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Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway

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Neural Regeneration Research 2024年第8期19卷 1802-1811页

作者： Fudong Li Xiaofei Sun Kaiqiang Sun Fanqi kong Xin Jiang Qingjie kong Department of Orthopedics Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Orthopedic Surgery Spine CenterShanghai Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Orthopedic Surgery Naval Medical CenterNaval Medical UniversityShanghaiChina Department of Anesthesiology Shanghai Changzheng HospitalNaval Medical UniversityShanghaiChina

Spinal cord injury-induced motor dysfunction is associated with *** have shown that the triterpenoid lupenone,a natural product found in various plants,has a remarkable anti-inflammatory effect in the context of chronic ***,the effects of lupenone on acute inflammation induced by spinal cord injury remain *** this study,we established an impact-induced mouse model of spinal cord injury,and then treated the injured mice with lupenone(8 mg/kg,twice a day)by intrape ritoneal *** also treated BV2 cells with lipopolysaccharide and adenosine5’-triphosphate to simulate the inflammatory response after spinal cord *** res ults showed that lupenone reduced IKBa activation and p65 nuclear translocation,inhibited NLRP3 inflammasome function by modulating nuclear factor kappa B,and enhanced the conve rsion of proinflammatory M1 mic roglial cells into anti-inflammatory M2 microglial ***,lupenone decreased NLRP3 inflammasome activation,NLRP3-induced mic roglial cell polarization,and microglia pyroptosis by inhibiting the nuclear factor kappa B *** findings suggest that lupenone protects against spinal cord injury by inhibiting inflammasomes.

关键词： inflammasome inflammation lupenone microglia polarization pyroptosis spinal cord injury

Male reproductive function before and after the adjustment of the COVID-19 prevention policy:a multicenter study in China

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Asian Journal of Andrology 2024年第3期26卷 308-314页

作者： Jian-zheng Li Han Wu Li Wang Yun-Shan Wang Feng kong Long-Qiao Cao Ming Liang Xiong Wang Ming-Zhen Yuan Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250000China Institute of Women Children and Reproductive HealthShandong UniversityJinan 250012China Engineering Laboratory of Urinary Organ and Functional Reconstruction of Shandong Province Jinan 250000China The First People’sHospital of Jining Jining 272000China Department of Reproductive Medicine The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250000China Reproductive Medicine Center Affiliated Yantai Yuhuangding Hospital of Qingdao UniversityYantai 264000China

At the end of 2022,the adjustment of the coronavirus disease 2019(COVID-19)pandemic control policy in China resulted in alarge-scale increase in public *** compare the fertility parameters of male patients before and after the adjustments ofthe COVID-19 pandemic control policy in China,we collected data on patients’medical histories and laboratory examinations ontheir first visits between June 2022 and March 2023 in five different *** were divided into five groups according tothe timeline of the policy *** data we collected from male patients included semen quality and serum reproductivehormone levels,and intergroup comparisons were made using the Mann–Whitney U and Chi-square *** total,16784 casesunderwent regular semen analysis,11180 had sperm morphology assessments,and 7200 had reproductive hormone *** showed declining trends in semen volume,sperm motility,and the progressive sperm motility rate after the policy *** comparison revealed an initial decrease and gradual recovery in progressive motility *** morphology analysisshowed increased neck and tail abnormalities after the policy *** significant change in hormone levels was *** the adjustment of the COVID-19 prevention policy in China,a decline in sperm motility and morphology was *** trend may gradually recover over 2 *** the policy adjustment,reproductive hormone levels were relatively stablethroughout,except for an increase in luteinizing hormone(LH).These changes in semen parameters suggest that the policyadjustment had a short-to medium-term impact on male reproductive function.

关键词： COVID-19 multicenter study reproduction SARS-CoV-2 semen analysis

PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong kong Mei-Ling Xu Jun-Jun Zhang Guang-Qiang Chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma xiang-Rong Zhao Chen-Yang Zhang Rong-zheng Chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

A Transfer Function Design for Medical Volume Data Using a Knowledge Database Based on Deep Image and Primitive Intensity Profile Features Retrieval

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Journal of Computer Science & Technology 2024年第2期39卷 320-335页

