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Sarcomatoid carcinoma of the prostate with bladder invasion shortly after androgen deprivation:Two case reports

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World Journal of Clinical Cases 2021年第7期9卷 1668-1675页

作者： Wei Wei Qi-Guang Li xian Long Gao-hua Hu hua-Jie He Yuan-Bi huang xian-Lin Yi Department of Radiology Cancer Hospital of Guangxi Medical University&Guangxi Cancer Research InstituteNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Urology Cancer Hospital of Guangxi Medical University&Guangxi Cancer Research InstituteNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Thyroid and Breast Surgery Qichun People’s HospitalQichun 435300Hubei ProvinceChina

BACKGROUND To summarize the imaging,morphological and biological characteristics of sarcomatoid carcinoma(SC)of the prostate with bladder invasion not long after *** SUMMARY Our two cases were initially diagnosed with adenocarcinoma of the prostate due to ***,prostate SC was diagnosed after transurethral resection of the prostate(TURP)and castration after only 5 and 10 mo,*** liver-like tissues appeared in the second TURP procedure in case 1,while a white,fish flesh-like,narrow pedicled soft globe protruded from the prostate to the bladder in case *** The sarcomatoid component of SC may arise from one of the specific groups of cancer cells that are resistant to hormonal *** characteristics of SCs can present as“red hepatization”and“fish flesh”.SCs grow rapidly and have a poor prognosis,and thus,extensive TURP plus radiation may be the treatment of choice.

关键词： Sarcomatoid carcinoma Prostate Androgen deprivation Bladder Prostatic adenocarcinoma Case report Wei

基于PERK-eIF2α-NF-κB信号通路研究苁蓉散治疗阿尔茨海默病的作用机制

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中国药理学通报 2025年第1期41卷 80-87页

作者：王曦龙清华蔡元钦王政喻陈显兵曾楚华湖北民族大学医学部湖北恩施445000 湖北民族大学风湿性疾病发生与干预湖北省重点实验室湖北恩施445000 云南中医药大学基础医学院云南昆明650000

目的基于PERK-eIF2α-NF-κB信号通路研究苁蓉散治疗阿尔茨海默病(Alzheimer’s disease,AD)的作用机制。方法将60只SD大鼠分为正常组,模型组、苁蓉散组(4.62、9.24、18.48 g·kg-1)和安理申组,每组10只。除正常组外其余大鼠组予双侧海... 详细信息

目的基于PERK-eIF2α-NF-κB信号通路研究苁蓉散治疗阿尔茨海默病(Alzheimer’s disease,AD)的作用机制。方法将60只SD大鼠分为正常组,模型组、苁蓉散组(4.62、9.24、18.48 g·kg-1)和安理申组,每组10只。除正常组外其余大鼠组予双侧海马注射Aβ1-42建立AD模型。灌胃结束后进行水迷宫行为学检测学习记忆能力;尼氏染色观察神经元及尼氏小体变化;免疫荧光检测NF-κB核转移情况;透射电镜观察大鼠海马区内质网形态;酶免疫测定Aβ1-42及炎症因子含量;Western blot检测PERK、eIF2α、NF-κB的蛋白表达水平。结果水迷宫结果显示,苁蓉散能提高AD大鼠的逃避潜伏期时间、增加穿越求生平台次数、延长目标象限停留时间(P<0.05或P<0.01);尼氏染色结果显示,苁蓉散各剂量组神经元细胞排列较整齐,胞核存在,尼氏小体较为丰富;免疫荧光表明,苁蓉散可降低AD大鼠脑内NF-κB入核表达(P<0.05或P<0.01);透射电镜结果显示,苁蓉散各剂量组内质网形态整齐、未见明显扩张,结构正常;ELISA结果表明,苁蓉散可降低AD海马中的Aβ1-42,IL-1,TNF-α的含量;Western blot结果显示,苁蓉散各剂量组p-PERK/PERK,p-eIF2α/eIF2α,p-NF-κB p65/NF-κB p65的蛋白比值明显下降(P<0.05或P<0.01)。结论苁蓉散可通过抑制PERK-eIF2α-NF-κB信号通路的活化,缓解神经元细胞ERS状态下免疫炎症反应,以改善AD大鼠的认知功能。

关键词：阿尔兹海默病苁蓉散内质网应激 PERK-eIF2α-NF-κB信号通路炎症 Aβ1-42

Major advances in microbeam analytical techniques and their applications in Earth Science

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Science Bulletin 2016年第23期61卷 1785-1787页

作者： xian-hua Li Qiu-Li Li State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth Science University of Chinese Academy of Sciences

Major breakthroughs in modem Earth Science research largely depend on innovations in observation and analytical techniques. Over the last two decades, there have been great advances in modem microbeam analytical tech- niques, which are widely used in various subject areas in the broad field of Earth Sciences. Remarkable enhancements to observation and analysis techniques at the micro- scale have significantly improved our understanding of the Earth＇s history and its many geological processes.

