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Gastrointestinal stromal tumors of the duodenum:Surgical management and survival results

World Journal of Gastroenterology 2013年第36期19卷 6000-6010页

作者： Xiao Liang Hong Yu Lin-Hua Zhu xian-fa wang Xiu-Jun Cai Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University

AIM:To provide long-term survival results of operable duodenal gastrointestinal stromal tumors(DGISTs)in a tertiary center in ***:In this retrospective study,the pathological data of 28 patients with DGISTs who had been treated surgically at the Second Department of General Surgery,Sir Run Run Shaw Hospital(SRRSH)from June1998 to December 2006 were *** pathological slides were examined by a single pathologist to confirm the *** patients whose diagnosis was not confirmed by immunohistochemistry at the time of resection,representative paraffin blocks were reassembled,and sections were studied using antibodies against CD117(c-kit),CD34,smooth muscle actin(SMA),vimentin,S-100,actin(HHF35),and *** procedures were classified as wedge resection(WR,local resection with pure closure,without duodenal transection or anastomosis),segmental resection[SR,duodenal transection with Roux-Y or BillrothⅡgastrojejunostomy(G-J),end-to-end duodenoduodenostomy(D-D),end-to-end or end-to-side duodenojejunostomy(D-J)],and pancreaticoduodenectomy(PD,Whipple operation with pancreatojejunostomy).R0 resection was pursued in all cases,and at least R1 resection was *** lymphadenectomy was not *** manifestations,surgery,medical treatment and follow-up data were retrospectively *** studies in the literature were ***:There were 12 males and 16 females patients,with a median age of 53 years(20-76 years).Their major complaints were"gastrointestinal bleeding"(57.2%)and"nonspecific discomfort"(32.1%).About14.3%,60.7%,17.9%,and 7.1%of the tumors originated in the first to fourth portion,respectively,with a median size of 5.8 cm(1.6-20 cm).Treatment was by WR in 5 cases(17.9%),SR in 13 cases(46.4%),and by PD in 10 cases(35.7%).The morbidity and mortality rates were 35.7%and 3.6%,*** median post-operative stay was 14.5 d(5-47 d).During a follow-up of 61(23-164)mo,the 2-year and 5-year relapse-free su

关键词： Gastrointestinal stromal tumors Duodenum Limited resection Pancreaticoduodenectomy Survival

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Pancreatic solid cystic desmoid tumor:Case report and literature review

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World Journal of Gastroenterology 2013年第46期19卷 8793-8798页

作者： Bin Xu Ling-Hua Zhu Jia-Guo Wu xian-fa wang Erik Matro Jun-Jun Ni Department of General Surgery Sir Run Run Shaw HospitalZhejiang University School of Medicine Department of Gastroenterology Sir Run Run Shaw HospitalZhejiang University School of Medicine

Desmoid tumors(DTs)are nonmetastatic,locally aggressive neoplasms with a high rate of postoperative *** DTs are especially rare;only a few cases have been reported to *** paper describes a case of a sporadic cystic DT of the pancreas managed successfully with central pancreatectomy,with no signs of recurrence 40 mo after *** to the literature,this is the first reported case in China of a pancreatic DT presenting as a solid cystic lesion,as well as the first pancreatic DT managed with central pancreatectomy and *** report the case for its rarity and emphasize disease management by concerted application of clinical,pathological,radiological and immunohistochemical analyses.

