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考虑变速条件的斯特封磨损寿命预测方法

机械工程学报 2024年第3期60卷 191-202页

作者：纪佳馨彭程项冲黄乐郭飞中国石油大学(华东)机电工程学院青岛266580 清华大学高端装备界面科学与技术全国重点实验室北京100084 广州机械科学研究院有限公司广州510700

磨损导致的泄漏是往复密封在服役期间常见的失效形式,目前密封圈磨损寿命的预测主要采用实验方法,其过程复杂且时间、经济成本较高,仿真是达到密封圈磨损寿命预测目的较好的途径,但当前缺少对磨损重要因素—速度合适的仿真处理方法。针... 详细信息

磨损导致的泄漏是往复密封在服役期间常见的失效形式,目前密封圈磨损寿命的预测主要采用实验方法,其过程复杂且时间、经济成本较高,仿真是达到密封圈磨损寿命预测目的较好的途径,但当前缺少对磨损重要因素—速度合适的仿真处理方法。针对实际工程应用密封系统磨损寿命评估的需求,基于混合润滑模型及Rhee磨损理论提出了考虑变速条件的往复密封磨损寿命预测方法,通过分析给定工况下的密封圈唇口轮廓磨损变化情况,模拟了唇口接触压力、接触宽度、接触变形以及反向泵回率等密封性能随磨损时间累加的演化过程,实现了密封圈磨损寿命预测的目标。结合实际工程应用斯特封,进行了与平均速度处理方法的寿命预测对比。结果表明:变速处理法下磨损失效周期泄漏率为3.24 mL/h,平均速度处理法下泄漏率为0.24 mL/h,预测结果存在明显差异,速度的瞬态变化是往复密封磨损仿真速度是不可忽略的因素。

关键词：往复密封混合润滑磨损仿真寿命预测

Application of fecal immunochemical test in colorectal cancer screening:A community-based,cross-sectional study in averagerisk individuals in Hainan

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3445-3456页

作者： Fan Zeng Da-Ya Zhang Shi-Ju Chen Run-xiang Chen Chen Chen Shi-Mei Huang Da Li Xiao-Dong Zhang Jia-Jia Chen Cui-Yi Mo Lei Gao Jun-Tao Zeng Jian-Xin Xiong Zhai Chen fei-Hu Bai Graduate School Hainan Medical UniversityHaikou 571199Hainan ProvinceChina Department of Gastroenterology Qionghai People’s HospitalQionghai 571400Hainan ProvinceChina Department of Gastroenterology Sanya Central HospitalSanya 572022Hainan ProvinceChina Department of Gastroenterology Hainan Second People’s HospitalWuzhishang 572299Hainan ProvinceChina Department of Gastroenterology Dongfang People’s HospitalDongfang 572699Hainan ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Hainan Medical UniversityHaikou 570216Hainan ProvinceChina The Gastroenterology Clinical Medical Center of Hainan Province Haikou 570216Hainan ProvinceChina

BACKGROUND The incidence of colorectal cancer(CRC)in China is steadily rising,with a high proportion of advanced-stage *** highlights the significance of early detection and prevention measures to enhance survival *** immunochemical testing(FIT)is a globally recommended CRC screening method;however,limited research has been conducted on its application in *** To assess the efficacy and adherence of FIT screening among average-risk individuals in Hainan,while also examining the risk factors associated with positive FIT *** This population-based cross-sectional study implemented FIT screening for CRC in 2000 asymptomatic participants aged 40-75 years from five cities and 21 community health centers in Hainan *** study was conducted from August 2022 to April 2023,employing a stratified sampling method to select *** with positive FIT results subsequently underwent *** predictive values for confirmed CRC and advanced adenoma were calculated,and the relationship between relevant variables and positive FIT results was analyzed usingχ2 tests and multivariate logistic *** A total of 1788 participants completed the FIT screening,with a median age of 57 years(interquartile range:40-75).Among them,503(28.1%)were males,and 1285(71.9%)were females,resulting in an 89.4%compliance rate for FIT *** overall positivity rate of FIT was 4.4%[79 out of 1788;95%confidence interval(CI):3%-5%].The specific positivity rates for Haikou,Sanya,Orient City,Qionghai City,and Wuzhishan City were 9.6%(45 of 468;95%CI:8%-11%),1.3%(6 of 445;95%CI:0.1%-3.1%),2.7%(8 of 293;95%CI:1.2%-4.3%),3.3%(9 of 276;95%CI:1.0%-6.3%),and 4.2%(11 of 406;95%CI:1.2%-7.3%),*** associations were found between age,dietary habits,and positive FIT *** of the 79 participants with positive FIT results,55 underwent colonoscopy,demonstrating an 82.2%compliance *** them,10 had a clean

