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茜草色素光泽汀与DNA相互作用机理的研究

现代食品科技 2014年第12期30卷 43-47,132页

作者：高颜李军生王倩倩李蔚仑黄国霞闫柳娟广西科技大学生物与化学工程学院广西柳州545006

在p H 7.41的生理条件下,以溴化乙锭(EB)作为光谱探针,采用紫外可见光谱和荧光光谱等方法对茜草色素光泽汀(Luc)与DNA的相互作用机理做了初步探讨。同时还研究了光泽汀对DNA分子的热变性以及粘度影响。在碘化钾(KI)效应实验中,以碘化钾... 详细信息

在p H 7.41的生理条件下,以溴化乙锭(EB)作为光谱探针,采用紫外可见光谱和荧光光谱等方法对茜草色素光泽汀(Luc)与DNA的相互作用机理做了初步探讨。同时还研究了光泽汀对DNA分子的热变性以及粘度影响。在碘化钾(KI)效应实验中,以碘化钾作为荧光猝灭剂探讨光泽汀与DNA分子之间的相互作用方式。循环伏安法法研究光泽汀在玻碳电极上的电化学规律,根据循环伏安曲线及溴化乙锭对光泽汀与DNA作用的影响,推断光泽汀与DNA主要作用方式为嵌插。结果显示:光泽汀与DNA之间相互作用的结合比为n(Luc):n(DNA)=2:1,Luc-DNA复合物的表观摩尔吸光系数ε=8.12×104 L/(mol·cm)。在光泽汀存在的条件下,DNA分子的热变性温度和粘度都会增加,并且在碘化钾效应实验中可降低碘化钾的荧光猝灭效应,同时Luc的电化学变化规律同EB相似。在本实验条件下,光泽汀与DNA分子之间的相互作用方式存在嵌插。

关键词：光泽汀光谱法循环伏安法嵌插机理

A Green Synthesis of 2-Ethylanthraquinone by Dehydration of 2-(4'-ethylbenzoyl) benzoic Acid over Solid Acid Catalysts

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Chinese Chemical Letters 2005年第12期16卷 1587-1589页

作者： Ren Shu XU Xin Wen guo Gui Ru WANG Zhu xia ZHANG State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012

The dehydration of 2-（4＇-ethylbenzoyl） benzoic acid （BE acid） to 2-ethylanthraquinone （2-EAQ） was investigated over solid acid catalysts. The results showed that H-beta zeolite catalyst modified by dilute HNO3 solution exhibited an excellent performance. In our study, the conversion of BE acid can reach 96.7%, and the selectivity to 2-EAQ is up to 99.6%.

关键词： 2-Ethylanthraquinone 2-(4'-ethylbenzoyl) benzoic acid H-beta dehydration

中医药对HIV/AIDS合并慢性非传染性疾病的实践与探讨

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时珍国医国药 2024年第5期35卷 1211-1214页

作者：刘梅君宋夕元郭润泽雷颀郝明玲金书情孟鹏飞马秀霞岳静宇胡之纲徐立然河南中医药大学河南郑州450000 河南中医药大学第一附属医院河南郑州450003 河南省中医药防治病毒性疾病重点实验室河南郑州450008 河南省中医中药治疗艾滋病项目办公室河南郑州450003

目的ART疗法的普及应用使得HIV/AIDS患者的生存率显著提升、预期寿命延长。随着HIV/AIDS患者出现老龄化,该病合并慢性非感染性疾病的患病率逐年上升,艾滋病防治工作依然严峻。既往研究表明中医药在防治艾滋病和慢性疾病方面有显著优势,... 详细信息

目的ART疗法的普及应用使得HIV/AIDS患者的生存率显著提升、预期寿命延长。随着HIV/AIDS患者出现老龄化,该病合并慢性非感染性疾病的患病率逐年上升,艾滋病防治工作依然严峻。既往研究表明中医药在防治艾滋病和慢性疾病方面有显著优势,文章通过分析HIV/AIDS合并心血管疾病、慢性阻塞性肺疾病、高脂血症、糖尿病、恶性肿瘤等常见的慢性非传染性疾病的研究现状,探讨中医药防治HIV/AIDS合并常见的慢性非传染性疾病目前存在的问题,并提出了相应的对策,以期为深入开展中医药防治HIV/AIDS合并慢性非感染性疾病的研究提供依据及参考。

关键词：人类免疫缺陷病毒艾滋病(获得性免疫缺陷综合征) 慢性非传染性疾病中医药心血管疾病慢性阻塞性肺疾病高脂血症糖尿病肾脏疾病恶性肿瘤

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周鹏治疗血瘀型寻常型银屑病经验及皮肤镜征象分析

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广州中医药大学学报 2024年第8期41卷 2109-2115页