关键词： Pancreatic tumor Desmoid tumor Cystic tumor Central pancreatectomy Pancreaticogastros-tomy

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Polypropylene mesh-reinforced pancreaticojejunostomy for periampullar neoplasm

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World Journal of Gastroenterology 2007年第45期13卷 6072-6075页

作者： Di-Yu Huang xian-fa wang Wei Zhou Ying Xin Yi-Ping Mou Xiu-Jun Cai Depatment of Surgery Sir Run Run Shaw Hospital School of Medicine of Zhejiang University Institute of Microinvasive Surgery of Zhejiang University Hangzhou 310016 Zheiiang Province China

AIM： To evaluate the effect of polypropylene mesh- reinforced pancreatojejunostomy on pancreatic leakage. METHODS： Seventeen consecutive patients with paraampullar malignancy received polyprolene meshreinforced pancreatodudeonectomy and the Child＇s method was used to rebuild the alimentary tract. RESULTS： The mean time of polyprolene mesh-reinforced pancreatojejunostomy was 22 rain. Anastomosis could endure 30-500 cm H20 pressure during operation. All patients recovered without pancreatic leakage. CONCLUSION： Polyprolene mesh-reinforced pancreatojejunostomy is a feasible and reliable procedure to prevent pancreatic leakage.

关键词： Pancreatic leakage Pancreatojejunostomy Anastomosis Pancreatodudenectomy

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Laparoscopic versus Open Resection of Small Bowel Gastrointestinal Stromal Tumors： Systematic Review and Meta-analysis

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Chinese Medical Journal 2017年第13期130卷 1595-1603页

作者： Ke Chen Bin Zhang Yue-Long Liang Lin Ji Shun-Jie Xia Yu Pan Xue-Yong Zheng xian-fa wang Xiu-Jun Cai Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou Zhejiang 310016 China School of Medicine Zhejiang University Hangzhou Zhejiang 310058 China

Background： Laparoscopic resection （LAP） for small bowel gastrointestinal stromal tumors （GISTs） is not as common as for stomach. This study aimed to evaluate the safety and efficacy of LAP for small bowel GISTs with systematic review and meta-analysis. Methods： The Web of Science, Cochrane Library, Embase, and PubMed databases before December 2016 were comprehensively searched to retrieve comparative trials of LAP and conventional open resection （OPEN） for GISTs of small bowel with a relevance of review object. These researches reported intraoperative and postoperative clinical course （operation time, blood loss, time to first flatus and oral intake, hospital stay, morbidity, and mortality）, oncologic outcomes, and long-term survival status. Results： Six studies involving 391 patients were identified. Compared to （）PEN, LAP had associated with a shorter operation time （weighted mean difference [WMD] = -27.97 rain, 95% confidence interval [CI]： 49.40 -6.54, P 〈 0.01）： less intraoperative blood loss （WMD - -0.72 ml： 95% CI： 1.30--0.13, P = 0.02）; earlier time to flatus （WMD = -0.83 day; 95% C/： 1.44- 0.22, P 〈 0.01）; earlier time to restart oral intake （WMD - 1.95 days; 95% CI： -3.31 -0.60, P 〈 0.01 ）; shorter hospital stay （WMD = -3.00 days; 95% CI： -4.87 -1.13, P 〈 0.01）; and a decrease in overall complications （risk ratio = 0.56, 95% CI： 0.33-0.97, P 0.04）. In addition, the tumor recurrence and long-term survival rate showed that there was no significant difference between the two groups of patients. Conclusions： LAP for small bowel GISTs is a safe and feasible procedure with shorter operation time, less blood loss, less overall complications, and quicker recovery. Besides, tumor recurrence and the long-term survival rate are similar to open approach. Because of the limitations of this study, methodologically high-quality studies are needed for certain appraisal.

关键词： Complications Enterectomy Gastrointestinal Stromal Tumor Laparoscopy Meta-analysis

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factors influencing the results of treatment of bile duct injuries during laparoscopic cholecystectomy

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 113-116页

作者： Li-Bo Li, Xiu-Jun Cai, Yi-Ping Mou, Qi Wei and xian-fa wang Hangzhou, China Department of General Surgery, Sir Run Run Shaw Hospital, Zhejiang University Medical College, Hangzhou 310016, China Department of General Surgery Sir Run Run Shaw Hospital Zhejiang University Medical College Hangzhou 310016 China. lilibo1970@***

