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Biomedical and Environmental Sciences 2024年第7期37卷 739-753页

作者： Keyuan Xu Xiaoting Tang yun xiang Yiding Shen Zhennan Deng Pingping Ma Xinkun Shen Department of Orthopaedics The Third Affiliated Hospital of Wenzhou Medical University(Ruian People’s Hospital)Wenzhou 325016ZhejiangChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325027ZhejiangChina

Objective A high sodium(HS)diet is believed to affect bone metabolism *** its impact on osseointegration of titanium(Ti)implants holds significant implications for postoperative dietary management of implanted *** This investigation probed the impact of sodium ions(Na^(+))on neovascularization and osteogenesis around Ti implants in vivo,utilizing micro-computed tomography,hematoxylin and eosin staining,and immunohistochemical ***,in vitro experiments assessed the effects of varied Na^(+)concentrations and exposure durations on human umbilical vein endothelial cells(HUVECs)and MC3T3-E1 *** In vivo,increased dietary sodium(0.8%-6.0%)led to a substantial decline in CD34 positive HUVECs and new bone formation around Ti implants,alongside an increase in inflammatory *** vitro,an increase in Na^(+)concentration(140-150 mmol/L)adversely affected the proliferation,angiogenesis,and migration of HUVECs,especially with prolonged *** MC3T3-E1 cells initially exhibited less susceptibility to high Na^(+)concentrations compared to HUVECs during short-term exposure,prolonged exposure to a HS environment progressively diminished their proliferation,differentiation,and osteogenic *** These findings suggest that HS diet had a negative effect on the early osseointegration of Ti implants by interfering with the process of postoperative vascularized bone regeneration.

关键词： High-sodium Implants Vascularization Osseointegration

Actin-depolymerizing factors 8 and 11 promote root hair elongation at high pH

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Plant Communications 2024年第3期5卷 232-247页

作者： Dong Qian Tian Li Chen Zheng Yue Niu Yingzhi Niu Chengying Li Muxuan Wang Yang Yang Lizhe An yun xiang Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations School of Life SciencesLanzhou UniversityLanzhou 730000China These authors contributed equally to this article

A root hair is a polarly elongated single-celled structure that derives from a root epidermal cell and func-tions in uptake of water and nutrients from the surrounding *** reports have demon-strated that short periods of high pH inhibit root hair extension;but the effects of long-term high-pH treat-ment on root hair growth are still ***,we report that the duration of root hair elongation is signicantly prolonged with increasing external pH,which counteracts the effect of decreasing root hair elongation rate and ultimately produces longer root hairs,whereas loss of actin-depolymerizing factor 8 and 11(ADF8/11)function causes shortening of root hair length at high pH(pH 7.4).Accumulation of ADF8/11 at the tips of root hairs is inhibited by high pH,and increasing environmental pH affects the actinlament(F-actin)meshwork at the root hair *** high pH,the tip-focused F-actin meshwork is absent in root hairs of the adf8/11 mutant,actinlaments are disordered at the adf8/11 root hair tips,and actin turn-over is *** and recycling vesicles do not aggregate in the apical region of adf8/11 root hairs at high ***,our results suggest that,under long-term exposure to high extracellular pH,ADF8/11 may establish and maintain the tip-focused F-actin meshwork to regulate polar trafcking of secretory/recycling vesicles at the root hair tips,thereby promoting root hair elongation.

