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Cr12MoV钢渗硼工艺及渗层的组织与性能

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金属热处理 2006年第7期31卷 67-71页

作者：郝少祥孙玉福杨凯军郑州大学材料科学与工程学院

采用正交试验方法,优化出Cr12MoV钢最佳的渗硼工艺参数为950℃×5 h及最佳的稀土加入量为0.3wt%。与普通工艺的渗硼层相比,优化的渗硼层较厚且致密,疏松和空洞减少,硬度压痕完整,渗层脆性较低,渗层前沿较齐整。经X-ray衍射分析表明,渗... 详细信息

采用正交试验方法,优化出Cr12MoV钢最佳的渗硼工艺参数为950℃×5 h及最佳的稀土加入量为0.3wt%。与普通工艺的渗硼层相比,优化的渗硼层较厚且致密,疏松和空洞减少,硬度压痕完整,渗层脆性较低,渗层前沿较齐整。经X-ray衍射分析表明,渗硼层主要由FeB、Fe2B、(Fe、Cr)3C、(Cr、Fe)7C3组成。经优化渗硼后再经970℃淬火、200℃回火处理后,其渗层耐磨性比优化渗硼层提高15倍。

关键词： Cr12MoV钢渗硼工艺渗硼层组织性能

TMEM16A contributes to endothelial dysfunction through accelerating Nox2 NADPH oxidase-derived ROS generation in hypertension

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中国药理学与毒理学杂志 2016年第10期30卷 1049-1050页

作者： MA Ming-ming GAO Min GUO Kai-min LI xiang-yu WANG Mi ZENG Xue-lin sun Lu Lyu Xiao-fei DU Yan-hua WANG Guan-lei ZHOU Jia-guo GUAN Yong-yuan Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-Sen University Department of Pharmacy the Sixth Affiliated Hospital of Sun Yat-Sen University Department of Obstetrics and Gynecology Guangzhou Women and Children Medical Center affiliated to Guangzhou Medical University Department of Cardiology the Second Xiangya Hospital of Central South University

OBJECTIVE The Ca2+-activated Cl-channel(Ca CC)plays a crucial role in various physiological *** evidences suggest TMEM16A encodes CaC C in various cells,including endothelial ***,the role of TMEM16A in the vascular endothelial dysfunction in hypertension is *** In the study,RT-PCR,Western blotting,co-immunopricipitation,confocal imaging,patch-clamp,and endothelial-specific TMEM16A transgenic and knockout mice were *** We found that TMEM16A was expressed abundantly and functioned as Ca CC in endothelial ***Ⅱ(AngⅡ)induced endothelial dysfunction with an increase in TMEM16A expression,which was alleviated by TMEM16A *** studies revealed that TMEM16A endothelial-specific knockout significantly lowered the blood pressure and ameliorated endothelial dysfunction in AngⅡ-induced hypertension,whereas,TMEM16A endothelial-specific overexpression showed the opposite *** results were related to the increased reactive oxygen species(ROS)generation,NADPH oxidase activation,and Nox2,p22phox expression facilitated by TMEM16A upon AngⅡ-induced hypertensive ***,TMEM16A directly interacted with Nox2 monomer and reduced the degradation of Nox2 through the proteasome-dependent endoplasmic recticulum-associated degradation ***16A also potentiated the translocation of p47phox and p67phox from cytosol to cell membrane and the subsequent interaction with *** Our results demonstrated that TMEM16A,as Ca CC,is a positive regulator of ROS generation via upregulating the activation of Nox2 NADPH oxidase in the vascular endothelium,and therefore facilitates endothelial dysfunction and *** of TMEM16A may be a novel therapeutic strategy for endothelial dysfunction-associated cardiovascular diseases.

关键词： TMEM16A endothelial dysfunction ROS NADPH oxidase Nox2 angiotensinⅡ

Base－Catalyzed　Rearrangement　of　11－Isopropylidene－anti－4，5－Epoxyendo－Tricyclo［6．2．1．0^（2，7）］　Undeca－4，9－Diene－3，6－Dione

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Chinese Chemical Letters 1996年第10期7卷 902-904页

作者： Xiao Pei GUAN Jian Guang sun and Yong Zhong yu(College of Chemical Engineering and Materials Science, Beijing Institute of Technology, 100081 Beijing) Coll. of Chem. Eng. and Mat. Science Beijing Institute of Technology 100081 Beijing

Treatment of 11-isopropylidene-anti-4, 5-epoxy-endo-tricyclo[6. 2. 1. 02.7] undeca-4, 9-diene-3,6-dione(6) with methanolic sodium hydroxide results in Favorskii-type ring contraction with concomitant Cope rearrangement and Haller-Bauer cleavage, thereby affording dimethyl9-isopropxlidene-cis-bicyclo[4. 3. 0 ] nonane-(2S)-2, 3-dicarboxylate(7) as the ultimate product. The structure of 7 was confirmed by single crystal X-ray analysis

关键词： Rearrangement Isopropylidene Base Catalyzed

Microengineered platforms for characterizing the contractile function of in vitro cardiac models