BACKGROUND: The short-term results of repair of lapa- roscopic bile duct injuries have been well discussed, but the long-term results have been rarely reported. This study was undertaken to evaluate the factors influencing the outcome of repair of bile duct injuries caused by laparoscopic chole- cystectomy. METHODS: The outcomes of repair of bile duct injuries caused by laparoscopic cholecystectomy in 31 patients were reviewed retrospectively, and the effects of injury recogni- tion, cholangiography, repair modality and techniques on the long-term results were analyzed. RESULTS: Bile duct injuries were repaired successfully in 19 (95%) of 20 patients with injuries who had been recog- nized intraoperatively, and in 10 (90%) of 11 patients with injuries who had been recognized postoperatively. Repair was successful in 29 (93% ) of the 31 patients after complete cholangiography. Closure of partial division, laceration, or small perforation of the bile duct with or without T tube drainage was satisfactory in the 23 patients. End to end re- pair over T tube was successful in 2 transection patients, who were detected intraoperatively. Roux-en-Y hepatico- jejunostomy was used successfully to repair transection, ex- cision or stricture of the bile duct in 4 of 5 patients (80% ). CONCLUSION: Early detection of bile duct injuries caused by laparoscopy, complete evaluation of the biliary duct, and appropriate surgical modality and techniques are help- ful to improve the results of repair for laparoscopic bile duct injuries.

关键词： cholecystectomy laparoscopic injuries bile duct

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老年Stanford A型急性主动脉夹层的手术治疗

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西安交通大学学报（医学版） 2017年第5期38卷 768-772页

作者：陆政日法宪恩王宏山郑州大学第二附属医院心血管外科河南郑州450014

目的总结外科治疗老年Stanford A型急性主动脉夹层的临床经验,探讨手术方式及疗效。方法收集2013年6月至2016年9月手术治疗的Stanford A型急性主动脉夹层患者(年龄≥60岁)共24例,均在全麻、深低温停循环加双侧顺行脑灌注下行外科手术。... 详细信息

目的总结外科治疗老年Stanford A型急性主动脉夹层的临床经验,探讨手术方式及疗效。方法收集2013年6月至2016年9月手术治疗的Stanford A型急性主动脉夹层患者(年龄≥60岁)共24例,均在全麻、深低温停循环加双侧顺行脑灌注下行外科手术。根据病情采用相应术式,其中Bentall术3例;David术1例;部分弓置换+Bentall术3例;全主动脉弓置换+象鼻支架术+Bentall术12例;全主动脉弓置换+象鼻支架术+升主动脉置换5例;同期行冠脉搭桥术3例。结果 24例患者均手术成功,全组体外循环时间(192.9±37.1)min,主动脉阻断时间(120±28.72)min,脑灌注时间(36.2.±11.3)min,手术时间(544.8±91.2)min,术后近期死亡2例,1例死于肾功能不全、感染,1例死于多器官功能衰竭;术后并发脑神经功能障碍2例,肾功能不全行CRRT治疗4例,3例术后脱离呼吸机困难,同时合并肺部感染需行气管切开,术后下肢功能障碍1例,低氧血症3例,切口感染2例。随访2~38个月,其中因心包积液再次入院治疗1例,不明原因猝死1例。结论手术治疗老年Stanford A型急性主动脉夹层可以明显降低死亡率,改善患者生存质量;全主动脉弓置换+象鼻支架置入是治疗Stanford A型急性主动脉夹层的经典术式;根据病情选择恰当的外科处理可获得满意的治疗效果。

关键词：急性主动脉夹层老年手术治疗并发症

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β-Ga_(2)O_(3)热电性能的第一性原理计算

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原子与分子物理学报 2025年第1期42卷 180-188页

