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Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang li Tian-Shuo Feng Ji Gao Xin-xiang Yang xiang-cheng li Zhen-Hua Deng Yong-xiang Xia Zheng-Shan Wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of living Donor liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 liver transplantation

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Generation of Polycyclic Aromatic Hydrocarbons During Coking

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Journal of Iron and Steel Research International 2010年第12期17卷 6-10页

作者： cheng xiang-li li En-ke CANG Da-qiang SHI Yan li Mao-jing State Key Laboratory of Advanced Steel Processing and Products Central Iron and Steel Research Institute Beijing 100081 China Tangshan Environmental Protection Bureau Tangshan 063000 Hebei China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China College of Metallurgy and Energy Hebei Polytechnic University Tangshan 063009 Hebei China

The generation of polycyclic aromatic hydrocarbons （PAHs） during coking was studied and the contents of sixteen PAHs were measured by the devices of ultrasonic abstraction and high performance liquid chromatography for single coal coking and blended coal coking. The results indicated that the amount of generated PAHs during the first 1--4 h of coking is the most. Among these PAHs, the tetranuclear PAHs have a major portion and the Benzo[a]pyrene which can cause cancer, and teratogenesis and mutation is generated for a larger concentration more than emission standard value. Two PAHs are the main pollutants of PAHs pollution.

关键词： polycyclic aromatic hydrocarbon coking single coal blended coal

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Reduction and melting behavior of carbon composite lateritic bauxite pellets

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International Journal of Minerals,Metallurgy and Materials 2015年第4期22卷 381-388页

作者： Ying-yi Zhang Jie Zhao Yuan-hong Qi xiang-li cheng Zong-shu Zou State Key Laboratory of Advance Steel Processes and Products Central Iron and Steel Research Institute School of Material and Metallurgy Northeast University

Direct reduction of low-grade lateritic bauxite was studied at high temperature to recover Fe and beneficiate AlzO3 slag. The re- sults show that a metallization rate of 97.9% and a nugget recovery rate of 85.1% can be achieved when the reducing and melting tempera- tures are 1350 and 1480℃, respectively. Moreover, a higher-grade calcium aluminate slag （A1203 = 50.52wt%） can also be obtained, which is mainly composed of ct-A1203, hercynite （FeAI：O4）, and gehlenite （Ca2A12SiO7）. In addition, high-quality iron nuggets have been produced from low-grade lateritic bauxite. The nugget is mainly composed of iron （93.82wt%） and carbon （3.86wt%）, with almost no gangue （slag）.

关键词： bauxite ore pellets direct reduction process melting behavior metallization

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Characteristics and Mechanism of Reduction and Smelting-separation Process of Copper Slag

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Journal of Iron and Steel Research International 2015年第2期22卷 121-127页

作者： Jun ZHANG Yuan-hong QI Ding-liu YAN xiang-li cheng Peng HE State Key Laboratory of Advanced Steel Processes and Products China Iron and Steel Research Institute Group

The characteristics And mechanism of the reduction and smelting-separation process of the copper slag were studied by investigating the variation ：rule of metallization ratio, yield as well as carbon content of iron nuggets. The formation of molten slag is necessary for slag-iron separation, And iron is in half-molten state during smelting-separa- tion process, the carbon content of which is about 1.25 %. Carburization occurs through direct contact between car- bon and iron in essence, no matter in solid or molten state. The carburization rate is slow below 1 200 ℃ , which is inhibited by the existence of slag. Residual FeO in molten slag tends to form fayalite with SiOz in the copper slag, which is the root cause for the low mehing temperature of copper slag. The addition of CaO improves the reducibility of the copper slag, but Al2 O3 addition has no obvious effect. The melting temperature of slag affects the carburiza- tion extent in solid state, while the content of FeO in molten slag affects that in molten state, both of which co-de termine the carbon content in iron nuggets.