关键词： Fecal immunochemical test Colorectal cancer Adenoma Screening Hainan Province

就业生态视域下绿色创新人才数字韧性的本土建构

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理论与现代化 2024年第2期 65-79页

作者：相飞齐鲁工业大学(山东省科学院)经济与管理学部

“双碳”战略实施迫切需要绿色化创新发展,绿色创新人才高质量充分就业为此提供了重要保障。数字技术作为创新驱动的引擎,在赋能创新价值实现的同时,结合就业生态特征,也给创新人才数字韧性建构带来新的挑战。数字韧性能够在一定程度上... 详细信息

“双碳”战略实施迫切需要绿色化创新发展,绿色创新人才高质量充分就业为此提供了重要保障。数字技术作为创新驱动的引擎,在赋能创新价值实现的同时,结合就业生态特征,也给创新人才数字韧性建构带来新的挑战。数字韧性能够在一定程度上减少数字风险带来的损伤,帮助个体更好地适应数字化生活。本文采用扎根理论方法探析绿色创新人才数字韧性内涵,提出包含数字心理韧性、数字行为韧性、数字技术韧性、数字环境韧性4个风险应对维度及其12个构面,以及“数字心理韧性→自主韧性”“数字行为韧性→自主韧性”“数字技术韧性→培育韧性”“数字环境韧性→治理韧性”共促数字韧性建构的内涵要素模型。从就业生态视角来看,源自个体、学校、社会等各方面的因素,都会不同程度影响数字韧性,使个体形成应对绿色化数字化环境中风险挑战的复原力。本文结合当前就业生态环境对绿色创新人才就业的影响,提出促进数字韧性建构、进一步推动该类人才高质量充分就业,从而助推“双碳”战略实施的建议。

关键词： “双碳”战略就业生态绿色创新人才数字韧性

Jianpi-Huatan-Huoxue-Anshen formula ameliorates gastrointestinal inflammation and microecological imbalance in chemotherapytreated mice transplanted with H22 hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4209-4231页

作者： Ya-Nan Wang xiang-Yang Zhai Zheng Wang Chun-Ling Gao Sui-Cai Mi Wen-Li Tang Xue-Min Fu Huai-Bang Li Li-Feng Yue Peng-fei Li Sheng-Yan Xi Department of TCM Xiang’an HospitalSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Faculty of Chinese Medicine and State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China Department of Radiotherapy Chenggong Hospital of Xiamen UniversityPLA 73rd Army HospitalXiamen 361003Fujian ProvinceChina Department of Oncology Xiamen Hospital of Traditional Chinese MedicineXiamen 361015Fujian ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China

BACKGROUND Jianpi-Huatan-Huoxue-Anshen formula[Tzu-Chi cancer-antagonizing&lifeprotecting II decoction(TCCL)]is a Chinese medical formula that has been clinically shown to reduce the gastrointestinal side effects of chemotherapy in cancer patients and improve their quality of ***,its effect and mechanism on the intestinal microecology after chemotherapy are not yet *** To discover the potential mechanisms of TCCL on gastrointestinal inflammation and microecological imbalance in chemotherapy-treated mice transplanted with hepatocellular carcinoma(HCC).METHODS Ninety-six mice were inoculated subcutaneously with HCC *** week later,the mice received a large dose of 5-fluorouracil by intraperitoneal injection to establish a HCC chemotherapy ***-six mice were randomly selected before administration,and feces,ileal tissue,and ileal contents were collected from each *** remaining mice were randomized into normal saline,continuous chemotherapy,Yangzheng Xiaoji capsulestreated,and three TCCL-treated *** treatment,feces,tumors,liver,spleen,thymus,stomach,jejunum,ileum,and colon tissues,and ileal contents were *** changes,serum levels of IL-1β,IL-6,IL-8,IL-10,IL-22,TNF-α,and TGF-β,intestinal SIgA,and protein and mRNA expression of ZO-1,NF-κB,Occludin,MUC-2,Claudin-1,and IκB-αin colon tissues were *** effect of TCCL on the abundance and diversity of intestinal flora was analyzed using 16S rDNA *** TCCL treatment improved thymus and spleen weight,thymus and spleen indexes,and body weight,decreased tumor volumes and tumor tissue cell density,and alleviated injury to gastric,ileal,and colonic mucosal *** proteins and genes associated with inflammation,IL-10,TGF-β,SIgA,ZO-1,MUC-2,and Occludin were upregulated,whereas NF-κB,IL-1β,IL-6,TNF-α,IL-22,IL-8,and IκB-αwere ***,TCCL increased the proportions of fecal Actinobacteria,AF12,Adlercreutzia,Clostridium,Coriobac