作者：邓南发周贤中广东工业大学集成电路学院广州510006

通过使用第一性原理计算方法和玻尔兹曼输运理论,计算了β-Ga_(2)O_(3)的电学、热学和热电性质,并得出了热电性能因子随载流子浓度和温度的变化规律.此外,还考虑了声子散射和极性光学声子散射对平均电子弛豫时间的影响,并详细描述了不... 详细信息

通过使用第一性原理计算方法和玻尔兹曼输运理论,计算了β-Ga_(2)O_(3)的电学、热学和热电性质,并得出了热电性能因子随载流子浓度和温度的变化规律.此外,还考虑了声子散射和极性光学声子散射对平均电子弛豫时间的影响,并详细描述了不同载流子浓度和温度下β-Ga_(2)O_(3)的Seebeck系数、电导率、电热导率和功率因数的计算结果.最后,给出了β-Ga_(2)O_(3)的热电性能因子随载流子浓度和温度的变化趋势.结果表明,在高载流子浓度和高温下,β-Ga_(2)O_(3)具有较高的热电性能因子.

关键词： Ga_(2)O_(3) 第一性原理计算波尔兹曼输运理论热电性质

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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A Coupling Dynamic Model for Dissolution and Reduction of Chromium Ore in a Smelting Reduction Converter

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Journal of Iron and Steel Research International 2012年第1期19卷 5-10页

作者： LIU Yan JIANG Mao-fa XU Li-xian wang De-yong Liaoning Provincial Key Laboratory of Advanced Materials and Preparation Technology Shenyang UniversityShenyang 110044LiaoningChina School of Materials and Metallurgy Northeastern UniversityShenyang 110004LiaoningChina

For describing and resolving the process of chromium ore smelting reduction in a converter preferably, the coupling dynamic model was established based on the kinetic models of chromium ore dissolution and interfacial re- ducing reaction between the slag and metal. When 150 t stainless steel crude melts with chromium of 12% are produced in a smelting reduction converter with no initial chromium in metal at 1 560℃, the results of the coupling dynamic model show that the mean reduction rate and injection rate of chromium ore are 0. 091% ·min^-1 and 467 kg · min^-1 , respectively. The foundation of the coupling dynamic model provides a reference and basis on the constitution of rational processing route for a practical stainless steelmaking.

关键词： coupling dynamic model smelting reduction stainless steel crude melt converter

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略论唐代宰相制度

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史学集刊 2025年第1期 88-97页

作者：孟宪实中国人民大学历史学院北京100872

在中国古代政治制度史中,宰相制度无疑是一个重要课题。众所周知,在讨论中国的皇帝制度时,有一个重要的观点是讨论“君权”与“相权”的斗争,而君权的不断增长、相权的不断被削弱,正是君主专制持续发展的重要途径。事实上,各个时期的宰... 详细信息

在中国古代政治制度史中,宰相制度无疑是一个重要课题。众所周知,在讨论中国的皇帝制度时,有一个重要的观点是讨论“君权”与“相权”的斗争,而君权的不断增长、相权的不断被削弱,正是君主专制持续发展的重要途径。事实上,各个时期的宰相制度既有变迁,又各具特色,从每个朝代的宰相制度是否能够得出君主专制获得发展的结论,显然是需要具体论证的。唐代宰相制度的研究,通常是在三省制的背景下展开的,而唐代的宰相制度也有自己的发展变化。唐代宰相制度经过三个历史时期,政事堂时期是兼职宰相时期,中书门下时期是专职宰相时期。自唐后期至北宋,是首相制时期。唐代宰相制度的变化,是不是君相斗争的结果?而从兼职宰相到专职宰相再到首相制,宰相的职权明显是处在加强的进程中,按照君相斗争的习惯思路,难道是君主在君相斗争中败下阵来?恐怕不能得出这样的结论。此外,唐宋历史的关系,向来有“唐宋变革论”,强调唐宋之别,但从宰相制度来看,唐宋历史的联系性似乎更突出。

关键词：唐代政事堂中书门下首相制

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