作者： Younhyun Jung Jim kong 盛斌 Jinman Kim School of Computing Gachon UniversitySeongnam 13120Korea School of Computer Science The University of SydneySydney 2006Australia Department of Computer Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Direct volume rendering(DVR)is a technique that emphasizes structures of interest(SOIs)within a volume visually,while simultaneously depicting adjacent regional information,e.g.,the spatial location of a structure concerning its *** DVR,transfer function(TF)plays a key role by enabling accurate identification of SOIs interactively as well as ensuring appropriate visibility of *** generation typically involves non-intuitive trial-and-error optimization of rendering parameters,which is time-consuming and *** at mitigating this manual process have led to approaches that make use of a knowledge database consisting of pre-designed TFs by domain *** these approaches,a user navigates the knowledge database to find the most suitable pre-designed TF for their input volume to visualize the *** these approaches potentially reduce the workload to generate the TFs,they,however,require manual TF navigation of the knowledge database,as well as the likely fine tuning of the selected TF to suit the *** this work,we propose a TF design approach,CBR-TF,where we introduce a new content-based retrieval(CBR)method to automatically navigate the knowledge *** of pre-designed TFs,our knowledge database contains volumes with SOI *** an input volume,our CBR-TF approach retrieves relevant volumes(with SOI labels)from the knowledge database;the retrieved labels are then used to generate and optimize TFs of the *** approach largely reduces manual TF navigation and fine *** our CBR-TF approach,we introduce a novel volumetric image feature which includes both a local primitive intensity profile along the SOIs and regional spatial semantics available from the co-planar images to the *** the regional spatial semantics,we adopt a convolutional neural network to obtain high-level image feature *** the intensity profile,we extend the dynamic time warping technique to address subtle alignment

关键词： data retrieval direct volume rendering ray analysis transfer function

Electrochemical deposition of Li_(2)S_(2)/Li_(2)S in aprotic Li–S batteries

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Particuology 2024年第7期90卷 516-521页

作者： Zhifeng Yao Xiaozhong Fan Long kong School of Civil Engineering Xi'an University of Architecture&TechnologyXi'an 710055China Institute of Flexible Electronics(IFE) Northwestern Polytechnical UniversityXi'an 710129China

Lithium–sulfur(Li–S)batteries stand out the energy storage systems because of extremely high energy density(2600 W h Kg−1)and low-cost sulfur ***,the sluggish deposition from liquid Li polysulfides(LiPSs)to solid Li2S leads to mild power density and short cycle *** and regulating Li_(2)S_(2)/Li2S deposition are conceived to be importance to deliver second-plateau capacity in acceptable kinetics,which has the potential to operation Li–S batteries under electrolyte-lean *** perspective aims to summarize the proposed models that can describe the nucleation and propagation of three-dimensional Li_(2)S_(2)/Li2S,as well as affords critical views how electrolyte dictates LiPS conversion from liquid to *** hopes to encourage necessary scaffold strategies and electrolyte formulations to further improve energy density and life span of Li–S batteries.

关键词： Lithium–sulfur batteries Electrolyte Li_(2)S precipitation Characterization

Analysis of influencing factors of anxiety and depression in patients with periodontitis

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World Journal of Psychiatry 2024年第1期14卷 141-147页

作者： Yao kong Department of Stomatology Xinxiang Central HospitalXinxiang 453000Henan ProvinceChina

BACKGROUND Periodontitis is a chronic oral disease caused by pathogenic microorganisms that corrode tooth tissue,form periodontal pockets,absorb alveolar bone,and finally lead to tooth *** treatment,patients are prone to anxiety,tension,and other negative emotions,which affect their ability to face the disease and may also lead to aggravation of the original condition and affect oral ***,it is important to improve the negative psychology of patients with periodontitis to clarify the factors that may lead to negative psychological *** To investigate the risk factors that may lead to anxiety and depression in patients with *** One hundred patients with periodontitis were selected between March 2022 and March 2023 at our *** patients were assessed with the Zung Self-rating Depression Scale(SDS)(≥53 points indicate a depressive state)and Zung Selfrating Anxiety Scale(SAS)(≥50 points indicates an anxious state).In this study,patients who experienced anxiety or depression were included in the occurrence group and those without anxiety or depression were included in the nonoccurrence *** baseline data of the two groups were compared to explore the risk factors for anxiety and depression in patients with *** A total of 100 patients with periodontitis were included in this *** to the SDS,38 patients(38.00%)developed depression,with an average SDS score of(68.52±5.85)*** to the SAS,40 patients(40.00%)developed anxiety,and the average SAS score was(72.15±4.15)*** this study,56 patients with anxiety or depression were *** with the nonoccurrence group,the occurrence group had higher ages(≥60 years),lower level of hope(low level),educational level(high school or below),disease perception(poor),and sleep disorder(yes).The negative coping dimension scores of the simplified coping style questionnaire(SCSQ)and Dental Fear Scale(DFS)in the occurrence group were