作者：石国傲陈锐明吉祥李仲贤熊永琴周夏芸李晶晶(指导) 周鹏(指导) 广州中医药大学第七临床医学院/深圳市宝安中医院集团广东深圳518133 广州中医药大学针灸康复临床医学院广东广州510006

总结周鹏教授治疗血瘀型寻常型银屑病的经验。通过深入探讨寻常型银屑病的病理特点,强调本病通常表现为虚实夹杂,导致频繁复发,并持久难治,进而可能引发患者的心理和情绪问题。阐述了血瘀对银屑病发病机制、病程进展及预后的影响,并提... 详细信息

总结周鹏教授治疗血瘀型寻常型银屑病的经验。通过深入探讨寻常型银屑病的病理特点,强调本病通常表现为虚实夹杂,导致频繁复发,并持久难治,进而可能引发患者的心理和情绪问题。阐述了血瘀对银屑病发病机制、病程进展及预后的影响,并提出了结合岭南火针和毫针针刺技术治疗寻常型银屑病血瘀证的新方法。周鹏教授认为本病的治疗原则是“调神为先,理血为本,辨证祛邪”,旨在综合考虑病因与症状,以期达到更有效的治疗结果。结合皮肤镜征象分析,以一种新的视角,对寻常型银屑病的治疗提供了可能的改进方向。

关键词：岭南火针调神固本针法寻常型银屑病血瘀型皮肤镜征象周鹏名医经验

Epigallocatechin-3-gallate Modulates MicroRNA Expression Profiles in Human Nasopharyngeal Carcinoma CNE2 Cells

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Chinese Medical Journal 2017年第1期130卷 93-99页

作者： Bin-Bin Li guo-Liang Huang Hua-Hui Li xia Kong Zhi-Wei He Department of Pathophysiology Guangdong Medical University Dongguan Guangdong 523808 China Sino-American Cancer Research Institute Key Laboratory for Medical Diagnostics of Guangdong Province Guangdong Medical University Dongguan Guangdong 523808 China

Background： Epigallocatechin-3-gallate （EGCG） has exhibited antitumor properties in several types of cancers, including nasopharyngeal carcinoma （NPC）, but the molecular mechanisms underlying this function remain incompletely understood. The aim of the present study was to characterize the global impact of EGCG on the expression of microRNAs （miRNAs） in NPC cells. Methods： Using microarray analysis, the alterations of miRNA expression profiles were investigated in EGCG-treated CNE2 cells. Furthermore, the target genes and signaling pathways regulated by EGCG-specific miRNAs were identified using target prediction program and gene ontology analysis. Results： A total of 14 miRNAs exhibited 〉2-fold expression changes in a dose-dependent manner after treatment with 20 μmol/L and 40 μmol/L EGCG. Totally 43, 49, and 52 target genes from these differentially expressed miRNAs were associated with the apoptosis, cell cycle regulation, and cell proliferation, respectively. A total of 66 signaling pathways, primarily involved in cancer development and lipid and glucose metabolism, were shown to be regulated by EGCG-specific miRNAs. Conclusion： EGCG induces considerable alterations of miRNA expression profiles in CNE2 cells, which provides mechanistic insights into cellular responses and antitumor activity mediated by EGCG.

关键词： Antitumor Agents Epigallocatechin-3-gallate MicroRNAs Nasopharyngeal Carcinoma

Outcomes of 4 surgical adjuvants used for internal limiting membrane peeling in macular hole surgery: a systematic review and network Meta-analysis

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 481-487页

作者： xia-Wei Wang Yan Long Yang-Shun Gu Dong-Yu guo Department of Ophthalmology the First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

AIM:To compare the outcomes of four adjuvants used for internal limiting membrane(ILM)peeling in macular hole surgery,including indocyanine green(ICG),brilliant blue G(BBG),triamcinolone(TA)and trypan blue(TB),through systematic review and random-effects Bayesian network ***:PubMed,Cochrane library databases and Web of Science were searched until August 2018 for clinical trials comparing the above four *** for postoperative best corrected visual acuity(BCVA)improvement and primary macular hole closure rates were compared between the different ***:Twenty-seven eligible articles were *** postoperative BCVA improvement,results of BBGassisted peeling were significantly more favorable than those of ICG(WMD 0.08,95%credible interval 0.01-0.16)and TA ranked *** significant differences were found between any other two groups in postoperative BCVA *** postoperative primary macular hole closure rates,BBG ranked ***,no significant differences were shown between any two ***:TA and BBG are the optimum adjuvants for achieving postoperative BCVA improvement macular hole surgery with adjuvant-assisted ILM *** all adjuvants,the use of BBG is associated with the highest postoperative macular hole closure rate.

