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X-ray excited Mn^(2+)-doped persistent luminescence materials with biological window emission for in vivo bioimaging

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Journal of Rare Earths 2024年第1期42卷 28-35,I0001页

作者： Hanrun Zheng Lin Liu Yi’ang Li Rui Rong Liang Song Junpeng Shi Jing Teng xia sun Yun Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou350002China University of the Chinese Academy of Sciences Beijing100049China xiamen Hospital of Traditional Chinese Medicine Xiamen361015China Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China Fuzhou350108China

In recent years,persistent luminescence materials(PLMs)excited by X-rays and emitting in biological windows have received extensive attention in the field of high-sensitivity bioimaging.Transition metal Mn^(2+)is an ideal emission center,but few studies focus on Mn^(2+)-doped PLMs with X-ray excitation and biological window emission.Here,we report a Mn^(2+)-doped PLM,LiYGeO_(4):Mn^(2+)(LYGM),with excellent biological window persistent luminescence emission.After excitation by UV,LYGM produces a durable biological window of persistent luminescence emission at 660 nm for up to 20 h.More importantly.LYGM can be repeatedly excited by X-rays,resulting in long-term biological window persistent luminescence emission.In addition,we obtain LYGM around 200 nm in diameter by ball milling and centrifugation and improve its biocompatibility by surface modification to apply it to in vivo imaging in mice.After LYGM are injected into mice through the tail vein,in situ excitation of X-rays can be achieved.After the persistent luminescence decays,LYGM can be re-excited for repeated imaging.Therefore,LYGM shows potential prospects for in vivo deep tissue and long-term bioimaging.

关键词： Persistent luminescence X-ray Biological window In vivo imaging Rare earths

Extended survival with metastatic pancreatic cancer under fruquintinib treatment after failed chemotherapy:Two case reports

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World Journal of Clinical Cases 2024年第7期12卷 1296-1304页

作者： Dan Wu Qiong Wang Shuai Yan xia sun Ya Qin Ming Yuan Nan-Yao Wang xian-Ting Huang Department of Oncology Jiangyin People's HospitalWuxi 214400Jiangsu ProvinceChina

BACKGROUND Pancreatic cancer is a highly malignant disease.After decades of treatment progress,the current five-year survival rate for patients is still less than 10%.For later-line treatment,the treatment options are even more limited.Anti-angiogenic drugs can improve progression-free survival in patients with advanced pancreatic cancer.Preclinical data show that fruquintinib might improve the prognosis of advanced pancreatic cancer by targeting angiogenesis and lymphopoiesis,improving the abnormal vascular structure,and modulating the tumour immune microenvironment.CASE SUMMARY We present two cases of third-line fruquintinib monotherapy that brought an extraprolonged progress-free survival(PFS)of 10 months.Patient 1 took adjuvant gemcitabine-based and first-line nab-paclitaxel-based chemotherapy and then used local radiotherapy combined with programmed cell death 1 receptor(PD-1).Each line lasted approximately 7 months.Moreover,the patient took third-line fruquintinib,which was followed by stable disease for 10 months,during which no additional adverse effect was observed.The patient later refused to take fruquintinib due to difficulty urinating and lower abdominal pain after the coronavirus disease 2019(COVID-19)infection.The patient died in February 2023.Patient 2 also took two prior lines of chemotherapy and then local radiotherapy combined with S-1.After confirmed disease progression,the patient experienced a continuous partial response after using fruquintinib monotherapy in the third line.After the patient had COVID-19 in December 2022,fruquintinib was discontinued.The patient died in January 2023 due to disease progression.CONCLUSION Both cases achieved a PFS benefit from later-line single-agent fruquintinib therapy.With its better safety profile,fruquintinib may be worth exploring and studying in more depth as a later-line treatment for pancreatic cancer patients.

关键词： Pancreatic cancer Anti-vascular endothelial growth factor receptor Fruquintinib Case report

Changes in the root system of the herbaceous peony and soil properties under different years of continuous planting and replanting

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Horticultural Plant Journal 2023年第4期9卷 801-810页

作者： Anqi Xie Limin sun Dongliang Zhang Yang Li Zemiao Liu Xue Li xia sun College of Horticulture State Key Laboratory of Crop BiologyShandong Agricultural UniversityTai'anShandong 271018China College of Forestry Shandong Agricultural UniversityTai'anShandong 271018China