关键词： pH ADF actin Rab GTPase vesicle root hair

Electroacupuncture Promotes Functional Recovery after Facial Nerve Injury in Rats by Regulating Autophagy via GDNF and PI3K/m TOR Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第3期30卷 251-259页

作者： YAO Jun-peng FENG Xiu-mei WANG Lu LI Yan-qiu ZHU Zi-yue YAN xiang-yun YANG Yu-qing LI Ying ZHANG Wei Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu611137China Department of Rehabilitation Medicine Guanghan People’s HospitalGuanghanSichuan Province618399China Academic Affairs Office Chengdu University of Traditional Chinese MedicineChengdu611137China

Objective:To explore the mechanism of electroacupuncture(EA) in promoting recovery of the facial function with the involvement of autophagy,glial cell line-derived neurotrophic factor(GDNF),and phosphatidylinositol-3-kinase(PI3K)/mammalian target of rapamycin(mTOR) signaling ***:Seventy-two male Sprague-Dawley rats were randomly allocated into the control,sham-operated,facial nerve injury(FNI),EA,EA+3-methyladenine(3-MA),and EA+GDNF antagonist groups using a random number table,with 12 rats in each *** FNI rat model was established with facial nerve crushing *** intervention was conducted at Dicang(ST 4),Jiache(ST 6),Yifeng(SJ 17),and Hegu(LI 4) acupoints for 2 *** Simone’s 10-Point Scale was utilized to monitor the recovery of facial *** histopathological evaluation of facial nerves was performed using hematoxylin-eosin(HE) *** levels of Beclin-1,light chain 3(LC3),and P62 were detected by immunohistochemistry(IHC),immunofluorescence,and reverse transcriptionpolymerase chain reaction,***,IHC was also used to detect the levels of GDNF,Rai,PI3K,and ***:The facial functional scores were significantly increased in the EA group than the FNI group(P<0.05 or P<0.01).HE staining showed nerve axons and myelin sheaths,which were destroyed immediately after the injury,were recovered with EA *** expressions of Beclin-1 and LC3 were significantly elevated and the expression of P62 was markedly reduced in FNI rats(P<0.01);however,EA treatment reversed these abnormal changes(P<0.01).Meanwhile,EA stimulation significantly increased the levels of GDNF,Rai,PI3K,and mTOR(P<0.01).After exogenous administration with autophagy inhibitor 3-MA or GDNF antagonist,the repair effect of EA on facial function was attenuated(P<0.05 or P<0.01).Conclusions:EA could promote the recovery of facial function and repair the facial nerve damages in a rat model of *** may exert this neuroreparative effect through

关键词： electroacupuncture facial nerve injury autophagy glial cell line-derived neurotrophic factor phosphatidylinositol-3-kinase/mammalian target of rapamycin Chinese medicine

Loads and Dynamic Response Characteristic on FPSO Under Internal Solitary Waves

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China Ocean Engineering 2024年第5期38卷 785-796页

作者： ZHANG Rui-rui LI Cui PU Chun-rong LIU Qian YOU yun-xiang School of Naval Architecture and Ocean Engineering Jiangsu University of Science and Technology China Resources (Nanjing) Municipal Design Co. Ltd. State Key Laboratory of Ocean Engineering Shanghai Jiaotong University

According to the established prediction model of internal solitary wave loads on FPSO in the previous work, the lumped mass model and the movement equations of finite displacement in time domain, the dynamic response model of interaction between internal solitary waves and FPSO with mooring lines were established. Through calculations and analysis, time histories of dynamic loads of FPSO exerted by internal solitary waves, FPSO's motion and dynamic tension of mooring line were obtained. The effects of the horizontal pretension of mooring line, the amplitude of internal solitary wave and layer fluid depth on dynamic response behavior of FPSO were mastered. It was shown that the internal solitary waves had significant influence on FPSO, such as the large magnitude horizontal drift and a sudden tension increment. With internal solitary wave of-170 m amplitude in the ocean with upper and lower layer fluid depth ratio being 60:550, the dynamic loads reached 991.132 kN(horizontal force), 18067.3 kN(vertical force)and-5042.92 kN·m(pitching moment). Maximum of FPSO's horizontal drift was 117.56 m. Tension increment of upstream mooring line approached 401.48 kN and that of backflow mooring line was-140 kN. Moreover, the loads remained nearly constant with different pretension but increased obviously with the changing amplitude and layer fluid depth ratio. Tension increments of mooring lines also changed little with the pretension but increased rapidly when amplitude and layer fluid depth ratio increased. However, FPSO's motion increased quickly with not only the horizontal pretension but also the amplitude of internal solitary wave and layer fluid depth ratio.

