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Ubiquitin-specific protease 21 promotes tumorigenicity and stemness of colorectal cancer by deubiquitinating and stabilizing ZEB1

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 1006-1018页

作者： Jun-Jun Lin ye-Cai Lu Department of Gastrointestinal Surgery Chaohu Hospital of Anhui Medical UniversityChaohu 238000Anhui ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one very usual tumor together with higher death ***-specific protease 21(USP21)has been confirmed to take part into the regulation of CRC progression through serving as a ***,the promotive function of USP21 has also discovered in the progression of ***1 has illustrated to be modulated by USP7,USP22 and USP51 in ***,the regulatory functions of USP21 on ZEB1 in CRC progression need more *** To investigate the relationship between USP21 and ZEB1 in CRC *** The mRNA and protein expressions were assessed through RT-qPCR,western blot and IHC *** interaction between USP21 and ZEB1 was evaluated through Co-IP and GST pull down *** cell proliferation was detected through colony formation *** cell migration and invasion abilities were determined through Transwell *** stemness was tested through sphere formation *** tumor growth was evaluated through in vivo mice *** In this work,USP21 and ZEB1 exhibited higher expression in CRC,and resulted into poor ***,the interaction between USP21 and ZEB1 was further *** was demonstrated that USP21 contributed to the stability of ZEB1 through modulating ubiquitination *** addition,USP21 streng-thened cell proliferation,migration and stemness through regulating *** last,through in vivo assays,it was illustrated that USP21/ZEB1 axis aggravated tumor *** For the first time,these above findings manifested that USP21 promoted tumorigenicity and stemness of CRC by deubiquitinating and stabilizing *** discovery suggested that USP21/ZEB1 axis may provide novel sights for the treatment of CRC.

关键词： Ubiquitin-specific protease 21 ZEB1 Stemness Colorectal cancer

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Molecular mechanisms of Buqing granule for the treatment of diabetic retinopathy:Network pharmacology analysis and experimental validation

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World Journal of Diabetes 2024年第9期15卷 1942-1961页

作者： Yi-Fan Yang Ling Yuan xiang-Yang Li Qian Liu Wen-Jie Jiang Tai-Qiang Jiao Jia-Qing Li Meng-Yi ye Yang Niu Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic retinopathy(DR)is a common microvascular complication of diabetes *** blindness rate is high;therefore,finding a reasonable and safe treatment plan to prevent and control DR is ***,there are abundant and diverse research results on the treatment of DR by Chinese medicine Traditional Chinese medicine compounds are potentially advantageous for DR prevention and treatment because of its safe and effective therapeutic *** To investigate the effects of Buqing granule(BQKL)on DR and its mechanism from a systemic perspective and at the molecular level by combining network pharmacology and in vivo *** This study collected information on the drug targets of BQKL and the therapeutic targets of DR for intersecting target gene analysis and protein-protein interactions(PPI),identified various biological pathways related to DR treatment by BQKL through Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses,and preliminarily validated the screened core targets by molecular ***,we constructed a diabetic rat model with a high-fat and high-sugar diet and intraperitoneal streptozotocin injection,and administered the appropriate drugs for 12 weeks after the model was successfully *** mass and fasting blood glucose and lipid levels were measured,and pathological changes in retinal tissue were detected by hematoxylin and eosin *** was used to detect the oxidative stress index expression in serum and retinal tissue,and immunohistochemistry,real-time quantitative reverse transcription PCR,and western blotting were used to verify the changes in the expression of core *** Six potential therapeutic targets of BQKL for DR treatment,including Caspase-3,c-Jun,TP53,AKT1,MAPK1,and MAPK3,were screened using *** analysis indicated that the MAPK signaling pathway might be the core target pathway of BQKL in DR *** docking prediction indica

关键词： Diabetic retinopathy Network pharmacology Animal models Oxidative stress Inflammatory

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Associations between Social Media Use and Sleep Quality in China:Exploring the Mediating Role of Social Media Addiction

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International Journal of Mental Health Promotion 2024年第5期26卷 361-376页

作者： Yijie ye Han Wang Liujiang ye Hao Gao School of Journalism and Communication Nanjing Normal UniversityNanjing210097China School of Journalism and Communication Jinan UniversityGuangzhou510632China

