Microengineered platforms for characterizing the contractile function of in vitro cardiac models

作     者：Wenkun Dou Manpreet Malhi Qili Zhao Li Wang Zongjie Huang Junhui Law Na Liu Craig A.Simmons Jason T.Maynes Yu Sun 

作者机构：Department of Mechanical and Industrial EngineeringUniversity of TorontoTorontoON M5S 3G8Canada Program in Molecular MedicineThe Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of BiochemistryUniversity of TorontoTorontoON M5S 1A8Canada Institute of Robotics and Automatic Information System and the Tianjin Key Laboratory of Intelligent RoboticsNankai UniversityTianjin 300350China School of Mechanical&Automotive EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China School of Mechatronics Engineering and AutomationShanghai UniversityShanghai 200444China Institute of Biomedical EngineeringUniversity of TorontoTorontoON M5S 3G9Canada Translational Biology&Engineering ProgramTed Rogers Centre for Heart ResearchTorontoON M5G 1M1Canada Department of Anesthesiology and Pain MedicineUniversity of TorontoTorontoON M5S 1A8Canada Department of Anesthesia and Pain MedicineThe Hospital for Sick ChildrenTorontoON M5G 1X8Canada Department of Electrical and Computer EngineeringUniversity of TorontoTorontoON M5S 3G4Canada Department of Computer ScienceUniversity of TorontoTorontoON M5T 3A1Canada 

出 版 物：《Microsystems & Nanoengineering》 (微系统与纳米工程（英文）)

年 卷 期：2022年第8卷第1期

页      面：29-50页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：The authors acknowledge the Canadian Institutes of Health Research(CIHR)and the Natural Sciences and Engineering Research Council of Canada(NSERC)for financial support through a Collaborative Health Research Projects(CHRP)grant.W.K.D.acknowledges the Ted Rogers Centre for Heart Research Education Fund for a fellowship N.L.acknowledges the National Natural Science Foundation of China(NSFC)for financial support under Grant 61933008 

主　　题：cardiac contractile regularity 

摘      要：Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology,disease modeling and drug cardiotoxicity as well as for therapeutic *** still exist in obtaining the complete capability of in situ sensing to fully evaluate the complex functional properties of cardiac cell/tissue *** to contractile strength(contractility)and beating regularity(rhythm)are particularly important to generate accurate,predictive *** new platforms and technologies to assess the contractile functions of in vitro cardiac models is essential to provide information on cell/tissue physiologies,drug-induced inotropic responses,and the mechanisms of cardiac *** this review,we discuss recent advances in biosensing platforms for the measurement of contractile functions of in vitro cardiac models,including single cardiomyocytes,2D monolayers of cardiomyocytes,and 3D cardiac *** characteristics and performance of current platforms are reviewed in terms of sensing principles,measured parameters,performance,cell sources,cell/tissue model configurations,advantages,and *** addition,we highlight applications of these platforms and relevant discoveries in fundamental investigations,drug testing,and disease ***,challenges and future outlooks of heart-on-a-chip platforms for in vitro measurement of cardiac functional properties are discussed.