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Tungsten 2025年第1期 183-194页

作者： Xin-Ran sun Hao-ming Yuan Guo-Da Zhang Chao Wang Shu-Juan sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

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MicroRNAs: regulators of cancer metastasis and epithelialmesenchymal transition(EMT)

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Chinese Journal of Cancer 2014年第3期33卷 140-147页

作者： xiang-ming Ding Department of Obstetrics and Gynecology David Geffen School of Medicine at UCLA

Tumor metastasis is the main cause of death in patients with solid tumors. The epithelial-mesenchymal transition(EMT) process, in which epithelial cells are converted into mesenchymal cells, is frequently activated during cancer invasion and metastasis. MicroRNAs(miRNAs) are small, non-coding RNAs that provide widespread expressional control by repressing mRNA translation and inducing mRNA degradation. The fundamental roles of miRNAs in tumor growth and metastasis have been increasingly well recognized. A growing number of miRNAs are reported to regulate tumor invasion/metastasis through EMT-related and/or non-EMT–related mechanisms. In this review, we discuss the functional role and molecular mechanism of miRNAs in regulating cancer metastasis and EMT.

关键词： MicroRNA(miRNA) cancer metastasis EMT

单细胞转录组测序技术在骨质疏松症研究中的应用与进展

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中国组织工程研究 2025年第13期29卷 2812-2821页

作者：孙成涛孙广江戚晓楠程茗姚啸生辽宁中医药大学辽宁省沈阳市110847 辽宁中医药大学附属第二医院骨伤一科辽宁省沈阳市110034 辽宁中医药大学附属医院骨伤一科辽宁省沈阳市110032 中国医科大学沈阳市第四人民医院辽宁省沈阳市110031

背景:骨质疏松导致的脆性骨折发病率逐年上升,亟需探索其病理生理、潜在生物标志物、治疗靶点及有效药物。骨微环境中存在多种细胞,对骨代谢的维持至关重要。近几年,单细胞RNA测序(scRNA-seq)技术被开发用于表征单个细胞的转录组,并逐... 详细信息

背景:骨质疏松导致的脆性骨折发病率逐年上升,亟需探索其病理生理、潜在生物标志物、治疗靶点及有效药物。骨微环境中存在多种细胞,对骨代谢的维持至关重要。近几年,单细胞RNA测序(scRNA-seq)技术被开发用于表征单个细胞的转录组,并逐步应用到骨质疏松症防治的研究。目的:综述单细胞转录组测序技术在骨质疏松症研究中的应用与进展。方法:由第一作者使用计算机检索Web of Science,PubMed和中国知网数据库中2009-2023年出版的文献,英文检索词为:“single-cell RNA sequencing,bone marrow derived stromal cells,osteoblasts,osteocytes,osteoclasts,immune cells,Bone marrow vascular endothelial cells”;中文检索词为:“单细胞转录组测序,骨髓间充质干细胞,成骨细胞,骨细胞,破骨细胞,免疫细胞,骨髓血管内皮细胞”;通过阅读筛选相关文献,最终纳入89篇文献进行综述分析。结果与结论:①单细胞转录组测序技术能够深入了解细胞发育、增殖、分化的轨迹及其调控机制。②影响骨密度的候选基因主要富集在骨髓间充质干细胞亚群,其中Sox9是关键的转录因子。③成骨细胞不同亚群中差异表达Runx2控制骨髓间充质干细胞向成骨细胞方向分化。④破骨细胞分化过程中RAB38与组蛋白修饰和转录调控动态变化有关。⑤单细胞层面研究证实,骨微环境中存在多种细胞间通讯,破骨细胞可能通过CD160-TNFRSF14配体-受体结合进行细胞间通讯;中性粒/单核细胞与成骨细胞间可能通过RESISTIN通路进行交互;浆样树突状细胞与成骨细胞系通过表皮生长因子通路进行交流;均可以为靶点预测和药物研发提供方向。⑥新的骨髓毛细血管内皮细胞亚群,称为S型内皮细胞,完全起源于骨骺次级骨化中心,甚至比H型血管更具有可塑性。⑦文章从细胞角度总结单细胞转录组测序技术在表征不同骨组织细胞的分化命运和分化轨迹、识别新的细胞亚群、鉴定细胞调控因子及明确细胞间通讯的研究进展,为探讨骨质疏松症的病理机制、筛选潜在诊断标志物、预测治疗靶点及探究药物作用机制提供细胞层面的信息。⑧未来单细胞测序技术将向单细胞多组学(基因组、蛋白组学及代谢组学)方向及结合其他诸如空间转录组技术为骨组织细胞变化提供更有价值的信息。

关键词：单细胞转录组测序骨质疏松骨代谢骨髓间充质干细胞骨细胞破骨细胞骨免疫学骨髓血管内皮细胞

Asymptotic Formulae for Brillouin Index on Riemannian Manifolds

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Acta Mathematica Sinica,English Series 2007年第7期23卷 1297-1302页

作者： Wen xiang sun LMAM School of Mathematical SciencesPeking University

We establish several asymptotic formulae for Brillouin index on fiat tori. As an application of these formulae it is proved that the topological entropy of a geodesic flow on a fiat torus is zero.

