检索结果-南通市图书馆

赤芍煎剂治疗重症急性胰腺炎随机对照临床研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中西医结合学报 2008年第6期6卷 569-575页

作者：张敏朱德增李兆申湛先保第二军医大学长海医院中医科上海200433 第二军医大学长海医院消化内科上海200433

比较赤芍煎剂和生大黄治疗早期重症急性胰腺炎（severe acute pancreatitis，SAP）的临床疗效。方法：将符合SAP诊断标准的96例患者随机分成两组。对照组48例，应用常规西医疗法加用生大黄15～30g开水泡制150ml．胃管内注入后夹闭胃管30... 详细信息

比较赤芍煎剂和生大黄治疗早期重症急性胰腺炎（severe acute pancreatitis，SAP）的临床疗效。方法：将符合SAP诊断标准的96例患者随机分成两组。对照组48例，应用常规西医疗法加用生大黄15～30g开水泡制150ml．胃管内注入后夹闭胃管30～60min，2次／d，强要时加以灌肠；治疗组48例，在西医疗法基础上加用赤芍煎剂．用法同对照组。观察指标：腹胀、发热、腹部压痛消失时间；抗生素、胰酶抑制剂、蛋白酶抑制剂应用时间；发病至肠内营养应用时间、鼻空肠营养时间；胃肠减压时间、禁食时间；平均住院日、住院费用及死亡率；两组中药应用过程中的不良反应等。结果：治疗组患者的腹部压痛、腹胀、发热时间均少于对照组（P〈0．05）；治疗组应用抗细菌药物、抗真菌药物的时间短于对照组（P〈0．05）；两组抑制胰腺分泌药物及蛋白酶抑制剂应用时间比较，差异无统计学意义（P〉0.05）；治疗组的患者可以更快地耐受鼻空肠内营养，其肠内营养时间、胃肠减压时间及禁食时间均短于对照组，治疗组住院时间及费用均少于对照组（P〈0．05）。两组死亡率及用药副反应比较．差异亦无统计学意义（P〉0．05）。结论：赤芍煎剂同单味生大黄比较，其治疗SAP的疗效更明显．病人耐受程度好。

关键词：急性坏死性胰腺炎中医疗法中西医结合赤芍大黄

食管“Z”型支架术后局部粘膜血流量及通透性变化分析

在线全文

学校读者我要写书评

暂无评论

世界华人消化杂志 2000年第1期8卷 10-14页

作者：宛新建李兆申许国铭王雯湛先保刘婧中国人民解放军第二军医大学长海医院消化内科上海市200433

目的研究实验犬食管支架术后2,24h局部粘膜血流量的变化,食管对PEG_(400)通透性的变化,以及食管粘膜电镜下形态的变化。方法选择成年健康犬12只,均分两组,分别置入“Z”型食管支架,采用多谱勒血流仪检测支架术后2,24h局部粘膜血流量的变... 详细信息

目的研究实验犬食管支架术后2,24h局部粘膜血流量的变化,食管对PEG_(400)通透性的变化,以及食管粘膜电镜下形态的变化。方法选择成年健康犬12只,均分两组,分别置入“Z”型食管支架,采用多谱勒血流仪检测支架术后2,24h局部粘膜血流量的变化,与正常食管粘膜进行比较,支架术后2h选择第1组实验犬进行食管持续恒压PEG_(400)灌流,2h后取出置架部位的食管组织及等量正常食管组织,通过气相色谱分析法检测组织中PEC_(400)的含量,并进行比较。第2组实验犬于术后24h同样方法进行气相色谱分析。电镜分析支架术后2h及24h粘膜结构的变化。结果支架术后2,24h局部粘膜血流量较正常食管均明显减少;术后2h食管组织中PEG_(400)的含量较正常明显升高,主要表现为一些低分子量的PEG_(400)术后24h PEG_(400)的通透性进一步增强,可检测到一些高分子量的PEG_(400);电镜发现支架术后上皮细胞间桥粒明显减少、破坏,细胞间隙扩大,上皮基底膜破坏,术后24h较2h变化更为明显。结论支架置入可导致食管局部粘膜血流量明显降低,从而促进粘膜的损害;支架术后上皮细胞间连接及粘膜结构破坏明显,对PDG_(400)通透性显著升高,从而为外源性致病原的介入创造条件。这些均说明支架对粘膜具有明显的破坏作用。

关键词：食管狭窄治疗血液供给支架

Hemoglobin integrated red blood cell membrane-coated metalorganic framework nano-platform for improving the self-adaptive blood glucose management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 618-627页