The herbaceous peony(Paeonia lactiflora Pall.)has high ornamental value.Replanting problems occur when seedlings are replanted into previous holes.We studied the root system and soil environment of the'Dongjingnvlang'variety under a continuous planting regime of one,four,and seven years,and a replanting regime of one and four years.Under the condition of continuous planting,with the increase of number of years,pH,ammonium nitrogen,and nitrate nitrogen decreased in the rhizosphere and non-rhizosphere soils,whereas organic matter,available phosphorus and potassium,enzyme activities,and the number of bacteria,fungi,and actinomycetes increased.Under the condition of replanting,with the increase of number of years,fungi and actinomycetes in both soils increased,while pH,organic matter,nutrients,enzyme activities,and bacterial number decreased.pH,organic matter,nutrient content,enzyme activity and the number of bacterial were lower in soil replanted for four years,whereas the abundance of fungi and actinomycetes was higher,altering the soil from“bacterial high-fertility”to“fungal low-fertility”with increasing years of replanting.The activity of antioxidant enzymes and MDA content in roots of peony in replanting were higher than those in continuous planting,while the content of osmotic regulatory substances in replanting was lower than that in continuous planting.The results showed that there were no obvious adverse factors in soil during seven years of continuous planting,and herbaceous peony could maintain normal growth and development.However,soils after four years of replanting were not suitable for herbaceous peony growth.Benzoic acid increased with years of replanting,which potentially caused replanting problems.This study provides a theoretical basis for understanding the mechanism of replanting problems in the herbaceous peony.

关键词： Herbaceous peony Replanting problems Continuous planting Soil environment Phenolic acids Paeoniflorin

Calcitriol Suppressed Isoproterenol-induced Proliferation of Cardiac Fibroblasts via Integrinβ3/FAK/Akt Pathway

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Current Medical Science 2023年第1期43卷 48-57页

作者： Xin-feng WANG Qian LI xia sun Li-ming ZHENG Shao-li CHENG Yan-he ZHU Department of Physiology and Pathophysiology School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an710061China Department of Ultrasound the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an710004China Basic Medical Experimental Teaching Center School of Basic Medical SciencesXi’an Jiaotong University Health Science CenterXi’an710061China Institute of Endemic Diseases School of Public HealthXi’an Jiaotong University Health Science CenterXi’an710061China

Objective Cardiac fibroblasts(CFs)proliferation and extracellular matrix deposition are important features of cardiac fibrosis.Various studies have indicated that vitamin D displays an anti-fibrotic property in chronic heart diseases.This study explored the role of vitamin D in the growth of CFs via an integrin signaling pathway.Methods MTT and 5-ethynyl-2′-deoxyuridine assays were performed to determine cell viability.Western blotting was performed to detect the expression of proliferating cell nuclear antigen(PCNA)and integrin signaling pathway.The fibronectin was observed by ELISA.Immunohistochemical staining was employed to evaluate the expression of integrinβ3.Results The PCNA expression in the CFs was enhanced after isoproterenol(ISO)stimulation accompanied by an elevated expression of integrin beta-3(β3).The blockade of the integrinβ3 with a specific integrinβ3 antibody reduced the PCNA expression induced by the ISO.Decreasing the integrinβ3 by siRNA reduced the ISO-triggered phosphorylation of FAK and Akt.Both the FAK inhibitor and Akt inhibitor suppressed the PCNA expression induced by the ISO in the CFs.Calcitriol(CAL),an active form of vitamin D,attenuated the ISO-induced CFs proliferation by downregulating the integrinβ3 expression,and phosphorylation of FAK and Akt.Moreover,CAL reduced the increased levels of fibronectin and hydroxyproline in the CFs culture medium triggered by the ISO.The administration of calcitriol decreased the integrinβ3 expression in the ISO-induced myocardial injury model.Conclusion These findings revealed a novel role for CAL in suppressing the CFs growth by the downregulation of the integrinβ3/FAK/Akt pathway.

