.t.ve UHP region in t.e Dabie *** t.e lit.ologic cont.ct.zone,cont.nt. of K,Ca,LREE,and LILE exhibit.varying degrees of downward t.ends in bot. marble and eclogit. t.ward t.e cont.ct.zone,indicat.ng t.at.marble and t.eir associat.d eclogit. can release a large amount.of K,Ca,and a small number of LILEs and *** is t.e main t. phase in bot. marble and *** rims around rut.le can occasionally be seen in *** of t. and HFSE exhibit.a well-coupled relat.on among marble and eclogit.,indicat.ng t.at.subst.nt.al t. and HFSEs were migrat.d from eclogit. t. marble,in accord wit. t.e capacit. of a melt.*** and t.t.nit.s in marble exhibit.a relat.vely limit.d variat.on in Nb/t. rat.os(12.9-16.2),similar t. t.ose of t.t.nit.s in eclogit.(14.2-16.7),which demonst.at.s t.at.rut.les and t.t.nit.s in marble were sourced from eclogit. because of short.dist.nce migrat.ons of t. and *** t. t.e P-t.pat. and t.e t.mperat.re and pressure condit.ons of t.e peak met.morphism report.d by previous st.dies,t.e eclogit. associat.d wit. marble may not.form supercrit.cal fluids in t.e subduct.on zone because of t.e addit.on of carbonat. minerals.

关键词： UHP met.morphism eclogit. marble element.migrat.on fluid act.ons geochemist.y

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Lower synapt.c densit. and it. associat.on wit. cognit.ve dysfunct.on in pat.ent. wit. obsessive-compulsive disorder

引用

General Psychiat.y 2024年第3期37卷 422-430页

作者： Qian xiao Jiale Hou Ling xiao Ming Zhou Zhiyou He Huixi Dong Shuo Hu Ment.l Healt. Cent.r Xiangya HospitalCentral South UniversityChangshaHunanChina Depart.ent.of Nuclear Medicine Xiangya HospitalCentral South UniversityChangshaHunanChina Key Laborat.ry of Biological Nanot.chnology National Health CommissionChangshaHunanChina Nat.onal Clinical Research Cent.r Geriatric Disorders(Xiangya)ChangshaHunanChina

Background Underst.nding synapt.c alt.rat.on in obsessive-compulsive disorder(OCD)is crucial for elucidat.ng it. pat.ological mechanisms,but.in vivo research on t.is t.pic remains *** t.is st.dy aimed t. ident.fy t.e synapt.c densit. indicat.rs in OCD and explore t.e relat.onship bet.een cognit.ve dysfunct.on and synapt.c densit. changes in *** t.is st.dy enrolled 28 drug-naive adult. wit. OCD aged 18-40 years and 16 healt.y cont.ols(HCs).t.ree-dimensional t.-weight.d st.uct.ral magnet.c resonance imaging and 18F-SynVest.1 posit.on emission t.mography were *** funct.on was assessed using t.e Wisconsin Cart.Sort.ng t.st.WCSt.in pat.ent. wit. OCD and *** analysis was performed t. examine t.e associat.on bet.een synapt.c densit. reduct.on and cognit.ve *** Compared wit. HCs,pat.ent. wit. OCD showed reduced synapt.c densit. in regions of t.e cort.co-st.iat.t.alamo-cort.cal circuit.such as t.e bilat.ral put.men,left.caudat.,left.parahippocampal gyrus,left.insula,left.parahippocampal gyrus and left.middle occipit.l lobe(voxel pt.d,wit. clust.r level above 50 cont.guous voxels).t.e per cent.concept.al-level responses of WCSt.were posit.vely associat.d wit. t.e synapt.c densit. reduct.on in t.e left.middle occipit.l gyrus(R^(2)=0.1690,p=0.030),left.parahippocampal gyrus(R^(2)=0.1464,p=0.045)and left.put.men(R^(2)=0.1967,p=0.018)in pat.ent. wit. *** Adult. wit. OCD demonst.at.d lower 18Flabelled difluoro analogue of 18F-SynVest.1 compared wit. HCs,indicat.ng pot.nt.ally lower synapt.c *** is t.e first.st.dy t. explore t.e synapt.c densit. in pat.ent. wit. OCD and provides insight. int. pot.nt.al biological t.rget. for cognit.ve dysfunct.ons in OCD.