作者： Shuai Wu Li Zhu Sheng Ni Xiong Zhao Meng Yan Yuan Zhong Karissa Kusuma Yi Liang Kaiwen bao Kai Qu xian Qin Kun zhang Wuquan Deng Da Sun Wei Wu Key Laboratory of Biorheological Science and Technology Ministry of EducationCollege of BioengineeringChongqing UniversityChongqing 400044China Chongqing University Three Gorges Hospital Chongqing Municipality Clinical Research Center for Endocrinology and Metabolic DiseasesChongqing 404000China Institute of Life Sciences&Biomedical Collaborative Innovation Center of Zhejiang Province Wenzhou UniversityWenzhou 325035China Department of Endocrinology School of MedicineChongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400014China

Diabetes,a prevalent chronic metabolic disorder,often leads to severe ***,existing treatment methods may pose life-threatening risks due to poor patient compliance and inaccurate dosing of subcutaneous insulin ***,a biomimetic red blood cell(RBC)membrane-coated glucose-responsive nanoplatform is developed for controlling insulin *** nanoplatforms with RBC membrane can prolong the half-life of nano-formulation in vivo mediated by the biomimetic immune ***,the cascade catalytic effect of glucose oxidase(GOx)encapsulated in metal-organic frameworks(MOFs)and hemoglobin(Hb)in the RBC membrane are able to not only facilitate glucose-responsive insulin release,but also eliminate the detrimental by-product hydrogen peroxide(H_(2)O_(2))resulting from the Hb mediated H_(2)O_(2)*** in vitro and in vivo studies have demonstrated the favorable glucose-responsive performances of this advanced nano-platform with a single intravenous injection maintaining blood glucose balance in Type 1 Diabetes(T1D)mice for an extended duration without the hypoglycemia ***,this biomimetic insulin delivery system is poised to function as a strategy for the intravenous insulin administration,offering a promising drug candidate for the self-adaptive long-term T1D treatment.

关键词： glucose-responsive metal-organic frameworks red blood cell membrane insulin delivery glucose oxidase hemoglobin

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao zhang Li Jia Xiu-Jun zhan Charity Ngina Qing-Rui zhang Xiao-Ge Li Qi-bao Jiang Shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Effect of Barrier Materials on Discharge Properties in Air at Low Pressure

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高电压技术 2007年第12期33卷 80-84页

作者： LIMing LI Cheng-rong zhan Hua-mao XU Jin-bao zhanG xian-jun Beijing Key Laboratory of High Voltage ~ EMC School of Electric and Electronic Engineering North China Electric Power University Beijing 102206 China

Dielectric barrier discharge(DBD) is widely investigated in order to obtain uniform low-temperature *** studies have proved that some barrier materials,especially electrets,can improve the uniformity of *** is regarded as an available way to get atmospheric pressure glow discharge(APGD).In this paper,discharge forms with 4 different barrier materials(alumina,quartz,PTFE and PET) are investigated,and the transition of discharge form depending on the air pressure are recorded to estimate the influence of barrier materials on *** using electrets as barrier materials,homogeneous discharges can be obtained in a more wide pressure *** the same experimental conditions,discharges with electrets are more uniform or have larger uniform areas due to the storage and desorption of charges on the surface of *** electrons deposited in the surface layer can be released on next half cycle when the polarity of the applied voltage changes,and provide a number of seed electrons,which makes the discharge more *** capacitance and the permittivity of barrier materials have no effect on the discharge form directly.

关键词：放电特性低气压电子跃迁电介体表面电荷栅栏

Permeability measurement of the fracture-matrix system with 3D embedded discrete fracture model

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2022年第4期19卷 1757-1765页

作者： bao Jia Cheng-Gang xian State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Bejing)Beijing 102249China Unconventional Petroleum Research Institute China University of Petroleum(Bejing)Bejing 102249China

In this work, we performed the pulse-decay experiment on a fractured shale core and applied the 3 D embedded discrete fracture model(EDFM) to simulate the experiment process. The irregularly rough fracture surface was depicted in detail using a 3 D scanner. Then the fracture surface profile was imported in the discrete fracture network model to simulate the flow process in the fracture-matrix system realistically. History matching was efficiently performed to simultaneously obtain porosity and permeability for the matrix and fracture. Gas properties after applying nanopore confinement were obtained by modifying Sutton's viscosity correlation with sensitivity analysis on the pore diameter ranging from 2 to50 nm. Nanopore confinement results in low matched permeability due to viscosity reduction in the matrix-only porous media. The fracture-matrix system complicates the interpretation of nanopore confinement impact on flow behavior in shale reservoirs. Different scenarios of the highly fractured and matrix-dominated systems were discussed in detail by constructing the digital twin model.