关键词： vitamin D cardiac fibroblast proliferation integrin myocardial fibrosis

Spatial variation of lipophilic marine algal toxins and its relationship with physicochemical parameters in spring in Laizhou Bay,China

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Journal of Oceanology and Limnology 2022年第6期40卷 2242-2255页

作者： Xiuping HE Junhui CHEN Jiuming WANG xia sun Ming XIN Baodong WANG Shengkang LIANG Marine Bioresource and Environment Research Center Key Laboratory of Marine Eco-Environmental Science and TechnologyFirst Institute of OceanographyMinistry of Natural ResourcesQingdao 266061China Laboratory for Marine Ecology and Environmental Science Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Qingdao Key Laboratory of Analytical Technology Development and Standardization of Chinese Medicines Qingdao 266590China Shandong University of Science and Technology Qingdao 266590China Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationOcean University of ChinaQingdao 266100China

Lipophilic marine algal toxins(LMATs)are produced by some toxigenic microalgae,which pose a serious threat to marine ecosystem and even human health.The occurrence and environmental control factors of LMATs in the surface seawater and phytoplankton in spring in Laizhou Bay in which Huanghe(Yellow)River estuary is included,in Shandong,East China were investigated.Okadaic acid(OA),pectenotoxin-2(PTX2),dinophysistoxin-1(DTX1),pectenotoxin-2 seco acid(PTX2 SA),DTX2,7-epi-PTX2 SA,PTX11,and 13-desmethyl spirolide C(SPX1)were detected from the surface seawater samples,and PTX2,7-epi-PTX2 SA,OA,DTX2,DTX1,PTX2 SA,and PTX11 were discovered in the phytoplankton samples showed a decreasing trend.The concentrations of∑LMATs in the seawater and phytoplankton ranged 2.03-74.38 ng/L on average of 13.72 ng/L and 0.98-479.27 pg/L on average of 50.20 pg/L,respectively.The joint influence of terrigenous input and internal circulation could promote the growth,toxin production,and toxin release of toxin-producing algae,leading to a higher content of LMATs in the bay nearby the Huanghe River estuary in both seawater and phytoplankton.The concentration of LMATs in spring was higher than that in summer,showing obvious seasonal variation.In addition,no significant correlation between most of the physiochemical parameters and LMAT contents in seawater was revealed by correlation analysis except for the positive correlation between DTX2 and chlorophyll a,OA and NH4-N.However,the increase of dissolved inorganic nitrogen content in seawater could enhance the production of OA,DTX1,and DTX2 in phytoplankton due probably to that the inorganic N input could benefit the growth and stimulate toxin production of toxin-producing algae.The result also proved that some PTX2 may be originated from Procentrum spp.and OA,DTXs and part of PTX2 may be originated from Dinophysis spp.

关键词： lipophilic marine algal toxin Laizhou Bay seawater phytoplankton environmental factor

Highly-sensitive electrochemiluminescence biosensor for detection of inosine monophosphate in meat based on graphdiyne/AuNPs/luminol nanocomposites

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Food Science and Human Wellness 2023年第4期12卷 1149-1156页

作者： Jing Liu Yizhong Shen Guangxian Wang Yaodong xiang Yemin Guo xia sun Yuan Liu School of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255049China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China

Inosine monophosphate(IMP),as a critical umami substance,is one of the most important indicators for evaluating the quality of meat products.Here,a sensitive electrochemiluminescence(ECL)biosensor based on graphdiyne(GDY)/AuNPs/luminol nanocomposites was constructed to detect IMP.The GDY/AuNPs/luminol nanocomposites were synthesized by using simple one-pot method.GDY utilized its 2D framework to disperse and fix gold nanoparticles,which inhibited the agglomeration of gold nanoparticles and greatly improved its stability and catalytic properties.Importantly,GDY/AuNPs/luminol nanocomposites showed excellent catalytic ability and superior ECL activity towards luminol-H_(2)O_(2) systems due to the synergistic effect of GDY and AuNPs.Under optimal conditions,the prepared biosensor exhibited a wide linear range from 0.01 g/L to 20 g/L,a satisfactory limit detection of 0.0013 g/L,as well as an excellent specificity.Moreover,we carried out the precise analysis of IMP in actual meat samples with acceptable results compared to the liquid chromatography.We believe that this work could offer an efficient ECL platform for accurate and reliable report of IMP levels,which is significant for maintaining food quality and safety.

关键词： Inosine monophosphate(IMP) Electrochemiluminescence Graphdiyne(GDY)/AuNPs/luminol Bienzyme

Predictors of angle widening after laser iridotomy in Chinese patients with primary angle-closure suspect using ultrasound biomicroscopy

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International Journal of Ophthalmology(English edition) 2022年第2期15卷 233-241页

作者： Xue-Ting Pei Shu-Hua Wang xia sun Hong Chen Bing-Song Wang Shu-Ning Li Tao Wang Beijing Tongren Eye Center Beijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology and Visual Science Key LaboratoryBeijing 100730China