关键词：

Luteolin promotes neuronogenesis in hippocampus of chronic unpredictable mild stress rats and primary hippocampus of fetal rats

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Journal of Traditional Chinese Medicine 2024年第4期44卷 670-679页

作者： LIU Tongtong ZHANG Xi YANG Hui LIN Xiaoyuan LIU Jian ZHANG Xiuli GUO Dongwei ZHAO Hongqing ZOU Manshu LEI Chang LONG Hongping LUO Yan xiang yun GE Jinwen WANG Yuhong MENG Pan Institute of Innovation and Applied Research in Chinese Medicine Hunan University of Chinese MedicineChangsha 410208China the Second People's Hospital of Hunan Province Changsha 410007China The First Affiliated Hospital Hunan University of Chinese MedicineChangsha 410007China Hunan Academy of Chinese Medicine Changsha 410013China

OBJECTIVE:To investigate the effects of luteolin on chronic unpredictable mild stress(CUMS)-induced depressive rats and corticosterone(CORT)-induced depressive primary hippocampal neurons,and to elucidate the mechanism behind the ***:The antidepressant mechanism of luteolin was studied by using CUMS rat model and primary hippocampal neurons in fetal *** vivo,novelty suppressed feeding,open-field and sucrose preference tests as well as Morris water maze were *** content of brain derived neurotrophic factor(BDNF),5-hydroxytryptamine(5-HT),norepinephrine(NE),and dopamine(DA)in serum were detected by enzyme-linked immunosorbent *** mechanisms of luteolin were explored based on neurotrophin and hippocampal neurogenesis,and *** of the septotemporal axis in hippocampus was assayed using the 5-bromo-2-deoxyuridine(BrdU),the expression of BDNF,neurotrophin-3(NT-3),and nerve growth factor(NGF)in hippocampus dentate gyrus region were measured by *** vitro,BDNF,NT-3,tropomyosin receptor kinase B(TrkB),and phosphorylated cyclic adenosine monophosphate responsive element binding protein(p-CREB)were detected through the high content analysis(HCA)to investigate neurotrophin and ***:Induction of CUMS in rats induced depressive symptoms,while luteolin significantly enhanced sucrose consumption,decreased feeding latency,increased locomotor activity,escape latency,distance of target quadrant and regulated the content of depressive-like *** analysis revealed that luteolin increased the abundance of new born neurons that had been labeled with BrdU,BrdU+neuronal nuclear antigen,and BrdU+doublecortin in septo-temporal axis of S2(mid-septal)and T3(mid-temporal).Moreover,expression of BDNF,NT-3,and NGF increased significantly in the septo-temporal axis of S2 and *** showed increased expression of BDNF,NT-3,TrkB and p-CREB in primary hippocampal ***:The results provided direct ev

关键词： fetal rats Survival

Searching for the Highest Energy of Pulsation and Critical Luminosity of Swift J0243.6+6124 Observed by Insight-HXMT

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Research in Astronomy and Astrophysics 2024年第5期24卷 61-69页

作者： Qing-Xia Zhao Xian Hou Ming-Yu Ge Shuang-Nan Zhang yun-xiang Xiao You-Li Tuo Zi-Xu Yang Ling-Da Kong Jin-Lu Qu Shu Zhang Jian-Cheng Wang yunnan Observatories Chinese Academy of SciencesKunming 650216China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences ChineseAcademy of SciencesBeijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China Institut fur Astronomic und Astrophysik Sand 1D-72076 TabingenGemany School of Physics and Optoelectronic Engineering Shandong University of TechnologyZibo 255000China