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Microsystems & Nanoengineering 2022年第1期8卷 29-50页

作者： Wenkun Dou Manpreet Malhi Qili Zhao Li Wang Zongjie Huang Junhui Law Na Liu Craig A.Simmons Jason T.Maynes yu sun Department of Mechanical and Industrial Engineering University of TorontoTorontoON M5S 3G8Canada Program in Molecular Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Biochemistry University of TorontoTorontoON M5S 1A8Canada Institute of Robotics and Automatic Information System and the Tianjin Key Laboratory of Intelligent Robotics Nankai UniversityTianjin 300350China School of Mechanical&Automotive Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Mechatronics Engineering and Automation Shanghai UniversityShanghai 200444China Institute of Biomedical Engineering University of TorontoTorontoON M5S 3G9Canada Translational Biology&Engineering Program Ted Rogers Centre for Heart ResearchTorontoON M5G 1M1Canada Department of Anesthesiology and Pain Medicine University of TorontoTorontoON M5S 1A8Canada Department of Anesthesia and Pain Medicine The Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Electrical and Computer Engineering University of TorontoTorontoON M5S 3G4Canada Department of Computer Science University of TorontoTorontoON M5T 3A1Canada

Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology,disease modeling and drug cardiotoxicity as well as for therapeutic *** still exist in obtaining the complete capability of in situ sensing to fully evaluate the complex functional properties of cardiac cell/tissue *** to contractile strength(contractility)and beating regularity(rhythm)are particularly important to generate accurate,predictive *** new platforms and technologies to assess the contractile functions of in vitro cardiac models is essential to provide information on cell/tissue physiologies,drug-induced inotropic responses,and the mechanisms of cardiac *** this review,we discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models,including single cardiomyocytes,2D monolayers of cardiomyocytes,and 3D cardiac *** characteristics and performance of current platforms are reviewed in terms of sensing principles,measured parameters,performance,cell sources,cell/tissue model configurations,advantages,and *** addition,we highlight applications of these platforms and relevant discoveries in fundamental investigations,drug testing,and disease ***,challenges and future outlooks of heart-on-a-chip platforms for in vitro measurement of cardiac functional properties are discussed.

关键词： cardiac contractile regularity

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匹配场处理舰船辐射噪声级估计方法

声学学报 2014年第5期39卷 570-576页

作者：向龙凤孙超西北工业大学航海学院西安710072

针对水声信道对舰船辐射噪声声传播的影响,进而导致声源级测量结果不准确的问题,提出了基于匹配场处理的舰船辐射噪声级估计方法。在海洋环境噪声为空间均匀高斯白噪声的假设下,当海洋环境参数已知、信噪比满足一定要求时,匹配场处理能... 详细信息

针对水声信道对舰船辐射噪声声传播的影响,进而导致声源级测量结果不准确的问题,提出了基于匹配场处理的舰船辐射噪声级估计方法。在海洋环境噪声为空间均匀高斯白噪声的假设下,当海洋环境参数已知、信噪比满足一定要求时,匹配场处理能有效地给出被测噪声源的位置信息及该位置处的能量响应。从能量估计角度出发,推导了声源位置处匹配场输出响应的能量修正因子计算公式,从理论上证明了匹配场处理在被测声源位置处输出响应与能量修正因子的乘积为真实声源级的最小方差无偏(MVU)估计。该方法首先选择合适的声场计算模型计算拷贝场向量,对接收到的辐射噪声信号进行匹配场处理,得出接收信号级和被测声源位置;其次利用该位置所对应的拷贝场向量替换能量修正因子公式中的真实信道传输函数以计算能量修正因子的估计值;最后由接收信号级与能量修正因子估计值相乘得出舰船辐射噪声声源级的MVU估计。针对典型的浅海水声信道,进行了计算机仿真试验,结果表明:该方法能有效地进行舰船辐射噪声测量,当信噪比满足一定要求时,测量得到的声源级与实际声源级相比,误差小于1 dB。

关键词：舰船辐射噪声匹配场处理估计方法噪声级能量响应位置信息修正因子计算模型

Catalytically active atomically thin cuprate with periodic Cu single sites

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National Science Review 2023年第1期10卷 226-235页

作者： Huimin Yang Shibo Xi Na Guo Mu Wang Lingmei Liu Pin Lyu Xiaolong yu Jing Li Haomin Xu Xiao Hai Zejun Li Xinzhe Li Tao sun Xiaoxu Zhao yu Han Wei yu Jie Wu Chun Zhang Honghan Fei Ming Joo Koh Jiong Lu Department of Chemistry National University of Singapore Institute of Chemical and Engineering Sciences Department of Physics National University of Singapore Advanced Membranes and Porous Materials Center King Abdullah University of Science and Technology SDU-ANU Joint Science College Shandong University School of Materials Science and Engineering Peking University Centre for Advanced 2D Materials and Graphene Research Centre National University of Singapore Department of Chemistry Tongji University