关键词： flat torus Brillouin index geodesic flow topological entropy

Topological Entropy of a Graph Map

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Acta Mathematica Sinica,English Series 2018年第2期34卷 194-208页

作者： Tai xiang sun Guangxi Key Laboratory Cultivation Base of Cross-border E-commerce Intelligent Information Processing Guangxi University of Finance and Economics

Let G be a graph and f： G → G be a continuous map. Denote by h（f）, P（f）, AP（f）, R（f） and w（x, f） the topological entropy of f, the set of periodic points of f, the set of almost periodic points of f, the set of recurrent points of f and the w-limit set of x under f, respectively. In this paper, we show that the following statements are equivalent：（1） h（f）〉 O. （2） There exists an x ∈ G such that w（x, f） ∩ P（f） ≠θ and w（x, f） is an infinite set. （3） There exists an x ∈ G such that w（x, f） contains two minimal sets. （4） There exist x, y ∈G such that w（x, f） - w（y, f） is an uncountable set andw（y,f）∩w（x,f）≠θ. （5） There exist anx C Gand a closed subset A w（x,f） with f（A） A such that w（x,f） - A is an uncountable set. （6） R（f） - nP（f） ≠θ. （7） f｜P（f） is not pointwise equicontinuous.

关键词： Topological entropy periodic point w-limit set recurrent point

A new synthetic route to MgO–MgAl2O4–ZrO2 highly dispersed composite material through formation of Mg5Al2.4Zr1.7O12 metastable phase: synthesis and physical properties

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International Journal of Minerals,Metallurgy and Materials 2017年第3期24卷 332-341页

作者： Peng Jiang Guo-xiang Yin ming-wei Yan Jia-lin sun Bin Li Yong Li School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Beijing 100083 China

Mg_5Al_(2.4)Zr_(1.7)O_(12) metastable phase was successfully synthesized from analytical-grade Mg O,α-Al_2O_3,MgAl_2O_4,and ZrO_2 under an N_2 *** sintering temperature was varied from 1650 to 1780°C,and the highest amount of Mg_5Al_(2.4)Zr_(1.7)O_(12) appeared in the composite material when the sintering temperature was 1760°*** to our research of the formation mechanism of Mg_5Al_(2.4)Zr_(1.7)O_(12),the formation and growth of MgAl_2O_4 dominated when the temperature was not higher than 1650°*** the temperature was higher than 1650°C,MgO and ZrO_2 tended to diffuse into MgAl_2O_4 and the Mg_5Al_(2.4)Zr_(1.7)O_(12) solid solution was *** the temperature reached 1760°C,the formation of Mg_5Al_(2.4)Zr_(1.7)O_(12) was *** effect of Mg Al_2O_4 spinel crystals was also studied,and their introduction into the composite material promoted the formation and growth of Mg_5Al_(2.4)Zr_(1.7)O_(12).A highly dispersed MgO–Mg Al_2O_4–ZrO_2 composite material was prepared through the decomposition of the Mg_5Al_(2.4)Zr_(1.7)O_(12) metastable *** as-prepared composite material showed improved overall physical properties because of the good dispersion of MgO,MgAl_2O_4,and ZrO_2 phases.

关键词： metastable phases formation mechanisms composite materials refractory materials synthesis physical properties

Microscopic transduodenal excision of an ampullary adenoma:A case report and review of the literature

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World Journal of Clinical Cases 2021年第18期9卷 4844-4851页

作者： xiang Zheng Qing-Jing sun Bo Zhou ming Jin Sheng Yan Department of General Surgery The Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina The Affiliated Hospital of Stomatology School of StomatologyZhejiang University School of Medicineand Key Laboratory of Oral Biomedical Research of Zhejiang ProvinceHangzhou 310006Zhejiang ProvinceChina

BACKGROUND Transduodenal local excision is an alternative treatment approach for benign ampullary ***,this procedure has technical difficulties,especially during reconstruction of the pancreaticobiliary *** operating microscope has been widely used by surgeons for delicate surgery due to its major advantages of magnification,illumination,and stereoscopic *** application of an operating microscope in transduodenal excision of ampullary tumors has not been *** SUMMARY A 55-year-old woman was admitted for investigation of recurrent upper abdominal *** examination and laboratory tests found no *** identified a large mass in the descending part of the *** revealed a 3.5-cm-sized villous growth over the major duodenal *** of the endoscopic biopsy indicated a villous adenoma with low-grade *** transduodenal excision of the ampullary tumor was *** final pathological diagnosis was villous-tubular adenoma with low-grade *** patient was discharged on postoperative day 12 after an uneventful *** retrograde cholangiopancreatography was performed 3 mo postoperatively and showed no bile duct or pancreatic duct strictures and no tumor *** patient is continuing follow-up at our clinic and remains *** Operating microscope-assisted transduodenal local excision is a feasible and effective option for benign ampullary tumors.