Owing to the broad energy coverage of Insight-HXMT in the hard X-ray band,we detected the highest energy of pulsation exceeding 200 keV around the 2017–2018 outburst peak of the first Galactic pulsating ultraluminous X-ray source (PULX) Swift J0243.6+6124,which is the highest energy detected from PULXs to *** also obtained the highest energy of pulsation of every exposure during the outburst in 2017–2018,and found the highest energy is roughly positively correlated with *** our newly developed method,we identified the critical luminosity being 4×10^(38)erg s^(-1) when the main peaks of the low and high energy pulse profiles became aligned,which separates the fan-beam dominated and pencil-beam dominated accretion *** the critical luminosity,the phase of the main peak shifted gradually from 0.5 to 0.8 until the outburst peak in al energy bands is reached,which is in agreement with the phase shift found previously at low *** result is consistent with what is derived from spectral analysis.

关键词： (stars:)pulsars-individual(Swift J0243.6+6124)-X-rays binaries–stars neutron

基于DEMATEL法的充填管道磨损风险评估可拓云模型

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矿业研究与开发 2024年第6期44卷 172-180页

作者：向韫长沙矿山研究院有限责任公司湖南长沙410012

为科学合理地确定充填管道磨损风险等级,引入了DEMATEL法和可拓云理论,建立了充填管道磨损风险评价DEMATEL-改进CRITIC-可拓云模型。在构建评估体系基础上,应用DEMATEL法研究指标因素之间的影响关系,采用DEMATEL中心度-改进CRITIC法获... 详细信息

为科学合理地确定充填管道磨损风险等级,引入了DEMATEL法和可拓云理论,建立了充填管道磨损风险评价DEMATEL-改进CRITIC-可拓云模型。在构建评估体系基础上,应用DEMATEL法研究指标因素之间的影响关系,采用DEMATEL中心度-改进CRITIC法获取指标综合权重,根据可拓云理论原理,以4座矿山为例,通过计算云综合关联度,评估磨损风险状况。结果显示,管径和料浆浓度是深井充填管道磨损的关键因素,4座矿山管道磨损风险均处于较大风险等级,与未确知测度和可变模糊集理论的评判结果完全一致,表明DEMATEL-改进CRITIC-可拓云模型在管道磨损风险评价方面具有适用性和有效性。

关键词：充填采矿法管道磨损 DEMATEL法可拓云风险评估

基于PPRR理论的岩爆应急管理能力评估模型研究

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矿业研究与开发 2024年第4期44卷 185-194页

作者：向韫长沙矿山研究院有限责任公司湖南长沙410012

针对深部矿山岩爆应急管理能力评估具有复杂性、模糊性、未确知性的特点,为进一步提升评估的可靠性,建立了基于改进可拓云的综合评价模型。首先,根据PPRR (Prevention, Preparation, Response, Recovery)危机管理理论,结合岩爆事故的特... 详细信息

针对深部矿山岩爆应急管理能力评估具有复杂性、模糊性、未确知性的特点,为进一步提升评估的可靠性,建立了基于改进可拓云的综合评价模型。首先,根据PPRR (Prevention, Preparation, Response, Recovery)危机管理理论,结合岩爆事故的特点,构建了多层次的岩爆应急管理能力评价指标体系;其次,借助序关系分析法(G1法)-反熵权法(A-EWM法)和组合赋权法(CW法)确定指标综合权重;引入了盲数理论,建立盲数矩阵对定性指标数据处理,改进了传统可拓云模型专家直观打分的赋权模式,基于可拓云模型原理,通过计算不同等级下的综合云关联度,按照最大隶属度判别要求,综合分析和评估应急管理能力等级。最后,应用所建立的评价模型对3座矿山岩爆应急管理能力进行实例分析,并与模糊数学和随机Petri网(SPN)评价模型结果相比较。结果显示:3座矿山应急能力均为Ⅳ级,与专家现场调研结论相符合,且3种评价模型评估结果基本一致,验证了本模型在岩爆应急管理能力评估方面具有适应性和有效性。该评价模型可以为危机管理能力的量化评估提供一种切实可行、合理有效的方法。

