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Asperuloside Promotes Apoptosis of Cervical Cancer Cells through Endoplasmic Reticulum Stress-Mitochondrial Pathway

Chinese Journal of Integrative Medicine 2024年第1期30卷 34-41页

作者： QI Zhi-min WANG xia.LIU xia.ZHAO juan Medical Examination Center Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Department of Gynaecology and Obstetrics Hebei Province Hospital of Chinese MedicineShijiazhuang(050011)China Experimental Center for Teaching Hebei Medical UniversityShijiazhuang(050017)China

Objective: To investigate the effects of asperuloside on cervical cancer based on endoplasmic reticulum(ER) stress and mitochondrial pathway. Methods: Different doses(12.5–800 μg/mL) of asperuloside were used to treat cervical cancer cell lines Hela and CaSki to calculate the half maximal inhibitory concentration(IC_(50)) of asperuloside. The cell proliferation was analyzed by clone formation assay. Cell apoptosis, intracellular reactive oxygen species(ROS) and mitochondrial membrane potential were determined by flow cytometry. The protein expressions of cleaved-caspase-3, Bcl-2, Bax, Cyt-c, cleaved-caspase-4 and glucose-regulated protein 78(GRP78) were analyzed by Western blot. And the inhibitor of ER stress, 4-phenyl butyric acid(4-PBA) was used to treat cervical cancer cells to further verify the role of ER stress in the apoptosis of cervical cancer cells induced by asperuloside. Results: Asperuloside of 325, 650, and 1300 μg/mL significantly inhibited the proliferation and promoted apoptosis of Hela and CaSki cells(P<0.01). All doses of asperuloside significantly increased intracellular ROS levels, reduced mitochondrial membrane potential, significantly reduced Bcl-2 protein expression level, and increased Bax, Cyt-c, GRP78 and cleaved-caspase-4 expressions(P<0.01). In addition, 10 mmol/L 4-PBA treatment significantly promoted cell proliferation and reduced apoptosis(P<0.05), and 650 μg/mL asperuloside could reverse 4-PBA-induced increased cell proliferation, decreased apoptosis and cleaved-caspase-3,-4 and GRP78 protein expressions(P<0.05). Conclusion: Our study revealed the role of asperuloside in cervical cancer, suggesting that asperuloside promotes apoptosis of cervical cancer cells through ER stress-mitochondrial pathway.

关键词： asperuloside Chinese medicine cervical cancer endoplasmic reticulum stress mitochondrial damage apoptosis

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Bibliometric analysis of research in epilepsy and comorbid depression from 2014 to 2023

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World Journal of Psychiatry 2024年第6期14卷 985-998页

作者： Ling Chen xia.-Hui He xia.Ling Li juan Yang Hao huang Department of Neurology The Affiliated Hospital of Zunyi Medical UniversityZunyi 563003Guizhou ProvinceChina Department of Neurology Xinqiao Hospital and the Second Affiliated HospitalArmy Medical University(Third Military Medical University)Chongqing 400010China

BACKGROUND Epilepsy and depression have complicated bidirectional *** study aimed to explore the field of epilepsy comorbid with depression in a bibliometric perspective from *** To improve our understanding of epilepsy and depression by evaluating the relationship between epilepsy and depression,bibliometric analyses were *** Epilepsy and depression-related publications from the last decade were retrieved from the Web of Science Core *** conducted bibliometric and visual analysis using VOSviewer and CiteSpace,examining authorships,countries,institutions,journals of publication,co-citations of references,connections between keywords,clusters of keywords,and keywords with citation *** Over the past ten years,we collected 1045 research papers focusing on the field of epilepsy and comorbid *** on epilepsy and depression have shown a general upward trend over time,though with some *** United States,with 287 articles,and the University of Melbourne,contributing 34 articles,were the top countries and institutions,*** addition,in the field of epilepsy and depression,Professor Lee,who has published 30 articles,was the most contributing *** hot topics pay attention to the quality of life in patients with epilepsy and *** We reported that quality of life and stigma in patients with epilepsy comorbid with depression are possible future hot topics and directions in the field of epilepsy and depression research.

关键词： Epilepsy Depression Bibliometrics VOSviewer CiteSpace Visualization analysis

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Performance Enhancement of Single-Phase Immersion Liquid-Cooled Data Center Servers

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Journal of Thermal Science 2024年第5期33卷 1757-1772页

作者： GE Junlei xia.Feifan ZHANG Chengbin huang Yongping School of Energy and Environment Southeast UniversityNanjing 210096China Wuhan Digital Engineering Research Institute Wuhan 430205China

As the promising cooling method for the next generation of data centers,the internal heat transport mechanism and enhancement mechanism of single-phase immersion liquid-cooled(SPILC)systems are not yet well *** address this,a steady-state three-dimensional numerical model is constructed herein to analyze flow and thermal transport capacities in servers using SPILC and traditional air-cooling ***,this paper emphasizes the influence of component positioning,and underscores the benefits of optimizing coolant flow distribution using *** results indicate that the SPILC system outperforms the traditional air-cooling approach at the same inlet Reynolds number(Re).When Re=10000,the SPILC method reduces the maximum temperature by up to 70.13%,increases the average convective heat transfer coefficient by287.5%,and provides better overall thermal uniformity in data center ***,placing devices downstream of high-power components creates"thermal barriers"and degrades thermal transport for upstream devices due to increased flow *** spacing between high-power devices can lead to the formation of bypass channels,further deteriorating heat ***,the addition of baffles in the inlet section of SPILC systems effectively enhances heat dissipation *** maximize the heat dissipation capacity,minimizing bypass channels and optimizing the flow distribution of coolants are crucial.