关键词： Operating microscope Transduodenal local excision Ampullary tumor Endoscopic papillectomy Pancreaticoduodenectomy Case report

Highly enhanced microwave absorption for carbon nanotube/barium ferrite composite with ultra-low carbon nanotube loading

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Journal of Materials Science & Technology 2022年第7期102卷 115-122页

作者： Yue-Yi Wang Song-Yang Wen-Jin sun Kun Dai Ding-xiang Yan Zhong-ming Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001China School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China

Barium ferrite(BaFe_(12)O_(19))is considered as potential microwave absorption(MA)material thanks to the large saturation magnetization,high Curie temperature,and excellent chemical *** integration of carbon nanotube(CNT)can improve the dielectric loss of BaFe_(12)O_(19)for further enhanced MA perfor-mance,nevertheless,the MA performance is still not desirable because of the poor CNT dispersion in the CNT/BaFe_(12)O_(19)composites,which usually prepared via the ball-milling method,unless high CNT loading was ***,according to the thermal stability of CNT in different atmosphere and the formation mechanism of BaFe_(12)O_(19)from precursor,CNT was introduced in the precursor of BaFe_(12)O_(19)uniformly during auto-ignition process and calcined under different *** CNT loading is only 2.0 wt%,the CNT/BaFe_(12)O_(19)composites obtained exhibits a minimum reflection loss(RL_(min))of-43.9 dB and effective bandwidth(with RL<-10 dB)of 3.9 GHz with the thickness of 1.5 mm,which are much supe-rior to-10.2 dB and 2.2 GHz for pure BaFe_(12)O_(19),and-13.6 dB and 2.5 GHz for CNT/BaFe_(12)O_(19)composite prepared by ball-milling *** results may pave the way to design high-performance BaFe_(12)O_(19)based microwave absorbers.

关键词： Carbon nanotube Barium ferrite Microwave absorption

Gradient Estimate for the Positive Solutions of Lu=0 and Lu=?u/?t on Conformal Solitons

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Acta Mathematica Sinica,English Series 2021年第11期37卷 1768-1782页

作者： xiang LI Jun sun School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026P.R.China School of Mathematics and Statistics Wuhan UniversityWuhan 430072P.R.China Hubei Key Laboratory of Computational Science Wuhan UniversityWuhan 430072P.R.China

In this paper,we prove gradient estimates for the positive solutions of Lu=0 and Lu=?u/?t on conformal solitons,where L(·)=Δ(·)+.We also give some applications for them.

关键词： Gradient estimate conformal solitons

Precision Calculations of Atomic Polarizabilities： A Relevant Physical Quantity in Modern Atomic Frequency Standard

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Chinese Physics Letters 2010年第6期27卷 78-81页

作者： GAO xiang LI Jia-ming Department of Physics Shanghai Jiao Tong University Shanghai 200240 Department of Physics and Key Laboratory of Atomic and Molecular Nanosciences of Ministry of Education Tsinghua University Beijing 100084

Electric dipole polarizabilities of atoms are very important in many different physical applications, such as the precision atomic frequency standard. Calculations of these properties are very important and challenging. We propose a calculation strategy to calculate the frequency dependent dipole polarizabilities with high precision variationally by using a set of high quality orbital bases where the electron correlations can be taken into account adequately. The static polarizabilitiez of the ground state of Na are calculated accurately by such a method and can be compared with precision experiment measurement directly. The calculation result is in excellent agreement with the available experimental measurements within about 0.1~, which demonstrates the validity of our strategy. Our calculation strategy has a wide usage, not only in polarizibilies, but also in other fields such as theoretical treatment of electron-atom scattering processes. Using the same orbital bases, we carry out precision calculation of Na- affinities. Our calculated affinity is in excellent agreement with precision laser spectroscopy measurements within 0. 1%.

关键词： PHYSICAL constants ATOMIC frequency standards DIPOLE moments POLARIZABILITY (Electricity) VARIATIONAL principles ATOMIC orbitals SCATTERING (Physics) LASER spectroscopy