关键词： Permeability Fracture Pulse-decay Shale Viscosity

Energy Expenditure of Trotting Gait Under Different Gait Parameters

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2017年第4期30卷 943-950页

作者： xian-bao Chen Feng Gao State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University Shanghai 200240 China

Robots driven by batteries are clean, quiet, and can work indoors or in space. However, the battery endurance is a great problem. A new gait parameter design energy saving strategy to extend the working hours of the quadruped robot is proposed. A dynamic model of the robot is established to estimate and analyze the energy expenditures during trotting. Given a trotting speed, opti- mal stride frequency and stride length can minimize the energy expenditure. However, the relationship between the speed and the optimal gait parameters is nonlinear, which is difficult for practical application. Therefore, a simplified gait parameter design method for energy saving is pro- posed. A critical trotting speed of the quadruped robot is found and can be used to decide the gait parameters. When the robot is travelling lower than this speed, it is better to keep a constant stride length and change the cycle period. When the robot is travelling higher than this speed, it is better to keep a constant cycle period and change the stride length. Simulations and experiments on the quadruped robot show that by using the proposed gait parameter design approach, the energy expenditure can be reduced by about 54% compared with the 100 mm stride length under 500 mm/s speed. In general, an energy expenditure model based on the gait parameter of the quadruped robot is built and the trotting gait parameters design approach for energy saving is proposed.

关键词： Quadruped robot Energy expenditure Gait Bezier curve

Theoretical Study on the Stable Structures and Aromaticities for Pnictogen Dianionic Sb4^2-, Bi4^2-, and （SbBi）2^2- Clusters

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Physics 2009年第1期22卷 75-81页

作者： Xing-bao Wang xian-xing Chi School of Physics and Electronic Information Wenzhou University Wenzhou 325027 China

Through the theoretical calculation of structural optimization, vibrational frequencies and atomization energies with one method of density functional theory （B3LYP） and two post- Hartree-Fock approaches （MP2, CCSD（T））, several stable isomers for new three pnictogen dianionic Sb4^2-, Bi4^2-, and （SbBi）2^2- species were determined. For two homoatomic Sb4^2- and Bi4^2- species, there are three stable isomers： square （D4h）, roof-shaped （C2v-1）, and C2v-2 structure with the square isomer being the ground state. For the heteroatomic dian- ionic （SbBi）2^2- species, there are also three stable isomers： rhombus （D2h）, roof-shaped （C1）, and C2v structures with the rhombic isomer being the ground state. The calculated NICS values show that nucleus-independent chemical shifts （NICS） values of roof-shaped isomers for Sb4^2-, Bi4^2-, and （SbBi）2^2- species are all negative, consequently indicating that these roof-shaped isomers possess aromaticities. NICS values for the planar ring isomers are all positive, suggesting that these three planar ring isomers have antiaromatic characters. The aromaticity for the two stable roof-shaped and square isomers are preliminarily explained and discussed with MO analysis.

关键词： Pnictogen cluster Ab initio Aromaticity Nucleus-independent chemical shift

Dexmedetomidine mitigates isoflurane-induced neurodegeneration in fetal rats during the second trimester of pregnancy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第8期12卷 1329-1337页

作者： Zhi-yuan Su Qing Ye xian-bao Liu Yu-zhong Chen Hong zhan Shi-yuan Xu Department of Anesthesia The Third Affiliated Hospital of Guangzhou Medical University Department of Anesthesia Zhujiang Hospital of Southern Medical University

Dexmedetomidine has significant neuroprotective effects. However, whether its protective effects can reduce neurotoxicity caused by isoflurane in fetal brain during the second trimester of pregnancy remains unclear. In this study, timed-pregnancy rats at gestational day 14 spontaneously inhaled 1.5% isoflurane for 4 hours, and were intraperitoneally injected with dexmedetomidine at dosages of 5, 10, 20, and 20 μg/kg 15 minutes before inhalation and after inhalation for 2 hours. Our results demonstrate that 4 hours after inhaling isoflurane, 20 μg/kg dexmedetomidine visibly mitigated isoflurane-induced neuronal apoptosis, reversed downregulation of brain-derived neurotrophic factor expression, and lessened decreased spatial learning and memory ability in adulthood in the fetal rats. Altogether, these findings indicate that dexmedetomidine can reduce neurodegeneration induced by isoflurane in fetal rats during the second trimester of pregnancy. Further, brain-derived neurotrophic factor participates in this process.

关键词： nerve regeneration dexmedetornidine isoflurane fetal rat apoptosis brain-derived neurotrophic factor behavior neuroprotection neurodegeneration neural regeneration