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Expression of programmed death 1 and its ligands in the liver of autoimmune hepatitis C57BL/6 mice

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Chinese Medical Journal 2009年第16期122卷 1941-1946页

作者： CAO Jin LIU Feng-xia YU meng-xue Department of Rheumatology Peking Union Medical College Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100730 China

Background Autoimmune hepatitis （AIH） is a chronic inflammatory liver disease with unknown etiology. Programmed death 1 （PD-1） and its ligands （PD-L1 and PD-L2）, BT-H1/PD-L1 and B7-DC/PD-L2, are new CD28-B7 family members that are involved in the regulation of immune responses. Previous observation suggests that PD-1 system plays an inhibitory role in regulating peripheral blood T cells, B cells and myeloid cells, thus their abnormality may be related to autoimmune diseases. This study aimed to explore the role of PD-1/PD-L1, L2 system in the pathogenesis of AIH. Methods The mice model of experimental autoimmune hepatitis （EAH） was established in C57BL/6 mice and the expression levels of PD-1 and PD-L1, L2 in the murine liver and the cytokines, including interferon （IFN）-γ, tumor necrosis factor （TNF）-α and interleukin （IL）-4 in the spleen were detected using reverse transcription-polymerase chain reaction （RT-PCR）, and the results were compared with those of normal controls. Results The expression levels of PD-1, PD-L1, PD-L2 mRNA were higher in EAH compared with normal controls （P 〈0.05）, the PD-L2/PD-1 ratio was relatively lower in EAH （EAH -0.08±0.35, normal controls 0.52±0.07, P=0.009）. In the EAH, the expression of the three cytokines were all upregulated compared with normal controls. PD-L1 had a positive correlation with the expression of IFN-γ （r =0.289, P 〈0.05）, while PD-L2 showed a positive correlation with both expressions of IL-4 （r=0.378, P 〈0.01） and IFN-γ （r =0.261, P 〈0.05）. While TNF-α showed no correlation with PD-L1 （r=0.044, P=0.736） or PD-L2 （r=0.127, P=0.335）. Conclusions The expression of PD-1/PD-L1, L2 is upregulated in EAH and regulated by IFN-γ and IL-4. PD-1 system may play an important role in the pathogenesis of AIH.

关键词： autoimmune hepatitis programmed death 1 programmed death 1 ligands reverse transcription-polymerase chain reaction cytokine

Five patients in a Chinese family with multiple epiphyseal dysplasia

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Chinese Medical Journal 2009年第17期122卷 2076-2078页

作者： LIU Feng-xia YU meng-xue LI Yong-zhe CAO jin Depaitment of Rheumatology Peking Union Medical CollegeHospital Peking Union Medical College & Chinese Academy ofMedical Sciences Beijing 100730 China

Multiple epiphyseal dysplasia （MED） is an .osteochondrodysplasia characterized clinically by mild short stature and early-onset degenerative joint disease and radiographically by epiphyseal hypoplasia/ dysplasia. However, the intelligence of the patients is within the normal range. We report a rare case of a MED family with five affected individuals seen in 2009 as follows.

关键词： multiple epiphyseal dysplasia gene mutation

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临空经济对区域金融影响的差异分析

华东经济管理 2018年第8期32卷 72-79页

作者：刘霞孟雪珂郑州大学商学院河南郑州450001

文章选取东部、中西部21个空港城市2007-2016年的面板数据,试图利用Panel Data模型、门限回归模型、面板分位数模型和空间面板模型,从不同角度探究临空经济对区域金融影响的差异。实证结果显示,临空经济对东部区域金融的促进作用大于中... 详细信息

文章选取东部、中西部21个空港城市2007-2016年的面板数据,试图利用Panel Data模型、门限回归模型、面板分位数模型和空间面板模型,从不同角度探究临空经济对区域金融影响的差异。实证结果显示,临空经济对东部区域金融的促进作用大于中西部区域,东部区域的旅客吞吐量、货邮吞吐量、起降架次均对其金融业产值有显著的正向作用,中西部区域的旅客吞吐量、起降架次对其金融业产值的促进作用比较大,而货邮吞吐量的影响则不显著。东部、中西部临空产业指标对金融业产值的影响较小。进一步利用空间面板模型考察各地区金融发展水平的空间依赖性,东部区域金融发展水平呈现正自相关特征,中西部区域为负自相关特征;通过估计合适的空间面板模型发现,临空经济对区域金融的空间效应在样本期内还不是很显著。最后结合实证结论提出了差异性措施。

关键词：临空经济区域金融差异分析面板模型

Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI Ke XIE meng xia Huarong CHENG Anyu LIU Yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing Key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing xue Yuejia Ma Ke Ye xue Zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang Qing xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