Sleep quality is closely linked to people’s health,and during the COVID-19 pandemic,the sleep patterns of residents in China were notably *** lockdown in China led to an increase in social media use,prompting questions about its impact on ***,this study investigates the association between social media use and sleep quality among Chinese residents during the COVID-19 outbreak,highlighting the potential mediating role of social media *** were collected via questionnaires through a cross-sectional survey with 779 valid *** analysis was used to test for differences in social media use among different demographic *** correlation analysis was employed to explore the relationships between variables,while regression analysis investigated the correlations between various media factors and sleep ***,Bootstrap sampling was utilized to analyze the potential mediating influence of social media addiction in the relationship between social media use and *** study's findings reveal a significant correlation between social media use,particularly before bedtime,and sleep quality(p<0.01),with pre-sleep activity notably linked to poorer overall sleep scores(β=0.141,p=0.004).Although the daily use of social media did not directly impact most individuals’sleep quality,specific platforms like news apps,short video apps,dating apps,and content community platforms were associated with higher levels of social media addiction,subsequently negatively affecting sleep ***,the use of news apps(B=0.068,95%CI[0.000,0.019]),short video apps(B=0.112,95%CI[0.001,0.031]),dating apps(B=0.147,95%CI[0.000,0.028]),and content community platforms(B=0.106,95%CI[0.001,0.028])was found to increase the risk of social media addiction,subsequently leading to adverse effects on sleep *** study underscores a notable link between social media use and sleep quality,suggesting that mindful social media habits,pa

关键词： Social media use social media addiction sleep quality

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Intravitreal conbercept injection with panretinal photocoagulation for high-risk proliferative diabetic retinopathy with vitreous hemorrhage

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1066-1072页

作者： Yao Xu Qing ye Wei Shen Department of Ophthalmology the Fourth Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology Suzhou Kowloon HospitalShanghai Jiao Tong University School of MedcineSuzhou 215000Jiangsu ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated by mild or moderate vitreous hemorrhage(VH),with or without diabetic macular edema(DME).METHODS:Patients diagnosed with VH with/without DME secondary to HR-PDR and received PRP combined with IVC injections were recruited in this retrospective *** establishing the patient’s diagnosis,an initial IVC was performed,followed by prompt administration of *** cases who significant bleeding persisted and impeded the laser operation,IVC was sustained before supplementing with *** the completion of PRP,patients were meticulously monitored for a minimum of six *** therapy and IVC injections were judiciously adjusted based on fundus fluorescein angiography(FFA)*** effect and the incidence of adverse events were ***:Out of 42 patients(74 eyes),29 were male and 13 were female,with a mean age of 59.17±12.74y(33-84y).The diabetic history was between 1wk and 26y,and the interval between the onset of visual symptoms and diagnosis of HR-PDR was *** affected eye received 2.59±1.87(1-10)IVC injections and underwent 5.5±1.02(4-8)sessions of *** these,68 eyes received PRP following 1 IVC injection,5 eyes after 2 IVC injections,and 1 eye after 3 IVC *** absorption of VH was observed in all 74 eyes 5-50wk after initial treatment,with resolution of DME in 51 eyes 3-48wk after initial treatment.A newly developed epiretinal membrane was noted in one *** acuity significantly improved in 25 *** complications such as glaucoma,retinal detachment,or endophthalmitis were ***:The study suggests that the combination of PRP with IVC injections is an effective and safe modality for treating diabetic VH in patients with HR-PDR.

关键词： conbercept panretinal photocoagulation high-risk proliferative diabetic retinopathy vitreous hemorrhage

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MCDM technique using single-valued neutrosophic trigonometric weighted aggregation operators

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Journal of Management Analytics 2024年第1期11卷 45-61页

作者： Jun ye Shigui Du Rui Yong School of Civil and Environmental Engineering Ningbo UniversityNingboPeople’s Republic of China

Motivated based on the trigonometric t-norm and t-conorm,the aims of this article are to present the trigonometric t-norm and t-conorm operational laws of SvNNs and then to propose the SvNN trigonometric weighted average and geometric aggregation operators for the modelling of a multiple criteria decision making(MCDM)technique in an inconsistent and indeterminate *** realize the aims,this paper first proposes the trigonometric t-norm and t-conorm operational laws of SvNNs,which contain the hybrid operations of the tangent and arctangent functions and the cotangent and inverse cotangent functions,and presents the SvNN trigonometric weighted average and geometric operators and their ***,an MCDM technique is proposed in view of the presented two aggregation operators in the circumstance of *** the end,an actual case of the choice issue of slope treatment schemes is provided to indicate the practicability and effectivity of the proposed MCDM technique.