关键词： Chinese medicine Chemotherapy H22 hepatocellular carcinoma Intestinal barrier function Intestinal microecological balance

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基于天塞主镜的多尺度长焦成像系统设计

航空兵器 2024年第1期31卷 111-116页

作者：刘飞太智超张敏洁相萌于纯邵晓鹏西安电子科技大学光电工程学院西安710071 西安市计算成像重点实验室西安710071

针对提升多尺度成像系统的分辨率以满足对远距离目标精确识别的需求,从提升主镜焦距的角度出发,本文提出一种基于天塞结构主镜的多尺度长焦成像系统设计,分析了为满足次级镜头的线性排布而需要对主镜添加的两个约束条件,针对次级镜头阵... 详细信息

针对提升多尺度成像系统的分辨率以满足对远距离目标精确识别的需求,从提升主镜焦距的角度出发,本文提出一种基于天塞结构主镜的多尺度长焦成像系统设计,分析了为满足次级镜头的线性排布而需要对主镜添加的两个约束条件,针对次级镜头阵列中随离轴角增加使系统在对应视场成像质量下降的问题,对邻近区域次级镜头进行协同优化,同时在离轴位置次级镜头的优化中应用自由曲面面型完成像差校正。所设计系统不同视场区域成像的MTF曲线一致性较好,表明系统在全视场范围内成像质量理想。采用天塞结构主镜设计的多尺度成像系统,其空间分辨率达14μrad,相较于共心球透镜的多尺度系统有显著提高。

关键词：多尺度系统高分辨率天塞结构长焦系统光学设计光电成像

Magnesium cantharidate suppresses PP2A and ERK1/2 pathway to inhibit hepatocellular carcinoma cells

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Toxicology Advances 2024年第1期6卷 16-27页

作者： Ze Wang Yu-Xi Huang Tian-Mu He xiang-Yu Tan Xiao-fei Li Yun Liu Rong Yan School of Pharmacy Zunyi Medical UniversityZunyi 563000China School of Basic Medicine Zunyi Medical UniversityZunyi 563000China Guizhou Provincial College-based Key Lab for Tumor Prevention and Treatment with Distinctive Medicines Zunyi Medical UniversityZunyi 563000China

Background:Magnesium cantharidate(MC)is a protein phosphatase 2A(PP2A)inhibitor antitumor ***,its antitumor mechanism in hepatocellular carcinoma cell(HCC)remains ***:PP2A lentiviral vector over expression strategy was utilized both in vivo and in vitro to explore the antitumor effect in MC and okadaic acid(OA).Tumor weight was detected in mice after MC and OA *** proliferation,cell cycle,apoptosis rate,and western blotting were detected to explore the effects on MC and OA in human hepatocarcinoma SMMC-7721 ***:In vivo results demonstrated that MC inhibited HCC progression while OA promoted tumor *** vitro results demonstrated that MC effectively inhibited the growth of SMMC-7721 cells by arresting the cell cycle at the G2/M phase with inhibiting Cdc25C and activating the phosphorylation of the Cdc2 *** cytometry results further showed that MC increased ***,the expression of phosphorylated ERK1/2 was lower in the MC group but higher in the OA *** docking results showed that MC docked well with ERK1/***:MC inhibited HCC progression by suppressing the growth and activating the apoptosis of cancer cells and suppressing the expression of PP2A and ERK1/2.