关键词： internal limiting membrane surgical adjuvants best corrected visual acuity improvement primary macular hole closure rate network Meta-analysis

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杂交糯高粱新品种引种试验

现代农业科技 2010年第19期 50-51页

作者：任健朱建忠宋其龙梁明清郭声楷魏新琦罗莹夏万国四川省泸州市粮油作物站四川泸州646000 合江县农技站

引进了多个杂交糯高粱新品种,进行了品种比较试验。结果表明,泸糯8号、泸糯10号产量比常规高粱增产50%以上,出酒率提高0.6个百分点,适宜在川南地区推广种植。

关键词：杂交糯高粱新品种引种试验农艺性状产量出酒率

Influence of(Mg_(1/3)Nb_(2/3))complex substitutions on crystal structures and microwave dielectric properties of Li2TiO3 ceramics with extreme low loss

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Journal of Materiomics 2018年第4期4卷 368-382页

作者： Huan-Huan guo Di Zhou Li-xia Pang Jin-Zhan Su Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education&International Center for Dielectric ResearchSchool of Electronic and Information EngineeringXi'an Jiaotong UniversityXi'an710049China Micro-optoelectronic Systems Laboratories Xi'an Technological UniversityXi'an710032ShaanxiChina International Research Centre for Renewable Energy State Key Laboratory of Multiphase Flow in Power EngineeringXi'an Jiaotong UniversityXi'anShaanxi710049China

A systematic investigation of the Li2Ti1-x(Mg_(1/3)Nb_(2/3))xO_(3)(0.1≤x≤0.35)solid solutions synthesized by traditional solid-state reaction method is reported in this *** the composition range of 0.1≤x≤0.25,a monoclinic rock salt structured solid solution was *** x increased to 0.3,a phase transition from monoclinic to cubic phase,along with an order-disorder phase transition,was *** x increased from 0.1 to 0.35,the microwave permittivity(εr)and temperature coefficient of resonant frequency(TCF)of the Li2Ti1-x(Mg_(1/3)Nb_(2/3))xO_(3)ceramics decreased linearly from 21.0 to 18.6,+27.1 to-19.4 ppm/℃,*** Li_(2)Ti_(0.75)(Mg_(1/3)Nb_(2/3))0.25O_(3)ceramic sintered at 1170℃shows high performance of microwave dielectric properties with aεr~19.6,a Qf(Q=quality factor=1/dielectric loss;f=resonant frequency)~109,770 GHz(at 7.7 GHz)and a near zero TCF~t 1.2 ppm/℃.Moreover,the burying sintering process can reduce the volatilization of lithium so that the porosity of Li_(2)Ti_(0.75)(Mg_(1/3)Nb_(2/3))0.25O_(3)ceramic was reduced effectively,which made Li_(2)Ti_(0.75)(Mg_(1/3)Nb_(2/3))0.25O_(3)ceramic promising for future *** area electron diffraction patterns,high-resolution transmission electron microscopy,Raman and far-infrared spectra were employed to study the relation between crystal structure and microwave dielectric properties in detail.

关键词： Microwave dielectric properties Phase evolution Crystal structure High quality

Ultrasonic elastography in clinical quantitative assessment of fatty liver

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World Journal of Gastroenterology 2010年第37期16卷 4733-4737页

作者： Yin-Yan Li Xue-Mei Wang Yi-xia Zhang guo-Cheng Ou Department of Ultrasonic Diagnosis the First Af��liated Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

AIM: To investigate the clinical application of ultrasonic elastography in quantitative assessment of fatty liver grading. METHODS: A total of 105 patients with fatty liver were divided into mild group (n = 46), moderate group (n = 39), and severe group (n = 20). Forty-five healthy individuals served as a normal control group. All patients who underwent routine ultrasound scan and further ultrasonic elastography were evaluated accordingly to the evaluation standards for ultrasonic elastography. The ratio of surface areas of blue region/total surface area in the desired region was measured. RESULTS: Ultrasonic elastography technique, in comparison to traditional ultrasound, had a rather high consistence in grading of fatty liver [κ value = (95.3%63.6%)/(1%-63.6%) = 0.87, P = 0.001]. The score of ultrasonic elastography increased with the severity of fatty liver with a sensitivity of 97.14% and a specificity of 91.11%. A significant difference was found in the ratio of surface areas of blue regions between different groups (P < 0.05).CONCLUSION: Ultrasonic elastography can be used in quantitative assessment of the severity of fatty liver.

关键词： Transient elastography Ultrasonic elastography evaluation Fatty liver Quantitative diagnosis Grading of fatty liver