关键词： Single-valued neutrosophic number trigonometric t-norm and t-conorm trigonometric weighted aggregation operator decision making

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Transient NOE driven signal enhancement of INADEQUATE solid-state NMR spectroscopy for the structural analysis of rubbers

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Magnetic Resonance Letters 2024年第3期4卷 35-41页

作者： Zhiwei Yan Yue-Qi ye Rongchun Zhang South China Advanced Institute for Soft Matter Science and Technology(AISMST) School of Emergent Soft Matter(SESM)South China University of TechnologyGuangzhou510640China JEOL(Beijing)Co. Ltd.Haidian DistrictBeijing100190China JEOL Ltd. MusashinoAkishimaTokyo196-8558Japan Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

INADEQUATE(Incredible Natural Abundance DoublE QUAntum Transfer Experiment)is one of the most important techniques in revealing the carbon skeleton of organic solids in solid-state NMR ***,its use for structural analysis is quite limited due to the low natural abundance of^(13)C-^(13)C connectivity(~0.01%)and thus low ***,in semi-solids like rubbers,the sensitivity will be further significantly reduced by the inefficient cross polarization from 1H to^(13)C due to molecular motions induced averaging of^(1)H-^(13)C dipolar ***,in this study,we demonstrate that transient nuclear Overhauser effect(NOE)can be used to efficiently enhance^(13)C signals,and thus enable rapid acquisition of two-dimensional(2D)^(13)C INADEQUATE spectra of *** chlorobutyl rubber as the model system,it is found that an overall signalto-noise ratio(SNR)enhancement about 22%can be achieved,leading to significant timesaving by about 33%as compared to the direct polarization-based INADEQUATE *** experimental results on natural rubber and ethylene propylene diene monomer(EPDM)rubber are also shown to demonstrate the robust performance of transient NOE enhanced INADEQUATE experiment.

关键词： Transient NOE INADEQUATE Carbon skeleton Rubbers

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Discriminatively Constrained Semi-Supervised Multi-View Nonnegative Matrix Factorization with Graph Regularization

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Big Data Mining and Analytics 2024年第1期7卷 55-74页

作者： Guosheng Cui ye Li Jianzhong Li Jianping Fan Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Joint Engineering Research Center for Health Big Data Intelligent Analysis Technology Shenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China School of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Nonnegative Matrix Factorization(NMF)is one of the most popular feature learning technologies in the field of machine learning and pattern *** has been widely used and studied in the multi-view clustering tasks because of its *** study proposes a general semi-supervised multi-view nonnegative matrix factorization *** algorithm incorporates discriminative and geometric information on data to learn a better-fused representation,and adopts a feature normalizing strategy to align the different *** specific implementations of this algorithm are developed to validate the effectiveness of the proposed framework:Graph regularization based Discriminatively Constrained Multi-View Nonnegative Matrix Factorization(GDCMVNMF)and Extended Multi-View Constrained Nonnegative Matrix Factorization(ExMVCNMF).The intrinsic connection between these two specific implementations is discussed,and the optimization based on multiply update rules is *** on six datasets show that the effectiveness of GDCMVNMF and ExMVCNMF outperforms several representative unsupervised and semi-supervised multi-view NMF approaches.

关键词： multi-view semi-supervised clustering discriminative information geometric information feature normalizing strategy

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Evolution and Determinants of Population Agglomeration in Less Developed Metropolitan Areas:A Case Study of the Taiyuan Metropolitan Area,China

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Chinese Geographical Science 2024年第4期34卷 739-751页

作者： QIN Zhiqin LIANG ye AN Shuwei DOU Yongjing School of Economics and Management Shanxi UniversityTaiyuan 030031China School of Urban Economics and Public Affairs Capital University of Economics and BusinessBeijing 100070China School of Geography Science Taiyuan Normal UniversityJinzhong 030619China

It is of importance to enhance the urban areas'capacity for population aggregation in underdeveloped regions,aiming to rectify the imbalanced and insufficient pattern of economic development in *** the Taiyuan Metropolitan Area(TMA)in central China as a case study,this paper examines the evolutionary process and characteristics of population agglomeration from 2000 to 2020,and identifies factors associated with agglomeration and their spatial *** findings indicated that:1)against the background of sustained population shrinkage in the provincial area,the TMA showed a demographic trend of steady increase,albeit with a decelerated growth *** the metropolitan area,urban population size continued to grow rapidly,whereas the rural areas endured sustained *** in city size continued to widen,and the polarization of concentrated population in the core cities kept increasing.2)Agglomerations in both secondary and service industries had significant positive effects on local population agglomeration,with the former effect being *** economic development,government fiscal expenditure,and financial advancement all contributed to facilitating local population *** a spatial spillover perspective,service agglomeration and financial development promoted population agglomeration in surrounding ***,fiscal expenditure inhibited such *** for industrial agglomeration and regional economic development,their spatial spillover effects were *** results obtained reveal several policy implications aimed at enhancing the population agglomeration capacity of the metropolitan area in underdeveloped regions during the new era.