关键词： magnesium cantharidate ERK1/2 HCC PP2A

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等规聚丙烯拉伸取向片晶结构的温度关联性

高分子通报 2024年第3期37卷 358-367页

作者：林浩严飞国江黄想姜胜宝许梦伊中国电力科学研究院武汉430074

为了探究加工温度对热拉伸聚丙烯取向晶体结构的影响规律,将等规聚丙烯(iPP)铸片在不同温度下拉伸到相同应变,并通过二维广角/小角X射线散射、差示扫描量热仪、动态力学分析等手段,对拉伸取向iPP的微观结构特性进行了系统研究。结果表明... 详细信息

为了探究加工温度对热拉伸聚丙烯取向晶体结构的影响规律,将等规聚丙烯(iPP)铸片在不同温度下拉伸到相同应变,并通过二维广角/小角X射线散射、差示扫描量热仪、动态力学分析等手段,对拉伸取向iPP的微观结构特性进行了系统研究。结果表明:经过热拉伸后,由球晶形貌演变成纤维晶形貌,纤维晶体由高度取向片晶和无定形层交替堆叠排列构成;升高温度引起结晶性能增强,结晶度和片晶平均厚度随温度连续递增;提高温度造成结晶相与无定形相之间的物性差异变大,两相链段运动松弛温度的变化趋势相反;热拉伸过程中新形成了不同厚度(熔点)的片晶,高熔点片晶是通过熔融-再结晶机理形成,而低熔点片晶由应变诱导结晶方式获得。本研究初步阐明了拉伸温度对聚丙烯取向片晶结构的影响规律和作用机制,对于开展结晶聚合物拉伸加工过程中多层次结构调控与性能优化具有参考价值。

关键词：等规聚丙烯拉伸温度片晶结晶度熔点

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金属纳米图案对钙钛矿电池的光学增强

物理学报 2024年第16期73卷 209-216页

作者：韩非江舟王晨周华沈向前新疆大学物理科学与技术学院新疆固态物理与器件重点实验室乌鲁木齐830046 山东大学物理学院济南250100 上海交通大学金属基复合材料国家重点实验室上海200240

表面等离激元共振(SPR)是调控太阳电池光谱响应、增强能量转换效率的重要策略之一.但对于平面异质型的钙钛矿电池,由于各功能层厚度对金属纳米结构的尺寸限制,SPR的响应波段通常被束缚在很窄的可见光区域,且共振能量的消散以外层电子的... 详细信息

表面等离激元共振(SPR)是调控太阳电池光谱响应、增强能量转换效率的重要策略之一.但对于平面异质型的钙钛矿电池,由于各功能层厚度对金属纳米结构的尺寸限制,SPR的响应波段通常被束缚在很窄的可见光区域,且共振能量的消散以外层电子的热吸收为主.本文基于时域有限差分方法(FDTD)和严格耦合波分析(RCWA),系统研究了不同金属图案的SPR图谱.结果表明,通过对图案形状、厚度、周期等特征参数的优化,可以在近红外区域观察到明显的SPR现象,同时散射在消光中占据主导地位.对于最优的金属圆环,SPR峰值对应的波长为772 nm,此时相对吸收、散射和消光截面分别为0.54,1.39和1.93,钙钛矿响应层在700-850 nm之间的加权平均吸收从53.61%提升到65.36%.相应器件的光生电流密度从20.39 mA/cm^2增至22.72 mA/cm^2,光电转换效率相对提升了11.45%.

关键词：金属纳米图案等离激元共振钙钛矿电池转换效率

习近平文化思想的出场语境、理论创新及当代价值

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南昌航空大学学报（社会科学版） 2024年第3期26卷 1-9页

作者：孟祥健范兆飞安徽医科大学马克思主义学院合肥230032 合肥工业大学马克思主义学院合肥230601

习近平文化思想是新时代文化建设的最新成果,亦是“第二个结合”的具体展现。习近平文化思想是基于发展马克思主义文化理论的内在要求、满足人民对美好精神文化的现实需要与顺应构建人类文明新形态的发展大势所凝练出来的。习近平文化... 详细信息

习近平文化思想是新时代文化建设的最新成果,亦是“第二个结合”的具体展现。习近平文化思想是基于发展马克思主义文化理论的内在要求、满足人民对美好精神文化的现实需要与顺应构建人类文明新形态的发展大势所凝练出来的。习近平文化思想的理论创新既包括“党的文化领导权”“文化自信”等先前有所论述但未成体系的拓展性创新思想,也包括“两个结合”“全球文明倡议”等前人未言的开拓性创新理论。在新时代文化建设进程中,习近平文化思想锚定了推动马克思主义文化理论发展的方向,提供了践行社会主义核心价值观的理论指引,并为实现人类命运共同体的文化建构贡献了中国智慧。

关键词：习近平文化思想理论创新新时代文化建设文化自信