关键词：微束分析技术地球科学应用科学科学研究微观尺度地质过程

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian Jia Jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian Jiashu Lian Xin hua Jianhong Dong Zheyu Fang Yuqing Liu Sibing Chen Xiumin Xue Juanqing Yue Minyu Zhu Ying Wang Zhihui huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Phosphorus fertilization alters complexity of paddy soil dissolved organic matter

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Journal of Integrative Agriculture 2020年第9期19卷 2301-2312页

作者： ZHANG Zhi-jian WANG xian-zhe LIANG Lu-yi huang En TAO Xing-hua College of Environmental and Resource Science Zhejiang UniversityHangzhou 310058P.R.China China Academy of West Region Development Zhejiang UniversityHangzhou 310058P.R.China Hangzhou Gusheng Agricultural Technology Company Limited Hangzhou 311108P.R.China

The structural complexity of soil dissolved organic matter(DOM)may reflect soil biogeochemical processes due to its spectral ***,the features of DOM structural complexity in paddy soil amended with long-term chemical P fertilization are still unclear,which may limit understanding of nutrient-related soil C *** collected soil samples from field experiments receiving application of 0,30,60,and 90 kg P ha–1 yr–1 to assess the effect of exogenous P on the complexity of soil DOM ***-dimensional excitation-emission matrix fluorescence analysis and enzymatic activity assay were used to determine the features of soil DOM molecular structure and the associated microbial *** results showed that P input increased the biodegradability of DOM,indicating by the increased lower molecular weight components and decreased humic degree in the DOM.P input also reduced the structural complexity of DOM with blue shifts of fluorescent *** fluorescence index andβ/αindex of DOM increased with increasing P application by 4–5%and 3–11%,respectively,while humification index decreased by 8–13%.The P input increased the abundance of bacteria and fungi by 34–167%and 159–964%,respectively,while 29–54%increments were found for theβ-1,4-glucosidase *** results implicated that P fertilization accelerated the soil DOM cycle,although the structural complexity of DOM declined,which potentially benefits soil C sequestration in paddy fields and may be a C sequestration mechanism in the P-dependent paddy.

关键词： soil carbon fertilization fluorescence humification agroecosystem

Hyperspectral image super resolution using deep internal and self-supervised learning

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 128-141页

作者： Zhe Liu xian-hua Han Graduate School of Science and Technology for Innovation Yamaguchi UniversityYamaguchiJapan Graduate School of Artificial Intelligence and Science Rikkyo UniversityTokyoJapan

By automatically learning the priors embedded in images with powerful modelling ca-pabilities,deep learning-based algorithms have recently made considerable progress in reconstructing the high-resolution hyperspectral(HR-HS)*** previously collected large-amount of external data,these methods are intuitively realised under the full supervision of the ground-truth ***,the database construction in merging the low-resolution(LR)HS(LR-HS)and HR multispectral(MS)or RGB image research paradigm,commonly named as HSI SR,requires collecting corresponding training triplets:HR-MS(RGB),LR-HS and HR-HS image simultaneously,and often faces dif-ficulties in *** learned models with the training datasets collected simultaneously under controlled conditions may significantly degrade the HSI super-resolved perfor-mance to the real images captured under diverse *** handle the above-mentioned limitations,the authors propose to leverage the deep internal and self-supervised learning to solve the HSI SR *** authors advocate that it is possible to train a specific CNN model at test time,called as deep internal learning(DIL),by on-line preparing the training triplet samples from the observed LR-HS/HR-MS(or RGB)images and the down-sampled LR-HS ***,the number of the training triplets extracted solely from the transformed data of the observation itself is extremely few particularly for the HSI SR tasks with large spatial upscale factors,which would result in limited reconstruction *** solve this problem,the authors further exploit deep self-supervised learning(DSL)by considering the observations as the unlabelled training ***,the degradation modules inside the network were elaborated to realise the spatial and spectral down-sampling procedures for transforming the generated HR-HS estimation to the high-resolution RGB/LR-HS approximation,and then the reconstruction errors of the observations were formulated for mea

