Gastrointestinal stromal tumors of the duodenum:Surgical management and survival results

作     者：Xiao Liang Hong Yu Lin-Hua Zhu Xian-Fa Wang Xiu-Jun Cai 

作者机构：Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第36期

页      面：6000-6010页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grants from Science and Technology Departmentof Zhejiang Province No.2012C13020-2 

主　　题：Gastrointestinal stromal tumors Duodenum Limited resection Pancreaticoduodenectomy Survival 

摘      要：AIM:To provide long-term survival results of operable duodenal gastrointestinal stromal tumors(DGISTs)in a tertiary center in ***:In this retrospective study,the pathological data of 28 patients with DGISTs who had been treated surgically at the Second Department of General Surgery,Sir Run Run Shaw Hospital(SRRSH)from June1998 to December 2006 were *** pathological slides were examined by a single pathologist to confirm the *** patients whose diagnosis was not confirmed by immunohistochemistry at the time of resection,representative paraffin blocks were reassembled,and sections were studied using antibodies against CD117(c-kit),CD34,smooth muscle actin(SMA),vimentin,S-100,actin(HHF35),and *** procedures were classified as wedge resection(WR,local resection with pure closure,without duodenal transection or anastomosis),segmental resection[SR,duodenal transection with Roux-Y or BillrothⅡgastrojejunostomy(G-J),end-to-end duodenoduodenostomy(D-D),end-to-end or end-to-side duodenojejunostomy(D-J)],and pancreaticoduodenectomy(PD,Whipple operation with pancreatojejunostomy).R0 resection was pursued in all cases,and at least R1 resection was *** lymphadenectomy was not *** manifestations,surgery,medical treatment and follow-up data were retrospectively *** studies in the literature were ***:There were 12 males and 16 females patients,with a median age of 53 years(20-76 years).Their major complaints weregastrointestinal bleeding(57.2%)andnonspecific discomfort(32.1%).About14.3%,60.7%,17.9%,and 7.1%of the tumors originated in the first to fourth portion,respectively,with a median size of 5.8 cm(1.6-20 cm).Treatment was by WR in 5 cases(17.9%),SR in 13 cases(46.4%),and by PD in 10 cases(35.7%).The morbidity and mortality rates were 35.7%and 3.6%,*** median post-operative stay was 14.5 d(5-47 d).During a follow-up of 61(23-164)mo,the 2-year and 5-year relapse-free su