关键词： single-phase immersion liquid-cooled performance enhancement data center

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Intensifying electrified flow-through water treatment technologies via local environment modification

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 17-25页

作者： Zheng-Yang Huo xia.xiong Wang xia.huang Menachem Elimelech School of Environment and Natural Resources Institute of Ecological CivilizationRenmin University of ChinaBeijing 100872China Institute for Ocean Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Center of Double Helix Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Department of Chemical and Environmental Engineering Yale UniversityNew HavenCT 06520-8286USA

Removing high-risk and persistent contaminants from water is challenging,because they typically exist at low concentrations in complex water *** flow-through technologies are viable to overcome the limitations induced by mass transport for efficient contaminant *** the local environment of the flow-through electrodes offers opportunities to further improve the reaction kinetics and selectivity for achieving near-complete removal of these contaminants from ***,we present state-of-the-art local environment modification approaches that can be incorporated into electrified flow-through technologies to intensify water *** first show methods of nanospace incorporation,local geometry adjustment,and microporous structure optimization that can induce spatial confinement,enhanced local electric field,and microperiodic vortex,respectively,for local environment *** then discuss why local environment modification can complement the flow-through electrodes for improving the reaction rate and ***,we outline appropriate scenarios of intensifying electrified flow-through technologies through local environment modification for fit-for-purpose water treatment applications.

关键词： Point-of-use water treatment Electrified membrane Advection-enhanced mass transport Water decontamination and disinfection Emerging contaminants

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A NEW GLOBAL OPTIMIZATION ALGORITHM FOR MIXED-INTEGER QUADRATICALLY CONSTRAINED QUADRATIC FRACTIONAL PROGRAMMING PROBLEM

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Journal of Computational Mathematics 2024年第3期42卷 784-813页

作者： Bo Zhang Yuelin Gao xia.Liu xia.li huang School of Civil and Hydraulic Engineering School of Mathematics and StatisticsNingxia UniversityYinchuan 750021China School of Mathematics and Information Science North Minzu UniversityYinchuan 750021China Ningxia.Province Key Laboratory of Intelligent Information and Data Processing Yinchuan 750021China School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China

The mixed-integer quadratically constrained quadratic fractional programming(MIQCQFP)problem often appears in various fields such as engineering practice,management science and network ***,most of the solutions to such problems are often designed for their unique *** paper puts forward a new global optimization algorithm for solving the problem *** first convert the MIQCQFP into an equivalent generalized bilinear fractional programming(EIGBFP)problem with integer ***,we linearly underestimate and linearly overestimate the quadratic functions in the numerator and the denominator respectively,and then give a linear fractional relaxation technique for EIGBFP on the basis of non-negative *** that,combining rectangular adjustment-segmentation technique and midpointsampling strategy with the branch-and-bound procedure,an efficient algorithm for solving MIQCQFP globally is ***,a series of test problems are given to illustrate the effectiveness,feasibility and other performance of this algorithm.

关键词： Global optimization Branch and bound Quadratic fractional programming Mixed integer programming

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Engineering W/O/W pickering emulsion for the enhanced antigen delivery and immune responses

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Particuology 2024年第9期92卷 224-233页

作者： Sihua Wu xia.nan huang Yin Ma Naoki Asakawa Yufei xia State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100081China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China Division of Molecular Science Graduate School of Science and TechnologyGunma University1-5-1Tenjin-choKiryu376-8515Japan Sinovac Biotech Ltd. Beijing100085China School of Chemical Engineering Nanjing Tech UniversityNanjing211816China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Tumor immunotherapy,particularly cancer vaccines,holds promise for combating cancer by harnessing tailored immune responses against malignant ***,conventional approaches face challenges in efficiently delivering antigens for optimal immune *** adjuvants,like MF59,enhance cellular uptake but struggle to induce robust CD8^(+)T cell ***,we introduce a novel strategy employing a water-in-oil-in-water(W/O/W)multiple Pickering emulsion(mPE)for antigen *** mPE,utilizing biocompatible,pH-sensitive particles,encapsulates antigens within the inner water phase,ensuring enhanced intracellular processing and dictating the intracellular fate of antigens for improved *** vitro and in vivo studies demonstrated that mPEs induced robust dendritic cells activation and antigen cross-presentation,leading to a significantly enhanced immune ***,calcium phosphate-stabilized mPE(CaP-mPE)illustrated the more robust IFN-γ^(+)T cell *** comparison with traditional surfactant-stabilized multiple emulsions,CaP-mPE significantly inhibit tumor growth and effectively prolong the survival of tumor-bearing *** innovative approach offers a promising avenue for the development of effective cancer vaccines with potent cellular immune responses.