关键词： computer vision deep learning deep neural networks hyperspectral image enhancement

Multiple microRNAs control ecdysone signaling in the midgut of Spodoptera litura

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Insect Science 2020年第6期27卷 1208-1223页

作者： Wei Luo Li-Xia huang Shuang-Kang Qin xian Zhang Qi-Li Feng Jun Gu Li-hua huang Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Guangzhou Key Laboratory of Insect Development Regulation and Application Research Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Hubei Key Laboratory of Application of Plant-Cancer Active Ingredients School of Chemistry and Life SciencesHubei University of EducationWuhanChina

Metamorphosis is one of the most important physiological processes in *** is regulated by a serial of ecdysone cascade ***,lots o f microRNAs(miRNAs)were investigated in insects;however,their function in metamorphosis is largely *** the present study,the dynamics of a small RNA population was investigated by RNA sequencing from the midgut of a lepidopteran pest Spodoptera litura during larval-pupal metamorphosis.A total of 101 miRNAs were identified,and 75 miRNAs were differentially expressed during the metamorphic *** relationship between these differentially expressed miRNAs and 12 ecdysone cascade genes was analyzed by four classical software programs,and a multiple-to-multiple regulatory network was found to exist between these miRNAs and their *** them,miR-14-3p and its two targets(EcR and E75)were chosen for further ***-14-3p had higher expression level in the 6 th instar larvae as compared with either the prepupae or pupae,which was opposite to that of both EcR and E75,two ecdysone cascade *** reporter assay confirmed that both EcR and E75 were regulated by ***,the 3'untranslated regions are nearly identical to each other among different transcript variants of the ecdysone cascade genes,including EcR,USP,E75,E74,E78,E93,Hr3,Hr4,Hr39,K rhl and F ***,different transcript variants of one ecdysone cascade gene could be regulated by the same mi *** above data suggest that the ecdysone signaling pathway is under the tight control of *** findings expand our understanding of the mechanism of insect metamorphosis and may also provide a novel possibility for the control of pest insects in the future.

关键词： ecdysone EcR E75 metamorphosis microRNA midgut

A multiscale Galerkin method for the hypersingular integral equation reduced by the harmonic equation

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Applied Mathematics(A Journal of Chinese Universities) 2013年第1期28卷 75-89页

作者： LI Song-hua xian Jun Department of Mathematics Hunan institute of science and technology Department of Mathematics and Guangdong Province Key Laboratory of Computational Science Sun Yat-sen University

The aim of this paper is to investigate the numerical solution of the hypersingular integral equation reduced by the harmonic equation. First, we transform the hypersingular integral equation into 2π-periodic hypersingular integral equation with the map x=cot（θ/2）. Second, we initiate the study of the multiscale Galerkin method for the 2π-periodic hypersingular integral equation. The trigonometric wavelets are used as trial functions. Consequently, the 2j＋1 × 2j＋1 stiffness matrix Kj can be partitioned j×j block matrices. Furthermore, these block matrices are zeros except main diagonal block matrices. These main diagonal block matrices are symmetrical and circulant matrices, and hence the solution of the associated linear algebraic system can be solved with the fast Fourier transform and the inverse fast Fourier transform instead of the inverse matrix. Finally, we provide several numerical examples to demonstrate our method has good accuracy even though the exact solutions are multi-peak and almost singular.

关键词： Trigonometric wavelet multiscale Galerkin method matrix decomposition FFT hypersingular integral equation harmonic equation.

The Geographic Information Grid System Based on Mobile Agent

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Wuhan University Journal of Natural Sciences 2006年第1期11卷 304-308页

作者： SHEN Zhi-dong TONG Qiang huang xian-feng WANG hua-min School of Computer Wuhan University Wuhan 430072 Hubei China Software College Northeastern University Shenyang 110004 Liaoning China State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing Wuhan University Wuhan 430072 Hubei China Research Center of Spatial Information and Digital Engineering Wuhan University Wuhan 430072 Hubei China

We analyze the deficiencies of current application systems, and discuss the key requirements of distributed Geographie Information serviee （GIS）, We construct the distributed GIS on grid platform. Considering the flexibility and efficiency, we integrate the mobile agent technology into the system. We propose a new prototype system, the Geographic Information Grid System （GIGS） based on mobile agent. This system has flexible services and high performance, and improves the sharing of distributed resources. The service strategy of the system and the examples are also presented.

关键词： grid geographic information system (GIS) spatial data mobile agent