AIM:To assess the predictive value of baseline parameters of ultrasound biomicroscopy(UBM) for angle widening after prophylactic laser peripheral iridotomy(LPI) in patients with primary angle-closure suspect(PACS).METHODS:Angle-opening distance(AOD),trabecular iris angle(TIA),iris thickness,trabecular-ciliary process angle,and trabecular-ciliary process distance were measured using UBM performed before and two weeks after LPI.Iris convexity(IC),iris insertion,angulation,and ciliary body(CB) size and position were graded.Uni-and multivariate regression analyses were used to determine factors predicting the change in AOD(ΔAOD500,calculated as an angle width change before and after LPI) in all quadrants and in subgroup quadrants based on IC.RESULTS:In 94 eyes of 94 patients with PACS,LPI led to angle widening with increases in AOD500 and TIA(P<0.01).Multivariable regression analysis showed that IC(P<0.001),CB position(P=0.007) and iris insertion(P=0.049) were significantly predictive for ΔAOD500.All quadrants were categorized into extreme IC(27.8%),moderate IC(62.3%),and absent IC(9.9%) subgroups.The AOD500 increased by 220% and no other predictive factor was found in the extreme IC quadrants.The AOD500 increased by 55%,and baseline iris angulation was predictive for smaller changes in ΔAOD500 in the moderate IC quadrants.CONCLUSION:In PACS patients,quadrants with greater iris bowing predict substantial angle widening after LPI.Quadrants with a flatter iris,anteriorly positioned CB,and basal iris insertion are associated with less angle widening after LPI.Quadrants with iris angulation as well as a flatter iris configuration predict a smaller angle change after LPI.

关键词： laser peripheral iridotomy angle opening distance ultrasound biomicroscopy iris convexity iris angulation

Rapid CO_(2)-laser scribing fabrication of an electrochemical sensor for the direct detection of Pb^(2+) and Cd^(2+)

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Nano Research 2023年第5期16卷 7671-7681页

作者： Guanglei Chu Yanyan Zhang Zhongrui Zhou Weixuan Zeng Dongfei Chen Siping Yu Jiemin Wang Yemin Guo xia sun Ming Li Hunan Agricultural Equipment Research Institute Hunan Academy of Agricultural SciencesChangsha 410125China School of Agriculture Engineering and Food Science Shandong University of TechnologyZibo 255049China School of Chemistry University of New South WalesSydneyNSW 2052Australia Hunan Rice Research Institute Hunan Academy of Agricultural SciencesChangsha 410125China Longping Branch College of BiologyHunan UniversityChangsha 410125China Department of Materials Science and Engineering National University of SingaporeNo.21 Lower Kent Ridge RoadSingapore 119077Singapore

Laser-induced graphene(LIG)is a highly promising preparation material for electrochemical sensors;however,its preparation speed and nanomaterial modification steps significantly limit its mass production.Herein,this study proposed a new laser printing strategy that considerably improved the preparation speed of LIG with excellent electrochemical performance.Using the optimal parameters(laser power of 1%,scribing spacing of 0.12 mm,scribing speed of 100 mm·s^(−1)),it took only 14.2 s to complete the preparation of the detection electrode.Thus,we successfully detected Cd^(2+)and Pb^(2+)without any toxic reagents or electrode modification steps.The limits of detection of the sensor were 0.914 and 0.916μg·L^(−1)for Cd^(2+)and Pb^(2+),respectively,which are significantly lower than the required values for drinking-water quality,according to the World Health Organization guidelines.This study provides a novel approach for the rapid detection of heavy-metal ions.

关键词： laser-induced graphene electrochemical sensor rapid fabrication heavy-metal ions

Advanced Mathematics in Vocational Universities

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Journal of Contemporary Educational Research 2022年第6期6卷 13-18页

作者： xia sun Yuan Yang Department of Public and Basic Education Yunnan Open UniversityKunming 650500Yunnan ProvinceChina College of Communication and Information Engineering Yunnan Open UniversityKunming 650500Yunnan ProvinceChina

Science and technology are advancing at a breakneck pace.Only individuals with strong mathematical skills and knowledge will be able to adapt to social development and progress.However,advanced mathematics education is often neglected in vocational universities.Student and conceptual factors are invariably to blame.Therefore,it is urgent to improve the teaching quality of advanced mathematics in vocational universities.In improving the teaching quality,it is necessary to change the teaching mode,advocate interest in learning,emphasize on the cultivation of students’skills during teaching,implement stratified teaching,lay emphasis on mathematical models,and strengthen the evaluation and assessment of students.

关键词： Advanced mathematics Vocational education Vocational university