关键词： Periodontitis Anxiety Depression Mental state Influencing factor

Toward Human-centered XAIin Practice:A survey

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Machine Intelligence Research 2024年第4期21卷 740-770页

作者： xiangwei kong Shujie Liu Luhao Zhu Department of Data Science and Management Engineering School of ManagementZhejiang UniversityHangzhou 310058China

Human adoption of artificial intelligence(AI)technique is largely hampered because of the increasing complexity and opacity of AI *** AI(XAI)techniques with various methods and tools have been developed to bridge this gap between high-performance black-box AI models and human ***,the current adoption of XAI technique stil lacks"human-centered"guidance for designing proper solutions to meet different stakeholders'needs in XAI *** first summarize a human-centered demand framework to categorize different stakeholders into five key roles with specific demands by reviewing existing research and then extract six commonly used human-centered XAI evaluation measures which are helpful for validating the effect of *** addition,a taxonomy of XAI methods is developed for visual computing with analysis of method *** clearer human demands and XAI methods in mind,we take a medical image diagnosis scenario as an example to present an overview of how extant XAI approaches for visual computing fulfil stakeholders'human-centered demands in *** we check the availability of open-source XAI tools for stakeholders'*** survey provides further guidance for matching diverse human demands with appropriate XAI methods or tools in specific applications with a summary of main challenges and future work toward human-centered XAI in practice.

关键词： Artificial intelligence(AI)application explainable AI(XAI) human-centered design visual computing medical diagnosis.

Acupoint catgut-embedding therapy ameliorates DNCB-induced atopic dermatitis in BALB/c mice by regulating Th2 type immune response and reducing infiltration of CD4^(+)and CD8^(+)cells

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Traditional Medicine Research 2024年第9期9卷 14-20页

作者： Cheng Qin xiang-Yi kong Fang Wang Jin Xu Zhuo Zhang Xue-Song Yang Jian-Zhou Ye College of First Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 650500China Yunnan Key Laboratory of Dai and Yi Medicines Yunnan University of Chinese MedicineKunming 650500China Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine Yunnan University of Chinese MedicineKunming 650500China Department of Dermatology The First Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021China

Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c *** also conducted an initial examination of the underlying molecular ***:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding *** DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day *** in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut *** was assessed using SCORAD on treatment days 1,10,and *** day 18,nine mice per group were euthanized,and the remaining on day *** changes were observed using hematoxylin-eosin and immunohistochemistry ***-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western ***:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like *** decreases occurred in serum IL-4,IL-6,IL-13,and TNF-α*** analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein ***:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.

关键词： atopic dermatitis acupoint catgut-embedding therapy Th2 type immune response

Improving surface integrity of micro-holes in ECDM using ultrahigh-speed rotary of tool cathode and non-water-based electrolyte

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Chinese Journal of Aeronautics 2024年第5期37卷 506-519页

作者： Jiwen SHEN Weijing kong zhengyang XU Yongbin ZENG Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The surface integrity of metal micro-hole structures produced by electrochemical discharge machining is unsatisfactory owing to the insufficient reaction area and strength of electrolysis action.A novel ultrahigh-speed Rotary Electrochemical Discharge Machining(R-ECDM)using non-water-based electrolyte is proposed to improve surface integrity by changing the breakdown medium of spark discharge and increasing the reaction area and strength of electrolysis.A mathematical model was developed to establish the relationship between rotational speed and forces acting on the *** on the magnitude of forces,controlling rotational speed changed the behavior and departure radius of bubbles on the cathode ***-speed photographs validate that,in the mathematical model,the number and departure radius of bubbles on the cathode surface gradually decrease with the increase of rotational *** experimental results show that the roughness(Ra)of the micro-hole sidewall decreases from 2.54μm to 0.20μm when the rotational speed increases from 500 r/min to 40000 r/*** length loss and wear ratio of the cathode are only 9.75μm and 6.5%,***,the micro-holes array with recast-free and surface roughness of 0.20μm is fabricated,demonstrating that the proposed approach contributes to improving surface integrity of metal micro-holes.

关键词： Electrochemical discharge machining Micro-holes Recast layer Ultrahigh-speed rotary Bubbles Force analysis Non-water-based solution