关键词：巷道岩爆应急管理能力可拓云盲数理论

论“第二个结合”开启的文明视野与文艺的文明维度

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中央民族大学学报（哲学社会科学版） 2024年第1期51卷 36-48页

作者：向云驹中国文艺评论家协会北京100083

习近平总书记在文化传承发展座谈会上的讲话中系统而深刻地阐述了一种中国式的新型文明观。其中,“第二个结合”的论述为我们开启了文明的视野。打开文艺的文明维度是中华优秀传统文化创造性转化、创新性发展的重要空间。在文明的发生... 详细信息

习近平总书记在文化传承发展座谈会上的讲话中系统而深刻地阐述了一种中国式的新型文明观。其中,“第二个结合”的论述为我们开启了文明的视野。打开文艺的文明维度是中华优秀传统文化创造性转化、创新性发展的重要空间。在文明的发生时代、轴心时代、全球化现代文明时代和当下又一个文明时代,中华文明都在其中且是唯一未中断的文明。发出全球文明倡议具有深远意义。人类文明具有特定的层次、性质、范畴。文明体有三个立面:历史立面、社会立面、艺术立面。文艺是文明的重要形式和形象。在文明发展的不同阶段都有不同的艺术发生。艺术与文明的关系也显现出若干重要的质的规定性和史的规律性。中华文明的五个突出特性也体现在中国艺术的发展历程中,构成了中国艺术的审美风范,彰显了中华文明的精神特征。以艺通心,更易沟通世界。历史证明,各美其美、美人之美、美美与共,是艺术与文明继续深化关系、拓展关联的必由之路。以艺术形象展示国家形象,通过彰显中华审美风范的艺术感染力,在有形与无形中润物于无声、通情于无形、达理于无言,是新时代中国文艺的历史贡献和文明职责所在。

关键词：中华文明文明史艺术与文明艺术的文明规律中华审美风范

Assessment of early factors for identification or prediction severe acute pancreatitis in pregnancy

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World Journal of Clinical Cases 2024年第24期12卷 5502-5512页

作者： Li-Fen Mei Quan Gan Jing Hu yun-xiang Li Rui Tian Cheng-Jian Shi Department of Critical Care Medicine Maternal and Child Health Hospital of Hubei ProvinceWuhan 430000Hubei ProvinceChina Department of Biliary-Pancreatic Surgery Tongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Acute pancreatitis in pregnancy(APIP)is a rare and serious condition,and severe APIP(SAPIP)can lead to pancreatic necrosis,abscess,multiple organ dysfunction,and other adverse maternal and infant ***,early identification or prediction of SAPIP is *** To assess factors for early identification or prediction of *** The clinical data of patients with APIP were retrospectively *** were classified with mild acute pancreatitis or severe acute pancreatitis,and the clinical characteristics and laboratory biochemical indexes were compared between the two *** regression and receiver operating characteristic curve analyses were performed to assess the efficacy of the factors for identification or prediction of *** A total of 45 APIP patients were *** with the mild acute pancreatitis group,the severe acute pancreatitis group had significantly increased(P<0.01)heart rate(HR),hemoglobin,neutrophil ratio(NEUT%),and neutrophil–lymphocyte ratio(NLR),while lymphocytes were significantly decreased(P<0.01).Logical regression analysis showed that HR,NEUT%,NLR,and lymphocyte count differed significantly(P<0.01)between the *** may be factors for early identification or prediction of *** area under the curve of HR,NEUT%,NLR,and lymphocyte count in the receiver operating characteristic curve analysis was 0.748,0.732,0.821,and 0.774,*** combined analysis showed that the area under the curve,sensitivity,and specificity were 0.869,90.5%,and 70.8%,*** HR,NEUT%,NLR,and lymphocyte count can be used for early identification or prediction of SAPIP,and the combination of the four factors is expected to improve identification or prediction of SAPIP.

关键词： Severe acute pancreatitis in pregnancy Early identification factors Early predictive factors Clinical features Laboratory biochemical index