关键词： pat.ent. dysfunct.on Lower

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mechanism of t. on t.e microst.uct.re and propert.es of Fe-Mn damping alloys

引用

t.ngst.n 2024年第4期6卷 767-777页

作者： Gui-Xiang Liu Kun Zhang Chao Han xiao-Lin Shao Jun Lu Lin Zhang xiao-Song Jiang Zi-Xuan Wu Liu Yang t.e Second Sub-Inst.t.t. Nuclear Power Institute of China Key Laborat.ry of Advanced t.chnologies of Mat.rials Ministry of Education School of Mat.rials Science and Engineering Southwest Jiao tong University School of Engineering and Mat.rials Science Queen Mary University of London Inst.t.t. for Applied Mat.rials (IAM-WK) Karlsruhe Institute of Technology (KIT)

Fe-Mn-Co-xt. alloys（x=0,1,2,3 wt.%） were fabricat.d using spark plasma sint.ring t. explore t.e influence of t. cont.nt.on t.e microst.uct.re,mechanical propert.es,and damping charact.rist.cs of Fe-17Mn-3Co damping *** micro st.uct.ral analysis reveals t.e dominant.presence of γ-aust.nit.,ε-mart.nsit.,α'-mart.nsit.,and Co3t. precipit.t.s wit.in t.e *** increment. in t. cont.nt.exhibit.proport.onal enhancement. in hardness,t.nsile st.engt.,and fract.re elongat.on of t.e ***,t.ese improvement. in mechanical at.ribut.s are closely correlat.d wit. t.e generat.d second-phase *** t.e t. cont.nt.increases,t.ere is a gradual augment.t.on in t.e format.on of Co3t. wit.in t.e ***,t.e damping propert. init.ally experiences an ascent.followed by a subsequent.decline wit. rising t. *** damping behavior finds it. origins in mult.ple mechanisms,including grain boundary damping st.mming from reduced grain size,int.rfacial damping induced by t.e generat.d Co3t.,and dislocat.on *** is not.wort.y t.at.t.e emergence of t.e secondary phase wields a dual impact.on damping *** t.e one hand,t.e proliferat.on of t.e second phase fost.rs increased int.rfaces for energy *** t.e ot.er hand,t.ese int.rfaces give rise t. compressive st.esses,const.aining int.rface movement.and t.us impeding damping propert. enhancement.

关键词： Damping Fe–Mn–Co Mechanical propert.es Spark plasma sint.ring t.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Int.ract.ve effect. of soils,local environment.l condit.ons and herbivores on secondary chemicals in t.llow t.ee

引用

Journal of Plant.Ecology 2024年第4期17卷 167-180页

作者： Li xiao Wei Huang Juli Carrillo Jianqing Ding Evan Siemann College of Life and Environment.l Science Central South University of Forestry and TechnologyChangsha 410004China Nat.onal Engineering Laborat.ry of Applied t.chnology for Forest.y&Ecology in Sout.ern China Central South University of Forestry and TechnologyChangsha 410004China CAS Key Laborat.ry of Aquat.c Bot.ny and Wat.rshed Ecology Wuhan Botanical GardenChinese Academy of SciencesWuhan 430074China Facult. of Land and Food Syst.ms Centre for Sustainable Food SystemsBiodiversity Research CentreUniversity of British ColumbiaVancouver V6T 1Z4Canada St.t. Key Laborat.ry of Crop St.ess Adapt.t.on and Improvement School of Life SciencesHenan UniversityKaifeng 475004China Biosciences Depart.ent Rice UniversityHoustonTX 77005USA

Plant. produce secondary chemicals t.at.may vary along wit. lat.t.de due t. changing abiot.c and biot.c st.ess gradient. and local environment.l *** apart.t.e individual and combined effect. of t.ese different.abiot.c,such as soil nut.ient.,and biot.c fact.rs,such as soil biot. and herbivores,on secondary chemicals is crit.cal for underst.nding plant.responses t. changing *** conduct.d an experiment.at.different.lat.t.des in China,using t.llow t.ee(t.iadica sebifera)seedlings sourced from a populat.on at.31°*** seedlings were cult.vat.d in gardens locat.d at.low,middle and high lat.t.des,wit. eit.er local soil or soil from t.e original seed collect.on sit.(origin soil).t.e seedlings were exposed t. nat.ral levels of aboveground herbivores or had t.em *** secondary chemicals(bot. foliar and root.,aboveground herbivores and soil charact.rist.cs were *** showed t.at.most.leaf and root.secondary met.bolit.s depended on t.e int.ract.on of t.e experiment.l sit. and soil *** and root.phenolic and t.nnin concent.at.ons were higher at.t.e middle lat.t.de sit.,especially in t.e origin *** and foliar flavonoid concent.at.ons increased when aboveground herbivores were *** communit.es depended st.ongly on soil *** different.responses of t.nnins versus flavonoids suggest.t.at.t.ese t.o chemical classes differ in t.eir responses t. t.e varying abiot.c and biot.c fact.rs in t.ese sit.s along *** t.get.er,our result. emphasize t.e import.nce of considering t.e int.ract.ve effect. of local environment.l condit.ons,soil propert.es and herbivory in regulat.ng plant.chemical defenses.

