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Chinese Chemical Letters 2011年第4期22卷 477-480页

作者： hong xia Hao hong Zhou Jing Chang Jun Zhu Tian Xin Wei Key Laboratory of Evidence Science(CUPL) Ministry of EducationBeijing 100088China Forensic Sciences Institute Ministry of Public SecurityBeijing 100038China Department of Science Beijing Institute of TechnologyBeijing 100081China

Molecular imprinting technology is applied in surface plasmon resonance spectroscopy for highly sensitive and selective detection of morphine（MO）.As SPR-based sensor of MO,the preparation of molecular imprinted polymer is as follows： methacryhc acids（MAA）,ethylene glycol dimethacrylate（EGDMA）,azodiisobutyronitrile（AIBN） were used as functional monomer,cross-linker and initiator,*** experiment results showed that morphine imprinted polymer had the performance of high sensitivity and specificity,*** relative signal of SPR response was proportional to the concentration of morphine in acetonitrile in the range of 10^（-9）mol/L to 10^（-6）mol/L（1 ppb-1 ppm） with LOD of 10^（-10）mol/L,and MO was distinguished from its analogs,such as codeine.

关键词： Molecular imprinting technique(MIT) Surface plasmon resonance(SPR) Morphine Toxicological analysis

QSPR Studies on lgK_(ow) and lgK_(oc) of Fluorobenzenes and Property Parameters Based on HF and DFT Calculations

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Chinese Journal of Structural Chemistry 2006年第7期25卷 823-829页

作者： ZHANG Xing-Chuan YU Jing WANG Zun-Yao LIU hong-xia College of Biological and Chemical Engineering Jiaxing University Zhejiang 314001 China Department of Material and Chemical Engineering Guilin Institute of Technology Guilin Guangxi 541004 China

Quantum chemistry parameters of 22 fluorobenzenes were computed at six levels using Hartree-Fock and DFT methods. Based on the experimental data of n-octanol/water partition coefficient （lgKow）, a three-parameter （dipole moments （μ）, zero point energy （ZPE） and free energy （G°）） quantitative correlation equation that can predict IgKow was developed using structural and thermodynamic parameters as theoretical descriptors. Similarly, based on experimental data of soil organic carbon sorption coefficient （lgKoc）, the other three-parameter （the most negative atomic net charge of molecule （q^-）, dipole moments （μ） and molecular volume （Vi）） quantitative correlation equation that can predict lgKoc was given. Quantitative correlation equations based on B3LYP/6- 311 G^＊＊ calculation were validated by VIF （variance inflation factors） and t-test and used to predict IgKow and lgKoc of a series of compounds. The result showed that the correlation and prediction ability of lgKoc equations based on three levels of HF/STO-3G, B3LYP/6-31 G^＊ and B3LYP/6- 311G^＊＊ are all more advantageous than those based on AMI.

关键词： fluorobenzene linear solvation energy theory Hartree-Fock density functional theory QSPR n-octanol/water partition coefficient (lgKow) soil organic carbon sorption coefficient (lgKoc)

A Macaca mulatta model of fulminant hepatic failure

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World Journal of Gastroenterology 2012年第5期18卷 435-444页

作者： Ping Zhou Jie xia Gang Guo Zi-Xing Huang Qiang Lu Li Li hong-xia Li Yu-Jun Shi hong Bu Department of Pathology West ChinaHospital Sichuan University Chengdu 610041 Sichuan Prov-ince China Key Labo-ratory of Transplant Engineering and Immunology Ministryof Health West China Hospital Sichuan University Chengdu610041 Sichuan Province China Department of Radiology West China HospitalSichuan University Chengdu 610041 Sichuan Province China Department of Ultrasound West China Hospital Si-chuan University Chengdu 610041 Sichuan Province China National Chengdu Center for Safety Evalua-tion of Drugs West China Hospital Sichuan University Chengdu610041 Sichuan Province China

AIM:To establish an appropriate primate model of fulminant hepatic failure (FHF).METHODS:We have,for the first time,established a large animal model of FHF in Macaca mulatta by intraperitoneal infusion of amatoxin and *** features,biochemical indexes,histopathology and iconography were examined to dynamically investigate the progress and outcome of the animal ***:Our results showed that the enzymes and serum bilirubin were markedly increased and the enzyme-bilirubin segregation emerged 36 h after toxin *** activity was significantly *** deteriorated parenchymal abnormality was detected by magnetic resonance imaging (MRI) and ultrasonography at 48 *** liver biopsy showed marked hepatocyte steatosis and massive parenchymal necrosis at 36 h and 49 h,*** autopsy showed typical yellow atrophy of the *** encephalopathy of the models was also confirmed by hepatic coma,MRI and pathological changes of cerebral *** lethal effects of the extrahepatic organ dysfunction were ruled out by their biochemical indices,imaging and ***:We have established an appropriate large primate model of FHF,which is closely similar to clinic cases,and can be used for investigation of the mechanism of FHF and for evaluation of potential medical therapies.