关键词： copper slag reduction smelting-separation earburization iron nugget

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Direct Reduction Experiment on Iron-Bearing Waste Slag

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Journal of Iron and Steel Research International 2013年第3期20卷 24-29,35页

作者： cheng xiang-li ZHAO Kai QI Yuan-hong SHI Xue-feng ZHEN Chang-liang State Key Laboratory of Advanced Steel Process and Products Central Iron and Steel Research Institute

A lot of iron-bearing slags were produced,and whose grade is much more than that of industrial iron ore *** analysis and phase identification shows that the iron-bearing slag is amorphous,has fayalite main phase,iron grade is 36.10%,and is difficult to recover iron from the *** calculation indicates that CO cannot reduce fayalite at high temperature and carbon direct reduction can be ***,the reaction begins at 770 ℃ and the temperature can be reduced down to 500℃ when CaO is *** this basis,a method is put forward to making direct enrichment of iron by taking carbon contained pellets to realize the rapid reduction of fayalite,and the direct reduction process were studied in this *** show that xC/xO should be less than 1.5 for the need of reduction and carburization,and CaO and Al2O3 can spur the reduction of *** conditions that xC/xO is 1.2,metallization rate can be 77% when temperature is 1 250 ℃ and only carbon is added,and metallization rate can be 74% when temperature is 1 200 ℃ and only CaO is *** the addition of Al2O3 can get a higher metallization rate（10% or so） than usual as R is between 0.4 and *** the optimized condition of R equals to 0.6,temperature of 1 250 ℃,slag melting point of 1 320 ℃,and time of 30 min,the metallization rate can reach 88.43%.

关键词： iron-bearing slag fayalite metallization rate basicity

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Drainage by urostomy bag after blockage of abdominal drain in patients with cirrhosis undergoing hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2013年第1期12卷 99-102页

作者： Guo-Qiang li Feng Zhang Hao Lu ling Lu xiang-cheng li Xue-Hao Wang Bei-cheng Sun liver Transplantation Center First Affiliated HospitalNanjing Medical University Key Laboratory of living Donor liver Transplantation of Ministry of Public Health

Abdominal drainage was previously recommended as a post-hepatectomy procedure for patients with *** report introduces a simple technique that prevents leakage of ascitic fluid after cirrhotic hepatectomy complicated by blockage of the abdominal *** 59 patients who had had cirrhotic hepatectomy complicated by leakage of ascites in the drain site after drainage removal between January 2001 and April 2011,31 underwent suture ligation(sutured group) and 28 were given urostomy bag at the abdominal drainage site(drainage group).The mean length of postoperative hospital stay in the drainage group was shorter than in the sutured group(16.11±2.61 vs 34.23±4.86 days,P=0.000).Meanwhile,the drainage group showed decreased postoperative complications,including leakage of ascites,wound infection,and collection of *** by urostomy bag can prevent prolonged leakage of ascitic fluid after the blockage of abdominal drains in patients undergoing cirrhotic hepatectomy.

关键词： abdominal drain ascitic fluid leak hepatectomy urostomy bag

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Calculation model of mass action concentrations for CaO-MgO-SiO_2-Al_2O_3-Cr_2O_3 penta-slag

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Chinese Chemical Letters 2010年第2期21卷 229-233页

作者： Guo, Hua Hu, Yu Ting Cang, Da Qiang Jin, Yi Wang, li Xin cheng, xiang li Bai, Hao Zong, Yan Bing Univ Sci & Technol Beijing Sch Met & Ecol Engn Beijing 100083 Peoples R China Taiyuan Iron & Steel Co Ltd Taiyuan 030003 Peoples R China

Two calculation models of mass action concentrations for CaO-MgO-SiO_2-Al_2O_3-Cr_2O_3 penta-slag was presented whether 3CaO·Cr_2O_3·3SiO_2 was existence or *** mass action concentration of each element structure was *** the models results were compared with experimental *** final results illustrated the model without 3CaO·Cr_2O_33SiO_2 was suit for *** model could response the element structure of slag as well.