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区间线性不等式组的AE区间解

高校应用数学学报（A辑） 2024年第4期39卷 485-492页

作者：夏梦雪李好好中国人民解放军陆军炮兵防空兵学院基础部安徽合肥230000 浙江财经大学数据科学学院浙江杭州310018

区间线性系统中描述问题的参数带有不确定性,因而在工程及科技实践中更具有实际应用价值和理论研究意义.文中主要探讨区间不等式系统的区间解问题,首次基于逻辑量词提出AE区间解的概念,并刻画了区间线性不等式系统AE区间解的解集特征.... 详细信息

区间线性系统中描述问题的参数带有不确定性,因而在工程及科技实践中更具有实际应用价值和理论研究意义.文中主要探讨区间不等式系统的区间解问题,首次基于逻辑量词提出AE区间解的概念,并刻画了区间线性不等式系统AE区间解的解集特征.主要结果涵盖了区间线性不等式系统中若干类型区间解的既有判别条件为其特例,为统一研究约束域为区间线性不等式组的区间优化问题提供了重要的理论基础.

关键词：区间系统区间线性不等式组 AE区间解

Recombinant chitinase-3-like protein 1 alleviates learning and memory impairments via M2 microglia polarization in postoperative cognitive dysfunction mice

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Neural Regeneration Research 2025年第9期20卷 2727-2736页

作者： Yujia Liu xue Han Yan Su Yiming Zhou Minhui Xu Jiyan Xu Zhengliang Ma xiaoping Gu Tianjiao xia Department of Anesthesiology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina Medical School Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory of Molecular Medicine Nanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology Zhongshan HospitalFudan UniversityShanghaiChina

Postoperative cognitive dysfunction is a seve re complication of the central nervous system that occurs after anesthesia and surgery,and has received attention for its high incidence and effect on the quality of life of *** date,there are no viable treatment options for postoperative cognitive *** identification of postoperative cognitive dysfunction hub genes could provide new research directions and therapeutic targets for future *** identify the signaling mechanisms contributing to postoperative cognitive dysfunction,we first conducted Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the Gene Expression Omnibus GSE95426 dataset,which consists of mRNAs and long non-coding RNAs differentially expressed in mouse hippocampus3 days after tibial *** dataset was enriched in genes associated with the biological process"regulation of immune cells,"of which Chill was identified as a hub ***,we investigated the contribution of chitinase-3-like protein 1 protein expression changes to postoperative cognitive dysfunction in the mouse model of tibial fractu re *** were intraperitoneally injected with vehicle or recombinant chitinase-3-like protein 124 hours post-surgery,and the injection groups were compared with untreated control mice for learning and memory capacities using the Y-maze and fear conditioning *** addition,protein expression levels of proinflammatory factors(interleukin-1βand inducible nitric oxide synthase),M2-type macrophage markers(CD206 and arginase-1),and cognition-related proteins(brain-derived neurotropic factor and phosphorylated NMDA receptor subunit NR2B)were measured in hippocampus by western *** with recombinant chitinase-3-like protein 1 prevented surgery-induced cognitive impairment,downregulated interleukin-1βand nducible nitric oxide synthase expression,and upregulated CD206,arginase-1,pNR2B,and brain-derived neurotropic factor expr

关键词： Chil1 hippocampus learning and memory M2 microglia neuroinflammation postoperative cognitive dysfunction(POCD) recombinant CHI3L1

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区间凸二次规划问题弱最优解的判别

高师理科学刊 2017年第10期37卷 8-11页

作者：夏梦雪陆军军官学院基础部安徽合肥310018

基于凸二次规划中的KKT条件,讨论了带区间数的凸二次规划的最优解问题.针对约束域为不等式且变量有符号限制的区间凸二次规划,给出了检验弱可行解是否为弱最优解的充要条件.

关键词：区间凸二次规划弱最优解 KKT条件

An ultra-wideband circularly polarized microstrip patch antenna loaded with split-ring resonator

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Optoelectronics Letters 2025年

作者： WANG Shike xia Dan Lü Lianrong QIN Juan WANG meng REN Haiping School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In this paper， the effect of a single-opening split-ring resonator （SRR） structure on the performance of ultra-wideband （UWB） microstrip patch antenna （MPA） is studied. Here a UWB MPA based on partial grounding is proposed， and the SRR structure is utilized to optimize other characteristics of the low-profile microstrip antenna while ensuring the bandwidth and gain remain unchanged. The proposed metamaterial structure， consisting of a 2 × 2 array of SRR， is loaded on the reverse side of the substrate. The volume of the proposed antenna is 61.6×67.6×1.5mm3. According to simulation and experimental results， the proposed microstrip antenna loaded with 2×2 SRRs performs better than that without SRR structure. It produces an operating band of 1.62 GHz-8 GHz while achieving circular polarization characteristics with an axial ratio （AR） bandwidth of 3.92 GHz-4.57 GHz. In addition， the performance of the proposed antenna is superior to relevant works of literature The antenna can be widely utilized in wireless communication systems.

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