关键词： population agglomeration population shrinkage spatial spillover effects Taiyuan Metropolitan Area(TMA) China

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Social Robot Detection Method with Improved Graph Neural Networks

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Computers, Materials & Continua 2024年第2期78卷 1773-1795页

作者： Zhenhua Yu Liangxue Bai Ou ye Xuya Cong Institute of Systems Security and Control College of Computer Science and TechnologyXi’an University of Science and TechnologyXi’an710054China

Social robot accounts controlled by artificial intelligence or humans are active in social networks,bringing negative impacts to network security and social *** social robot detection methods based on graph neural networks suffer from the problem of many social network nodes and complex relationships,which makes it difficult to accurately describe the difference between the topological relations of nodes,resulting in low detection accuracy of social *** paper proposes a social robot detection method with the use of an improved neural ***,social relationship subgraphs are constructed by leveraging the user’s social network to disentangle intricate social relationships ***,a linear modulated graph attention residual network model is devised to extract the node and network topology features of the social relation subgraph,thereby generating comprehensive social relation subgraph features,and the feature-wise linear modulation module of the model can better learn the differences between the ***,user text content and behavioral gene sequences are extracted to construct social behavioral features combined with the social relationship subgraph ***,social robots can be more accurately identified by combining user behavioral and relationship *** carrying out experimental studies based on the publicly available datasets TwiBot-20 and Cresci-15,the suggested method’s detection accuracies can achieve 86.73%and 97.86%,*** with the existing mainstream approaches,the accuracy of the proposed method is 2.2%and 1.35%higher on the two *** results show that the method proposed in this paper can effectively detect social robots and maintain a healthy ecological environment of social networks.

关键词： Social robot detection social relationship subgraph graph attention network feature linear modulation behavioral gene sequences

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Studying the effect of surfactant assisted low-salinity water flooding on clay-rich sandstones

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Petroleum 2024年第2期10卷 306-318页

作者： Saeed Khezerloo-ye Aghdam Alireza Kazemi Mohammad Ahmadi Department of Petroleum Engineering Amirkabir University of Technology(AUT)TehranIran Department of Petroleum and Chemical Engineering College of EngineeringSultan Qaboos UniversityMuscatOman

Sandstone reservoirs often contain clay particles that can cause damage and reduce permeability during low-salinity water *** this study,the effect of surfactants on fine migration in clay-rich sandstones and its impact on oil recovery was ***,the impact of surfactants on interparticle forces in fine-matrix,fine-fine,and oil-matrix systems was *** results showed that both CTAB(cetyltrimethyl ammonium bromide)and QS(quillaja saponin)cause EDL compaction,weakening the repulsive ***,SDS(sodium dodecyl sulfate)and TX(triton X-100)do not affect the ***,the effect of surfactants on IFT reduction and wettability alteration was experimentally *** surfactants reduced IFT due to the surface excessive concentration *** wettability alteration experiment illustrated that although QS and CTAB compact EDL around oil and matrix particles leading to attraction force augmentation,they both alter wettability through adsorption on matrix and carboxylic groups present in crude oil,*** aqueous solutions were then injected into various clay-rich sandstone sanpacks,which resulted in increased oil ***,the mechanisms leading to enhanced oil recovery variedby surfactant *** increased recovery by 10%through IFT reduction and wettability alteration,while SDS and TX increased recovery by 12%and 9%,respectively,through wettability alteration and extreme fine *** contrast,partial fine migration in the QS flooding experiment reached a recovery increase of 18%.Permeability trends through experiments were also *** CTAB injection,permeability did not reduce,while QS aqueous solution reduced rock permeability to 5 m *** and TX reduced the magnitude of permeability to 2 m *** conclusion,this study demonstrates that surfactants can effectively improve oil recovery in clay-rich sandstones by altering the interparticle forces,reducing IFT,and changing *** results

关键词： Surfactant flooding Smart water Fine migration Recovery factor

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