关键词： Slag Cr_2O_3 Co-existence theory Thermodynamic calculation model

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Advances in electrical impedance tomography-based brain imaging

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Military Medical Research 2022年第6期9卷 705-726页

作者： Xi-Yang Ke Wei Hou Qi Huang Xue Hou Xue-Ying Bao Wei-Xuan Kong cheng-xiang li Yu-Qi Qiu Si-Yi Hu li-Hua Dong Department of Radiation Oncology and Therapy the First Hospital of Jilin UniversityChangchun 130021China Jilin Provincial Key Laboratory of Radiation Oncology and Therapy the First Hospital of Jilin UniversityChangchun 130021China NHC Key Laboratory of Radiobiology School of Public HealthJilin UniversityChangchun 130021China CAS Key Laboratory of Bio-Medical Diagnostics Suzhou Institute of Biomedical Engineering and TechnologyChinese Academy of SciencesSuzhou 215163JiangsuChina

Novel advances in the field of brain imaging have enabled the unprecedented clinical application of various imaging modalities to facilitate disease diagnosis and treatment. Electrical impedance tomography(EIT) is a functional imaging technique that measures the transfer impedances between electrodes on the body surface to estimate the spatial distribution of electrical properties of tissues. EIT offers many advantages over other neuroimaging technologies,which has led to its potential clinical use. This qualitative review provides an overview of the basic principles,algorithms, and system composition of EIT. Recent advances in the field of EIT are discussed in the context of epilepsy,stroke, brain injuries and edema, and other brain diseases. Further, we summarize factors limiting the development of brain EIT and highlight prospects for the field. In epilepsy imaging, there have been advances in EIT imaging depth,from cortical to subcortical regions. In stroke research, a bedside EIT stroke monitoring system has been developed for clinical practice, and data support the role of EIT in multi-modal imaging for diagnosing stroke. Additionally, EIT has been applied to monitor the changes in brain water content associated with cerebral edema, enabling the early identification of brain edema and the evaluation of mannitol dehydration. However, anatomically realistic geometry,inhomogeneity, cranium completeness, anisotropy and skull type, etc., must be considered to improve the accuracy of EIT modeling. Thus, the further establishment of EIT as a mature and routine diagnostic technique will necessitate the accumulation of more supporting evidence.

关键词： Electrical impedance tomography(EIT) Brain diseases Tissue impedance Microelectrode array

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Safety evaluation of donors for living-donor liver transplantation in Chinese mainland:A single-center report

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World Journal of Gastroenterology 2007年第32期13卷 4379-4384页

作者： Guo-Qiang li Feng Zhang xiang-cheng li Bei-cheng Sun Feng cheng Wen-Gang Ge Xue-Hao Wang liver Transplantation Center First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China

AIM： To discuss the safety of donors during living donor liver transplantation （LDLT） and the authors＇ experience with 50 cases. METHODS： Between January 1995 and March 2006, 50 patients with end-stage liver disease received LDLT in our department. Donors （at the age of 27-58 years） were healthy and antibody （ABO）-compatible. The protocol of evaluation and selection of donors, choice of surgical methods and strategy applied in the safety evaluation of donors were analyzed. RESULTS： A total of 115 candidate donors were evaluated for LDLT at our center. Of these, 50 underwent successful hepatectomy for living donation. The elimination rate for donors was 43.5%. Positive hepatitis serology and ABO incompatibility were the main factors for excluding candidates. All donors recovered uneventfully. The follow-up time ranged from 3 to 135 too. The incidence of major and minor medical complications was 12.0% and 28.0%, respectively. CONCLUSION： LDLT provides an excellent approach to the problem of donor shortage in China. With a thorough and complete preoperative workup and meticulous intra-and postoperative management, LDLT can be performed with minimal donor morbidity.

关键词： liver transplantation living donor Safety Evaluation

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Caspofungin in salvage treatment of severe pneumocystis pneumonia： case report and literature review

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Chinese Medical Journal 2009年第8期122卷 996-999页

作者： MU xiang-dong QUE cheng-li HE Bing WANG Guang-fa li Hai-chao Department of Respiratory Medicine Peking University First Hospital Beijing 100034 China

Pneumocystis pneumonia （PCP） is one of the most critical and life-threatening infections in immunocompromised patients with AIDS （especially CD4^＋ T cell less than 0.2×10^9/L）, hematological malignancies, organ transplantation or connective tissue diseases. It is caused by a fungus called Pneumocystis jiroveci （P. jiroveci, formerly called P carinii）.

关键词： pneumocystis jiroveci pneumonia 1, 3-beta-D-glucan caspofungin trimethoprim-sulfamethoxazole

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