关键词： phenolics t.nnins flavonoids abiot.c fact.rs soil charact.rist.cs t.iadica sebifera

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immunomodulat.on of adipose-derived mesenchymal st.m cells on peripheral blood mononuclear cells in colorect.l cancer pat.ent. wit. COVID-19

引用

World Journal of Gast.oint.st.nal Oncology 2024年第5期16卷 2113-2122页

作者： Jun-Feng Wang xiao-Xia Yang Jian Zhang Yan Zheng Fu-Qing Zhang xiao-Feng Shi Yu-Liang Wang Depart.ent.of Colorect.l Oncology Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060China Depart.ent.of Neurology Tianjin First Center HospitalTianjin 300192China Prost.odont.cs St.dio Tianjin Stomatological HospitalTianjin 300041China Depart.ent.of Clinical Laborat.ry Medicine Tianjin Institute of UrologyThe Second Hospital of Tianjin Medical UniversityTianjin 300211China Depart.ent.of Emergency Tianjin First Central HospitalTianjin 300192China

BACKGROUND Accumulat.ng evidence has shown t.at.adipose t.ssue-derived mesenchymal st.m cells(ADSCs)are an effect.ve t.erapeut.c approach for managing coronavirus disease 2019(COVID-19);however,furt.er elucidat.on is required t. det.rmine t.eir underlying immunomodulat.ry effect.on t.e mRNA expression of t.helper cell-relat.d t.anscript.on fact.rs(t.s)and cyt.kine release in peripheral blood mononuclear cells(PBMCs).AIM t. invest.gat. t.e impact.of ADSCs on t.e mRNA expression of t.s and cyt.kine release in PBMCs from colorect.l cancer(CRC)pat.ent. wit. severe COVID-19(CRC^(+)pat.ent.).MEt.ODS PBMCs from CRC^(+)pat.ent.(PBMCs-C+)and age-mat.hed CRC pat.ent.(PBMCs-C)were st.mulat.d and cult.red in t.e presence/absence of *** mRNA levels of t.box t. t.X21(t.bet.,GAt. binding prot.in 3(GAt.-3),RAR-relat.d orphan recept.r C(RORC),and forkhead box P3(FoxP3)in t.e PBMCs were det.rmined by reverse t.anscript.se-polymerase chain *** supernat.nt. were evaluat.d for levels of int.rferon gamma(IFN-γ),int.rleukin 4(IL-4),IL-17A,and t.ansforming growt. fact.r bet. 1(t.F-β1)using an enzyme-linked immunosorbent.*** Compared wit. PBMCs-C,PBMCs-C+exhibit.d higher mRNA levels of t.bet.and RORC,and increased levels of IFN-γ and ***,a significant.decrease in FoxP3 mRNA and t.F-β1,as well as an increase in t.et.GAt.-3,RORC/FoxP3,IFN-γ/IL-4,and IL-17A/t.F-β1 rat.os were observed in PBMCs-C+.Furt.ermore,ADSCs significant.y induced a funct.onal regulat.ry t.cell(t.eg)subset.as evidenced by an increase in FoxP3 mRNA and t.F-β1 release *** was accompanied by a significant.decrease in t.e mRNA levels of t.bet.and RORC,release of IFN-γ and IL-17A,and t.bet.GAt.-3,RORC/FoxP3,IFN-γ/IL-4,and IL-17A/t.F-β1 rat.os,compared wit. t.e PBMCs-C+*** t.e present.in vit.o st.dies showed t.at.ADSCs cont.ibut.d t. t.e immunosuppressive effect. on PBMCs-C+,favoring t.eg ***,ADSC-based cell t.erapy could be a beneficial approach for p

关键词： Colorect.l cancer COVID-19 Adipose-derived mesenchymal st.m cells t.helper cell Immunomodulat.on

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

t.e E3 ubiquit.n ligase t.AF6 cont.ols Ct.A-4 t.rnover and promot.s t.cell-mediat.d ant.t.mor immunit.

引用

Cellular & Molecular Immunology 2024年第1期21卷 97-99页

作者： xiao-Liang Jie Hua Guo Guang-Biao Zhou St.t. Key Laborat.ry of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College100021 BejingChina

Yu et.al.[1]report.d t.at.t.e t.mor necrosis fact.r(t.F)recept.r OX40(CD134)-t.F recept.r-associat.d fact.r 6(t.AF6)axis mediat.s Lys63-linked ubiquit.nat.on and subsequent.lysosomal degradat.on of cyt.t.xic t.lymphocyt. ant.gen 4(Ct.A-4),leading t. t.e enhancement.of CD8^(+)t.cell-mediat.d ant.t.mor *** findings unveil a previously unknown mechanism in cont.olling t.e st.bilit. of t.e immune checkpoint.Ct.A-4 and provide a pot.nt.al t.erapeut.c t.rget.for t.e improvement.of t.ell-based immunot.erapy.

关键词： immunit. OX40 ubiquit.n

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：