关键词： Fulminant hepatic failure Macaca mulatta Biochemistry Imaging Pathology

Brain functional network connectivity based on a visual task: visual information processing-related brain regions are significantly activated in the task state

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Neural Regeneration Research 2015年第2期10卷 298-307页

作者： Yan-li Yang hong-xia Deng Gui-yang Xing xiao-luan xia Hai-fang Li School of Computer Science and Technology Taiyuan University of Technology

It is not clear whether the method used in functional brain-network related research can be applied to explore the feature binding mechanism of visual perception. In this study, we inves-tigated feature binding of color and shape in visual perception. Functional magnetic resonance imaging data were collected from 38 healthy volunteers at rest and while performing a visual perception task to construct brain networks active during resting and task states. Results showed that brain regions involved in visual information processing were obviously activated during the task. The components were partitioned using a greedy algorithm, indicating the visual network existed during the resting state.Z-values in the vision-related brain regions were calculated, conifrming the dynamic balance of the brain network. Connectivity between brain regions was determined, and the result showed that occipital and lingual gyri were stable brain regions in the visual system network, the parietal lobe played a very important role in the binding process of color features and shape features, and the fusiform and inferior temporal gyri were crucial for processing color and shape information. Experimental ifndings indicate that understanding visual feature binding and cognitive processes will help establish computational models of vision, improve image recognition technology, and provide a new theoretical mechanism for feature binding in visual perception.

关键词： nerve regeneration functional magnetic resonance imaging resting state task state brain network module division feature binding Fisher’s Z transform connectivity visual stimuli NSFC grants neural regeneration

Fast Wavelet Transform for Toeplitz Matrices and Property Analysis

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Acta Mathematicae Applicatae Sinica 2005年第3期21卷 459-468页

作者： hong-xia Wang Li-zhi Cheng Department of Mathematics & System Science National University of Defense Technology Changsha 410073China

Fast wavelet transform algorithms for Toeplitz matrices are proposed in this paper. Distinctive from the well known discrete trigonometric transforms, such as the discrete cosine transform （DCT） and the discrete Fourier transform （DFT） for Toeplitz matrices, the new algorithms are achieved by compactly supported wavelet that preserve the character of a Toeplitz matrix after transform, which is quite useful in many applications involving a Toeplitz matrix. Results of numerical experiments show that the proposed method has good compression performance similar to using wavelet in the digital image coding. Since the proposed algorithms turn a dense Toeplitz matrix into a band-limited form, the arithmetic operations required by the new algorithms are O（N） that are reduced greatly compared with O（N log N） by the classical trigonometric transforms.

关键词： Wavelet transform Tocplitz matrix fast algorithm

Quantitative Analysis of Non-Crystalline and Crystalline Solids in Blast Furnace Slag

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Journal of Iron and Steel Research International 2011年第1期18卷 8-10页

作者： WANG Hai feng ZHANG Chun-xia QI Yuan hong State Key l.aboratory ot Advanced Steel Processes and Products Central Iron and Steel Research Institute Beijing 100081 China

The granulation of blast furnace slag （BFS） with water quenching treatment has some disadvantages, such as high water consumption and difficulty for recovery heat. So developing a new dry granulation technique to treat BFS is very important. The applicability of BFS directly depends on the content of non-crystalline solids in the slag after treatment. So it is of theoretical and practical significance to analyze the content of non-crystalline solids in the slag quantitatively and simply. Metallographical test is mainly adopted to quantify the non-crystalline in BFS so far with the shortages such as complex sample, difficult determination, ect. The diffraction intensity of non-crystalline is proportionate to the content of non-crystalline in BFS, ~ray diffraction method was adopted to quantify the noncrystalline and the crystalline solids in BFS. The quantitative coefficient between the crystalline and the non-crystalline solids of BFS is 0.70 of BFS whose main composition （mass percent, %） is： CaO 38.2, SiO2 35.7, Al2Oa 16.3, and MgO 8.3. The relative error of X-ray diffractometer for quantitatively analyzing non-crystalline content of BFS is less than 1%.