Rational design and synthesis of catalytically active two-dimensional(2D) materials with an abundance of atomically precise active sites in their basal planes remains a great ***,we report a ligand exchange strategy to exfoliate bulk [Cu4(OH)6] [O3S(CH2)4SO3] cuprate crystals into atomically thin 2D cuprate layers([Cu2(OH)3]+).The basal plane of 2D cuprate layers contains periodic arrays of accessible unsaturated Cu(Ⅱ) single sites(2D-CuSSs),which are found to promote efficient oxidative Chan-Lam *** me chanistic studies reveal that the reactions proceed via coordinatively unsaturated CuO4(Ⅰ) single sites with the formation of Cu(Ⅰ) species in the rate-limiting step,as corroborated by both operando experimental and theoretical *** robust stability of 2D-CuSSs in both batch and continuous flow reactions,coupled with their recyclability and good performance in complex molecule derivatization,render 2D-CuSSs attractive catalyst candidates for broad utility in fine chemical synthesis.

关键词： exfoliation nanosheet heterogeneous catalysis

EGFR/BRAF/MEK co-inhibition for EGFR-mutated lung adenocarcinoma patients with an acquired BRAF^(V600E) mutation: a case report and review of literature

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Cancer Drug Resistance 2021年第4期4卷 1019-1027页

作者： Ran Zeng Lifeng Luo Xianwen sun Zhiyao Bao Wei Du Ranran Dai Wei Tang Beili Gao Yi xiang Department of Respiratory and Critical Care Medicine Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Institute of Respiratory Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory of Emergency Prevention Diagnosis and Treatment of Respiratory Infectious DiseasesShanghai 200025China Department of respiratory disease Kashgar Prefecture Second People’s HospitalKashi 844000XinjiangChina

Despite the promising initial anti-tumor efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs),most advanced non-small-cell lung cancers(NSCLCs)progress eventually due to therapeutic resistance.V-Raf murine sarcoma viral oncogene homolog B1(BRAF)^(V600E) mutation has been considered as an uncommon mutation that contributes to acquired resistance for *** the presented case,BRAF^(V600E) mutation was detected as an acquired resistance-mediated mutation in a patient treated with osimertinib(a third-generation EGFR-TKI).The presented patient achieved partial regression and ongoing PFS of four months after the co-inhibition of osimertinib plus dabrafenib(BRAF inhibitor)and trametinib(MEK inhibitor).Our case further enriches the clinical evidence of the efficacy of EGFR/BRAF/MEK co-inhibition in patients with an acquired BRAF^(V600E) mutation,consistent with the review of the literature(eight cases).Additionally,our case highlights the important role of sample type,method,and platform of gene detection in patient management,life quality,and prognosis,as well as the understanding of acquired resistance mechanism.

关键词： NSCLC targeted therapy resistance mechanisms EGFR mutation BRAFV600E mutation case report

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基于云计算技术的大规模网络入侵检测

内蒙古师范大学学报（自然科学汉文版） 2017年第6期46卷 884-887,892页

作者：孙丽高向玉河北政法职业学院计算机系河北石家庄050000

针对当前网络入侵检测效率低的难题,提出了基于云计算技术的大规模网络入侵检测模型.首先收集网络入侵数据,并进行归一化处理,然后将整个数据集划分多个子集,采用云计算技术对每一个子集进行建模,最后采用KDD CUP数据集对模型的性能进... 详细信息

针对当前网络入侵检测效率低的难题,提出了基于云计算技术的大规模网络入侵检测模型.首先收集网络入侵数据,并进行归一化处理,然后将整个数据集划分多个子集,采用云计算技术对每一个子集进行建模,最后采用KDD CUP数据集对模型的性能进行分析.结果表明,该模型加快了网络入侵检测的速度,可以满足大规模网络入侵在线检测要求.

关键词：云计算技术大规模数据网络入侵检测神经网络

A NONLINEAR THERMOCAPILLARY MIGRATION OF DROPLETS DUE TO DEPENDENCE OF PHYSICAL PROPERTIES ON TEMPERATURE

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Journal of Hydrodynamics 2006年第4期18卷 469-474页

作者： sun Ren Department of Engineering Mechanics Shanghai Jiaotong University Shanghai 200240 China

A slow thermocapillary migration of a droplet at vanishingly small Reynolds and Marangoni numbers was theoretically investigated. A force on the droplet released in another liquid subjected to arbitrary configuration of the gravitational field and an imposed thermal gradient for the case of constant liquid properties was derived using the general solutions given by Lamb. A solution to the migration was thereby obtained, which corresponds to the well-known YGB result as t →∞. In the case of variable physical properties with temperature, a nonlinear migration of the droplet was described by the dynamical equation of motion, and the numerical results were compared with available experimental data. The comparison exhibits a reasonable agreement between the theoretical prediction and the experimental results, which shows the dependence of physical properties on temperature is a primary cause of the continuous velocity variation in the thermocapillary droplet migration.

关键词： thermocapillary migration droplet/bubble dynamics interfacial tension thermal gradient