关键词： Cancer vaccine Multiple pickeringemulsion Adjuvant Antigen delivery Anti-tumor response

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Starlet:Network defense resource allocation with multi-armed bandits for cloud-edge crowd sensing in IoT

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Digital Communications and Networks 2024年第3期10卷 586-596页

作者： Hui xia.Ning huang Xuecai Feng Rui Zhang Chao Liu College of Computer Science and Technology Ocean University of ChinaQingdao266100China

The cloud platform has limited defense resources to fully protect the edge servers used to process crowd sensing data in Internet of *** guarantee the network's overall security,we present a network defense resource allocation with multi-armed bandits to maximize the network's overall ***,we propose the method for dynamic setting of node defense resource thresholds to obtain the defender(attacker)benefit function of edge servers(nodes)and ***,we design a defense resource sharing mechanism for neighboring nodes to obtain the defense capability of ***,we use the decomposability and Lipschitz conti-nuity of the defender's total expected utility to reduce the difference between the utility's discrete and continuous arms and analyze the difference ***,experimental results show that the method maximizes the defender's total expected utility and reduces the difference between the discrete and continuous arms of the utility.

关键词： Internet of things Defense resource sharing Multi-armed bandits Defense resource allocation

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Added Benefit of the Early-Morning-Orbit Satellite Fengyun-3E on the Global Microwave Sounding of the Three-Orbit Constellation

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Advances in Atmospheric Sciences 2024年第1期41卷 39-52页

作者： juan LI Zhengkun QIN Guiqing LIU Jing huang CMA Earth System Modeling and Prediction Centre Beijing 100081China State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Joint Center for Data Assimilation Research and Applications School of Atmospheric SciencesNanjing University of Information Science&TechnologyNanjing 210044China

The three-orbit constellation can comprehensively increase the spatial coverage of polar-orbiting satellites,but the polar-orbiting satellites currently in operation are only mid-morning-orbit and afternoon-orbit ***-3E(FY-3E)was launched successfully on 5 July 2021 in *** an early-morning-orbit satellite,FY-3E can help form a complete three-orbit observation system together with the mid-morning and afternoon satellites in the current mainstream operational *** this study,we investigate the added benefit of FY-3E microwave sounding observations to the midmorning-orbit Meteorological Operational satellite-B(Met Op-B)and afternoon-orbit Fengyun-3D(FY-3D)microwave observations in the Chinese Meteorological Administration global forecast system(CMA-GFS).The results show that the additional FY-3E microwave temperature sounder-3(MWTS-3)and microwave humidity sounder-2(MWHS-2)data can increase the global coverage of microwave temperature and humidity sounding data by 14.8% and 10.6%,*** enables the CMA-GFS to achieve nearly 100% global coverage of microwave-sounding observations at each analysis ***,after effective quality control and bias correction,the global biases and standard deviations of the differences between observations and model simulations are also *** on the Advanced Microwave Sounding Unit A and the Microwave Humidity Sounder onboard Met Op-B,and the MWTS-2 and MWHS-2 onboard FY-3D,adding the microwave sounding data of FY-3E can further reduce the errors of analysis results and improve the global prediction skills of CMA-GFS,especially for the southern-hemisphere forecasts within 96 hours,all of which are significant at the 95% confidence level.

关键词： data assimilation microwave temperature sounder MWTS-3

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Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying xia.Ming Sun Hai huang Wei-Lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

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Facile preparation of Fe/N-based biomass porous carbon composite towards enhancing the thermal decomposition of DAP-4

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Defence Technology（防务技术） 2024年第1期31卷 288-294页

作者： Er-hai An xia.-xia.Li Cun-juan Yu Ying-xin Tan Zi-jun Fan Qing-xia.Li Peng Deng Xiong Cao School of Environment and Safety Engineering North University of ChinaTaiyuan030051PR China College of Safety and Emergency Management Engineering Taiyuan University of Science and TechnologyTaiyuan030024PR China

Fe/N-based biomass porous carbon composite(Fe/N-p Carbon) was prepared by a facile high-temperature carbonization method from biomass,and the effect of Fe/N-p Carbon on the thermal decomposition of energetic molecular perovskite-based material DAP-4 was *** porous carbonaceous materials was considered as the micro/nano support layers for in situ deposition of Fe/N ***/Np Carbon was prepared simply by the high-temperature carbonization *** was found that it showed the inherent catalysis properties for thermal decomposition of *** heat release of DAP-4/Fe/N-p Carbon by DSC curves tested had increased slightly,compared from DAP-4/Fe/N-p *** decomposition temperature peak of DAP-4 at the presence of Fe/N-p Carbon had reduced by 79°C from384.4°C(pure DAP-4) to 305.4°C(DAP-4/Fe/N-p Carbon-3).The apparent activation energy of DAP-4thermal decomposition also had decreased by 29.1 J/*** possible catalytic decomposition mechanism of DAP-4 with Fe/N-p Carbon was proposed.

关键词： Biomass materials Porous carbon DAP-4 Thermal decomposition Facile method

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