关键词： blast furnace slag non crystalline crystalline quantitative analysis

Professor Yongjia Duan: a distinguished plant pathologist and agricultural educator

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Protein & Cell 2019年第11期10卷 779-782页

作者： Fei Du Wei-Ping Deng xia-hong He hong Cai You-Yong Zhu State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan Yunnan Agricultural UniversityKunming 650201China Key Laboratory for Agro-biodiversity and Pest Control of Ministry of Education Yunnan Agricultural UniversityKunming 650201China

Professor Yongjia Duan(段永嘉)is a distinguished plant pathologist and agricultural educator in China He has devoted his entire life in developing and sharing his knowl?edge and experiences in Plant *** was born in 1910 in Siping,Jilin *** 1931,he went to Hokkaido University in Japan to study plant pathology,where he obtained his bachelors *** Japan,he met *** Omura,a primary school teacher(Fig.1).They fell in love and got *** 1937,*** and his wife went back to China,hoping that he could contribute to the development of scienee and technology in China.

关键词： has devoted distinguished

Feasibility of herpes simplex virus type 1 mutants labeled with radionuclides for tumor treatment

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World Journal of Gastroenterology 2008年第9期14卷 1321-1325页

作者： Yan-xia Mi Ya-hong Long Yun-Chun Li Department of Nuclear Medicine West China Hospital Sichuan University 37 Guoxue Alley Chengdu 610041 Sichuan Province China

For over one hundred years, viruses have been recognized as capable of killing tumor cells. At present, people are still researching and constructing more suitable oncolytic viruses for treating different malignant tumors. Although extensive studies have demonstrated that herpes simplex virus type 1 (HSV-1) is the most potential oncolytic virus, therapies based on herpes simplex virus type 1 vectors still arouse bio-safety and risk management issues. Researchers have therefore introduced the new idea of treating cancer with HSV-1 mutants labeled with radionuclides, combining radionuclide and oncolytic virus therapies. This overview briefly summarizes the status and mechanisms by which oncolytic viruses kill tumor cells, discusses the application of HSV-1 and HSV-1 derived vectors for tumor therapy, and demonstrates the feasibility and prospect of HSV-1 mutants labeled with radionuclides for treating tumors.

关键词： Oncolytic virus Herpes simplex virus type 1 Mutant Radionuclide Tumor therapy

Updating magnetic resonance imaging of small bowel:Imaging protocols and clinical indications

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World Journal of Gastroenterology 2008年第21期14卷 3403-3409页

作者： Jiong Zhu Jian-Rong Xu hong-xia Gong Yan Zhou Department of Radiology Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China

High soft tissue contrast resolution,acquisition of multi-planar images and the possibility to obtain functional information make magnetic resonance an interesting imaging technique to evaluate the small bowel *** absence of ionizing radiation is an important feature of magnetic resonance imaging(MRI) examinations because inflammatory diseases such as Crohn's disease(CD) are studied most frequently,which are prevalent among children and young ***,using modern equipment and a rigorous technical approach,can offer detailed morphologic information and functional data on the small *** article discusses the MRI protocols for small bowel and the MR imaging findings of small bowel diseases,such as CD and small bowel neoplasms.

关键词： Magnetic resonance imaging Small bowel Crohn's Neoplasm

Membrane materials in the pervaporation separation of aromatic/aliphatic hydrocarbon mixtures—A review

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Chinese Journal of Chemical Engineering 2018年第1期26卷 1-16页

作者： hong-xia Liu Naixin Wang Cui Zhao Shulan Ji Jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering College of Environmental and Energy EngineeringBeijing University of Technology

The separation of aromatic/aliphatic hydrocarbon mixtures is a significant process in chemical industry, but challenged in some cases. Compared with conventional separation technologies, pervaporation is quite promising in terms of its economical, energy-saving, and eco-friendly advantages. However, this technique has not been used in industry for separating aromatic/aliphatic mixtures yet. One of the main reasons is that the separation performance of existed pervaporation membranes is unsatisfactory. Membrane material is an important factor that affects the separation performance. This review provides an overview on the advances in studying membrane materials for the pervaporation separation of aromatic/aliphatic mixtures over the past decade. Explored pristine polymers and their hybrid materials(as hybrid membranes) are summarized to highlight their nature and separation performance. We anticipate that this review could provide some guidance in the development of new materials for the aromatic/aliphatic pervaporation separation.

关键词： Aromatic/aliphatic hydrocarbon mixtures Membrane materials Pervaporation separation